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Topic: Tumor suppressor gene

Ads by Google Related Topics gene therapy tumor suppressor gene Suppressor T cells brain tumor Tumor necrosis factor tumor suppressor gene Gastrointestinal stromal tumor tumor lysis syndrome Pituitary Tumors benign tumor Wilms tumor aniridia      Welcome to UTMJ Much of the anti-cancer gene therapy community is therefore currently approaching this potential therapeutic as an adjuvant to other therapies, including the more traditional surgery, radiation therapy, and chemotherapy regimens. Gene therapy is a rapidly emerging field that has come into its own only in the past 15 years. Reovirus therapy of tumors with activiated Ras pathway. http://www.utmj.org/issues/76.2/oncocontents.htm   (5673 words)      SSAT - 2000 Abstract: 2458: Tumor Suppressor Gene Therapy and COX 2 Inhibition Additively Reduces Intestinal Neoplasia. RESULTS: Examination of the intestines demonstrated a significant reduction in the overall number of intestinal polyps in all treatment groups, especially in the distal small bowel where polyp formation was greatest. It is very important that you consult a doctor about any specific medical problem or question. This study was performed to determine whether liposomal tumor suppressor APC gene therapy and further selective COX-2 inhibition with Vioxx may have an additive effect in the reduction of intestinal neoplasia in the Min mouse. http://www.ssat.com/cgi-bin/abstracts/00ddw/2458.cgi?affiliation=   (538 words)      VHL Tumor Suppressor Gene Found! In the families for which this testing works, it is much more reliable, and it can be used for individuals without other affected family members; but as explained above, it will only apply immediately to about 18% of families. Credit is also due to the many families affected with VHL who have contributed the blood and tissue samples used in this research. They were able to confirm that the VHL gene behaves as a typical tumor suppressor gene, as defined in Knudson's theory of human carcinogenesis http://www.vhl.org/newsletter/vhl1993/93bagene.htm   (1190 words)      1995.09.15: Role Found for VHL Tumor Suppressor Gene The discovery of the connection between VHL and Elongin is one of those wonderful occasions we all wait for when basic scientific research and medically-oriented research intersect, and lead to much more rapid progress than could have been made with either approach alone," said Joan Conaway. This work takes us from clinical medicine to understanding specific molecular events that may lead to cancer," said Linehan. Abnormalities in the VHL gene have also been detected in a high percentage of tumors from patients with a certain form of kidney cancer. http://www.hhs.gov/news/press/1995pres/950915.html   (990 words)      Identification of a Candidate Tumor Suppressor Gene in Human Lung Cancer - DERT This discovery may offer a new target for cancer therapy and may lead to new ways to diagnose some cancers and determine a patient's prognosis and response to treatment. If further research verifies the importance of the PTPRO gene to the cancer process, it may mean that measuring the degree of methylation of this gene in a patient's tumor will tell doctors something about the level of danger posed by that tumor or whether the tumor is responding well to treatment. That, in turn, affects certain proteins that PTPRO acts on, furthering the cancer process. http://www.niehs.nih.gov/dert/profiles/hilites/2004/lunggene.htm   (588 words)      Tumor Suppressor Gene Study: News: UI Health Care The research team seeks to better understand how epigenetic changes affect SOD levels. The researchers hope this information will suggest ways to reactivate the SOD2 gene -- a process that might lead to new cancer therapies. The long-term goal of the UI study is to understand the mechanisms that control expression of this important gene and to use that information to determine molecular targets that might lead to novel cancer therapies. http://www.uihealthcare.com/news/news/2003/12/29sod2.html   (412 words)      Eberly College of Science New Tumor-Suppressor Gene Discovered “When we introduced the human mats gene into the mutant fly’s body, we found it was able to perform the same function as a normal fly’s mats gene,” Lai says. The inserted material disrupted the gene’s function, which is to make a particular protein that works in particular ways. The researchers performed three experiments to test