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| | NGC - NGC Summary |
 | | Tissue plasminogen activator (t-PA) for acute ischemic stroke. |
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http://www.guideline.gov/summary/summary.aspx?ss=15&doc_id=3422&nbr=2648
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| | MedlinePlus Medical Encyclopedia: Thrombolytic therapy |
| | Physicians base their decisions about whether to give tPA for a heart attack on many factors, including a history of chest pain and the results of an ECG test. | | | The sooner thrombolytic therapy is given, the better the outcome. | | | Further therapy, such as cardiac catheterization, may be needed. |
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http://www.nlm.nih.gov/medlineplus/ency/article/007089.htm
(986 words)
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| | Tissue Plasminogen Activator (tPA) |
| | Tissue plasminogen activator (tPA) is a thrombolytic agent (clot-busting drug). | | | This kind of stroke is caused by blood clots that block blood flow to the brain. | | | This makes it very important for people who think they're having a stroke to seek help immediately. |
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http://www.americanheart.org/presenter.jhtml?identifier=4751
(303 words)
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| | Encyclopedia Search - Medical Dictionary Search Engines |
| | Aging changes in the bones - muscles - joints | | | Acting strangely see Behavior - unusual or strange | | | Activase thrombolytic agent see Thrombolytic therapy (tissue plasminogen activator - tPA) |
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http://medical-dictionary-search-engines.com/encyclopedia/?encyclopedia_name...
(474 words)
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| | Tissue Plasminogen Activator Activity |
| | Evaluate thrombotic risk in individuals with a history of thrombosis and negative tests for more common thrombotic risk factors; monitor thrombolytic therapy. | | | Determinants of tPA antigen and associations with coronary artery disease and acute cerebrovascular disease. | | | Prospective study of endogenous tissue plasminogen activator and risk of stroke. |
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http://www.labcorp.com/datasets/labcorp/html/chapter/mono/nf10004490.htm
(667 words)
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| | Stroke Treatment Advances |
| | tPA is one of several drugs that can dissolve the blood clots responsible for causing many strokes. | | | Anticoagulants (blood thinners) and aspirin are shown to be effective in lowering the risk of stroke in people with atrial fibrillation. | | | The FDA approves the use of tissue plasminogen activator (tPA) to treat ischemic stroke in the first three hours following the onset of symptoms. |
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http://www.americanheart.org/presenter.jhtml?identifier=4738
(563 words)
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| | Recombinant Human Tissue Plasminogen Activator - ENZ-263 |
| | ProSpec's Human TPA is fully biologically active when compared to World Health Organization (WHO) reference standard which is 5.8x10 | | | The use of intravenous recombinant tissue plasminogen activator in acute ischemic stroke. | | | Tissue plasminogen activator mediated blood-brain barrier damage in transient focal cerebral ischemia in rats: Relevance of interactions between thrombotic material and thrombolytic agent. |
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http://www.prospec.co.il/~prospec/cart/catalog/rHuTPA.html
(399 words)
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| | tissue plasminogen activator |
| | Use caution when moving patient to prevent bruising or bleeding | | | Plasmin digests the fibrin strands of the clot and restores perfusion to the occluded artery. | | | Tissue plasminogen activator is a naturally-occurring enzyme derived from DNA technology. |
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http://www.templejc.edu/dept/ems/drugs/tpa.html
(176 words)
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| | Tissue plasminogen activator - Wikipedia, the free encyclopedia |
| | Because of this, only about 3% of patients qualify for this treatment. | | | Recombinant tPA is used in diseases which feature blood clots, such as myocardial infarction and stroke. | | | To be effective, tPA must be administered within the first six or so hours of the attack. |
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http://en.wikipedia.org/wiki/Tissue_plasminogen_activator
(110 words)
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| | Tissue plasminogen activator (t-PA) for stroke |
| | Tissue plasminogen activator can be used to treat some people who are having a stroke caused by a blood clot (ischemic stroke | | | Effects of tissue plasminogen activator for acute ischemic stroke at one year. | | | Tissue plasminogen activator should be given within the first 3 hours after the first symptoms of stroke start. |
