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Topic: X chromosome



  
 Science Spectra [Article]
Not only does a new UEP arise on a particular Y chromosome at a particular time and in a particular person, it begins its history in the company of certain pre-existing microsatellite alleles.
Marina Faerman and her colleagues at the Hadassah Medical School in Jerusalem adopted this approach to identify the sex of infant skeletons too young and incomplete to be classified in any other way.
But small changes (called polymorphisms) do occur, and this article describes how the correct interpretation of these changes in the Y chromosome, when passed down from generation to generation, can illuminate our understanding of human history.
http://www.ucl.ac.uk/tcga/ScienceSpectra-pages/SciSpect-14-98.html   (3507 words)

  
 X chromosome definition - Allergies: allergy symptoms, treatment, and medications by MedicineNet.com
X chromosome definition - Allergies: allergy symptoms, treatment, and medications by MedicineNet.com
MedicineNet Home > MedTerms medical dictionary A-Z List > Allergies Home Page > X chromosome
This is consistent with the concept that the X and Y chromosomes evolved from an ancient pair of autosomal (nonsex) chromosomes and that the X chromosome retains much of its old autosomal information.
http://www.medterms.com/script/main/art.asp?articlekey=6030   (281 words)

  
 Triplo-X Syndrome :
Please share your story with other families who are raising girls with Triplo X Syndrome.  In order to post a story in our guestbook.
If you are a Doctor, Psychologist, Social Worker or Geneticist and are willing to answer questions regarding Triplo X Syndrome, please send us an
2.  There's a great support group for parents, parents-to-be, and their daughters to share resources and support regarding the diagnoses of Trisomy X
http://www.triplo-x.org   (362 words)

  
 Amazon.com: The X in Sex: How the X Chromosome Controls Our Lives: Books
A human baby is referred to as an "it" while an inantimate object such as a chromosome is referred to as a "he".
It always amuses me when people extol the human body as the epitome of creation excellence.
This book presents a few tidbits about the X chromosomes and the genes resident on it and how they affect our lives.
http://www.amazon.com/exec/obidos/tg/detail/-/0674010280?v=glance   (2065 words)

  
 X chromosome - Wikipedia, the free encyclopedia
The missing genetic material affects development and causes the characteristic features of the condition, including short stature and infertility (the inability to conceive a child).
Chromosomal conditions involving the sex chromosomes often affect sex determination (whether a person has the sexual characteristics of a male or a female), sexual development, and the ability to have children (fertility).
The extra genetic material may lead to mental retardation and other medical problems.
http://en.wikipedia.org/wiki/X_chromosome   (1106 words)

  
 Imprinting, the X-Chromosome, and the Male Brain: Explaining Sex Differences in the Liability to Autism -- SKUSE 47 ...
in which the expressed locus is on X
Krug DA, Arick J, Almond P 1980 Behavior checklist for identifying severely handicapped individuals with high levels of autistic behavior.
Rutter M, Bailey A, Bolton P, LeCouteur A 1994 Autism and known medical conditions: myth and substance.
http://www.pedresearch.org/cgi/content/full/47/1/9   (5669 words)

  
 X-Inactivation Mosaicism Demonstration
This results in a "mosaic effect" or a "patchwork effect" in the individual and can be demonstrated in humans and other mammals.
At an early stage of embryonic development in individuals with more than one X chromosome per cell, the extra X chromosome(s) condense, become heterochromatic, and are the genes are no longer transcribed.
Depicted below is a group of 16 cells each of which contains one
http://www.people.virginia.edu/~rjh9u/xinactanim.html   (216 words)

  
 The "X" Chromosome
For the most part, this disproportion was found to occur on the mother's side of the family.
Critics of the X chromosome theory point out inadequacies of the study.
Since homosexuality seemed to be linked with the mother's side of the family, the researchers centered their studies on the X chromosome.
http://salmon.psy.plym.ac.uk/year1/psychobiology_site_backups/homosexuality-debate/xchromo.htm   (678 words)

  
 Organ: X chromosome - CureResearch.com
Diseases list: The following list of medical conditions have 'X chromosome' or similar listed as an affected body part in our database:
Use of this site is subject to our TERMS OF USE.
There are various sex chromosome disorders that affect the entire X and Y chromosomes, such that a person has some combination other than XX or XY pair.
http://www.cureresearch.com/organ/x_chromosome.htm   (291 words)

