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| | Zanamivir -- Facts, Info, and Encyclopedia article |
 | | Zanamivir, therefore, is administered by inhalation - a route that was chosen for patient compliance with therapy. | | | Whilst zanamivir proved to be a potent and effective inhibitor of influenza neuraminidase and inhibitor of influenza virus replication in vitro and in vivo, this didn't necessarily translate into a successful clinical treatment for influenza. | | | Despite the limited commercial success of this drug, the work and strategies employed in the development of zanamivir were important first-steps in the development of further members of this class including (Click link for more info and facts about oseltamivir) oseltamivir and the candidate drug RWJ-270201 (Phase I trials). |
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http://www.absoluteastronomy.com/encyclopedia/z/za/zanamivir.htm
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| | Neuraminidase Inhibitors for Treatment of Influenza A and B Infections |
| | Although clinical data are limited regarding drug interactions with zanamivir, no known drug interactions with zanamivir have been reported, and no clinically important drug interactions have been predicted on the basis of in vitro data and data from studies in rats (14,49). | | | Influenza-specific antiviral drugs for chemoprophylaxis or therapy are an important adjunct to vaccine, but they are not a substitute for influenza vaccine. | | | However, recently published studies of zanamivir and oseltamivir for prophylaxis of influenza in community settings demonstrated both drugs to be similarly effective in preventing laboratory-confirmed clinical influenza with fever (efficacy: zanamivir, 84%; oseltamivir, 82%) (35,36). |
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http://www.cdc.gov/mmwr/preview/mmwrhtml/rr4814a1.htm
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| | zanamivir of Augusta, Georgia |
| | Zanamivir is available with a DISKHALER inhalation device and five ROTADISK foil packs that each contain 4 blisters of the drug. | | | Do not use zanamivir without first talking to your doctor if you have asthma, chronic obstructive pulmonary disease (COPD), or any other chronic lung condition. | | | Many, but not all, of the cases occurred in patients with asthma, chronic obstructive pulmonary disease (COPD), or another chronic lung condition. |
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http://www.universityhealth.org/17107.cfm
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| | MedlinePlus Drug Information: Zanamivir (Inhalation—Systemic) |
| | This medicine must be started within 2 days of having flu symptoms (weakness, headache, fever, cough, and sore throat). | | | Tell your health care professional if you are taking any other prescription or nonprescription (over the counter [OTC]) medicine before using zanamivir. | | | Read the directions carefully before using this medicine. |
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http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/500004.html
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| | ICAR: Clinical Efficacy Of Relenza (Zanamivir) Shown In People With Asthma And COPD |
| | During the sub-study, researchers analyzed 256 throat swabs taken on days 1 (baseline), 2, 3, and 6 from both zanamivir and placebo treated patients. | | | The study was a virologic sub-study of a randomized, double-blind placebo controlled clinical trial (NAI30008) and was designed to evaluate the safety and efficacy of zanamivir in people with asthma and COPD. | | | Although only one of these had a titre high enough for the NA assay, the other isolate was identified as positive by PCR. |
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http://www.pslgroup.com/dg/1F7BBE.htm
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| | Relenza - Drugs & Vitamins - Drug Library - DrugDigest |
| | Make sure you have an inhaler available when using zanamivir if you have asthma or other chronic lung disease. | | | There are no known drug interactions with zanamivir. | | | Contact your pediatrician or health care professional regarding the use of this medicine in children. |
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http://www.drugdigest.org/DD/DVH/Uses/0,3915,740Relenza,00.html
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| | MedlinePlus Drug Information: Zanamivir Inhalation |
| | if you use an inhaled medication to treat asthma or emphysema and you are scheduled to take that medication at the same time as zanamivir, you should take your regular medication before taking zanamivir. | | | tell your doctor and pharmacist if you are allergic to zanamivir or any other drugs. | | | Your prescription will come with instructions on how to use the Diskhaler. |
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http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a699021.html
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| | ICAAC: Intravenous Zanamivir Shows Promise In Treating And Preventing Flu |