whether the mats and wts genes interact genetically. http://www.science.psu.edu/alert/Lai3-2005.htm   (1229 words)      p53 Tumor Suppressor Gene: At the Crossroads of Molecular Carcinogenesis, Molecular Epidemiology, and Cancer Risk ... Environmental Health Perspectives (EHP) is a monthly journal of peer-reviewed research and news on the impact of the environment on human health. A different molecular signature in the p53 gene is found in skin cancer caused by sunlight. p53 is the prototypic tumor suppressor gene that is well suited as a molecular link between the causes of cancer, i.e., carcinogenic chemical and physical agents and certain viruses, and the development of clinical cancer. http://ehp.niehs.nih.gov/docs/1996/Suppl-3/harris.html   (370 words)      WWOX: A Fragile Gene on Chromosome 16 Acts as a Tumor Suppressor Gene - DERT Additional research with WWOX could have implications on prevention activities and cancer therapies. WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. Scientists may be able to utilize the tumor suppression activity of the gene's products to prevent the formation of tumors or treat them. http://www.niehs.nih.gov/dert/profiles/hilites/2001/wwox.htm   (269 words)      Homepage of Tumor Suppressor Gene Database This database is intended to serve as a useful resource for clinical and basic cancer research. Users can view information on each individual tumor suppressor gene, or query for such genes by using pertinent features.      The tumor suppressor gene database (TSGDB) contains updated information on 174 tumor suppressor genes and putative tumor suppressor genes in humans and other organisms. http://www.patcar.org/Databases/Tumor_Suppressor_Genes   (142 words)      Gene-targeting and the p53 tumor-suppressor gene. [Review] This review describes recent advances in the techniques used to construct mice with a variety of genetic alterations. Recent findings from experiments using gene targeted mice to study the p53 tumor-suppressor gene are discussed and the potential of gene-targeting for the discovery and study of novel tumor-suppressor genes are explored. In addition, an application of gene-targeting is illustrated in the study of a class of genes with tumor-suppressor function. http://bioscience.igh.cnrs.fr/knockout/ref/sands.htm   (141 words)      P53: part oncogene & part tumor suppressor gene There are many ways to knock out a given pathway, and that may profoundly affect clinical outcome P53: part oncogene & part tumor suppressor gene http://www.vcu.edu/anatomy/OB/p53   (41 words)      P53 Tumor Suppressor Gene Information TUESDAY, Feb. 8 (HealthDay News) -- Research in fish is shedding new light on how human skin moles develop into the deadly skin cancer melanoma. Mammary Carcinogenesis in Transgenic Rats Carrying Multiple Copies of a Rat ras Gene Driven by the Rat Harvey ras Promoter. Breast Cancer Chapman Homepage Molecular Homepage Molecular Test Listing Molecular Requisition LiFraumeni Syndrome (p53 Tumor Supressor Gene) Mutations in the p53 tumor suppressor gene are correlated with advanced... http://caraccessoriessite.com/audi-accessories/p53-tumor-suppressor-gene.html   (700 words)      Tumor Suppressor Genes p53 is one of important genes responsible in this pathway. - gene therapy is a novel approach to treating disease based on modifying the expression of a peson's genes genes such as p53, Rb, and p16, which have been implicated in a wide range of cancers, are prime targets for this kind of therapy. http://www.bol.ucla.edu/~kcrazy/tumorsuppressorgenetherapy.html   (295 words)      The p53 Tumor Suppressor Gene and Apoptosis Clin Cancer Res 1998 Apr;4(4):835-46 Adenovirus-mediated p53 gene therapy and paclitaxel have synergistic efficacy in models of human head and neck, ovarian, prostate, and breast cancer. Pathol Res Pract 1999;195(3):129-35 p53 gene alterations in prostate cancer after radiation failure and their association with clinical outcome: a molecular and immunohistochemical analysis. Cancer Chemother Pharmacol 1999;44(2):143-51 Adenovirus-mediated p53 gene therapy has greater efficacy when combined with chemotherapy against human head and neck, ovarian, prostate, and breast cancer. http://www.psa-rising.com/medsci/p53.htm   (1240 words)      Cloning of the X Chromosome's Putative Tumor Suppressor Gene Determining the genetic changes that occur in breast tumors should help to understand the mechanism of breast cancer, which in turn should elucidate novel approaches