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Topic: Vincristine



  
 Vincristine (Systemic) - MayoClinic.com
While you are being treated with vincristine, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval.
Vincristine is to be administered only by or under the immediate supervision of your doctor.
Before you begin treatment with vincristine, you and your doctor should talk about the good this medicine will do as well as the risks of using it.
http://www.mayoclinic.com/health/drug-information/DR202594   (1501 words)

  
 Vincristine factsheet
Vincristine is a drug which is used to treat leukaemia and some solid tumours.
This factsheet explains what vincristine is, how it is given and some of the possible side effects.
Sometimes the doctor may prescribe medicines to stimulate your child’s bowel function.
http://www.gosh.nhs.uk/factsheets/families/F000149   (560 words)

  
 Oncology Nursing Society.
The researchers did not advocate this approach, noting that, in pediatric patients, administering vincristine through a peripheral IV and a vincristine infusion, rather than bolus administration, greatly increases the risk of extravasation injury.
Upon autopsy, typical findings caused by inadvertent intrathecal vincristine administration included grossly edematous and congested brain and spinal cord tissue with axonal degeneration and myelin loss of the spinal nerves (Kwack et al., 1999; Williams et al., 1983).
The two patients who also received leucovorin following a 10-fold vincristine overdose recovered, although a more rapid recovery time was not observed when they were compared retrospectively to patients who survived a vincristine overdose but did not receive leucovorin (Grush and Morgan, 1979; Thomas et al., 1982).
http://www.ons.org/Publications/journals/ONF/Volume31/Issue5/3105897.asp   (5121 words)

  
 Vincristine
The most common complication of vincristine therapy is abdominal pain, constipation, elevated bilirubin and jaw pain.
While your child is being treated with vincristine no immunizations should be given.
Include any over the counter and homeopathic therapies you may be using.
http://www.novanews.org/VincristineGuide.htm   (560 words)

  
 Vincristine Sulphate - Serum Institute of India.
Jaw pain, pharyngeal pain, parotid gland pain, bone pain, back pain, limb pain, and with myalgias have been reported: pain in these areas may be severe.
Thrombocytopenia, if present when therapy with VINCRISTINE SULPHATE is begun, may actually improve before the appearance of marrow remission.
CNS leukemia has occurred in patients undergoing otherwise successful therapy with VINCRISTINE SULPHATE.
http://www.seruminstitute.com/content/products/product_vincristinesulphate.htm   (1932 words)

  
 MedlinePlus Drug Information: Vincristine
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Talk to your doctor about the possible risks of using this drug for your condition.
tell your doctor and pharmacist if you are allergic to vincristine or any other drugs.
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682822.html   (517 words)

  
 Vincristine: BC Cancer Agency
Doses of uricosuric drugs, including probenecid and sulfinpyrazone may need to be increased while receiving vincristine therapy.
Jeng MR, Feusner J. Itraconazole-enhanced vincristine neurotoxicity in a child with acute lymphoblastic leukemia.
Sathiapalan RK, El-Solh H. Enhanced vincristine neurotoxicity from drug interactions: case report and review of literature.
http://www.bccancer.bc.ca/HPI/DrugDatabase/DrugIndexPro/Vincristine.htm   (1882 words)

  
 In Vitro and in Vivo Characterization of Doxorubicin and Vincristine Coencapsulated within Liposomes through Use of ...
The Chou and Talalay analysis of vincristine and doxorubicin
Doxorubicin and vincristine encapsulation within 1,2 distearoyl-sn-glycero-3-phosphocholine/cholesterol (55/45 mol%) liposomes.
formulation was therapeutically no better than liposomal vincristine.
http://clincancerres.aacrjournals.org/cgi/content/full/10/2/728   (6898 words)

  
 vincristine of Augusta, Georgia
Your doctor will determine the correct amount and frequency of treatment with vincristine depending upon the type of cancer being treated and other factors.
If for any reason an overdose of vincristine is suspected, seek emergency medical attention or contact your healthcare provider immediately.
Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with vincristine to monitor progress and side effects.
http://www.universityhealth.org/17095.cfm   (1046 words)

  
 Lilly: Vincristine Sulfate Injection
Some patients treated with combination therapy which included vincristine sulfate have developed second malignancies.
There have been no clinical trials in humans to determine if vincristine sulfate causes malformations of the human fetus.
There have been no studies to determine whether immune suppression occurs in workers handling vincristine sulfate.
http://www.ehs.lilly.com/msds/msds_vincristine_sulfate_injection.html   (1717 words)

