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| | Reprogenetics: Everything associated with PGD: preimplantation genetic diagnosis - pgd |
 | | The concern regarding having a balanced translocation is that, though the individual is healthy, the egg or sperm of that individual can have an unbalanced chromosome make-up that leads to the resultant embryo or pregnancy being unbalanced. | | | This team has developed most of the techniques involved in PGD of translocations and has performed the most procedures of PGD of translocations. | | | Individuals with balanced translocations typically have no medical issues though some do have fertility concerns, such as reduced fertility. |
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http://www.reprogenetics.com/pgd_translocation.html
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| | Chromosome Translocation |
| | Statistics would suggest that 50 percent of the eggs would likely generate unbalanced translocations, 25 percent would be balanced translocations (like you) and 25 percent would be normal. | | | This condition is not like having an extra or missing chromosome. | | | This condition is not related to a woman's age. |
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http://health.ivillage.com/infertility/0,,5n04-p,00.html
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| | Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse |
| | By this means the translocation could be induced at different time points during development or in adult animals, and consequences monitored over time. | | | These results are consistent with previous experiments utilizing the Nes−Cre1 mouse, where recombination of floxed alleles has been demonstrated in various tissues including the spinal cord, muscle and germ cells (Bates et al., 1999; Trumpp et al., 1999). | | | We targeted introns that were frequently found to be the point of translocation in many human AMLs. |
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http://www.nature.com/embor/journal/v1/n2/full/embor610.html
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| | APPARENT ABSENCE OF BCL-2 REARRANGEMENT IN TEN SAUDI FOLLICULAR LYMPHOMAS: A PRELIMINARY REPORT: 14(3) |
| | In a study of 211 malignant lymphomas published from our laboratory, only six (3%) follicular lymphomas were encountered.26 This is in sharp contrast to the studies published from the Western countries where the follicular lymphoma may represent up to 50% of the malignant lymphomas. | | | We also used mcr and consensus JH primers to further analyze the possibility of translocation through a minor cluster region. | | | By contrast, the results from our study failed to reveal bcl-2 translocation in any of the follicular lymphomas through mbr (Figure 3) and mcr. |
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http://www.kfshrc.edu.sa/annals/143/93124.html
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| | Chromosome Translocations |
| | Many couples in which one member is a translocation carrier have experienced miscarriages or have had to face difficult decisions when learning about a pregnancy with an “unbalanced” result. | | | Polar body testing focuses on the maternal contribution, and is an earlier method of testing. | | | PGD can reduce the likelihood of couples having to deal with these particular circumstances. |
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http://www.reproductivegenetics.com/translocations.html
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| | [No title] |
| | Even the conventional G-banding techniques can be used in cases were the coarse detection of the translocation is regarded as sufficient. | | | Preferable methods are those suitable for use in clinical laboratories, such as MFISH and SKY. | | | A method of claim 10, characterized in that the detection is performed with multi-fluor |
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http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=03/66898.030814&ELEMENT_SET=DECL
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| | Figures |
| | All of these molecules are intracellular, so therapeutics must be designed to work in the intracellular milieu. | | | Chromosomal Translocation Products Engender New Intracellular Therapeutic Technologies | | | Mouse models of chromosomal translocation are essential for objective assessment of potential therapeutic reagents before clinical application. |
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http://www.medscape.com/content/2003/00/45/22/452202/452202_fig.html
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| | Fox Chase Cancer Center: Office of Business Development |
| | The end result is an aberrant pattern of bcl-2 expression, usually expressed at much higher levels due to the strong immunoglobulin promoter. | | | New, more effective delivery vehicles will lead to an in vivo therapy based on tumor-specific antisense oligonucleotides. | | | Further, this technique can be applied to targeting chromosomal translocations associated with other malignancies. |
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http://www.fccc.edu/techtransfer/techbriefs/Bcl2-2.html
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| | The invertor knock-in conditional chromosomal translocation mimic - Nature Methods |
| | The invertor knock-in conditional chromosomal translocation mimic - Nature Methods | | | A conditional version of the original knock-in approach, using a loxP-flanked (floxed) transcription stop (loxP-STOP), has been used to avoid embryonic lethality | | | Chromosomal translocations are well-studied cancer- associated abnormalities and many breakpoints have been characterized at the molecular level |
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http://www.nature.com/nmeth/journal/v2/n1/full/nmeth727.html
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| | Ask an Expert: Chromosomal translocation |
