|
| |
| | EMR Textbook - Oncologic Emergencies |
 | | There are several important priorities in the evaluation and management of oncologic emergencies: identifying the source of the problem, determining the urgency of the condition, considering the acute problem in its proper perspective, coordinating a multidisciplinary treatment plan, and responding to the psychological needs of patients and their families. | | | In addition, because of the proximity of the SVC and the spinal cord, the SVC syndrome and acute spinal cord compression occasionally occur simultaneously. | | | On chest x-ray, the majority of patients have an isolated lung mass and often an enlarged mediastinum, and 25% have a right-sided pleural effusion. |
|
http://www.antibiotic-consult.com/secure/articles/Textbook/99_oncologicalemerg.htm
(6607 words)
|
|
| |
| | NursingCenter - Professional Development - CE Article |
| | Timely and thorough patient and caregiver education, coupled with the initiation of prophylactic strategies and vigilant monitoring, are critical components of the nursing intervention and can literally mean the difference between the life and death of a patient. | | | 6 Less frequently, surgery and radiation are linked to the syndrome. | | | Averly’s plan of care included the use of antiemetic medications and close monitoring of his status after he left the treatment facility. |
|
http://www.nursingcenter.com/prodev/ce_article.asp?tid=498304
(2053 words)
|
|
| |
| | CHEST: ARDS associated with tumor lysis syndrome in a patient with non-Hodgkin's lymphoma - acute respiratory distress ... |
| | The use of high-dose cytokines as treatment for certain malignant neoplasms has been associated with an increase in pulmonary capillary pressure leading to the development of noncardiogenic pulmonary edema[12] and would support such a mechanism for ARDS occurring in the setting of TLS. | | | From the review of the medical literature, the natural history and mortality of TLS are not clearly defined. | | | Acute tumor lysis syndrome in patients with high-grade non-Hodgkin's lymphoma. |
|
http://www.findarticles.com/p/articles/mi_m0984/is_n2_v113/ai_20346672
(1129 words)
|
|
| |
| | Rasburicase (Elitek") Effectively Prevents Hyperuricemia Due to Chemotherapy |
| | The international compassionate use of Elitek was summarized by Belgium researchers in an article in the September 2003 issue of Cancer. | | | There have been no randomized trials comparing the effects of Elitek to conventional management. | | | These researchers treated 166 pediatric and 112 adult patients at high-risk for tumor lysis. |
|
http://professional.cancerconsultants.com/oncology_nhl_news.aspx?id=29648
(756 words)
|
|
| |
| | Fludara, Fludarabine - Chemotherapy Drugs |
| | Your health care provider will prescribe plenty of fluids to keep you hydrated. | | | Your health care provider will monitor your progress carefully during therapy. | | | Tumor lysis syndrome usually occurs within 24 - 48 hours of therapy. |
|
http://www.chemocare.com/bio/bio.sps?iBiographyID=9250
(1648 words)
|
|
| |
| | lysis |
| | Defense Secretary Donald Rumsfeld said the results were from a field test, which can be imperfect, and more ana-lysis needed to be done. | | | Immunologic and Virologic Analyses of an Acutely HIV Type 1... | | | ...on the pathophysiology and treatment of hypercalcemia with little more than a brief mention of the hypocalcemic phenomena accompanying tumor lysis syndrome. |
|
http://www.cancer-help.org/cancer/0604/lysis.html
(1109 words)
|
|
| |
| | Emergencies in Hematology and Oncology, Superior Vena Cava Syndrome, Hypercalcemia, Hyperleukocytosis |
| | Tumors and Lesions of the Spine and Sacrum | | | Hyperleukocytosis during induction therapy with arsenic trioxide for relapsed acute promyelocytic leukemia associated with central nervous system infarction :Arsenic trioxide is a new and investigational agent for the treatment of relapsed or refractory acute promyelocytic leukemia (APL). | | | Background: Hyperviscosity syndrome refers to the clinical sequelae of increased blood viscosity. |
|
http://www.worldoncology.net/emergencies.htm
(197 words)
|
|
| |
| | UpToDate Tumor lysis syndrome |
