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| | Transerrin and Iron Transport Physiology |
 | | These data support the idea that, while the transferrin pathway is important for meeting the needs of the erythron, it is not essential for iron uptake by all tissues. | | | Such radioactive tracer studies indicate that at least eighty percent of the iron bound to circulating transferrin is delivered to the bone marrow and incorporated into newly formed erythrocytes (Jandl and Katz, 1963); (Finch et al., 1982); Fig. | | | A broad body of literature now supports the concept that the iron-transferrin complex is internalized by receptor-mediated endocytosis. |
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http://sickle.bwh.harvard.edu/iron_transport.html
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| | [No title] |
| | The structure of the ectodomain has striking similarities to the membranebound carboxy peptidase II (Lawrence et al 1999), suggesting that they have evolved from a common peptidase (Bzdega et al 1997). | | | This review will focus on the clinical value of sTfR measurements. | | | The extracellular domain of TfR2 has 45% identity and 66% similarity with TfR. |
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http://www.ifcc.org/ejifcc/vol13no2/130201006n.htm
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| | Transferrin - Wikipedia, the free encyclopedia |
| | Transferrin are also associated with the innate immune system. | | | Transferrin levels may be checked in iron deficiency, hemochromatosis and other iron overload disorders. | | | Transferrin are found in the mucosa and bind iron, thus creating an environment low in free iron, where few bacteria are able to survive. |
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http://en.wikipedia.org/wiki/Transferrin
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| | K/DOQI Update 2000 |
| | There is insufficient evidence that serum transferrin is a more sensitive index of PEM than serum albumin in MD patients. | | | Serum transferrin may be more useful in nondialyzed patients with advanced CRF who are less likely to have increased blood loss and who are not receiving erythropoietin or iron therapy. | | | Transferrin is a negative acute-phase reactant and is limited by many of the same conditions that limit albumin and prealbumin as indicators of nutritional status. |
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http://www.kidney.org/professionals/kdoqi/guidelines_updates/nut_appx08a.html
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| | TIBC & Transferrin: The Test |
| | For more information on reference ranges, please read Reference Ranges and What They Mean. | | | It is customary to test for transferrin (instead of TIBC) when evaluating a patient's nutritional status or liver function. | | | A low TIBC or transferrin may occur if you have hemochromatosis, certain types of anemia in which iron accumulates, malnutrition, inflammation, liver disease, or nephrotic syndrome (a kidney disease that causes loss of protein in urine). |
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http://www.labtestsonline.org/understanding/analytes/tibc/test.html
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| | Transferrin Receptor antibody [B349 (DF1513)] (ab8598) datasheet |
| | Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients. | | | Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). | | | The transferrin receptor has been structurally characterized as a sulfide-bound dimer of identical glycoprotein subunits of 95 kD. |
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http://www.abcam.com/?datasheet=8598
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| | Transferrin |
| | Transferrin is normally only about one-third saturated and is responsible for circadian variation in serum iron (peak in AM) due to variable activity of the reticuloendothelial system. | | | Transferrin is responsible for 50% to 70% of the iron binding capacity of serum. | | | May not be elevated in iron-deficient states in which there is severe protein malnutrition (eg, kwashiorkor). |
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http://www.labcorp.com/datasets/labcorp/html/chapter/mono/sc020300.htm
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| | Progressive Desialidation of Human Transferrin |
| | Alterations in the electrophoretic mobility of transferrin may be encountered in forensic science case work, particularly in association with postmortem samples. | | | These experiments support the hypothesis that the “ladder” banding pattern of transferrin observed in some case samples is due to the removal of sialic acid residues by bacterial or endogenous neuraminidase. | | | To determine whether these altered transferrins are the result of sialic acid removal, serum samples of known transferrin type were treated with neuraminidase. |
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http://www.astm.org/JOURNALS/FORENSIC/PAGES/1108.htm
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| | Pfam 19.0 : Transferrin |
| | Transferrins are eukaryotic iron-binding glycoproteins that control thelevel of free iron in biological fluids PUBMED:3032619. | | | The proteins have arisen by duplication of adomain, each duplicated domain binding one iron atom. |
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http://pfam.wustl.edu/cgi-bin/getdesc?name=Transferrin
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