  
 CBC News: Women's X chromosome unique, analysis reveals
With the analysis in hand, researchers can now explore genetic sources of conditions like testicular cancer, as well as hemophilia and Duchenne muscular dystrophy that are more common in males.
The new analysis suggests that people owe their sex in part to chromosomes that evolved nearly 300 million years ago in a genderless organism.
LONDON - A woman's X chromosome is more complex than a man's, making more of certain proteins that could explain some gender differences, a study suggests.
http://www.cbc.ca/story/science/national/2005/03/16/X-chromosome050316.html   (354 words)

  
 triplo x chromosome
I am unclear from your question as to exactly how much information you have so far on the XXX defect, however I presume you are aware that it is similar to Down syndrome insofar as an extra chromosome is transmitted to the fetus,
There is one report in the literature from Sardinia, of a mother with triple X who transmitted a related genetic defect to her sons, so fertility is not necessarily affected.
A wide range of learning difficulties is however reported, ranging from severe difficulty with reading to almost no abnormality.
http://www.medhelp.org/forums/neuro/archive/2244.html   (356 words)

  
 Pharyngula::Evolution of the X chromosome
Excellent review of the article -- I now feel like I don't need to read the original myself (just kidding).
This kind of research is impossible to do and impossible to interpret except in terms of evolution.
The gradual erosion of the Y shows us what the fate of our other chromosomes would be, if there weren't recombination and selection working to keep them up.
http://pharyngula.org/index/weblog/comments/evolution_of_the_x_chromosome   (3726 words)

  
 Human X Chromosome Coded (washingtonpost.com)
Get a better body in 2006 with eDiets.com!
The X's unveiling also brings into focus the molecular underpinnings of hundreds of genetic diseases, far more than have been discovered on any other human chromosome.
The new findings are described in a pair of scientific reports published in today's issue of the journal Nature and clarify preliminary findings of the past few years.
http://www.washingtonpost.com/wp-dyn/articles/A41919-2005Mar16.html   (571 words)

  
 Scientists sequence human X chromosome
The X chromosome genome sequence has already allowed researchers to isolate more than 40 genes involved in medical conditions, improving their ability to diagnose the disorders and potentially opening up new avenues for development of treatments.
Scientists cloned the first human disease genes, for muscular dystrophy and an immune system disorder, chronic granulomatous disease, from the X chromosome in the early 1980s.
The X chromosome, by contrast, is sized much closer to the other human chromosomes not involved in sex determination, which are collectively known as autosomes.
http://mednews.wustl.edu/news/page/normal/4966.html   (596 words)

  
 genome.gov 2005 Release: Studies Expand Understanding of X Chromosome
The second study, which was supported by the NIH's National Institute of General Medical Sciences, focused on the activity of a large set of genes on the X chromosome.
Interestingly, almost 10 percent of the genes on the X chromosome are part of a somewhat mysterious family of "cancer-testis antigens," which are normally expressed in the testis but also appear in certain cancers, making them possible targets for immunotherapy.
NIH-Supported Research Sheds New Light on the Role Of Sex Chromosomes in Health and Disease
http://www.genome.gov/13514331   (1115 words)

  
 Team 61: X Chromosome
Initial sequencing and analysis of the human genome.
We have applied this approach to approximately one-third of the chromosome, mostly between Xq21.3-q27.3, and will extend the analysis to the whole chromosome.
Our group is interested in the structure, biology and evolution of the human X chromosome.
http://www.sanger.ac.uk/Teams/Team61   (1026 words)

  
 Genomic Sequencing & Gene Identification Group
Projects to contribute to the sequencing of chimpanzee chromosomes X and Y are initiated, which special emphasis to Xq28 and regions associated with mental retardation.
Our group is working on two main subjects: genomic sequencing in human and model organisms and clone and transcript mapping for providing sequence-ready maps as well as for disease gene identification.
One major topic of our group is the experimental verification of differences within the coding regions between chimpanzee and human.
http://www.molgen.mpg.de/~xteam   (362 words)