| | In one study of 102 patients with high-grade non-Hodgkin's lymphoma, the incidence of clinically significant tumor lysis syndrome was six percent [3]. | | | Most affected patients receive combination chemotherapy, but steroids alone may be sufficient to precipitate this syndrome in patients with lymphoma and ALL [11,12]. | | | Tumor lysis syndrome has also been described in patients with multiple myeloma [4], breast cancer [5], medulloblastoma, sarcomas [6], ovarian cancer [7], squamous cell carcinoma of the vulva [8], small cell lung cancer [9], and germ cell tumors [10]. |
|
http://patients.uptodate.com/topic.asp?file=minmetab/11747&title=undefined
(440 words)
|
|
| |
| | Elitek™ Approved by FDA for Tumor Lysis Syndrome |
| | When the cells are killed by therapy, they may spill their inner (intracellular) contents, which accumulate in the body faster than can be eliminated. | | | Tumor lysis syndrome is most often caused by the sudden, rapid death of cells, particularly cancer cells, in response to cancer therapies. | | | Tumor lysis syndrome occurs most frequently in patients with acute hematologic (blood) cancers, such as leukemias or lymphomas, that respond very rapidly to chemotherapy. |
|
http://patient.cancerconsultants.com/leukemia_cancer_news.aspx?id=17790
(578 words)
|
|
| |
| | Oncologic Emergencies: Tumor Lysis Syndrome and Pleural Effusion |
| | Filmed on-site in a documentary style at the University of Pittsburgh Cancer Institute in Pittsburgh, PA, this program presents today’s practicing nurse with information for the assessment, diagnosis, treatment and nursing implications of two oncologic emergencies. | | | Rust as guest experts are three of her colleagues from the University of Pittsburgh Cancer Institute: Judy Paulina, RN, BSN, collaborative practice nurse; Jennifer Simpson, RN, MSN, CRNP, program coordinator, Oncology and Acute Nurse Practitioner Program, and Cheryl Tompkins, RN, MSN, CRNP, OCN | | | "It is imperative that oncology nurses recognize patients at risk for tumor lysis syndrome or pleural effusion, and appropriately and aggressively initiate preventative measures for treatment of these conditions," states Ms. |
|
http://www.stratosinstitute.com/news/NEWSONT0002.htm
(482 words)
|
|
| |
| | Oncology Nursing Society. |
| | Choices a (superior vena cava syndrome), b (spinal cord compression), and c (increased intracranial pressure secondary to tumor effect) are oncologic emergencies that commonly are treated with radiation therapy, which provides excellent short-term results for these conditions. | | | Although the tumor may continue to enlarge during treatment, a metastatic brain tumor likely would not rapidly progress during treatment and glucocorticoid therapy. | | | With appropriate medication and rapid nursing intervention, the side effects of radiation therapy can be eliminated, whereas chemotherapy side effects cannot. |
|
http://www.ons.org/publications/journals/CJON/Volume7/Issue2/0702230.asp
(2263 words)
|
|
| |
| | Genentech: Products - Product Information - Rituxan Full Prescribing Information |
| | Rare instances of fatal outcome have been reported in the setting of TLS following treatment with RITUXAN. | | | Cardiac Events (See BOXED WARNINGS): Grade 3 or 4 cardiac related events include hypotension. | | | In patients with Waldenstrom's macroglobulinemia, following initiation of RITUXAN therapy transient increases in serum IgM levels have been observed which may result in hyperviscosity syndrome requiring plasmapheresis. |
|
http://www.gene.com/gene/products/information/oncology/rituxan/insert.jsp
(5189 words)
|
|
| |
| | Tumor lysis syndrome |
| | There's no good definition, but we can define it as metabolic derangement produced by rapid tumor breakdown as a consequence of therapy. | | | Tumor lysis syndrome: an uncommon complication of fludarabine therapy | | | When we treat patients with non-Hodgkin's lymphoma, we frequently find tumor lysis syndrome; many times it's not clinically significant. |
|
http://www.lymphomation.org/side-effect-tumor-lysis.htm
(293 words)
|
|
| |
| | Lymphoma, non-Hodgkin's, childhood: Treatment - Health Professional Information [NCI PDQ] -- Treatment Option Overview |
