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| | MedlinePlus Drug Information: Thyroglobulin |
 | | This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. | | | Talk to your doctor about the potential risks associated with this medication. | | | Your doctor will order certain lab tests to check your response to thyroglobulin. |
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http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a601119.html
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| | Profile |
| | The oral administration of human thyroglobulin does not affect the incidence of lymphocytic thyroiditis in the biobreeding Worcester rat. | | | Effects of iodine deficiency and high-fat diet on N-nitrosomethylurea-induced mammary cancers in rats. | | | 1971-1976, Research Career Development Award, NIH,, Thyroglobulin structure and relation to disease |
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http://myprofile.cos.com/dunnj38
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| | Full list of publications |
| | Predictive value of serum thyroglobulin concentratian in the outcome of therapy in patients with Graves' disease. | | | Uller, R.P., Van Herle, A.J., and Chopra, I.J. Comparison of alterations in circulating thyroglobulin, triiodothyronine an thyroxlne in response to exogenous (Bovine) and endogenous (human) thyrotropin. | | | Van Herle, A.J. Measurement and clinical significance of thyroglobulin in serum and body fluids. |
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http://www.endocrinology.med.ucla.edu/new_page_1.htm
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| | NGC - NGC Summary |
| | Other investigators, however, do not use radioiodine remnant ablation in these low-risk patients because of lack of evidence of improved outcome. | | | External irradiation is rarely used as adjunctive therapy in the initial management of patients with follicular cell-derived cancers. | | | I therapy in the patients with negative scans and high serum thyroglobulin levels. |
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http://www.guideline.gov/summary/summary.aspx?doc_id=2848
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| | Follow-up |
| | Periodic chest X rays may also be indicated. | | | Lack of impact of radioiodine therapy in Tg-positive, diagnostic whole-body scan-negative patients with follicular cell-derived thyroid cancer. | | | Hence the thyroglobulin alone is not 100% perfect in the follow-up of patients with thyroid cancer. |
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http://www.mythyroid.com/follow-up.htm
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| | [No title] |
| | Thyroid autoantiboidies are present in about 6-7% of normals and their incidence increases with age (6). | | | Thyroglobulin and or microsomal antibodies are present in most patients with goitrous thyroiditis (Hashimoto disease), atrophic thyroditis (myxedema) and about 70-90% of Graves disease (1). | | | Antibodies are also found in about half of the patients with primary hypothyroidism and thyrotoxicosis, and 10-20% of patients with simple goiters and thyroid tumors (4). |
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http://www.rapidtest.com/Thyroglobulin_1421.doc
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| | UCLA Biocybernetics Laboratory |
| | Honbo, A. Van Herle and J. DiStefano, III, "Peripheral Metabolism of Thyroglobulin in the Rat,'' Clinical Research, 26:106, 1978. | | | J.J. DiStefano, III, T. Malone, M. Jang and M. Broutman, "Maximally Accurate Parameters of Iodothyronine Metabolism from Only 5 or 6 Blood Samples: a New and Generally Applicable Approach to Kinetic Studies and Its Demonstration in Rats,'' Endocrinology, suppl. |
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http://www.biocyb.cs.ucla.edu/publications.html
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| | Thyroglobulin, Human, antibody |
| | MoAb s specifically recognize human thyroglobulin and do not interfere with anti-thyroglobulin autoantibodies. | | | Detection of human thyroglobulin in two-site enzyme immunoassay. | | | Clone 12G9 cross-reacts with bovine, pig, cat, rat, dog and mouse thyroglobulins. |
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http://www.hytest.fi/tuotteet24.php
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| | Thyroid gland |
| | papillary carcinoma with cystic change (positive for TTF-1, thyroglobulin) | | | Chronically stimulated (hyperplastic) follicular cells are tall and columnar, may be papillary | | | May be cyst, sinus, fistula or cartilage in anterolateral neck |