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http://www.webmd.com/hw/stroke/hw224370.asp
(721 words)
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| | p990908b - Tissue Plasminogen Activator (TPA) Guidelines |
| | Title: Recombinant tissue-type plasminogen activator: current concepts and guidelines for clinical use in acute myocardial infarction. | | | Future investigations must continue to focus on patient selection to allow treatment for all patients who would derive benefit and to establish dosing regimens and adjuvant therapies that will maximize coronary reperfusion while concomitantly limiting reocclusion and hemorrhagic complications. | | | Abstract: The extraordinarily high prevalence of coronary heart disease, coupled with the alarming incidence of MI in Western society, has encouraged the investigation and development of pharmacologic agents that can be employed widely, quickly, effectively, and safely. |
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http://www.emory.edu/WHSCL/grady/amreport/litsrch99/p990908b.html
(201 words)
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| | Gene Therapy Heart Disease |
| | Current approaches to treatment include the use of either clot-buster drugs such as TPA (tissue plasminogen activator) or angioplasty, a procedure that physically widens the vessels with a balloon. | | | Obstructed blood vessels in the heart are a leading cause of heart attack. |
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http://www.accessexcellence.org/WN/SUA11/genetherapyaha1197.html
(810 words)
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| | UniProtKB/Swiss-Prot entry P00750 [TPA_HUMAN] Tissue-type plasminogen activator |
| | Binding to laminin and fibronectin has also been demonstrated. | | | Ny T. Elgh F. Lund B. "The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains."; | | | Used in Acute Myocardial Infarction (AMI), in Acute Ischemic Stroke (AIS) and Pulmonary Embolism (PE) to initiate fibrinolysis. |
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http://www.expasy.org/uniprot/P00750
(1439 words)
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| | tissue plasminogen activator |
| | It has been shown to be more effective than streptokinase when used in conjunction with heparin, but it is much more expensive. | | | Naturally occurring substance in the body tissues that activates the enzyme plasmin that is able to dissolve blood clots. | | | Human tPA, produced in bacteria by genetic engineering, has, like streptokinase, been used to dissolve blood clots in the coronary arteries of heart-attack victims. |
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http://www.tiscali.co.uk/reference/encyclopaedia/hutchinson/m0024890.html
(116 words)
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| | Tissue Plasminogen Activator |
| | Fibrin essentially enhances the local concentration of t-PA by creating an additional interaction between t-PA and its substrate, plasminogen. | | | The structures involved in the enzymatic domain are in the B chain. | | | The presence of fibrin enhances, by two to three orders of magnitude, the efficacy with which t-PA activates plasminogen. |
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http://www.umich.edu/~pharm660/AnticoagAntiplat/tsld085.htm
(143 words)
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| | Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations |
| | Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link. | | | Two different retinal neuron insult models were used in the present study. | | | To investigate the role of tissue plasminogen activator (tPA) in retinal damage, tPA-deficient and wild-type mice were employed. |
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http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=20574318
(311 words)
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| | Tissue Plasminogen Activator |
| | Native tissue-type plasminogen activator (t-PA) is a serine proteinase with a molecular weight of 70,000. |
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http://www.umich.edu/~pharm660/AnticoagAntiplat/tsld084.htm
(109 words)
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| | ARUP: Tissue Plasminogen Activator, Antigen |
| | For additional interpretive data see Tissue Plasminogen Activator, Antigen in "ARUP's Guide to Clinical Laboratory Testing" | | | Test Mnemonic: TPA AG Methodology: Enzyme-Linked Immunosorbent Assay |
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http://www.aruplab.com/guides/ug/tests/0099187.jsp
(105 words)
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| | Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer ... |
| | Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion in vitro -- Díaz et al. | | | Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion in vitro | | | membrane of pancreatic cancer cells where it activates local |
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http://gut.bmjjournals.com/cgi/content/abstract/53/7/993
(408 words)
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