  
 Randomized Trial of Neoadjuvant Cisplatin, Vincristine, Bleomycin, and Radical Hysterectomy Versus Radiation Therapy ...
Randomized Trial of Neoadjuvant Cisplatin, Vincristine, Bleomycin, and Radical Hysterectomy Versus Radiation Therapy for Bulky Stage IB and IIA Cervical Cancer
Randomized Trial of Neoadjuvant Cisplatin, Vincristine, Bleomycin, and Radical Hysterectomy Versus Radiation Therapy for Bulky Stage IB and IIA Cervical Cancer -- Chang et al.
Chang HC, Lai CH, Chou PC, et al: Neoadjuvant chemotherapy with cisplatin, vincristine, and bleomycin and radical surgery in early-stage bulky cervical carcinoma.
http://www.jco.org/cgi/content/full/18/8/1740   (4769 words)

  
 Liposomal and Nonliposomal Drug Pharmacokinetics after Administration of Liposome-Encapsulated Vincristine and Their ...
To confirm that liposomal encapsulation of vincristine was not associated with detrimental levels of nonliposomal drug and
with liposomal vincristine was encapsulated within the liposomes.
vincristine arises from drug released from liposomes in the central
http://jpet.aspetjournals.org/cgi/content/full/298/3/1206   (4317 words)

  
 Vincristine
From personal experience, my son had a numbness in his fingers and no reflexes when his knee was tapped.
If you are not in the habit of checking your child's drugs before administration, administration by perhaps a tired and over-worked health professional, get into that habit!!
NOTE: Before I say anything else, you should be aware that vincristine given intrathecally -- into the spinal fluid -- is FATAL!
http://www.pfeist.net/ALL/vincristine.html   (314 words)

  
 Phase I Study of Liposomal Vincristine -- Gelmon et al. 17 (2): 697 -- Journal of Clinical Oncology
vincristine with the objective of greatly enhancing the drug's
PURPOSE: A phase I study of vincristine encapsulated inside
Improved Therapeutic Responses in a Xenograft Model of Human B Lymphoma (Namalwa) for Liposomal Vincristine versus Liposomal Doxorubicin Targeted via Anti-CD19 IgG2a or Fab' Fragments
http://www.jco.org/cgi/content/full/17/2/697   (4599 words)

  
 Vincristine: BC Cancer Agency
Tell your nurse or doctor immediately if you feel burning, stinging or any other change while the drug is being given.
Your hair will grow back once you stop treatment with vincristine.
Check with your doctor or pharmacist before you start taking any new drugs. 
http://www.bccancer.bc.ca/HPI/DrugDatabase/DrugIndexPt/Vincristine.htm   (494 words)

  
 Drug safety experts stunned by vincristine-related death - Drug Topics
The Fulton tragedy underscores the need for more oversight when it comes to vincristine administration, noted Larry Trissel, director of clinical pharmaceutics research program, M. Anderson Cancer Center in Houston.
But when he arrived, there were no medications present.
"Never send vincristine from the pharmacy if a patient is simultaneously getting intrathecal medications, such as methotrexate or cytarabine, until you get a call from the clinical staff that says they've completed the intrathecal therapy, redressed the lumbar puncture site, and are ready for the IV drug," he said.
http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=110937   (764 words)

  
 Pharmacokinetics of Vincristine Monotherapy in Childhood Acute Lymphoblastic Leukemia -- GRONINGER et al. 52 (1): 113 ...
after the introduction of vincristine in clinical practice.
of pharmacokinetics of vincristine as a single cytotoxic drug
an interaction of these drugs with vincristine pharmacokinetics
http://www.pedresearch.org/cgi/content/full/52/1/113   (3028 words)

  
 Vincristine
It is usually given in a hospital or clinic setting by a trained health care professional.
Talk to your prescriber or health care professional before taking any of these over-the-counter medicines:
The side effects you may experience with vincristine therapy depend upon the dose, other types of chemotherapy also given and the
http://www.lafn.org/medical/po.bd.treatment.Vincristne.html   (703 words)

  
 Institute for Safe Medication Practices
If vincristine is near an intrathecal medication during the drug administration process, the physician, focused on performing a lumbar puncture, maintaining sterility, and preventing patient movement, may overlook the syringe label and accidentally pick up the intrathecal medication.
A neurologist, who may not be familiar with cancer drugs or protocols, may administer the drug.
As a result, he suffered paralysis, agonizing pain, and awareness of his own impending death, which occurred on Christmas day, 10 weeks after a neurologist administered the drug.
http://www.ismp.org/msaarticles/intrathecalvinca.html   (496 words)