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http://www.pathologyoutlines.com/thyroid.html
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| | Thyroglobulin |
| | Although thyroglobulin levels may be elevated in patients with thyroid cancer, a large number of benign thyroid conditions may also be associated with elevated levels of thyroglobulin, hence an increased thyroglobulin alone in a patient not known to have thyroid cancer is not a sensitive or specific test for the diagnosis of thyroid cancer. | | | Ideally, the thyroglobulin levels will be low or undetectable after treatment (usually surgery followed by radioactive iodine). | | | There are certain pitfalls to the interpretation of thyroglobulin levels, which may include assay variability and the presence of thyroglobulin antibodies. |
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http://www.mythyroid.com/thyroglobulin.htm
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| | [No title] |
| | Each laboratory should determine an optimum working titer for use in its particular application. | | | ࡱ > p r o q _ bjbjt+t+ - A A r ] 8 ! r $ $ ( L L L L > = C L L $ " z$ L L * L L $ * * * " L L * * 0 L [' ^ $ SPECIFICATION SHEET Catalog #: E86059M Lot #: 6H23003 Description: MAb to Thyroglobulin Monoclonal Antibody to Human Thyroglobulin Specificity: Specifically recognizes human thyroglobulin. | | | Source: Ascites Immunogen: Thyroglobulin from human thyroid gland. |
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http://www.biodesign.com/spec.asp?catalog=E86059M
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| | Thyroglobulin - Wikipedia, the free encyclopedia |
| | Hence, a thyroglobulin deficient patient typically shows symptoms of slow speech, lack of energy, weight gain, hair loss, dry thick skin, and increased sensitivity to cold. | | | It is rarely perscribed to patients as many other proteins aid in these processes and an abundance of thyroglobulin unsurprisingly has similar side-effects to an unhealthily low amount. |
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http://en.wikipedia.org/wiki/Thyroglobulin
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| | The Scientist - New Tests Monitor Thyroid Cancer |
| | Patients who had been treated shouldn't have thyroglobulin mRNA, just as they wouldn't have thyroglobulin. | | | The test will be especially useful for patients who have antibodies to thyroglobulin. | | | In 77 patients and 10 healthy controls, the technique detected the telltale mRNA in all 14 patients with confirmed metastases; serum thyroglobulin testing found only eight. |
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http://www.the-scientist.com/yr1999/jan/lewis_p10_990118.html
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| | ThyCa: Thyroglobulin and Tg Antibody Testing |
| | Thyroglobulin (Tg) and Tg Antibody (TgAb) Testing for Patients Treated for Thyroid Cancers | | | The measurement of the protein Thyroglobulin (abbreviated Tg) in blood, is an important laboratory test for checking whether a patient still has some thyroid present. |
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http://www.thyca.org/thyroglobulin.htm
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| | MedlinePlus Medical Encyclopedia: Thyroid cancer |
| | Elevated serum calcitonin (for medullary cancer) or serum thyroglobulin (for papillary or follicular cancer) | | | This disease may also alter the results of the following tests: | | | Thyroid scan showing cold nodule (a nodule that does not light up on scan) |
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http://www.nlm.nih.gov/medlineplus/ency/article/001213.htm
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| | Serum thyroglobulin in hospitalized chronic geriatric patients: its relationship to age, non-thyroidal illness, goitre ... |
| | Serum thyroglobulin in hospitalized chronic geriatric patients: its relationship to age, non-thyroidal illness, goitre and thyroid dysfunction in a follow-up study. | | | Two-hundred and twenty-six non-selected, chronic hospitalized patients over 60 years old and 82 healthy adults (20-40 years) participated in the study, and TSH, thyroxine, free thyroxine, triiodothyronine and TG were estimated. | | | Nevertheless, the advantage of TG estimation to be more constant than TSH could be of benefit in screening studies. |
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http://www.arclab.org/medlineupdates/abstract_7952156.html