  
 FRAXA - Fragile X Research Foundation
Fragile X is the most common inherited cause of mental impairment.
It is also the most common known cause of autism.
FRAXA's mission is to find effective treatments and a cure for all children and adults with Fragile X. FRAXA has funded over $8 million in research at universities around the world.
http://www.fraxa.org   (199 words)

  
 X chromosome
The 23 pairs of chromosomes of a normal human male.
In humans, whether a person is male or female is determined by the particular combination of the two sex chromosomes in the body cells.
Early in the development of a female embryo, one of the X chromosomes becomes condensed so that most of its genes are inactivated.
http://www.tiscali.co.uk/reference/encyclopaedia/hutchinson/m0008138.html   (284 words)

  
 [No title]
X chromosome sequence might help uncover long-term effects of epigenetic-based oncology treatments.
The human X chromosome is a study in contradictions.
Testicles may be on the outside in the interests of equality.
http://www.nature.com/news/infocus/xchromosome.html   (380 words)

  
 USATODAY.com - Genes on X chromosomes behave differently
Women get more work out of hundreds of genes on the X chromosome than men do, and that could help explain biological differences between the sexes, a new study says.
More surprising, Willard said, was what researchers discovered about another 10% of the genes.
Chromosomes are the threadlike packages of genes and other DNA found in cells of the body.
http://www.usatoday.com/tech/science/genetics/2005-03-16-xchromosome_x.htm   (530 words)

  
 The Seattle Times: Health: Genes of female X chromosome cataloged
The X chromosomes of males are all the same in that regard," said the lead author, Huntington Willard of Duke University in Durham, N.C. The finding, researchers said, suggests that individual women are likely to have different susceptibility to diseases.
The sequencing was carried out by more than 250 researchers as part of the Human Genome Project.
Described by the head of the Human Genome Project as "a monumental achievement for biology and medicine," the genetic map should help scientists better understand more than 300 X-linked diseases &; such as hemophilia and Duchenne muscular dystrophy &; that mothers pass on to their sons.
http://seattletimes.nwsource.com/html/health/2002210123_xchrome17.html   (665 words)

  
 X-linked diseases
The overall pattern of the disease is therefore characterized by the transmission of the disease from affected males to male grandchildren through carrier daughters, a pattern sometimes described as a ‘knight’s move’.
This means they carry the disease-causing allele but generally show no disease symptoms since a functional copy of the gene is present on the other chromosome.
This is why men affected by X-linked diseases never pass the disease to their sons.
http://www.wellcome.ac.uk/en/genome/genesandbody/hg06b009.html   (499 words)

  
 BBC NEWS Science/Nature Female chromosome has X factor
A host of nasty diseases and disorders sit on the human X chromosome, including haemophilia, autism, muscular dystrophy and mental retardation.
The X chromosome can also protect - or harm - your health, depending on what sex you are.
Males, on the other hand, who have nothing to fall back on, are forced to fully express their faulty genes.
http://news.bbc.co.uk/1/hi/sci/tech/4355355.stm   (862 words)

  
 Sex Chromosomes
The choice is usually determined by the temperature at which early embryonic development takes place.
Unlike most cases of aneuploidy, which are lethal, the phenotypic effects of aneuploidy of the X chromosome are usually not severe.
An organism whose cells vary in effective gene content and hence in the expression of a trait, is called a genetic mosaic.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/SexChromosomes.html   (1638 words)

  
 Evolutionary Strata on the Mouse X Chromosome Correspond to Strata on the Human X Chromosome -- Sandstedt and Tucker 14 ...
X, so strata were not found in the same physical order on the
Human X chromosome genes cluster in strata by both their physical positions on the X and by their divergence from their gametologs (K
Mouse X chromosomal genes cluster in strata by degree of divergence from their Y-linked gametologs only, not by map position.
http://www.genome.org/cgi/content/full/14/2/267   (3467 words)

  
 New Scientist Breaking News - Sequencing reveals origins of X chromosome
Despite the fact that X is much larger than the tiny Y, it seems that both evolved from a pair of conventional chromosomes in early mammals sometime in the past 300 million years - an idea first proposed in 1967.
Now sequence comparisons with rats, mice and dogs show that the X chromosome seems to have changed little since the evolution of placental mammals, supporting the idea that once genes are transferred to X, they stay there.
The complete sequence of the human X chromosome was published in Nature this week.
http://www.newscientist.com/article.ns?id=dn7156   (304 words)