| | Children with NHL should be referred for treatment by a multidisciplinary team of pediatric oncologists at an institution with experience in treating pediatric cancers. | | | Hyperhydration and allopurinol or rasburicase (urate oxidase) are essential components of therapy in all but patients with the most limited disease.[6,7] A strategy used in Europe is to treat patients with an initial “prephase” consisting of low-dose cyclophosphamide and vincristine, but this does not obviate the need for allopurinol or rasburicase and hydration. | | | Tumor lysis syndrome results from rapid breakdown of malignant cells resulting in a number of metabolic abnormalities, most notably hyperuricemia, hyperkalemia, and hyperphosphatemia. |
|
http://www.webmd.com/hw/nonhodgkins_lymphoma/ncicdr0000062808-treatment-option-overview.asp
(934 words)
|
|
| |
| | GU AND ELECTROLYTE TOXICITIES |
| | There is no consistently effective treatment, although recovery has been seen after temporary dialysis. | | | Tumor lysis syndrome is characterized by hyperuricemia, hyperkalemia, | | | Most reports are in children treated for brain tumors. |
|
http://www.uic.edu/classes/pmpr/pmpr652/Final/bressler/guelec.html
(776 words)
|
|
| |
| | Rituximab: BC Cancer Agency |
| | These patients should only be treated with extreme caution, probably at a reduced infusion rate for the first infusion, and very closely monitored throughout the first infusion. | | | Subsequent rituximab therapy with prophylaxis for tumour lysis syndrome has been successful in a limited number of cases. | | | Patients can usually tolerate further rituximab therapy after recovery of symptoms. |
|
http://www.bccancer.bc.ca/HPI/DrugDatabase/DrugIndexPro/Rituximab.htm
(1899 words)
|
|
| |
| | Gale Encyclopedia of Cancer: Tumor lysis syndrome |
| | The Washington Manual of Medical Therapeutics associates the following cancer types with tumor lysis syndrome: | | | A doctor who specializes in nephrology will generally examine a high-risk patient before cancer treatment begins, to prepare for the possibility of dialysis treatment. | | | Usually, tumor lysis syndrome develops after the administration of combination chemotherapy regimens, but it may also occur spontaneously or as a result of radiation or corticosteroid therapy. |
|
http://www.findarticles.com/p/articles/mi_gGEC/is_0014/ai_2699001451
(1328 words)
|
|
| |
| | [No title] |
| | Chemotherapy Immunotherapy Diuretic therapy Radiation therapy (Answer D — Rationale: Emergent radiation therapy is started as soon as possible to shrink the tumor and open up the superior vena cava. | | | Brain metastases is progression of disease and will exhibit neurological symptoms such as headache, unsteady gate, cranial nerve abnormalities, etc.) 2. | | | Tumor lysis syndrome and DIC are also oncologic emergencies but do not exhibit the above signs and symptoms. |
|
http://www.smccd.net/accounts/felixf/NURS232/reviewquestions4.doc
(918 words)
|
|
| |
| | New approved drug one of few tested mostly in children - Drug Topics |
| | Said Susannah Koontz, Pharm.D., BCOP, clinical practice specialist, pediatric hematology and oncology, M. Anderson Cancer Center, Houston, "This is one drug for which we have a substantial amount of data collected in children." | | | According to Koontz, patients whose tumors have a high turnover rate, such as those with leukemia and lymphoma, or patients with a high tumor burden, as in those with certain types of lymphomas, are candidates for rasburicase therapy. | | | "Rasburicase is indicated as an adjunctive therapy for the prevention of tumor lysis syndrome," said Koontz. |
|
http://www.drugtopics.com/drugtopics/article/articleDetail.jsp?id=116688
(631 words)
|
|
| |
| | ClinicalTrials.gov - Information on Clinical Trials and Human Research Studies: Trial List |
| | Condition: Chronic refractory pain associated with failed back surgery syndrome, epidural fibrosis, peripheral causalgia, Complex Regional Pain Syndrome | | | A Study of DARBEPOETIN ALFA in Patients with Myelodysplastic Syndrome (MDS) | | | Study of Reyataz in HIV-Infected Patients With Lipodystrophy Syndrome |
|
http://clinicaltrials.gov/search/term=West+Syndrome
(934 words)
|
|
| |
| | Letter - Rituxan |
