|
| |
| | Valaciclovir: key clinical papers |
 | | Valaciclovir for the suppression of recurrent genital HSV infection: a placebo-controlled study of once-daily therapy. | | | Valaciclovir for the suppression of recurrent genital HSV infection: a placebo-controlled study of once-daily therapy | | | valaciclovir is the only anti-viral drug which has been shown to prevent the development of genital herpes lesions when used early in the attack. |
|
http://www.herpesweb.net/profess/effective/hmang13.htm
(1998 words)
|
|
| |
| | Aidsmap Valaciclovir |
| | Valaciclovir is a pro-drug of aciclovir, meaning that it is broken down into aciclovir within the body. | | | Recent research has shown that valaciclovir treatment reduces the onward transmission of herpes simplex virus type 2 (HSV-2) in couples where one partner has genital herpes by 50%, and in suppressing herpes simplex virus shedding from the genital tract (Gupta 2004). | | | The drug has been approved for the treatment of genital herpes as a once-daily medication. |
|
http://www.aidsmap.com/en/docs/50EB3B3C-4B77-4602-8650-D43AB24241DE.asp
(451 words)
|
|
| |
| | Valaciclovir versus aciclovir in patient initiated treatment of recurrent genital herpes |
| | From this and the results of the present study, it may be concluded that valaciclovir 500 mg twice daily achieves the same clinical efficacy in treating genital herpes recurrences as the standard oral aciclovir regimen. | | | Valaciclovir versus aciclovir in patient initiated treatment of recurrent genital herpes | | | Valaciclovir versus aciclovir in patient initiated treatment of recurrent genital herpes: a randomised, double blind clinical trial |
|
http://www.ahc-net.at/fach/studien/daten/abstr-herpes13.htm
(1110 words)
|
|
| |
| | What oral anti-viral medications exist? |
| | Valaciclovir also cuts down the time during which the virus is detected on genital skin surfaces ('viral shedding'). | | | When used as episodic treatment, valaciclovir helps the sores heal faster, and shortens the period of pain during the outbreak. | | | The severity of pain with outbreaks was also improved. |
|
http://www.herpesweb.net/general/treatment/opt08.htm
(516 words)
|
|
| |
| | OI-19 |
| | Valaciclovir and acyclovir for treatment of recurrent genital herpes simplex virus infections. | | | Preliminary results from a recent study suggest that twice-daily dosing of famciclovir is effective in suppressing recurrences of genital herpes (32); its effectiveness for the treatment of recurrent HSV is currently under study. | | | In preliminary studies, it appears to be as effective as acyclovir for the management of recurrent genital herpes and as well tolerated, requiring only twice-daily dosing (34). |
|
http://vhaaidsinfo.cio.med.va.gov/aidsctr/newsletters/oi/oi19.htm
(5776 words)
|
|
| |
| | International Herpes Alliance, Researchers confirm valaciclovir's efficacy in treating facial herpes |
| | By re-evaluating the results, using more clinically relevant assumptions, the researchers conclude that valaciclovir may be even more effective at preventing episodes of facial herpes and reducing healing time of blisters, than had previously been thought. | | | These are the findings of researchers who re-examined the studies used to support the licensing of the antiviral preparation for the treatment of cold sores. | | | In reality, a proportion of these participants would have achieved a positive response and so the efficacy of valaciclovir may have been under-estimated. |
|
http://www.herpesalliance.org/news/May2004/may_2004_2.htm
(317 words)
|
|
| |
| | International Herpes Alliance, New approach to preventing cold sores |
| | The authors of the study conclude that oral valaciclovir is effective and well tolerated for the prevention of recurrent cold sores. | | | As part of a larger study of the effect of valaciclovir on genital herpes transmission, 340 participants, who were HSV-1 positive and had a history of cold sores, were assigned to receive either 500mg valaciclovir once daily or a placebo (dummy pill). | | | Once-a-day treatment with the antiviral valaciclovir can help to prevent recurrent cold sores, according to new research. |