  
 Human Chromosome X
Recurrent Chromosome Aberrations in Cancer -- Cancer Gene Anatomy Project
GeneLoc -- an integrated map for each human chromosome
OMIM Chromosome Gene Map -- location of disease and other expressed genes
http://www.ornl.gov/hgmis/launchpad/chromX.html   (439 words)

  
 X chromosome
a sex chromosome of humans and most mammals that determines femaleness when paired with another Xchromosome and that occurs singly in males.
http://www.infoplease.com/dictionary/X+chromosome   (39 words)

  
 Nature web focus: The Human Genome
The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X
The sequence of the 'feminine' X chromosome is a prime hunting ground for geneticists interested in the evolution of the cognitive and cultural sophistication that defines the human species.
Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene
http://www.nature.com/nature/focus/humangenome/x.html   (286 words)

  
 Synergism of Xist RNA, DNA Methylation, and Histone Hypoacetylation in Maintaining X Chromosome Inactivation -- ...
The two genes analyzed, GFP and Hprt, are both subject to X
Hsp90 and environmental impacts on epigenetic states: a model for the trans-generational effects of diethylstibesterol on uterine development and cancer
However, deletion of Xist followed by 5-azadC treatment reactivated Hprt in a much higher proportion of cells than either treatment alone.
http://www.jcb.org/cgi/content/full/153/4/773   (6690 words)

  
 Chromosome X: Human Genome Landmarks Poster
These regions reflect the unique patterns of light and dark bands seen on human chromosomes that have been stained to allow viewing through a light microscope.
Chromosomal regions that vary in staining intensity and are sometimes called heterochromatin (meaning "different color").
The U.S. Department of Energy Biological and Environmental Research program funds this site.
http://www.ornl.gov/hgmis/posters/chromosome/chromoX.html   (348 words)

  
 X Chromosome
- the triple X syndrome "Triple X girls more frequently than other girls have a delayed development in motor function, speech, and maturation, though this does not make them patients or call for special treatment".
Many men live out their lives without ever even suspecting that they have an additional X chromosome.
Imprinting and X chromosome counting mechanisms determine Xist expression in early mouse development.
http://www-biology.ucsd.edu/classes/bimm110.SP05/lectures/L13.05_Xchromosome.htm   (1255 words)

  
 Fragile X chromosome definition - Medical Dictionary definitions of popular medical terms
Fragile X chromosome definition - Medical Dictionary definitions of popular medical terms
Please consult your healthcare provider before beginning any course of supplementation or treatment.
The fragile X chromosome was first sighted by Dr. Herbert A. Lubs in 1969 who termed it the "marker X.".
http://www.medterms.com/script/main/art.asp?articlekey=3516   (205 words)

  
 The DNA sequence of the human X chromosome : Nature
Of this number, 168 have been explained by mutations in 113 X-linked genes, which in many cases were characterized with the aid of the DNA sequence.
Our analysis illustrates the autosomal origin of the mammalian sex chromosomes, the stepwise process that led to the progressive loss of recombination between X and Y, and the extent of subsequent degradation of the Y chromosome.
LINE1 repeat elements cover one-third of the X chromosome, with a distribution that is consistent with their proposed role as way stations in the process of X-chromosome inactivation.
http://dx.doi.org/10.1038/nature03440   (543 words)

  
 XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for ...
The principles of sexual dimorphism and dosage compensation are conserved in multicellular eukaryotes, but the mechanisms
X chromosome is present, whereas XOL-1 overexpression is XX-lethal,
correlate with high SDC-2 expression and the assembly on the X
http://www.genesdev.org/cgi/content/full/17/8/977   (5626 words)

  
 X-chromosome silencing in the germline of C. elegans -- Kelly et al. 129 (2): 479 -- Development
X chromosome are detectably expressed at later stages of oocyte
The X chromosome in XO males is structurally
Silencing of the sex chromosome during early meiosis
http://dev.biologists.org/cgi/content/abstract/129/2/479   (278 words)