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| | ORGENTEC Diagnostika GmbH |
| | A main application for the thyroglobulin determination is the post surgical monitoring of patients with differentiated thyroid carcinoma. | | | With the help of the recovery reagent, that is included in the kit, the user can detect the presence of possible autoantibodies directed against thyroglobulin in the patient serum. | | | Elevated thyroglobulin serum concentrations have been reported in various thyroid diseases, such as hyperthyroidism, non-toxic goiter, thyroiditis, and differenciated thyroid carcinoma. |
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http://www.orgentec.com/cgi-bin/cj/messigent.pl?company=73&zoneid=210&pk=1339&action=show&tmplid=1
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| | Thyroid Panel |
| | Patients with positive rTSH-stimulated thyroglobulin concentrations and/or radioiodine scans can then be directed for appropriate therapy. | | | Thyroxine did not improve cognitive function and psychological wellbeing in healthy participants. | | | CONCLUSION: Radioiodine scanning and serum thyroglobulin measurement after intramuscular injection of rTSH are valuable new monitoring options in patients with treated thyroid cancer, avoiding the adverse effects of hypothyroidism. |
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http://www.thedoctorsdoctor.com/labtests/thyroid_panel.htm
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| | THE MERCK MANUAL, Sec. 2, Ch. 8, Thyroid Disorders |
| | The principle use of serum thyroglobulin is in evaluating patients after near-total or total thyroidectomy with or without | | | Autoantibodies to thyroid peroxidase and, less commonly, to thyroglobulin are present in almost all patients with Hashimoto's thyroiditis, and thyroid peroxidase autoantibodies are usually detected in patients with Graves' disease. | | | The major problem with the current immunometric assay and radioimmunoassay methods in measuring serum thyroglobulin is the presence of thyroglobulin antibodies, which usually results in an underestimation of serum thyroglobulin. |
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http://www.merck.com/pubs/mmanual/section2/chapter8/8a.htm
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| | Projects Brix: Extrathyroidal Thyroglobulin |
| | Circulating thyroglobulin is cleared within the liver via internalization by Kupffer cells, e.g. | | | Thyroglobulin binds to the cell surface of the macrophages, reaches endosomes within 5 minutes of endocytosis, and accumulates within lysosomes after 60 minutes (see Figure above). | | | Thyroglobulin is synthesized within epithelial cells of the thyroid and it is stored within the follicular lumen at high concentrations. |
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http://www.zellbiologie.uni-bonn.de/HTML/brix_circ_tg_e.htm
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| | Thyroglobulin |
| | The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for thyroglobulin even though sometimes only focal. | | | - This antibody reacts with human thyroglobulin, as demonstrated by a single band of immunoblotting in a lysate of human thyroid tissue. | | | Poorly differentiated carcinomas of the thyroid are nearly always thyroglobulin negative. |
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http://www.cellmarque.com/2000/Pages/catalog/thyro.html
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| | FBR Resource Guide: Anti-Thyroglobulin Antibodies (ATGA) |
| | Thyroglobulin antibodies are seen in patients with Hashimoto's thyroiditis and Graves' disease. | | | They may also be seen at lower levels in other thyroid and non-thyroid autoimmune diseases. |
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http://www.fbr.org/publications/resguide/rg-t_atga.html
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| | Thyroglobulin antibodies |
| | Elevated levels of this antibody may cause problems in tests to determine a patient's serum thyroglobulin level. | | | This anti-thyroglobulin (anti-Tg) is an auto antibody to thyroid thyroglobulin, and is a confirmation test for a diagnosis of Hashimoto's thyroiditis. |
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http://www.palpath.com/thytg.htm
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| | J. Clin. Invest. 102 (1998), 283-293 |