for cancer treatment. Our future experiments will focus on the evaluation of mechanisms by which these two genes are repressed in cancer cells. The discovery of novel tumor suppressor genes will have a great impact on the understanding of breast cancer etiology, pathogenesis and may be very important for disease prognosis and treatment. http://www.cbcrp.org/research/PageGrantPrintPage.asp?grant_id=2284   (1382 words)      Tumor Suppressor Genes Retinoblastoma is a cancerous tumor of the retina. These may result in a "loss of heterozygosity" or "LOH". Their function can also be blocked by methylation of their promoter. http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/TumorSuppressorGenes.html   (983 words)      Research Page: Analysis of a candidate lung tumor suppressor gene at 3p21.3 If the causes of smoking-associated cancers are better understood at the molecular level, more efficient early screening procedures and future gene therapy approaches may be developed. Lung cancers are strongly associated with cigarette smoking. The study should increase our understanding of the mechanisms of lung cancer initiation. http://www.trdrp.org/research/PageGrant.asp?grant_id=1867   (898 words)      The p53 tumor suppressor protein Help with unraveling the molecular mechanisms of cancerous growth has come from the use of mice as models for human cancer, in which powerful 'gene knockout' techniques can be used. This condition is rare, and is known as Li-Fraumeni syndrome. If a person inherits only one functional copy of the p53 gene from their parents, they are predisposed to cancer and usually develop several independent tumors in a variety of tissues in early adulthood. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.107   (262 words)      NIH News Release--Scientists Find New Tumor Suppressor Gene Involved in Breast, Prostate and Other Cancers- - 03/30/2001 Bethesda, Md. — Scientists at the National Human Genome Research Institute (NHGRI) and the M.D. Anderson Cancer Center at the University of Texas have found a novel tumor suppressor gene on human chromosome 7 that appears to be involved in a wide range of cancers. That generally means the gene plays an important function in the body. The genetic treatment eliminated the cancer cells' ability to produce tumors in mice. http://www.nih.gov/news/pr/mar2001/nhgri30a.htm   (707 words)      Tumor Suppressor Proteins Identification and functional analysis of proteins interacting with the tumor su... Inactivation of tumor suppressor proteins in lung cancer -- Weintraub 15 (2): 15... The Centrosomal, Putative Tumor Suppressor Protein TACC2 Is Dispensable for Norm... http://www.scienceoxygen.com/biology/458.html   (633 words)      HHMI News: Loss of Tumor Suppressor Gene Triggers Colon Cancer Similar mutations were found in about 85 percent of all colon cancers, including patients who had no family history of colon cancer. Mutations in the APC gene were found in the hundreds of polyps that populate the colons of patients with an inherited disease, familial adenomatous polyposis (FAP). “Master genes such as p53, another tumor suppressor, or APC usually don't work on just one pathway. http://www.hhmi.org/news/vogelstein.html   (680 words)      Tumor suppressor gene Discovery and analysis of tumor suppressor genes have contributed to a better understanding of the molecular basis of breast cancer development. However, it is likely that many, if not most, tumor suppressor genes responsible for sporadic breast cancer remain to be discovered. In the course of carcinogenesis, cells acquire a number of genetic changes most of which may have no effect on cellular function. http://hamaguchilab.cshl.edu/tsg.html   (183 words)      Scientist Identify Tumor Suppressor Gene Implicated In Breast Cancer Adding to this arsenal, sophisticated future treatments are expected to use gene therapy to restore functional tumor suppressor genes and will depend on the discovery of promising therapeutic targets such as the WT1 gene. While some breast tumors grow rapidly and are highly resistant to treatment, others can be either successfully treated or contained for decades. "The possible relationship between changes in the WT1 gene and mutations in the BRCA genes remains to be discovered," explains Roberts, who also serves as the director of research at Doernbecher Pediatric Research Laboratories located at OHSU. http://www.pslgroup.com/dg/314EE.htm   (756 words)      ISOLATION OF A SECOND WILMS TUMOR SUPPRESSOR