  
 Oncovin Online, Description, Chemistry, Ingredients - Vincristine Sulfate - RxList Monographs
It is extremely important that the intravenous needle or catheter be properly positioned before any vincristine is injected.
See WARNINGS section for the treatment of patients given intrathecal vincristine sulfate injection.
Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and are thought to minimize discomfort and the possibility of cellulitis.
http://www.rxlist.com/cgi/generic3/vincristine.htm   (316 words)

  
 Vincristine
Patients experience this in varying degrees, some have fever-blister like sores.
Vincristine is a drug used in the treatment of cancer.
You will be offered medication to control it if it does occur.
http://www.bmi.net/mcaron/vincris.html   (178 words)

  
 Vincristine (Oncovin)
Jaw pain, caused by the effect vincristine has on your nerves
The treatment plan for vincristine depends on which cancer you are being treated for.
Vincristine is used to treat a wide variety of cancers including breast cancer and lung cancer, as well as non Hodgkin's lymphoma and leukaemia.
http://www.cancerhelp.org.uk/help?page=4019   (1271 words)

  
 Vincristine (Oncovin, Vincasar) - VeterinaryPartner.com - a VIN company!
Humans report paresthesias, which include odd sensations such as occur when one's foot is "asleep."
Vincristine is a member of the vinca alkaloid class of chemotherapy drugs.
Vincristine is removed from the body by the liver.
http://www.veterinarypartner.com/Content.plx?P=A&A=1645&S=1   (488 words)

  
 VINCRISTINE - INJECTION (Oncovin, Vincasar) side effects, medical uses, and drug interactions.
Notify your doctor immediately if you feel pain or irritation at the injection site.
USES: Vincristine is one of a large group of drugs known as "antineoplastics"; these drugs are also known as cancer drugs, chemotherapy, or "chemo".
VINCRISTINE - INJECTION (Oncovin, Vincasar) side effects, medical uses, and drug interactions.
http://www.medicinenet.com/vincristine-injection/article.htm   (440 words)

  
 Onco TCS vincristine sulfate Information Onco TCS
In addition to the lead indication, relapsed aggressive NHL, Enzon and INEX intend to develop Onco TCS for use as a single-agent therapy or in combination therapy for several cancers in which vincristine is now used.
Onco TCS is currently being evaluated in several phase II clinical trials as a treatment for first-line NHL, relapsed small cell lung cancer, relapsed Hodgkin's disease, relapsed acute lymphoblastic leukemia, relapsed pediatric malignancies, relapsed NHL in combination with the approved cancer drug Rituxan(R) (rituximab), and relapsed NHL in combination with the approved cancer drug etoposide.
Onco TCS is a proprietary drug comprised of the widely used off-patent anticancer drug vincristine encapsulated in INEX's liposomal drug delivery technology.
http://www.drugs.com/NDA/onco_tcs_040521.html   (781 words)

  
 ADAP drugs: vincristine
Contraception should be practiced during and for at least 2 months after treatment is concluded.
Vincristine is given intravenously to treat KS and non-Hodgkinís lymphoma.
Vincristine is used alone and in combination with other chemotherapies.
http://www.atdn.org/access/drugs/vinc.html   (336 words)

  
 Cancerquest: Vincristine
Patients should not receive any immunizations (vaccinations) while taking this medication.
Vincristine may cause immunosuppression (weakened immunity) and vaccinations could lead to an illness.
Vincristine is administered intravenously and is used to treat many different types of cancer.
http://www.cancerquest.org/printfriendly.cfm?printpage=523   (232 words)

  
 Simple Method to Eliminate the Risk of Inadvertent Intrathecal Vincristine Administration -- Stefanou and Dooley 21 ...
Simple Method to Eliminate the Risk of Inadvertent Intrathecal Vincristine Administration -- Stefanou and Dooley 21 (10): 2044 -- Journal of Clinical Oncology
Dyer C: Doctors suspended after injecting wrong drug into spine.
We believe that this method of diluting vincristine for intravenous
http://www.jco.org/cgi/content/full/21/10/2044   (379 words)