|
http://www.herpesalliance.org/news/dec2003/Dec2003_2.htm
(164 words)
|
|
| |
| | Valtrex Tablets 500mg , SPC from the eMC |
| | Valaciclovir was not carcinogenic in bio-assays performed in mice and rats. | | | These findings have been observed in patients not treated with valaciclovir who have the same underlying or concurrent conditions. | | | Care is also required, with monitoring for changes in renal function (see 4.2, Posology and Method of Administration), if administering high-dose Valtrex with drugs which affect other aspects of renal physiology (e.g. |
|
http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=2185
(2509 words)
|
|
| |
| | Clinical Trial: Valaciclovir to Prevent Transmission of Herpes Simplex Virus |
| | The primary endpoint is the proportion of couples with clinical evidence of a first episode of genital HSV in the susceptible partner with laboratory confirmation. | | | Source partners who have a recurrence of genital HSV while on the study will be asked to have their lesions cultured and will be offered open-label valaciclovir treatment. | | | This study will evaluate the effectiveness of the drug valaciclovir in preventing transmission of genital herpes from an infected to an uninfected sexual partner. |
|
http://clinicaltrials.gov/show/NCT00001649
(1290 words)
|
|
| |
| | Valaciclovir - Patient UK |
| | Valaciclovir is used to treat viral infections such as shingles, it is also used to treat and prevent genital herpes. | | | Never give it to others even if their condition appears to be the same as yours. | | | Before taking any 'over-the-counter' medicines, check with your pharmacist which medicines are safe for you to take alongside valaciclovir. |
|
http://www.patient.co.uk/showdoc/30002348
(679 words)
|
|
| |
| | Clinical Trial: Effects of Long-Term Treatment with Valaciclovir (Valtrex) on Epstein-Barr Virus |
| | Patients in the multi-center study must be about to start valaciclovir therapy for at least 1 year. | | | This study will examine the effects of long-term antiviral therapy with valaciclovir (Valtrex) on Epstein-Barr virus infection. | | | Normal volunteers who are not taking any antiviral medicines and patients enrolled in NIH's protocol no. 97-I-0168 (Evaluation of Valaciclovir for Prevention of Herpes Simplex Virus Transmission) or Glaxo-Wellcome protocol HS2AB 3009 at collaborating centers may be eligible for this study. |
|
http://clinicaltrials.gov/show/NCT00005924
(970 words)
|
|
| |
| | Mexican valaciclovir generic valtrex rx - cheap online valaciclovir generic valtrex, mexican pharmacy valaciclovir ... |
| | This valaciclovir generic valtrex medication may be prescribed for other uses; ask your doctor or pharmacist for more valaciclovir generic valtrex information | | | Inform your doctor about all the medicines you use, (prescription and nonprescription) especially if you take high blood pressure medicine or MAO inhibitors (e.g., furazolidone, phenelzine, selegiline, tranylcypromine) or any other herpes medicine. | | | Tell your doctor your complete medical history especially if you have high blood pressure, an over-active thyroid, glaucoma, diabetes or emotional problems. |
|
http://www.cure-rx.com/mexican-valaciclovir-generic-valtrex.html
(702 words)
|
|
| |
| | Valaciclovir CMV Prophylaxis Trial - AIDS Clinical Care |
| | Valaciclovir CMV Prophylaxis Trial - AIDS Clinical Care | | | The authors emphasize that this condition has not | | | Published in AIDS Clinical Care February 1, 1998 |
|
http://aids-clinical-care.highwire.org/cgi/content/full/1998/201/4
(447 words)
|
|
| |
| | The Body: Herpes Labialis: One-Day Valaciclovir Treatment Shortens Course |
| | The effect of valaciclovir on the healing time of classical lesions (episodes that evolved to blisters or ulcers) was substantially greater (1.1-1.5 days, 18-24 percent). | | | They also examined the feasibility of very abbreviated treatments -- only one or two days of therapy -- to see if this patient-friendly dosing plan would be effective. | | | Spotswood Spruance and his coworkers at the University of Utah studied valaciclovir to see if higher drug concentrations would increase drug efficacy in herpes labialis. |