  
 Chromosomal basis of X chromosome inactivation: Identification of a multigene domain in Xp11.21-p11.22 that escapes X ...
A number of genes have been identified that escape mammalian X chromosome inactivation and are expressed from both active
This article has been cited by other articles in HighWire Press-hosted journals:
X inactivation, eight expressed sequences (representing at least
http://www.pnas.org/cgi/content/abstract/95/15/8709   (793 words)

  
 AskOxford: X chromosome
(in humans and other mammals) a sex chromosome, two of which are normally present in female cells (designated XX) and only one in male cells (designated XY).
http://www.askoxford.com/concise_oed/xchromosome?view=uk   (120 words)

  
 Insulite Labs - Dedicated to Healing and Preventing Insulin Resistance the cause of Metabolic Syndrome, PCOS, and ...
Are You Overweight and Have You Been Diagnosed with PCOS?
the cause of Metabolic Syndrome, Syndrome X, Polycystic Ovarian Syndrome (PCOS) and Pre-Diabetes
Do You Have a Family History of Heart Disease, Diabetes, Obesity or High Blood Pressure?
http://www.InsuliteLabs.com   (118 words)

  
 Identification of Developmentally Specific Enhancers for Tsix in the Regulation of X Chromosome Inactivation -- ...
First, we defined the major Tsix promoter and found that it
Mailing address: Department of Genetics, Harvard Medical School, Wellman 913, 50 Blossom St., Boston, MA 02114.
Identification of Developmentally Specific Enhancers for Tsix in the Regulation of X Chromosome Inactivation -- Stavropoulos et al.
http://mcb.asm.org/cgi/content/abstract/25/7/2757   (298 words)

  
 BCM Sequencing
Click on the link in the "Location" field to see a map.
Human Chromosome 3 -- Mapping data provided by The University of Texas Health Science Center at San Antonio, including seed clones chosen for draft sequencing.
These links will access a table of sequencing results for the region.
http://www.hgsc.bcm.tmc.edu/seq_data   (278 words)

  
 Evidence for a New Locus for X-Linked Retinitis Pigmentosa (RP23) -- Hardcastle et al. 41 (8): 2080 -- Investigative ...
The affected haplotype is shown as a shaded chromosome.
X-linked Retinitis Pigmentosa: RPGR Mutations in Most Families with Definite X Linkage and Clustering of Mutations in a Short Sequence Stretch of Exon ORF15
The order of microsatellites on the X-chromosome is shown in the key to the right of the figure.
http://www.iovs.org/cgi/content/full/41/8/2080   (3645 words)

  
 X chromosome
It produces a female when paired with another X chromosome, and produces a male when paired with a Y chromosome.
http://www.webref.org/psychology/x/x_chromosome.htm   (87 words)

  
 Crossover Maps
Click on the desired cytogenetic band location to view the first of several corresponding 2D-Map segments from that region.
Click on segment number to access the corresponding X map segment.
Map segments are numbered sequentially from pter (S1) to qter (S24).
http://www.genlink.wustl.edu/mmp/chrX/chrX.html   (128 words)

  
 Mapping and identification of essential gene functions on the X chromosome of Drosophila -- Peter et al. 3 (1): 34 -- ...
Mapping and identification of essential gene functions on the X chromosome of Drosophila -- Peter et al.
Mapping and identification of essential gene functions on the X chromosome of Drosophila
The Drosophila melanogaster genome consists of four chromosomes
http://emboreports.npgjournals.com/cgi/content/abstract/3/1/34   (673 words)

  
 NPR : Uncovering the Secrets of the X Chromosome
New research shows how the X and Y chromosomes evolved from a pair of regular chromosomes 300 million years ago.
Morning Edition, March 17, 2005 · Scientists expose the X chromosome's complete genetic sequence.
As Y Chromosome Shrinks, End of Men Pondered
http://www.npr.org/templates/story/story.php?storyId=4538587&sourceCode=RSS   (130 words)

  
 X chromosome
X chromosome: the larger of the two sex chromosomes.
Normal females possess two X chromosomes; normal males possess one X and one Y chromosome.
http://www.webref.org/anthropology/x/x_chromosome.htm   (91 words)

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