GENE Other studies have placed translocations in Beckwith-Weidemann Syndrome patients and loss of heterozygosity for Wilms tumor samples in this same region. The availability of the WT2 gene will broaden the understanding of tumor suppressor gene functions, provide important clues about the process of normal mammalian tissue development including genomic imprinting and impact upon treatment and detection of human cancer. Abstract: DESCRIPTION: (adapted from the investigator's abstract) The identification of human tumor suppressor genes has led to new insights into the mechanisms of human cancer development. http://www.med.unc.edu/wrkunits/1dean/research/weissman149.html   (554 words)      Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression -- Kwabi-Addo et al. 98 (20): ... The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphatidylinositol 3-kinase pathway and is inactivated tumors for which material was available and found no evidence human PTEN gene in prostate cancer and other human malignancies, http://www.pnas.org/cgi/content/full/98/20/11563   (5647 words)      Tumor suppressor gene - Wikipedia, the free encyclopedia Tumor suppressor genes, or more precisely, the proteins for which they code, either have a dampening or repressive effect on the regulation of the cell cycle or promote apoptosis, and sometimes do both. The first tumor suppressor protein discovered was the pRb protein in human retinoblastoma; however, recent evidence has also implicated pRb as a tumor survival factor. A tumor suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. http://en.wikipedia.org/wiki/Tumor_suppressor_gene   (278 words)      Chemists unlock secret to activating tumor suppressor gene It has also been linked to a cancer-prone condition called Cowden disease. Researchers have discovered the way to activate a key anti-cancer signal that goes AWOL in several gynecologic and brain cancers. With this newly reported knowledge about the inner workings of PTEN, Cho hopes a way will be found to treat patients with damaged or mutated PTEN genes. http://www.eurekalert.org/pub_releases/2003-06/uoia-cus061003.php   (498 words)      New Tumor Suppressor Gene Found The researchers also say that their work on ARF has revealed a process never before seen in mammalian cells. Scientists believe that genes are "read" or interpreted by cells in a single highly specific way to produce particular substances such as proteins. The two most common inactivated tumor suppressor genes found in human cancers are the p53 and INK4a genes. http://www.personalmd.com/news/a1997112802.shtml   (254 words)      GENETICALLY ENGINEERED MOUSE LACKING TUMOR SUPPRESSOR GENE IN THE BRAIN Mutation in the Pten tumor suppressor gene is associated with several human cancers and neurological abnormalities, such as enlarged brain (megacephaly), mental retardation, and malignant brain tumors. However, since a null mutation of the gene leads to death during embryogenesis, there hasn't been a defined in vivo model for studying the exact functions of PTEN in brain development and tumor formation. The mouse model can be used in the following applications: 1) preclinical screening for compounds with activities that target the PTEN controlled signaling pathways in treating cancer and other neurological abnormalities 2) stem cell research for understanding how PTEN is involved in neural stem cell development, neural regeneration, and neuronal differentiation. http://www.research.ucla.edu/tech/ucla03-053.htm   (250 words)      Biotechnology - Other Tumor Suppressor Gene Examples NF1 is a dominant genetic disorder characterized by the appearance of numerous cafe-au-lait spots and benign tumors on the skin known as neurofibromas. There are probably two or three genes that can cause the tumor, but the major locus is at 11p13, which was recognized because a small percentage of patients have a deletion there. It seems that the larger the gene the greater the likelihood a clinically significant mutation will occur. http://home.earthlink.net/~grant_cottam/Biotech/BioTumorSuppressor2.htm   (331 words)      Researchers Tease Out One Critical Role Of Tumor-Suppressor Gene The researchers hope that learning how this gene, called Rb, operates in health cells will give them a better idea of how cancer develops and progresses. But they don't know how Rb, which is found in every cell of the body, does this. Leone was part of a team of researchers led by Antonio Iavarone, a professor with the