| | Therefore, these patients should be treated with extreme caution and be closely monitored throughout each infusion. | | | In some cases symptoms worsened over time, while in others initial improvement was followed by clinical deterioration. | | | Review of the reports for these eight patients did not reveal a common pattern of predisposing factors. |
|
http://www.fda.gov/medwatch/safety/1998/rituxa.htm
(456 words)
|
|
| |
| | Tumors of the Nervous System - Internet Handbook of Neurology |
| | Tumors of the spine - Neurosurgical Focus, November | | | Active Therapies for CNS Tumors - Massachusetts General Hospital | | | Neurologic Paraneoplastic Syndromes Producing Weakness Or Sensory Loss - Jacksonville Medicine, August 2000 |
|
http://www.neuropat.dote.hu/tumor.htm
(751 words)
|
|
| |
| | Online Pharmacy, Tramadol, Paxil, antibiotics, amoxicillin, zithromax, Rx Online, pharmaceuticals, DHEA, prescription ... |
| | Incidence and treatment of tumor lysis syndrome in patients with acute leukemia. | | | Grade I tumor lysis was observed in 22 patients, grade II TLS in 2 patients and grade III in 1 patient. | | | Tumor lysis syndrome (TLS) is a complication associated with electrolyte abnormalities that is observed in patients with acute leukemia who are receiving intense doses of chemotherapy. |
|
http://www.hairmillion.com/rx-online-info/allopurinol-online-rx/allopurinol-online-rx.627.html
(557 words)
|
|
| |
| | Tumor lysis syndrome - Wikipedia, the free encyclopedia |
| | Pathophysiology, clinical consequences, and treatment of tumor lysis syndrome. | | | In patients who are being treated for massive lesions, prophylaxis with allopurinol may already have been given (see below). | | | In severe tumor lysis syndrome, individual abnormalities may need immediate treatment. |
|
http://en.wikipedia.org/wiki/Tumor_lysis_syndrome
(410 words)
|
|
| |
| | UpToDate Causes and treatment of hyperphosphatemia |
| | — The tumor lysis syndrome is most often caused by cytotoxic therapy in patients with a large burden of a tumor characterized by rapid cell turnover, such as lymphomas (particularly Burkitt's lymphoma and non-Hodgkin's lymphoma) and certain leukemias [3]. | | | Examples of marked tissue breakdown include the tumor lysis syndrome, muscle necrosis (rhabdomyolysis), and, rarely, marked hemolysis or transfusion of stored blood. | | | The ensuing hyperphosphatemia may then induce potentially symptomatic hypocalcemia due to calcium-phosphate precipitation in the tissues. |
|
http://patients.uptodate.com/topic.asp?file=minmetab/6240&title=undefined
(621 words)
|
|
| |
| | Summary New Frontiers in Cancer Treatment |
| | This program is designed for pharmacists and technicians who are interested in the management of patients with colorectal cancer as well as other types of cancer that are associated with tumor lysis syndrome. | | | An update on new treatment regimens for colon cancer will be reviewed with a focus on treatments for the metastatic disease. | | | The program will conclude with a review of TLS and the recommendations for identifying high-risk patients as well as preventing and treating TLS. |
|
http://www.ashpadvantage.com/04444/description.htm
(129 words)
|
|
| |
| | Ask an Expert: Rituxan |
| | Serious infusion reactions occur in less than 1% of patients receiving the drug. | | | The resulting group of problems is called the tumor lysis syndrome. | | | Patients with larger numbers of cancer cells in the blood are more likely to develop this reaction. |
|
http://www.netwellness.org/question.cfm/32502.htm
(716 words)
|
|
| |
| | Syndrome, Tumor Lysis : on Medical Dictionary Online |
| | A syndrome resulting from cytotoxic therapy, occurring generally in aggressive, rapidly proliferating lymphoproliferative disorders. | | | Syndrome, Tumor Lysis : on Medical Dictionary Online |
|
http://www.online-medical-dictionary.org/?q=Syndrome%2C+Tumor+Lysis
(134 words)
|
|
| |
| | RASBUR Protocol / Clinical Study |
| | Those patients who are being treated for lymphomas, leukemias, or solid tumor malignancies which have relapsed (come back after they were gone) or are refractory (did not respond to treatment) may possibly be at high risk for a side effect of chemotherapy called Tumor Lysis Syndrome. | | | Tumor Lysis Syndrome occurs as cancer cells break down in the body after chemotherapy. | | | It is intended to treat or prevent a side effect of the treatment for cancer (increased uric acid) and is considered supportive care. |