|
http://www.thebody.com/cdc/news_updates_archive/may29_02/herpes_labialis.html
(466 words)
|
|
| |
| | ICAR: Famciclovir More Effective Than Valaciclovir In Reducing Latent Herpes |
| | In contrast, virus was reactivated from the ganglia of 60 percent of mice treated with valaciclovir, another anti-herpes medication. | | | Based on these compelling results, a world-wide clinical trial is underway to determine if a single 10-day treatment with famciclovir during a patient's primary genital herpes outbreak will prevent future outbreaks and eliminate the need for further medication. | | | ICAR: Famciclovir More Effective Than Valaciclovir In Reducing Latent Herpes |
|
http://www.pslgroup.com/dg/6A4DA.htm
(563 words)
|
|
| |
| | Valaciclovir RSS Newsfeed |
| | Valaciclovir for the Suppression of Recurrent Genital HSV Infection:A Placebo Controlled Study of Once Daily Therapy. | | | Prevention of herpes simplex virus type 2 transmission with antiviral therapy. | | | Despite additional valaciclovir therapy the lesiongradually progressed in size. |
|
http://valaciclovir.diseasemap.com/rss.xml
(419 words)
|
|
| |
| | Attract |
| | Psychosocial morbidity: We found one RCT (1479 people) that evaluated the effect of daily oral antiviral treatment on a genital herpes quality of life scale.People receiving daily aciclovir or valaciclovir had significantly greater mean improvements from baseline than those receiving placebo". | | | The first RCT (1479 people with frequently recurring genital herpes) compared | | | Nausea and headache were infrequent, and participants rarely discontinued treatment because of adverse effects. |
|
http://www.attract.wales.nhs.uk/question_answers.cfm?question_id=1472
(936 words)
|
|
| |
| | 333 - Comparison of Valaciclovir and Acyclovir for the Treatment of Herpes Zoster in Immunocompetent Patients over 50 ... |
| | Median duration of pain was reduced by 13 days for valaciclovir compared with acyclovir in the intent-to-treat population or by 19 days in patients with pain after rash healing. | | | The cost variables described in the model (drug costs, cost of treating long-term pain, physician visits, hospitalization, treatment of severe ocular involvement, productivity losses) were tested by sensitivity analysis. | | | Comparison of Valaciclovir and Acyclovir for the Treatment of Herpes Zoster in Immunocompetent Patients over 50 Years of Age: A Cost-Consequence Model |
|
http://www.accp.com/pharmacotherapy/Abs17_2/333.htm
(163 words)
|
|
| |
| | NIAID Clinical Trials in Progress, March 1998 |
| | NIAID is participating in an international, multicenter trial recruiting heterosexual couples to evaluate the effect of the antiviral valaciclovir (Valtrex) in preventing transmission of genital herpes. | | | Heterosexual couples in which one partner has recurrent genital herpes and the other partner does not are invited to participate in the study. | | | Although valaciclovir is currently prescribed to prevent recurrences of genital herpes symptoms, it is not known whether it can actually reduce the rate of herpes transmission. |
|
http://www.niaid.nih.gov/publications/dateline/0398/clintrial.htm
(325 words)
|
|
| |
| | Excite UK Channels - Health |
| | The blood level of this medicine may be increased by the following medicines: | | | Herpes simplex infections of the skin, eg cold sores | | | Valaciclovir can be used to treat recurrent flare-ups of herpes simplex infection, in which case it is most effective at preventing the sores from developing if treatment is started as soon as the warning signs appear. |
|
http://www.netdoctor.co.uk/excite/medicines/show_main.asp?id=4100
(854 words)
|
|
| |
| | Valaciclovir Reduces the Incidence of Cytomegalovirus Disease and Acute Graft Rejection in CMV-Seronegative Recipients ... |