| | If you have information about the areas of the chromosomes involved in the translocation, you might want to talk to a geneticist or genetic counselor for additional information. | | | For many unbalanced rearrangements (translocations) it is not possible to predict what abnormalities to expect; for others the medical literature may provide information. | | | If all the chromosomal material is present, just rearranged - that is, switched places (translocated) - this person should have no health problems since all the chromosomal material needed is present and functioning properly. |
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http://www.netwellness.org/question.cfm/20373.htm
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| | Chromosomal translocation - Wikipedia, the free encyclopedia |
| | Cancer - several forms of cancer are caused by translocations; this has been described mainly in leukemia (acute myelogenous leukemia and chronic myelogenous leukemia). | | | Such translocations are usually harmless and may be | | | The most common translocation involves chromosomes 13 and 14 is seen in about 1 in 1300 persons, making it the most common chromosome rearrangement in humans. |
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http://en.wikipedia.org/wiki/Chromosomal_translocation
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| | BBC - Health - Conditions - Chromosomal translocation |
| | There may be no symptoms from a translocation if it's balanced. | | | BBC - Health - Conditions - Chromosomal translocation | | | Alternatively, if it's unbalanced, it may cause problems incompatible with life, leading to miscarriage of an affected foetus, or other major health problems depending on which chromosome has been translocated. |
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http://www.bbc.co.uk/health/conditions/chromosomaltranslocation1.shtml
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| | Chromosomal inversion - Wikipedia, the free encyclopedia |
| | Families that may be carriers of inversions may be offered genetic counseling and genetic testing. | | | The most common inversion seen in humans is on chromosome 9, at inv(9)(p11q12). | | | This inversion has no deleterious or harmful effects and does not appear to lead to an increased risk for miscarriage or abnormalities in offspring. |
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http://en.wikipedia.org/wiki/Chromosomal_inversion
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| | Untitled Document |
| | Chromosomal Translocation is another problem that can occur. | | | These include Chromosomal Conditions; Multifactorial Disorders; and Novel Mechanisms of Inheritance. | | | The affected individual may appear healthy, but the translocation might have reproductive implications. |
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http://www.chgosem.edu/geneticssite/unit1_manual_12.htm
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| | CAMB: Faculty: Frederic G. Barr M.D. Ph.D. |
| | The major focal points of my research program are chromosomal translocations, paired box transcription factors, and the pediatric malignancy rhabdomyosarcoma. | | | These issues are unified by a major research focus on the 2;13 and 1;13 chromosomal translocations in the pediatric cancer alveolar rhabdomyosarcoma (ARMS). | | | rhabdomyosarcoma (a cancer of the muscle lineage), chromosomal translocations, paired box transcription factors |
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http://www.med.upenn.edu/camb/faculty/cgc/barr.html
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| | BIOL2316 Genetics |
| | Explain two ways that a chromosomal translocation can result in a change in phenotype. | | | Explain two ways that a chromosomal inversion can result in a change in phenotype. | | | How are geneticists using translocation Down syndrome individuals to locate the gene(s) responsible for this disorder? |
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http://www.austincc.edu/pphelps/BIOL2316.notes.Ch13.05a.htm
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| | Miscarriages - Causes and Treatments - Chromosomal Causes |
| | May involve the same chromosomes, such as 13/13 or 21/21, where there is no chance for a normal offspring. | | | Preconceptional counseling and planning with respect to prenatal diagnosis is also important. | | | Unfortunately, there is no available treatment to “fix abnormal chromosomes” at this time. |
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http://www.infertilitytutorials.com/miscarriage_members/chromosomal.cfm
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| | ARUP: Five Prime-Nucleotidase5 Prime-NucleotidaseNucleotidase |
| | Individuals who do not show a fusion transcript may still be affected by the translocation. | | | Positive: There is evidence of the t(2;5) chromosomal translocation by RT-PCR analysis. | | | Negative: There is no evidence of the t(2;5) chromosomal translocation by RT- PCR analysis. |
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http://www.aruplab.com/guides/clt/tests/clt_118b.jsp
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| | NEJM -- Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas |
| | However, because performing accurate cytogenetic studies in solid hematolymphoid neoplasms is difficult, knowledge of the prevalence of the t(14;18) translocation and, by association, the extent of bcl-2 involvement in human lymphomas is limited. | | | One of the most common karyotypic abnormalities is the t(14;18) translocation, which is found in many lymphomas that have a characteristic follicular morphology. | | | No changes in bcl-2 were found in several other subtypes of Hodgkin's and non-Hodgkin's lymphomas, including those previously suggested to originate from follicular-center cells and those about which cytogenetic data have been difficult to obtain. |
