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Topic: Trimethylaminuria



  
 Trimethylaminuria
TRIMETHYLAMINURIA (FISH ODOR SYNDROME): A STUDY OF AN AFFECTED FAMILY: M. Al-Waiz, et al.; Clinical Science (March, 1988, issue 73(3)).
Genetic counseling may be of benefit for patients and their families.
Trimethylaminuria is a very rare metabolic disorder that may be inherited as an autosomal dominant genetic trait or occur as the result of treatment with large doses of the drug L-Carnitine (Levocarnitine).
http://www.bchealthguide.org/kbase/nord/nord997.htm

  
 Trimethylaminuria (Fish-Malodor Syndrome) and the Flavin Monooxygenases (CBM 99-2)
The bibliography has been organized into the two major categories of trimethylaminuria and the flavin monooxygenase system that reflect the differences between clinical research on the disease itself and the more basic research underpinning the disease state.
Thithapandha A. A pharmacogenetic study of trimethylaminuria in Orientals.
http://www.nlm.nih.gov/pubs/cbm/trimethylaminuria.html

  
 EP Editor's Desk - On Being Downwind From Disrupted Lives
Trimethylaminuria (TMAU or trimeth) is described as a life-disrupting condition.
When eight-year-olds with trimethylaminuria confide in you that they wish they had cancer or needed to use wheelchairs or had third-degree burns, so they wouldn’t have to explain the unexplainable to their classmates, you get a clear focus on the depth of their despair.
Trimethylaminuria seems to be a disorder that most certainly could have had its roots in classic mythology.
http://www.eparent.com/editorsdesk/editors_desk_3_03.htm

  
 Monell Chemical Senses Center - Health and Well Being
Experiments to elucidate the nature and causes of taste and smell problems associated with the use of medications
Study of the influence of body odors on human reproductive function
Monell scientists can often recommend treatments, dietary changes or other methods of reducing malodors.
http://www.monell.org/health.htm

  
 Trimethylamineuria (Fish Odor Syndrome)
Because the disease is practically unknown by any name, it may take years for a person with trimethylaminuria to find a doctor who can recognize the problem.
Few health professionals are aware of this disease, which is called trimethylaminuria, people experiencing its characteristic body odor may spend years seeking relief.
Some cases of trimethylaminuria may have no genetic component: Several patients seem to have developed the disorder after liver or kidney disease.
http://www.medical-library.net/sites/_fish_odor_syndrome.html

  
 TMAUHelp.com - Information and Support for Trimethylaminuria
From this perspective everyone has a responsibility to be involved to ensure continued quality medical care and treatment.
This site is dedicated to providing information, aid and support for persons afflicted with Trimethylaminuria (TMAU).
Approximately 18 cases of the inherited form of trimethylaminuria have been reported in the medical literature.
http://www.tmauhelp.com/

  
 Trimethylaminuria: The Fish Malodor Syndrome -- Mitchell and Smith 29 (4): 517 -- Drug Metabolism and Disposition
Thithapandha A (1997) A pharmacogenetic study of trimethylaminuria in Orientals.
is important to appreciate that some forms of trimethylaminuria
Recent studies suggest that both severe and variant mild trimethylaminuria
http://dmd.aspetjournals.org/cgi/content/full/29/4/517

  
 TRIMETHYLAMINURIA MIDWEST REGION FOUNDATION
Fields started her own support group in 1999-2000, after finding little support for her disorder.
We appreciate your continued support as the Trimethylaminuria Midwest Region Foundation searches for a “cure” for this rare metabolic disorder and/or for ways to reduce the ill side affects.
Trimethylaminuria (Fish Odor Syndrome) is a rare metabolic disease that usually produces a body odor, regardless of the amount of proper hygiene practices.
http://www.geocities.com/emporia962000/classic_blue.html

  
 genome.gov Learning About Trimethylaminuria
If this is true, people with trimethyaminuria may have side effects when taking these other drugs that people without the condition don't experience (or experience with less severity).
Although there is no cure for trimethylaminuria, it is possible for people with this condition to live normal, healthy lives without the fear of being shunned because they smell like rotten fish.
Due to the variability of symptoms people with trimethylaminuria experience, researchers hypothesize that a variety of genetic mutations can cause the disease, affecting time of onset and how strong the odor is. They also suspect that stress and diet play a role in triggering symptoms.
http://www.genome.gov/11508983

  
 DBGET Result: OMIM 136132
They pointed out that FMO3 is also a drug-metabolizing enzyme, and compromised activity is expected to have implications for the efficacy of drug treatment and the possibility of adverse drug reactions both in trimethylaminuric patients and in the general population.
.0013 TRIMETHYLAMINURIA FMO3, GLU32LYS In a patient with trimethylaminuria ( 602079), Zhang et al.
The patient was examined at the age of 3 years, at which time he was found to have 61% unmetabolized trimethylamine in urine, compatible with severe trimethylaminuria.
http://www.genome.ad.jp/htbin/www_bget?omim+136132