| | Inhaled zanamivir is effective in treating acute influenza. | | | However, this was the first study to show that the drug is also effective when administered by a systemic route in humans. | | | Zanamivir, one member of this new family of drugs, has been shown to be effective in human trials that assessed the ability of this drug to prevent infection and to lesson the severity of illness in subjects infected with influenza virus. |
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http://www.docguide.com/dg.nsf/PrintPrint/FF05FE06A5901B658525668D004BC32D
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| | SPREAD OF FLU IN FAMILIES REDUCES WITH ZANAMIVIR |
| | The double-blind, placebo-controlled clinical trial was designed to examine the effectiveness of zanamivir in preventing the spread of influenza A and B from one infected family member to other members. | | | However, in this study no resistance was observed with zanamivir. | | | The most common side effects for both treatment and prophylaxis included respiratory illness (17 percent placebo vs. 10 percent zanamivir), headaches (10 percent vs. 9 percent) and nasal signs and symptoms (8 percent vs. 9 percent). |
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http://www.healthsystem.virginia.edu/internet/news/archives00/zanamivir.cfm
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| | HEALTH-Pandemic-Zanamivir, Bgt |
| | Both zanamivir and oseltamivir are known as neuraminidase inhibitors, drugs that block the influenza virus's ability to spread throughout the respiratory system. | | | But governments should not overlook zanamivir, a commentary in a leading medical journal suggests. | | | As well, there have been no reports in the scientific literature of influenza viruses developing resistance to zanamivir, they noted. |
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http://www.cp.org/english/online/full/health/050811/x081128A.html
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| | Relenza Online, Description, Chemistry, Ingredients - Zanamivir - RxList Monographs |
| | Influenza Challenge Studies: Antiviral activity of zanamivir was supported for influenza A, and to a more limited extent for influenza B, by Phase 1 studies in volunteers who received intranasal inoculations of challenge strains of influenza virus, and received an intranasal formulation of zanamivir or placebo starting before or shortly after viral inoculation. | | | Only 1 of 4 children under age 8 had a measurable flow rate (see CLINICAL PHARMACOLOGY: Pediatric Patients, INDICATIONS AND USAGE: Description of Clinical Studies, and PRECAUTIONS: Pediatric Use). | | | Insufficient information is available to characterize the risk of emergence of zanamivir resistance in clinical use. |
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http://www.rxlist.com/cgi/generic2/zanam.htm
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| | Important New Warnings about the Flu Drug Zanamivir |
| | The labeling also warns that in such patients, zanamivir should be used under conditions of careful monitoring, proper observation and appropriate supportive care, including the availability of short-acting bronchodilators, for example a "puffer" containing albuterol (PROVENTIL). | | | C) accompanied by shaking chills and you are coughing up thick phlegm, or if coughing or breathing deeply causes sharp chest pain, you may have pneumonia, and should consult your doctor for diagnosis and appropriate treatment. | | | The precaution goes on to state that zanamivir should be stopped in any patient who develops bronchospasm or a decline in lung function. |
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http://www.citizen.org/HRG/NEWSLETTERS/relenza.htm
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| | Flu Drugs, NIAID Fact Sheet |
| | All four drugs are available by prescription only, and it is best to consult with your health care provider to determine what drug might be best for you. | | | Rimantadine and amantadine are effective only against type A influenza. | | | Zanamivir generally is not recommended for people with chronic respiratory diseases such as asthma or chronic obstructive pulmonary disease (COPD). |
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http://www.niaid.nih.gov/factsheets/fludrugs.htm
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| | Arch Intern Med -- Abstract: Impact of Zanamivir on Antibiotic Use for Respiratory Events Following Acute Influenza in ... |
| | The Department of Internal Medicine, Division of Epidemiology and Virology, University of Virginia School of Medicine, Charlottesville (Drs Kaiser and Hayden); Glaxo Wellcome Inc, Research Triangle Park, NC (Drs Elliot and Hammond); and Glaxo Wellcome Research and Development, Greenford, England (Mr Keene). | | | Arch Intern Med -- Abstract: Impact of Zanamivir on Antibiotic Use for Respiratory Events Following Acute Influenza in Adolescents and Adults, November 27, 2000, Kaiser et al. | | | of influenza illness with zanamivir reduced the number of these |
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http://archinte.ama-assn.org/cgi/content/abstract/160/21/3234
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| | zanamivir - Medical and health information on the common cold and flu |