| | Valaciclovir Reduces the Incidence of Cytomegalovirus Disease and Acute Graft Rejection in CMV-Seronegative Recipients of a Seropositive Cadaveric Renal Allograft | | | Conclusion: Valaciclovir is well-tolerated and effective for the prophylaxis of CMV disease in D+R- patients. | | | Results: Fifty-five confirmed CMV disease episodes, (41 episodes in 39 placebo patients: 14 episodes in 14 valaciclovir patients) were verified by an End-points Committee. |
|
http://www.a-s-t.org/abstracts98/abs61.htm
(360 words)
|
|
| |
| | Valtrex (Valaciclovir), order valtrex (valaciclovir) online |
| | Valtrex (valaciclovir) is an antiviral agent used in the treatment of herpes zoster (shingles), genital herpes and herpes simplex (cold sores). | | | Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. | | | It should not be construed to indicate that use of Valtrex (Valaciclovir) is safe, appropriate, or effective for you. |
|
http://www.no1onlinepharmacy.com/order/valtrex.aspx
(351 words)
|
|
| |
| | Chain Drug Review : Valaciclovir study. @ HighBeam Research |
| | RESEARCH TRIANGLE PARK, N.C.--Patients with shingles who were treated with the experimental antiviral drug valaciclovir had one to two weeks less pain than those treated with acyclovir, the medication most frequently used for treating shingles. | | | Acyclovir, available since 1990 for treating shingles, shortens the duration of the disease as well as the associated pain for many people. | | | Read 'Chain Drug Review: Valaciclovir study.' with a FREE Trial for instant access » |
|
http://static.elibrary.com/c/chaindrugreview/november081993/valaciclovirstudy/index.html
(189 words)
|
|
| |
| | International Herpes Alliance, Studies show Valtrex caplets can shorten life of cold sore outbreaks |
| | Commenting on the results, Dr Stephen Tyring, University of Texas Medical Branch of Galveston, told the IHA news desk: "These studies are encouraging as they show there may be a convenient and effective way for people with cold sores to treat their outbreaks. | | | The researchers reported that patients treated with valaciclovir had statistically significantly shorter outbreaks (5.2 days in the one-day group, 5.4 days in the two-day group and 6.2 days in the placebo group), as well as a shorter duration of pain and discomfort compared to placebo. | | | Valaciclovir, 2 grams twice daily for one day, has just been approved in the US for the treatment of cold sores, after the US Food and Drug Administration (FDA) reviewed the supplemental new drug application filed late last year. |
|
http://www.herpesalliance.org/news/sep2002/sep2002_4.htm
(306 words)
|
|
| |
| | References |
| | Patel R, Delahanty J: International Valaciclovir HSV Study Group: Valacyclovir for the treatment of first episode genital herpes. | | | Patel R, Crooks RJ, Bell AR: European/Australian Valaciclovir HSV Study Group: Once-daily valaciclovir for suppression of recurrent genital herpes. | | | Thackray AM, Field HJ: Differential effects of famciclovir and valaciclovir on the pathogenesis of herpes simplex virus in a murine infection model including reactivation from latency. |
|
http://www.medscape.com/content/1997/00/40/88/408858/408858_ref.html
(442 words)
|
|
| |
| | Valtrex, buy Valtrex, buy Valtrex online |
| | The above Valtrex (Valaciclovir) information is intended to supplement, not substitute for, the expertise and judgment of your physician, or other healthcare professional. | | | It should not be construed to indicate that to buy and use Valtrex (Valaciclovir) is safe, appropriate, or effective for you. | | | Consult your healthcare professional before you buy Valtrex (Valaciclovir) online. |
|
http://www.247-drugstore.com/products/valtrex_valaciclovir.aspx
(320 words)
|
|
| |
| | PR Newswire : New Study Shows Famvir(R) More Effective Than Valaciclovir in Reducing the Number of Herpes Virus ... |
| | Based on these compelling results, a worldwide clinical trial has been initiated to determine if treating a patient's initial genital herpes outbreak with Famvir for ten days will eliminate future outbreaks. | | | The study, which was presented today at the 37th annual meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), supports previous studies which showed that famciclovir but not valaciclovir treatment during acute HSV infection prevented the establishment of latency and/or subsequent viral reactivation. | | | preclinical study showed that Famvir(R) (famciclovir, SmithKline Beecham), when administered during initial herpes simplex virus (HSV) infection, was more effective than valaciclovir (Valtrex(R), Glaxo Wellcome) in reducing the number of cells containing latent (dormant) HSV even when treatment was delayed for several days. |