  
 Vincristine
Vincristine is one of the older chemotherapy drugs which has been around for many years.
It is imperative that patients would relay any side effects or problems to their medical oncologist.
The type and extent of a cancer will determine the method and schedule of administration of this drug.
http://www.tirgan.com/vincristine.htm   (135 words)

  
 Lymphoma Information Network - Vincristine
Vincristine (also called Oncovin or VCR) is a chemotherapy agent used in the treatment of Non-Hodgkin's lymphoma and Hodgkin's Disease.
It is in the vinca alkaloid family of drugs which includes vinblastine, a very different drug, sometimes used to treat Hodgkin's Disease.
It is more often than not given in conjunction with other chemotherapy agents in a multidrug regimen.
http://www.lymphomainfo.net/therapy/drugs/vincristine.html   (484 words)

  
 Vincristine Alkaloid - Antineoplastic Breast Cancer Treatment Drug A-Z Breast Cancer Information and Support
: Vincristine, alone or in combination with other antineoplastic medications, is used for many types of cancer including leukemia, lymphoma, breast cancer, lung cancer, malignant melanoma, cancer of the uterine cervix, colorectal cancer, and Wilms' tumor.
Vincristine may increase the amount of uric acid in the blood and the dosage on the other drugs that lower uric acid may need to be adjusted.
Vincristine’s major side effects are hair loss, changes in the sense of taste and a reversible peripheral neuropathy which may cause numbness or tingling in toes and fingers.
http://www.a-zbreastcancer.com/drugs/dVincristine.htm   (348 words)

  
 Cyberbotanica: Vinblastine, Vincristine, Vindesine, Vinorelbine
The side effects of this drug include diarrhea, nausea, and hair loss; it seems to be less of a nerve poison than vindesine.
Because of this, people with neuromuscular disorders should steer clear of this drug if possible.
Likewise, people with some forms of Charcot-Marie-Tooth syndrome should avoid vincristine.
http://biotech.icmb.utexas.edu/botany/vvv.html   (666 words)

  
 Liposome Research Unit - Abstract 183
Liposomal formulations of vincristine have been optimized for both liposome circulation longevity, drug retention characteristics and in vivo anti-tumor activity.
Vincristine is a potent therapeutic agent with activity against a variety of tumor types.
Liposomal vincristine is expected to be of wide utility in a variety of human malignancies.
http://www.liposomes.ubc.ca/abstracts/183.html   (236 words)

  
 Synergy of Topotecan in Combination with Vincristine for Treatment of Pediatric Solid Tumor Xenografts -- Thompson et ...
effects for combining topotecan with vincristine (11) ; in contrast,
Responses of D283 medulloblastoma xenografts to treatment with topotecan, vincristine, or the combination.
Responses of Rh12 RMS xenografts to treatment with topotecan, vincristine, or the combination.
http://clincancerres.aacrjournals.org/cgi/content/full/5/11/3617   (5989 words)

  
 Sloan-Kettering - Vincristine
A metallic taste in the mouth may occur while the drug is being given, but it is uncommon.
The information is selective and does not cover all possible side effects; others may occur.
Vincristine interferes with the ability of cancer cells to multiply and grow.
http://www.mskcc.org/patient_education/html/47189.cfm   (222 words)

  
 Definition of vincristine - Merriam-Webster Online Dictionary
For More Information on "vincristine" go to Britannica.com
Get the Top 10 Search Results for "vincristine"
http://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=vincristine   (98 words)

  
 API Synonym... VINCRISTINE
Compare Internet Pharmacies - We recommend that you check with each pharmacy to see if they do business in your country and state.
VINCRISTINE SULFATE Injection 1MG/ML VINCRISTINE SULFATE AM PARTNERS 071484 VINCRISTINE SULFATE Injection 1MG/ML VINCRISTINE SULFATE PFS Faulding 071426 VINCRISTINE SULFATE Injection 1MG/ML VINCASAR PFS Gensia Sicor 014103 VINCRISTINE SULFATE Injection 1MG/ML ONCOVIN LILLY 075493 VINCRISTINE SULFATE Injection 1MG/ML VINCRISTINE SULFATE PFS Sicor Vincristine Sulfate Injection, American Pharmaceutical Partners, Vincristine Sulfate Injection, American Pharmaceutical Partners,
http://www.betterchem.com/drugs/VINCRISTINE   (142 words)

  
 Product Label
FDA Oncology Tools Approval Summary for vincristine for
Study Details (Click on NDA or Supplement Number to view details)
http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=35   (19 words)

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