Institute for Cancer Genetics at Columbia University. http://researchnews.osu.edu/archive/rbsole.htm   (780 words)      PR Newswire: CANJI SCIENTISTS TO DISCUSS TUMOR SUPPRESSOR GENE RESEARCH AT GENE THERAPY OF CANCER MEETING@ HighBeam ... PR Newswire: CANJI SCIENTISTS TO DISCUSS TUMOR SUPPRESSOR GENE RESEARCH AT GENE THERAPY OF CANCER MEETING@ HighBeam Research SAN DIEGO, Nov. 9 /PRNewswire/ -- Canji, Inc., a privately held biopharmaceutical company focused on tumor suppressor genes for cancer treatment, today announced that it will present results from preclinical studies (in the form of three separate abstracts) at the Gene Therapy of Cancer meeting being held November 8 through 11, 1995, in San Diego. These results demonstrate the potential of Canji's tumor suppressor program to develop therapeutic products by supplying cancer cells with a new, normally functioning gene that can either block tumor growth or trigger the death of tumor... http://www.highbeam.com/library/doc0.asp?DOCID=1G1:17792174&refid=holomed_1   (199 words)      M6P/IGF-II receptor tumor suppressor gene (US5874222) The present invention relates, in general, to a tumor suppressor and, in particular, to the mannose 6-phosphate/insulin-like growth factor-II (M6P/IGF-II) receptor and to diagnostic and therapeutic approaches based on same. De Souza et al, "M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity", Nature Genetics 11:447-449 (1995). Jirtle, "9 Liver Tumor Promotion and Breast Cancer Chemoprevention: Common Mechanisms", Liver Tumor Promotion and Breast Cancer Chemoprevention, Ernst Schering Research Foundation, Workshop 10, Nongenotoxic Carcinogenesis, A. Cockburn, L. Smith eds., pp. http://www.delphion.com/details?pn=US05874222__&language=en   (365 words)      University of Miami School of Medicine - Glossary - Tumor suppressor gene BRCA1, an example of tumor suppressor genes, was the first breast cancer gene to be identified; mutated forms of this gene are responsible for some cases of inherited breast cancer, especially those that occur in younger women. When a tumor suppressor gene is mutated (altered), it may fail to keep a cancer from growing. University of Miami School of Medicine - Glossary - Tumor suppressor gene http://www.med.miami.edu/glossary/art.asp?articlekey=11940   (89 words)      p53 Tumor-Suppressor Gene 50% of human tumors lack a functional p53 gene http://alpha.furman.edu/~lthompso/bgy53/cell_cycle/tsld056.htm   (20 words)      The tetratricopeptide repeat containing Tg737 gene is a liver neoplasia tumor suppressor gene The Tg737 gene was found to be altered in approximately 40% of the rodent chemically-induced liver tumors, 40% of the human liver tumors, and in liver, kidney and pancreatic human tumor cell lines. Ectopic expression of the Tg737 gene results in multinucleated cells, loss of Tg737 gene expression results in the proliferation of liver stem cells (oval cells) without concomitant differentiation, and reexpression of the Tg737 gene reestablished responsiveness to external differentiation factors. We believe this is the first report demonstrating tumor suppression activity for a tetratricopeptide repeat gene family member and provides insights into the function of this family of genes in mammalian cells. http://www.nature.com/cgi-taf/DynaPage.taf?file=/onc/journal/v15/n15/abs/1201535a.html   (301 words)      p53 Tumor Suppressor Gene Protein, Immunohistochemical, Paraffin Block Multiple studies have supported the observation of alterations of p53 leading to tumor recurrence and shorter disease-free survival. Allred DC, Clark GM, Elledge R, et al, "Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer,&; J Natl Cancer Inst, 1993, 85(3):200-6. Alterations of the p53 tumor suppressor gene have been shown to serve as a powerful independent prognostic marker in a wide variety of tumor types such as colorectal, http://www.labcorp.com/datasets/labcorp/html/chapter/mono/tg002900.htm   (297 words)      tumor suppressor gene genes whose loss or deactivation leads to neoplastic transformation; compare with ONCOGENE and PROTOONCOGENE. http://crisp.cit.nih.gov/Thesaurus/00008258.htm   (14 words)      Antioncogene (tumor-suppressor gene) Deletion or inactivation of this gene is believed to be a necessary prerequisite for tumor development. A gene which suppresses the formation of tumors. http://www.cartage.org.lb/en/themes/Reference/dictionary/Biologie/A/642.html   (24 words)

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