|
http://static.highbeam.com/p/prnewswire/september291997/newstudyshowsfamvirrmoreeffectivethanvalacicloviri/index.html
(260 words)
|
|
| |
| | Comprehensive Center for Inflammatory Disorders |
| | The primary endpoint in this study will be to evaluate the proportion of subjects in whom cold sore lesion development is prevented/blocked. | | | Evaluation of Valaciclovir for the Prevention/Blockage of the Progression of Cold Sore Lesion Development | | | Other endpoints include the time until cessation of all signs and symptoms, the time until loss of crust, and the time to cessation of pain/discomfort. |
|
http://ccid.unc.edu/currentresearch/kutcher.htm
(61 words)
|
|
| |
| | ► valaciclovir |
| | What's more when you consider what your time is worth, you actually save money by ordering from us instead of getting your prescription medications the old fashioned way. | | | If you are looking for valaciclovir, then you've come to the right place. | | | We offer meds like valaciclovir via our online partner because many of these meds like valaciclovir are very expensive and many people can't afford valaciclovir. |
|
http://www.international-meds.net/valaciclovir.htm
(245 words)
|
|
| |
| | IngentaConnect MMF plus valaciclovir or aciclovir: no relevant interactions? |
| | Keywords: Aciclovir, pharmacokinetics; Aciclovir, drug interactions; Antivirals, drug interactions; Antivirals, pharmacokinetics; Drug-interactions; Immunosuppressants, drug interactions; Immunosuppressants, pharmacokinetics; Mycophenolate-mofetil, pharmacokinetics; Mycophenolate-mofetil, drug interactions; Valaciclovir, drug interactions; Valaciclovir, pharmacokinetics | | | MMF plus valaciclovir or aciclovir: no relevant interactions? | | | IngentaConnect MMF plus valaciclovir or aciclovir: no relevant interactions? |
|
http://api.ingentaconnect.com/content/adis/inp/2004/00000001/00001449/art00034
(96 words)
|
|
| |
| | AuRx, Inc |
| | For valaciclovir, the percentage of patients having a placebo effect was much lower than for the AuRx study. | | | The valaciclovir study results were 25% less effective for patients having more than 10 recurrences per year. | | | For valaciclovir, the patients enrolled had a median of 5 outbreaks per year, whereas the patients in the AuRx study had an average of 9 outbreaks, with a minimum of 5 per year. |
|
http://www.aurx.com
(511 words)
|
|
| |
| | [No title] |
| | Episodic treatment of herpes gladiatorum with valaciclovir or famciclovir | | | The efficacy of famiciclovir in the treatment of herpes gladiatorum should be investigated in a double-blind, randomized clinical trial (Research need recommendation) | | | Valaciclovir (500 mg once daily) should be used to prevent herpes gladiatorum recurrences in patients with a history of disease of more than 2 years (Category 2 recommendation). |
|
http://www.ihmfsecure.com/guidelines/summary12.asp
(2332 words)
|
|
| |
| | IngentaConnect Clostridium difficile colitis associated with valaciclovir |
| | Keywords: Adverse drug reactions; Clostridium difficile; Diarrhea; Pseudomembraneous colitis; Valaciclovir | | | Ojective: To report a case of Clostridium difficile colitis associated with valaciclovir treatment. | | | It should be included as a possible adverse effect of valaciclovir treatment by health professionals. |
|
http://www.ingentaconnect.com/content/klu/phar/2004/00000026/00000001/05145414
(312 words)
|
|
| |
| | (BETA) News Briefs: Valaciclovir (Valtrex) Approved for Herpes Zoster (Shingles) |
| | The drug is not recommended for use by immunocompromised individuals (people with HIV infection or bone marrow transplant or kidney transplant patients). | | | FDA has approved valaciclovir (Valtex), a prodrug of acyclovir, for the treatment of herpes zoster (shingles) in immunocompetent adults. | | | Adverse reactions among immunocompetent people may include GI upset, constipation and headache. |