|
http://www.stjude.org/protocols/0,2881,450_4562_16173,00.html
(679 words)
|
|
| |
| | Bioline International Official Site (site up-dated regularly) |
| | Hyperuricaemia is a component of ′tumor lysis syndrome′ which is a condition that occurs when patients with a high tumor burden (leukemias, lymphomas and solid tumor malignancies) are given chemotherapy. | | | This secondary increase in uric acid levels can lead to acute renal failure which is a severe and potentially life-threatening condition. | | | Rasburicase is a genetically engineered, recombinant form of urate oxidase enzyme that has recently been approved for use both in the United States and Europe, for the treatment and prophylaxis of hyperuricaemia associated with tumor lysis syndrome in pediatric patients. |
|
http://www.bioline.org.br/request?ph04043
(395 words)
|
|
| |
| | lysis |
| | ...pulmonary infiltrates, acute respiratory distress syndrome, myocardial infarction, ventricular fibrillation, cardiogenic shock, and tumor lysis syndrome. | | | Positive Data from Preliminary Phase II Study of Rituxan(R) in... | | | Thus, the cell lysis function that is the key to phospholipase's role in the inflammation process, can be contained. |
|
http://www.biometnews.com/biotechnology/lysis.html
(228 words)
|
|
| |
| | Campath Overdose, Contraindications and Information - Alemtuzumab - RxList Monographs |
| | One patient who received 80 mg as an initial dose by IV infusion experienced acute bronchospasm, cough, and shortness of breath, followed by anuria and death. | | | A review of the case suggested that tumor lysis syndrome may have played a role. | | | Single doses of Campath greater than 30 mg or a cumulative weekly dose greater than 90 mg should not be administered as higher doses have been associated with a higher incidence of pancytopenia. |
|
http://www.rxlist.com/cgi/generic/campath_od.htm
(152 words)
|
|
| |
| | Tumor Lysis Syndrome :: Center For Continuing Medical Education |
| | After viewing this program you will be able to: 1.) Describe signs and symptoms of tumor lysis syndrome. | | | Tumor Lysis Syndrome :: Center For Continuing Medical Education | | | 2.) Explain treatment options for tumor lysis syndrome. |
|
http://ccme.osu.edu/cmeactivities/onlineeducation/ondemand/program/index.cfm?id=156
(219 words)
|
|
| |
| | Baylor Health Care System: Rasburicase (Elitek): a novel agent for tumor lysis syndrome |
| | Rasburicase is a recombinant urate oxidase enzyme approved for use by the Food and Drug Administration in patients who are at risk of developing tumor lysis syndrome or for the management of elevated uric acid levels. | | | Several strategies are available for the prevention and treatment of tumor lysis syndrome, with rasburicase being the most recent. | | | Clinical trials have demonstrated rasburicase to be effective in both the pediatric and adult populations, although the drug is currently indicated only for use in the pediatric population. |
|
http://www.baylorhealth.edu/proceedings/18_3/18_3_Ueng.htm
(176 words)
|
|
| |
| | ASCO - Browse by Meeting - Rasburicase is safe and effective in treatment and prophylaxis of hyperuricemia in children ... |
| | The incidence of tumor lysis syndrome (TLS) and renal failure varies between 5-25% in subsets of leukemia and lymphoma patients. | | | Rasburicase is safe and effective in treatment and prophylaxis of hyperuricemia in children and adults with hematological malignancies at risk of tumor lysis syndrome | | | ASCO - Browse by Meeting - Rasburicase is safe and effective in treatment and prophylaxis of hyperuricemia in children and adults with hematological malignancies at risk of tumor lysis syndrome |
|
http://www.asco.org/ac/1,1003,_12-002627-00_18-0016-00_19-001595,00.asp
(903 words)
|
|
| |
| | Oncology Nursing Today - Oncologic Emergencies |
| | A major management strategy for tumor lysis syndrome is the prompt identification of high risk patients and prophylactic implementation of interventions for patients at risk for tumor lysis syndrome. | | | The objective of the "Oncologic Emergencies: Tumor Lysis Syndrome and Pleural Effusion" program is to present today’s practicing nurse with information for the assessment, diagnosis, treatment and nursing implications of two oncologic emergencies. | | | This segment describes the pathophysiology and clinical implications of tumor lysis syndrome. |