| | DRUG INTERACTIONS: There are no known interactions between zanamivir and other drugs. | | | Patients with respiratory diseases may experience breathing problems when treated with Zanamivir due to irritation of the breathing tubes by the particles from the inhaler. | | | Patients who have asthma or other breathing problems that make them sensitive to inhaled particles should have a fast acting, inhaled bronchodilator available to treat any breathing problem that may occur when zanamivir is used. |
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http://www.medicinenet.com/zanamivir/article.htm
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| | Zanamivir |
| | Do not stop taking the drug before the scheduled end of therapy even if you begin to feel better, as this may lead to a relapse. | | | Consult your doctor if you have any respiratory illness, such as chronic obstructive pulmonary disease or asthma. | | | There are no common side effects associated with zanamivir. |
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http://www.wholehealthmd.com/refshelf/drugs_view/1,1524,863,00.html
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| | Medinfo: Relenza - influenza treatment and the NHS |
| | Although it has been licensed to be prescribed by doctors in the UK for this purpose, it has been announced that its use will not immediately be allowed within the National Health Service. | | | Zanamivir (Relenza) is a new drug, just released in the UK, for the treatment of flu (influenza). | | | For further information on influenza treatment see the influenza page in the conditions section. |
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http://www.medinfo.co.uk/topics/relenza.html
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| | Inhouse Pharmacy Europe FDA APPROVES RELENZA (ZANAMIVIR FOR INHALATION) FOR INFLUENZA TREATMENT |
| | Any patient who develops bronchospasm should stop the drug and call their health care provider. | | | This product has not been shown to be effective, and may carry risk, in patients with severe or decompensated asthma or chronic obstructive pulmonary disease. | | | Patients with underlying respiratory disease should be instructed to have a fast-acting inhaled bronchodilator available when they are being treated with zanamivir. |
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http://www.inhousepharmacy-europe.com/general/relenza-article2.html
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| | Zanamivir |
| | If you have an allergy to zanamivir or any other part of the medicine. | | | Zanamivir prevents the flu from spreading inside the body. | | | It may be used for adults and children 7 years or older. |
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http://www.umm.edu/altmed/ConsDrugs/Zanamivircd.html
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| | Relenza, Zanamivir, side effects, drug interactions, overdose, dosage |
| | Nevertheless, if you suspect an overdose of Relenza, it would be wise to check with your doctor. | | | Relenza is an antiviral drug that hastens recovery from the flu. | | | Relenza, Zanamivir, side effects, drug interactions, overdose, dosage |
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http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/rel1536.shtml
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| | Zanamivir |
| | Zanamivir use should be avoided if the patient is undergoing any concurrent use of inhaled medications, or the patient is pregnant or breastfeeding. | | | Zanamivir is contraindicated in patients with a known hypersensitivity to any component of the formulation. | | | Zanamivir (generic name Relenza) is an orally inhaled antiviral, effective for the treatment of Influenza A or B infections in adults. |
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http://www.stanford.edu/group/virus/flavi/2000/zanamivir.htm
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| | Relenza (zanamivir) Information |
| | Relenza Approval, Review and Labeling Information (from Drugs@FDA) | | | This memo addresses several concerns raised by the Antiviral Drug Advisory Committee held on February 24, 1999. | | | This letter notifies health professionals of important revisions to the safety labeling for Relenza. |
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http://www.fda.gov/cder/news/relenza/default.htm
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| | Zanamivir :Drug News |
| | Click here to request further information on Drug News | | | The US FDA has approved zanamivir (RELENZA) for the treatment of influenza A and B in adults and adolescents over 12 years of age who have been symptomatic for no more than two days. | | | This neuraminidase inhibitor, developed by Glaxo Wellcome under license from Biota, was not approved for prophylaxis. |
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http://www.ims-global.com/insight/drugs_news/drugs_news_990809.htm
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| | Relenza , Zanamivir , influenza treatment |
| | Zanamivir (Relenza) is a new drug, for the treatment of flu (influenza). | | | Relenza (Zanamivir for Inhalation) has been approved for the treatment of uncomplicated acute illness due to influenza virus in adults and adolescents 12 years and older who have been symptomatic for no more than two days. | | | Patients inhale Relenza orally using a hand-held, breath activated device called a Diskhaler. |