|
http://www.aegis.com/pubs/beta/1995/be952618.html
(177 words)
|
|
| |
| | Cytomegalovirus (CMV) endpoint determination in an international study of valaciclovir (VACV) for CMV prophylaxis. |
| | Objective: To describe the processes involved in confirming CMV endpoints in a cohort of 1227 HIV/CMV co-infected patients participating in an international collaborative trial of valaciclovir for CMV prophylaxis. | | | Cytomegalovirus (CMV) endpoint determination in an international study of valaciclovir (VACV) for CMV prophylaxis. | | | The state of the art may have changed since the publication date. |
|
http://www.aegis.com/aidsline/1997/jan/m9713512.html
(520 words)
|
|
| |
| | WCN: No Benefit Found In Using Broad-Spectrum Antiviral For Multiple Sclerosis |
| | At the end of the study, the mean total of new lesions per patient was 11.9 for the valaciclovir group, and 14.5 for the placebo group, an insignificant difference (p=0.71). | | | Because the inter-patient variation was high though, Dr. Lycke retrospectively stratified patients into those with high and low baseline MRI activity. | | | Similarly, the number of new lesions per scan per patient was also not significantly different, with 1.9 for valaciclovir, versus 2.6 for placebo (p=0.44). |
|
http://www.docguide.com/dg.nsf/PrintPrint/7D82E89172F9797885256A730056F483
(433 words)
|
|
| |
| | Use of oral valaciclovir in a 12-year-old boy with herpes simplex encephalitis |
| | Oral valaciclovir was given as continuation therapy to complete the 3-week course of antiviral treatment and resulted in complete recovery without side effects. | | | This report illustrates the advantage of using the polymerase chain reaction to diagnose herpes simplex encephalitis and the potential use of newer antiviral agents, such as valaciclovir, as continuation therapy in the management of the infection. | | | The higher oral bioavailability of newer antiviral agents allows part of the extended treatment period of patients with herpes simplex encephalitis to be carried out as an ambulatory oral regimen. |
|
http://www.hkmj.org.hk/hkmj/abstracts/v6n1/119.htm
(174 words)
|
|
| |
| | Herpes Cure News |
| | None of the adverse events that occurred during treatment -- mainly diarrhea and nausea -- were serious enough to lead to discontinuation of the drug or withdrawal from the study, he said. | | | Valaciclovir Appears Safe for Treatment of Herpes Simplex in Children | | | In a study, 28 children ranging in age from 1 year to less than 12 years all were treated with an oral suspension of valaciclovir. |
|
http://www.herpes-pics.com/herpes_stds.htm
(880 words)
|
|
| |
| | PWAC: medical matters |
| | Furthermore, valaciclovir treatment seems to confer some level of survival benefit, with a trend toward lower mortality rates in valaciclovir-treated individuals compared to persons given the more standard prophylactic approach of acyclovir. | | | Administration of the new antiviral agent valaciclovir (Valtrex®, Glaxo Wellcome) to people with advanced HIV disease produces a definite preventive effect against cytomegalovirus (CMV) disease, according to Dr. Judith Feinberg from John Hopkins University School of Medicine in Baltimore, Maryland. | | | When high doses of valaciclovir (2 gm four times daily) are given to HIV positive people with very low CD4+ cell counts (median~32), CMV disease occurs much less frequently and when it does occur, the time to development of confirmed CMV disease is significantly longer. |
|
http://www.aidsinfonyc.org/pwac/9511/medical.html
(919 words)
|
|
| |
| | U.S. Pregrant 20040197396 - Anhydrous crystal form of valaciclovir hydrochloride |
| | The invention relates to anhydrous crystalline valaciclovir hydrochlorine, pharmaceutical compositions containing the same, its use in medical therapy and processes for preparing the same. | | | U.S. Pregrant 20040197396 - Anhydrous crystal form of valaciclovir hydrochloride |
|
http://cxp.paterra.com/uspregrant20040197396.html
(76 words)
|
|
|