  
 Trimethylaminuria
TMA oxidation occurs in the liver and is mediated by members of the flavine monooxygenase (FMO) family.
Trimethylaminuria is clinically characterized by a strong body odor of rotting fish resulting from abnormal excretion of trimethylamine in the breath, urine, sweat, saliva and vaginal secretions.
Drugs interfering with hepatic metabolism should also be avoided.
http://orphanet.infobiogen.fr/static/GB/trimethylaminuria.html

  
 Foul Smelling Bombs, Underarms And Pig Farms Under Investigation By Researchers
Another area of smelly research at Monell involves body odor.
Based on the results of the tests, Preti provides an extensive report that patients can then give to their doctors who can provide prescriptions for antibiotics to alleviate or reduce the smells.
Unfortunately, because trimethylaminuria can occur sporadically, doctors are not always able to diagnose the disease.
http://www.sciencedaily.com/releases/2002/01/020107074622.htm

  
 Interindividual Differences of Human Flavin-Containing Monooxygenase 3: Genetic Polymorphisms and Functional Variation ...
suffering from the condition of trimethylaminuria has provided
A number of common variants of human FMO3 have been reported.
conditions (also see the section on "transient trimethylaminuria",
http://dmd.aspetjournals.org/cgi/content/full/30/10/1043

  
 Fish-odor Syndrome Gene Found
British biochemist, Dr. Ian Phillips of the University of London, believes that until now, the public and the medical community may not have "understood there was a medical disease underlying some of these smelly disorders."
Fish-odor syndrome -- properly known as 'primary trimethylaminuria' -- is caused by an excessive bodily emission of the compound trimethylamine (TMA).
http://www.personalmd.com/news/a1997120305.shtml

  
 Rare Disorders board: HealthBoards - trimethylaminuria
HealthBoards > Health Issues > Rare Disorders > trimethylaminuria
http://www.healthboards.com/boards/archive/index.php/t-183297

  
 WAPD Knowledge Base - Trimethylaminuria (TMAU) Information
Trimethylaminuria, which from this point on for convenience sake I will abbreviate using its common abbreviation (TMAU), is also known as Fish Malodor Syndrome.
I say that because Trimethylaminuria (TMAU) robs its possessor of their independence.
It is a “rare” disorder which is caused by a mutated gene.
http://www.wapd.org/kb/tmau.html

  
 Zebra Card GE-006: fishy body odor
Trimethylaminuria in a girl with Prader-Willi syndrome and del(15)(q11q13).
Exacerbation of symptoms of fish-odour syndrome during menstruation [letter].
http://www.zebracards.com/GE-006.html

  
 MedlinePlus: Metabolic Disorders
Learning about Trimethylaminuria (National Human Genome Research Institute)
http://www.nlm.nih.gov/medlineplus/metabolicdisorders.html

  
 Metabolic genetic conditions
phenylketonuria (PKU), Pompe, porphyria, pseudo-Hurler, pyruvate dehydrogenase deficiency, Sandhoff, Sanfilippo, Scheie, Sly, Tay-Sachs, trimethylaminuria (Fish-Malodor syndrome), urea cycle conditions, vitamin D deficiency rickets
http://www.kumc.edu/gec/support/metaboli.html

  
 Best trimethylaminuria diet information at atkins-diet-links.com
Wise food choices and a balanced diet are key elements to a healthy lifestyle.
All what you want to know about trimethylaminuria diet
All rights reserved - 2004 © atkins-diet-links.com - Best information about trimethylaminuria diet.
http://www.atkins-diet-links.com/trimethylaminuria-diet/trimethylaminuria-diet.html

  
 Causes of Bad Breath, Detailed cuases.
Certain systemic diseases can give rise to distinct peculiar odors.
If any of the above odors are noticed as being emitted from your breath, you should consult a physician.
Bad breath has been reported as being associated with hepatic (liver) failure (producing a sulfur odor, rotten eggs or garlic), uremia or kidney failure ( ammonia odor), diabetic ketoacidosis ( acetone odor) and trimethylaminuria ( foul fishy odor).
http://www.hotwares.com/trioralcauses.html

  
 Second Workshop on Trimethylaminuria - Office of Rare Diseases
Second Workshop on Trimethylaminuria - Office of Rare Diseases
http://rarediseases.info.nih.gov/html/workshops/fy2002/Trimethylaminuria010921_01.html

  
 First International Workshop on Trimethylaminuria (Fish Malodor Syndrome)
First International Workshop on Trimethylaminuria (Fish Malodor Syndrome)
http://www.tech-res-intl.com/tri/fmo_register.html

  
 InterPro: Flavin-containing monooxygenase FMO
In man, lack of hepatic FMO-catalysed trimethylamine metabolism results in trimethylaminuria (fish odour syndrome).
Five mammalian forms of FMO are now known and have been designated FMO1-FMO5 [ 2, 3, 4, 5, 6 ].
FMOs have been implicated in the metabolism of a number of pharmaceuticals, pesticides and toxicants.
http://www.ebi.ac.uk/interpro/IEntry?ac=IPR000960

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