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http://content.nejm.org/cgi/content/short/317/19/1185
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| | High expression of c-myc gene is associated with chromosomal translocation in AIDS-related B-cell lymphoma. |
| | The state of the art may have changed since the publication date. | | | Our data also indicate that lymphomagenesis does not require HIV integration in the B-cell DNA, but is a result of complex interactions between viral and cellular factors produced in HIV-infected individuals. | | | However, the 3' region of the c-myc gene translocation and the elevated levels of c-myc RNA do not involve the T-cell receptor alpha-chain as reported for some non-HIV associated B-cell lymphoma. |
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http://www.aegis.com/aidsline/1992/dec/M92C4976.html
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| | JRM May1996: Identification of a Subtle Chromosomal Translocation in a Family with Recurrent . . . |
| | JRM May1996: Identification of a Subtle Chromosomal Translocation in a Family with Recurrent. | | | Small imbalances may lead to offspring with multiple congenital anomalies. | | | Although the parental chromosomes were previously reported to be normal in another laboratory, the pedigree was consistent with a chromosomal etiology, and parental blood samples were reevaluated. |
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http://www.jreprodmed.com/abs/JRM81.htm
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| | SO term tables |
| | Definition: A chromosome may be generated by recombination between two inverversions; presumed to have a deficiency or duplication at each end of the inversion. | | | Definition: A chromosome generated by recombination between two inversions; there is a deficiency at one end of the inversion and a duplication at the other end of the inversion. | | | Definition: A chromosome generated by recombination between two inversions; has a deficiency at one end and presumed to have a deficiency or duplication at the other end of the inversion. |
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http://toy.lbl.gov:9091/SOterm_tables
(1800 words)
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| | A Chromosomal Translocation |
| | translocation mutation has changed the number of chromosomes. | | | Since chimpanzees, gorillas, orangutans and bonobos all have 24 chromosome pairs, it is assumed that the common ancestor had 24 pairs. | | | On the left of the diagram is human chromosome number 2 (of 23). |
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http://www.don-lindsay-archive.org/creation/translocation.html
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| | Analysis of the V(D)J Recombination Efficiency at Lymphoid Chromosomal Translocation Breakpoints -- Raghavan et al. 276 ... |
| | V(D)J-mediated Translocations in Lymphoid Neoplasms: A Functional Assessment of Genomic Instability by Cryptic Sites | | | Departments of Pathology, Biochemistry and Molecular Biology, Molecular Microbiology and Immunology, and Biological Sciences, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90089-9176 and the | | | Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia |
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http://www.jbc.org/cgi/content/abstract/276/31/29126
(697 words)
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| | Molecular analysis and ontogenetic assignment of t(11;14) chromosomal translocation in mantle cell lymphoma (MCL) |
| | Conclusion: The t(11;14) translocation in MCL might have taken place in a more mature stage of B-cell ontogeny during VH-to-DJH rearrangement and it is postulated that various known recombination motifs within MTC may have contributed to an illegitimate recombination event between bcl-1 and DJH. | | | Molecular analysis and ontogenetic assignment of t(11;14) chromosomal translocation in mantle cell lymphoma (MCL) | | | t(11;14) is thought to result from an error of the recombinase during D-J lg gene assembly, but data on the mechanism and candidate recombination-targeting sequence (seq) in the major translocation cluster (MTC) of bcl-1 are lacking. |
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http://www.esmo.org/reference/abstracts/mo/579.htm
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| | Title page for ETD |
| | The author also retains the right to use in future works (such as articles or books) all or part of this thesis or dissertation. | | | ABSTRACT Nine 1B/1R translocated soft red winter wheat (SRWW) varieties and six non-1B/1R varities from two crop years (1995-1996 and 1996-1997), grown in two Virginia locations (Warsaw and Blacksburg), were studied to evaluate the effects of the 1R rye chromosome on soft wheat flour quality and baking performance. | | | The presence of the 1B/1R chromosomal translocation in wheat has been reported to provide disease resistance, but produce sticky doughs. |
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http://scholar.lib.vt.edu/theses/delayed/etd-32498-16139/etd-title.html
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| | ARS Publication request: The Effect of T1DL.1RS Wheat-Rye Chromosomal Translocation on Agronomic Performance and ... |
| | The effects of T1DL.1RS on agronomic performance were modified by wheat genetic background, while milling and baking qualities were less affected. | | | Technical Abstract: The translocation of rye (Secale cereale L.) chromatin 1RS to wheat (Triticum aestivum L.) genome has been observed to be beneficial to grain yield, but also has a negative impact on baking quality. | | | Interpretive Summary: Putting rye genes into wheat is beneficial to grain field yield, but also has a negative impact on baking quality. |
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http://www.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=160808&pf=1
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