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| | Ciência Rural - Physicochemical properties of three food proteins treated with transglutaminase |
 | | LC and ISP demonstrated lower emulsifying activity when they were enzymatically treated but the formed emulsions were stable, contrasting with HAP, which exhibited no changes in emulsifying properties. | | | HAP, either treated or not with transglutaminase, presented no considerable changes in emulsification values. | | | Results showed lowering emulsifying activities with time in the range of the experiment, both for LC and ISP. |
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http://www.scielo.br/scielo.php?pid=S0103-84782004000400039&script=sci_arttext&tlng=en
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| | Talking Point W.H.A.T. |
| | Several researchers have investigated in the past this question, but a widespread and currently updating talking point around this topic seems to be very interesting. | | | Most probably the strongest substrates play a role in physiological conditions too, whereas the others may become a good substrate under certain conditions (e.g. | | | I hope that the efforts Richard Eckert is making will be fruitful or that, alternatively, those among us who are more deeply engaged in this programme will rapidly take contacts with each other to make the necessary steps. |
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http://crisceb.unina2.it/what/talking_point.html
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| | eMedicine - Factor XIII : Article by Rajalaxmi McKenna, MD, FACP |
| | The potential use of transglutaminases to mechanically stabilize and allow cultured epithelial autografts to take when used to repair extensive skin wounds supports a possible role of FXIII in the formation of de novo dermoepidermal junctions, thereby facilitating permanent skin replacement (Kawamura, 1997). | | | Prospective clinical trials must prove any thromboprophylactic efficacy of altering fibrin structure using specific drugs. | | | Tissue transglutaminases are involved in apoptosis, and inhibition of their activity by NO prevents apoptosis (Catani, 1998; Bernassola, 1999). |
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http://www.emedicine.com/med/topic3491.htm
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| | TDL: Latest Tests |
| | TDL has incorporated tissue transglutaminase IgA autoantibody testing into the gluten sensitivity profile, with no change in turnaround time or price. | | | The particular mechanism by which tissue transglutaminase causes damage in coeliac disease is unknown, but it is thought to be immune mediated. | | | Because of the high sensitivity, tTG antibodies may prove useful for the screening of coeliac disease in patients. |
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http://www.tdlplc.co.uk/testinfo/lt_tissuetrans.htm
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| | Secretion of Active-Form Streptoverticillium mobaraense Transglutaminase by Corynebacterium glutamicum: Processing of ... |
| | Secretion of Active-Form Streptoverticillium mobaraense Transglutaminase by Corynebacterium glutamicum: Processing of the Pro-Transglutaminase by a Cosecreted Subtilisin-Like Protease from Streptomyces albogriseolus -- Kikuchi et al. | | | Secretion of Active-Form Streptoverticillium mobaraense Transglutaminase by Corynebacterium glutamicum : Processing of the Pro-Transglutaminase by a Cosecreted Subtilisin-Like Protease from Streptomyces albogriseolus | | | Overproduction of microbial transglutaminase in Escherichia coli, in vitro refolding, and characterization of the refolded form. |
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http://aem.asm.org/cgi/content/full/69/1/358
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| | ARUP: Tissue Transglutaminase Antibody, IgA |
| | Human tTG antigen is utilized in this assay. | | | Detection of tissue transglutaminase antibodies is an aid in the diagnosis of certain gluten-sensitive enteropathies, such as celiac disease and dermatitis herpetiformis. | | | For additional interpretive data see Tissue Transglutaminase Antibody, IgA in "ARUP's Guide to Clinical Laboratory Testing" |
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http://www.arupcs.com/guides/ug/tests/0097709.jsp
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| | OMIM Entry 190196 |
| | demonstrated that tissue transglutaminase is the autoantigen involved in celiac disease ( 212750). | | | Northern blot analysis revealed that tissue transglutaminase is expressed as a 3.6-kb mRNA in human endothelial cells. | | | The differences in the primary structures of these different transglutaminases are probably responsible for the diverse biologic functions that they play in physiologic processes such as blood coagulation, epidermal differentiation, seminal fluid coagulation and fertilization, cell differentiation, and apoptosis. |
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http://www.hgmp.mrc.ac.uk/cgi-bin/wrapomim?190196
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| | Transglutaminase - Wikipedia, the free encyclopedia |
| | The catalytic reaction is generally viewed as being irreversible and must be closely monitored through extensive control mechanisms. | | | These biological polymers are indispensable for the organism in order to create barriers and stable structures. | | | Transglutaminase is now produced by Streptoverticillium mobaraense fermentation in commercial quantities and is used in a variety of industrial processes, including the production of processed meat and fish products. |
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http://en.wikipedia.org/wiki/Transglutaminase