|
http://www.stratosinstitute.com/ONToday/ONT0002out.htm
(280 words)
|
|
| |
| | Osmotic lysis - encyclopedia article about Osmotic lysis. |
| | Osmotic lysis is often the result of a stroke, since a stroke leads to a malfunctioning of the cell's metabolism Metabolism (from μεταβολισμος ("metabolismos"), the Greek word for "change", or "overthrow" (Etymonline)), is the biochemical modification of chemical compounds in living organisms and cells. | | | This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. | | | An osmotic lysis is a cytolysis caused by excessive osmosis Osmosis is the diffusion of a solvent through a semipermeable membrane from a region of low solute concentration to a region of high solute concentration. |
|
http://encyclopedia.thefreedictionary.com/Osmotic%20lysis
(388 words)
|
|
| |
| | Healthlinks.net and Healthlinks.com Index of healthcare categories and subjects |
| | Systemic Inflammatory Response Syndrome : Article by Lewis Kaplan, MD Systemic Inflammatory Response Syndrome - Sepsis is a vast clinical entity that takes a variety of forms. | | | Eighty-five percent of early-onset infection presents within 24 hours; however, 5% may present by 48 hours, and a smaller percentage of patients present within 6 days of life. | | | Early-onset sepsis syndrome is associated with acquisition of microorganisms from the mother. |
|
http://www.healthlinks.net/cgi-bin/directory/hyperseek.cgi?search=CAT&Category=Diseases-Disorders%20II%3ANutritional-Metabolic&Rank=76&Qualifier=&Hits_Per_Page=&rt=106
(1968 words)
|
|
| |
| | Tumor Lysis Syndrome |
| | Alternatively, chemotherapy can induce this syndrome in patients whose cancers are very sensitive to treatment e.g. | | | Death of cancer cells could be natural or secondary to | | | Uric acid and Calcium Phosphate can precipitate in kidneys and cause kidney failure. |
|
http://www.tirgan.com/tumolys.htm
(151 words)
|
|
| |
| | Online Pharmacy, Tramadol, Paxil, antibiotics, amoxicillin, zithromax, Rx Online, pharmaceuticals, DHEA, prescription ... |
| | In the fifth patient, CVVH allowed full-dose chemotherapy to continue. | | | A subgroup of patients at very high risk for TLS and renal failure can be identified based on the level of serum lactate dehydrogenase (LDH) and urine output. | | | The prospective use of CVVH could potentially decrease the morbidity and mortality associated with induction chemotherapy in very high-risk patients with a large tumor burden. |
|
http://www.hairmillion.com/rx-online-info/allopurinol-online-rx/allopurinol-online-rx.589.html
(990 words)
|
|
| |
| | News - Elitek (rasburicase) Has Been Approved By the FDA in the United States |
| | The rapid increase of plasma uric acid levels is one of the main elements of tumor lysis syndrome, which may be seen shortly following the initiation of treatment of hematological malignancies, especially in children. | | | Elitek is indicated for the initial management of plasma uric acid levels in pediatric patients with leukemia, lymphoma, and solid tumor malignancies who are receiving anti-cancer therapy expected to result in tumor lysis and subsequent elevation of plasma uric acid. | | | One of the major complications of tumor lysis syndrome is acute renal failure caused by precipitation of crystals of uric acid in the kidneys. |
|
http://www.docguide.com/news/content.nsf/news/8525697700573E1885256BF90060D9F3
(453 words)
|
|
| |
| | Tumor lysis syndrome - allnurses.com Nursing for Nurses |
| | Tumor lysis syndrome is an oncologic emergency and requires immediate intervention. | | | Tumor lysis syndrome - allnurses.com Nursing for Nurses | | | Be sure that you are up-to-date on your knowledge of risk factors, pathophysiology, prevention, and management by exploring |
|
http://allnurses.com/forums/f37/tumor-lysis-syndrome-64885.html
(466 words)
|
|
| |
| | Renal Deposition Disease |
| | Most patients present with proteinuria, without frank nephrotic syndrome |
|
http://www.outlinemed.com/demo/nephrol/11882.htm
(84 words)
|
|
|