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http://www.anagen.net/relenzin.htm
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| | Relenza Side Effects, and Drug Interactions - Zanamivir - RxList Monographs |
| | No clinically significant pharmacokinetic drug interactions are predicted based on data from in vitro studies. | | | These were reported in similar proportions of zanamivir and lactose vehicle placebo recipients with acute influenza-like illness. | | | In a subset with chronic respiratory disease, lower respiratory adverse events (described as asthma, cough, or viral respiratory infections which could include influenza-like symptoms) were reported in 7 of 7 zanamivir recipients and 5 of 12 placebo recipients. |
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http://www.rxlist.com/cgi/generic2/zanam_ad.htm
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| | MedlinePlus Medical Encyclopedia: The flu |
| | Treatment is usually not necessary for children, but if the illness is diagnosed early and the patient is at risk of developing a severe case, it can be started. | | | Oseltamivir (Tamiflu) and zanamivir (Relenza) are active against both influenza A and B. Each of these medicines has different side effects and affects different viruses. | | | Your doctor will determine which one is best for you. |
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http://www.nlm.nih.gov/medlineplus/ency/article/000080.htm
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| | CIDRAP >> CDC advises on antiviral use in flu outbreaks |
| | When used for treatment within the first 48 hours of illness, they can shorten the time of illness by 1 to 2 days and reduce virus shedding. | | | Zanamivir is approved for treatment of flu in people aged 7 and older but not for prevention. | | | Dec 18, 2003 (CIDRAP News) – The Centers for Disease Control and Prevention (CDC) yesterday issued guidelines for using antiviral drugs to prevent and treat influenza during the current season. |
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http://www.cidrap.umn.edu/cidrap/content/hot/flu/news/dec1803antivirals.html
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| | Relenza-Biota Holdings |
| | Biota's Relenza™ (Zanamivir) represents a new class of antiviral drugs and a new way to treat the influenza virus, more commonly known as "the flu". | | | Relenza™ works simply and directly by preventing the spread of influenza from one cell to another within the respiratory tract. |
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http://www.biota.com.au/products/relenza.html
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| | CNN.com - How to avoid -- gesundheit! -- the cold and flu - Dec 13, 2004 |
| | Otherwise, doctors recommend basic treatments for colds and flus: bed rest, plenty of fluids, aspirin or acetaminophen for fevers and headaches and over-the-counter medication to temporarily relieve symptoms. | | | People who come down with the flu can take prescription medications to reduce the time they're sick -- but only if taken within 48 hours of the first symptom's appearance, according to the American Lung Association. | | | The medicines oseltamivir, zanamivir, amantadine and rimantadine (sold under the brand names Tamiflu, Relenza, Symmetrel and Flumadine, respectively) can lessen flu's severity and length by at least a day, depending on the strain of the flu. |
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http://www.cnn.com/2004/HEALTH/12/13/cold.flu.overview/index.html
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| | Q & A on the flu: What you need to know ajc.com |
| | Those three drugs, plus a fourth drug, zanamivir (Relenza) can reduce the seriousness of symptoms if taken within two days of falling ill. The drugs are not widely available and all require a doctor's prescription. | | | Sources: American Lung Association, Centers for Disease Control and Prevention, Center for medicare and medicaid Services, Georgia Division of Public Health, MedImmune Vaccines, Inc., National Library of Medicine |
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http://www.ajc.com/health/content/health/1004/22fluqa.html
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| | Beat the Winter Bugs |
| | Relenza (zanamivir) and Tamiflu (oseltamivir), both approved for use in 1999, are to treat uncomplicated cases of influenza caused by types A and B flu virus. | | | Tamiflu also is approved for preventive use, while Relenza is approved only for treatment. | | | He discovered her symptoms occurred because she had taken two different products, both containing a decongestant. |
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http://www.pueblo.gsa.gov/cic_text/health/coldsandflu/coldsandflu.htm
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| | Essential Oil - Research On Essential Oils And Hepatitis ☼ |
| | The world's first influenza drug, Relenza™ (zanamivir), will be available to treat 'flu victims in Australia this winter following regulatory recommendation for approval, granted yesterday by the Australian Drug Evaluation Committee. |
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http://www.finest-essential-oils.net/researchonessentialoilsandhepatitis
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