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| | Retinoic acid and 4-hydroxyphenylretinamide induce growth inhibition and tissue transglutaminase through different ... |
| | -dependent signaling pathway in the induction of tissue transglutaminase and apoptosis by retinoids. | | | Melino,G., Annicchiarico-Petruzzelli,M., Piredda,L., Candi,E., Gentile,V., Davies,P.J. and Piacentini,M. (1994) Tissue transglutaminase and apoptosis: sense and antisense transfection studies with human neuroblastoma cells. | | | Nagy,L., Thomazy,V.A., Chandraratna,R.A., Heyman,R.A. and Davies,P.J. (1996) Retinoid-regulated expression of BCL-2 and tissue transglutaminase during the differentiation and apoptosis of human myeloid leukemia (HL-60) cells. |
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http://carcin.oupjournals.org/cgi/content/full/20/6/1133
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| | Gail V |
| | Tissue transglutaminase is essential for neurite outgrowth in human neuroblastoma SH-SY5Y cells, Neuroscience, 102:481-491. | | | Because a polypeptide bound glutamine is the primary determining factor for a transglutaminase substrate, it had been hypothesized that tissue transglutaminase may be involved the pathogenesis of Huntington's disease by abnormally modifying mutant huntingtin. | | | These studies will help elucidate the normal metabolism and function of tau protein and increase our understanding of the role of tau in the pathogenesis of Alzheimer's disease and FTDP-17. |
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http://www.dpo.uab.edu/~gvwj
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| | AJINOMOTO - Activa TG (Transglutaminase) |
| | TG preparations of transglutaminase are dry powders that have been developed for specialized applications to make them work very effectively in specific food applications. | | | Transglutaminase from fermented sources tend to be easy to use in many different food systems. | | | Transglutaminase is a revolutionary new way to improve existing food products or allow "out of the box" thinking in making new food products. |
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http://www.activatg.com
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| | Diabetes Care: The High Prevalence of Autoantibodies to Tissue Transglutaminase in First-Degree Relatives of Patients ... |
| | Serum was incubated overnight with in vitro transcribed and translated human [[blank].sup.35]S-labeled human tissue transglutaminase C (received from Dr. E. | | | Transglutaminase antibodies were found to persist in 10 of 30 patients and in 30 of 59 relatives with follow-up samples taken at least 2 years after the initial sample. | | | Diabetes Care: The High Prevalence of Autoantibodies to Tissue Transglutaminase in First-Degree Relatives of Patients With Type 1 Diabetes Is Not Associated With Islet Autoimmunity |
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http://www.findarticles.com/p/articles/mi_m0CUH/is_3_24/ai_71901268
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| | INTRODUCTION |
| | Transglutaminase is produced in the cytosol of cells, however it has been shown that the tTGase is also associated with the extracellular portion of the cell membrane. | | | Tissue transglutaminase also can function as a GTPase. | | | While the structure for human tissue transglutaminase (tTGase) is not known it is known that there are four domains of the protein: N-terminal β region, α-helical core domain, and two β sheet domains at the C-terminal. |
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http://www.stanford.edu/group/khosla/People/webjp.html
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| | Transglutaminase |
| | Recombinant Human Tissue Transglutaminase for Diagnosis and Follow-up of Childhood Coeliac Disease. | | | Comparison ELISAs for ELISA for tissue transglutaminase autobodies wich | | | 4 - Maki M. Tissue Transglutaminase as the autoantigen of coeliac disease. |
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http://www.radim.it/transglutaminase.html
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| | Peter J. A. Davies, M.D., Ph.D. |
| | We are using a variety of molecular techniques to investigate the molecular basis for the effects of rexinoids on gene expression in cultured adipocytes and diabetic rodents. | | | R esearch in my laboratory introduces students to the use of animal models of human diseases such as diabetes and breast cancer, as well as various transgenic mouse models, to delineate the molecular mechanisms of hormone action in vivo. | | | A second area of particular interest to the laboratory is the investigation of the factors controlling the expression of the enzyme tissue transglutaminase. |
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http://ibp.med.uth.tmc.edu/faculty/pdavies/pdavies.htm
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| | The Great Plains Laboratory, your center of testing and analysis for Autism, Pervasive Developmental Disorder (PDD), ... |
| | In the medical disorder called celiac disease, there is a reduced ability to digest wheat and there is often a direct toxic effect of gluten on the lining of the intestine called the intestinal mucosa. | | | Researchers in Norway think that transglutaminase facilitates the physical linkage of the carboxamide group of an amino acid called glutamine in gluten to an epsilon-amino group of a lysine residue in transglutaminase in the intestinal tract. | | | This abnormally linked molecule is then perceived as a foreign antigen by the immune system and antibodies to transglutaminase begin to be produced, inhibiting the normal function of transglutaminase in repairing damaged intestinal mucosa. |
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http://www.greatplainslaboratory.com/russian/test16.html
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| | Pfam 17.0 : Transglut_core |
| | Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII. | | | On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase [2], it is proposed that many, if not all, microbial homologues of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease. | | | On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase MEDLINE:9791169, it is proposed that many, if not all, microbial homologs of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease MEDLINE:10452618. |
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http://pfam.wustl.edu/cgi-bin/getdesc?acc=PF01841
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| | TGM4 - Transglutaminase 4 (prostate) - aka: pTGase - Cancer GeneticsWeb |
| | Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment. | | | The human prostate-specific transglutaminase gene (TGM4): genomic organization, tissue-specific expression, and promoter characterization. | | | Changes in tissue transglutaminase activity and expression during retinoic acid-induced growth arrest and apoptosis in primary cultures of human epithelial prostate cells. |
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http://www.cancerindex.org/geneweb/TGM4.htm
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| | Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation -- Egberts et al. 117 ... |
| | CTSD stimulates transglutaminase 1 (TG1) activity in primary keratinocytes in vitro. | | | Inactive zymogen and highly active proteolytically processed membrane-bound forms of the transglutaminase 1 enzyme in human epidermal keratinocytes. | | | Rosenthal, D. S., Griffiths, C. E., Yuspa, S. H., Roop, D. and Voorhees, J. Acute or chronic topical retinoic acid treatment of human skin in vivo alters the expression of epidermal transglutaminase, loricrin, involucrin, filaggrin, and keratins 6 and 13 but not keratins 1, 10, and 14. |
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http://jcs.biologists.org/cgi/content/full/117/11/2295
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| | Polymer Hydrogels |
| | Extensive transglutaminase-mediated crosslinking of soluble proteins is believed to be responsible for rapid physical gelation of certain biological fluids. | | | A common biological strategy for regulating the activity of transglutaminase enzymes is control of intracellular and extracellular Ca concentration, mediated by lipid bilayer membranes. | | | Natural proteins and synthetic polypeptides determined to be transglutaminase substrates are under investigation, in combination with Factor XIII and tissue transglutaminase, to formulate solutions which undergo rapid gelation upon activation of the enzyme by exposure to Ca (Collaborative project with Prof. |
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http://www.chem.purdue.edu/thompson/polymer.htm
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| | Enzymatic treatment of proteinaceous animal by-product materials to impart cohesion and strength (US6200789) |
| | Akamittath, J.G., et al., "Transglutaminase Mediated Polymerization of Crude Actomyosin Refined from Mechanically Deboned Poultry Meat", Journal of Muscle Foods, vol. | | | Sakamoto, H., et al., "Strength of Protein Gels Prepared with Microbial Transglutaminase as Related to Reaction Conditions", Journal of Food Science, vol. | | | Enzyme preparation for use in the binding of food materials and process for producing bound food |
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http://www.delphion.com/details?pn=US06200789__
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| | [No title] |
| | Interestingly, epidermis of all 6 patients suffering from transglutaminase-1 deficient LI showed a clear lack of PAI-2 expression or a very faint intracellular immunostaining. | | | Considering the fact that PAI-2 does not show pericellular staining in transglutaminase-1 deficient epidermis, we propose that PAI-2 is in vivo incorporated in the CE by transglutaminase-1 suggesting a potential role in LI and other cornification disorders. | | | PAI-2 contains three acceptor sites, Gln83, Gln84, and Gln86, for transglutaminase-catalyzed amine incorporation as has been shown for tissue transglutaminase (TGM2) and factor XIIIa. |
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http://www.blackwellpublishing.com/esdr2004/abstract.asp?id=18555
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| | vitacost.com - Top brand vitamins at wholesale cost! |
| | Curcumin-induced cell death was neither due to apoptosis nor to any significant change in the expression of apoptosis-related genes, including Bcl-2, p53, cyclin B and transglutaminase. | | | Overall our results suggest that curcumin is a potent antiproliferative agent for breast tumor cells and may have potential as an anticancer agent. |
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http://www.vitacost.com/science/medstudies.cfm?litid=32
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| | Goff |
| | Francois Capel - Currently studying the functional properties of nutritionally-significant food polysaccharides (soluble fibre) with a view to higher-level additions through control of over-texturing. | | | Was studying the effects of transglutaminase on ice cream properties. |
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http://www.foodsci.uoguelph.ca/dairyedu/goff.html
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| | Internet links |
| | The 1996 pictorial human genome map from Science. | | | W.H.A.T. -Worldwide happenings about transglutminase, created to promote communication among transglutaminase workers. | | | Extensive list of WWW chemistry resources, from UCLA |
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http://sciencepark.mdacc.tmc.edu/documents/links.html
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