| | Clearance of thyroglobulin from the circulation occurs within the liver via internalization of thyroglobulin by macrophages. | | | Here, we have analyzed the interaction of thyroglobulin with the cell surface of J774 macrophages with the aim to identify the possible thyroglobulin binding sites on macrophages. | | | The in vitro interaction between histone H1 and thyroglobulin was analyzed by surface plasmon resonance which revealed a KD at 46 nM. |
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http://www.zellbiologie.uni-bonn.de/HTML/brix_lit_jci_1998.htm
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| | Medipan: Thyroid Diseases medipan,Tg,Thyroglobuline,Thyroglobulin,TSH receptor antibody,TRAB,thyroid-stimulating ... |
| | Therefore, the main indication of serum Tg is the monitoring of patients with differentiated thyroid cancer (DTC) after total thyroidectomy and ablative radioiodine treatment. | | | The determination of serum Tg can also be useful to distinguish between subacute thyroiditis and factitious thyrotoxicosis and for differential diagnosis of neonatal hypothyroidism. | | | AITD are characterized by the occurence of antibodies against several antigens in the thyroid gland, especially against the TSH receptor (TSH-R), thyroperoxidase (anti-TPO) and thyroglobulin (anti-Tg). |
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http://www.medipan.de/diseases/thyroid_disease.html
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| | Specialty Laboratories ::: we help doctors help patients |
| | Autoantibodies to thyroglobulin are associated with chronic lymphocytic (Hashimoto) thyroiditis (76-100%), primary myxedema (72%), hyperthyroidism (33%), colloid goiter (8%), adenoma (28%), thyroid cancer (13-65%), and autoimmune disease. | | | High levels also occur in goiter and in many types of hyperthyroidism. | | | High thyroglobulin values are reported with surgery or irradiation to the thyroid, with thyroiditis, T4-binding globulin deficiency, with administration of TRH, TSH, iodine, and with administration of anticancer drugs. |
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http://oncology.specialtylabs.com/tests/print_view.asp?id=3251
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| | Synthesis and Secretion of Thyroid Hormones |
| | Colloid-laden endosomes fuse with lysosomes, which contain hydrolytic enzymes that digest thyroglobluin, thereby liberating free thyroid hormones. | | | Each of the processes described above appears to be stimulated by thyroid-stimulating hormone from the anterior pituitary gland. | | | Iodination of tyrosines on thyroglobulin (also known as "organification of iodide"). |
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http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/thyroid/synthesis.html
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| | InterPro: Thyroglobulin type-1 |
| | Malthiery Y. Lissitzky S. Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA. | | | Please be aware that match views for entries matching more than 1000 proteins may be slow. | | | Galesa K. Pain R. Jongsma M.A. Turk V. Lenarcic B. Structural characterization of thyroglobulin type-1 domains of equistatin. |
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http://www.ebi.ac.uk/interpro/IEntry?ac=IPR000716
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| | IZOTOP Human Thyroglobulin (hTG) IRMA kit |
| | I] IRMA system provides a direct quantitative in vitro determination of human thyroglobulin (hTg) in human serum. | | | Thyroglobulin is a iodoglycoprotein consisting of heterogeneous molecules, the composition of which is in part depending on the degree of iodination. | | | Interference can be detected by using recovery test. |
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http://www.isotope-inst.com/immuno/rk51c.htm
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| | THYROGLOBULIN - serum |
| | g/L. Thyroglobulin should be undetectable in a patient who has had a total thyroidectomy. | | | This page will be permanently removed on 30th September 2004. |
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http://www.rcpa.edu.au/pathman/thyroglo.htm
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| | UniProt Entry - UniProt [the Universal Protein Resource] |
| | Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA. | | | Thyroglobulin gene point mutation associated with non-endemic simple goitre. | | | The revised 8307 base pair coding sequence of human thyroglobulin transiently expressed in eukaryotic cells. |
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http://www.pir.uniprot.org/cgi-bin/upEntry?id=P01266
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| | Thyroglobulin antibody [12G9] (ab1983) datasheet |
| | But please do contact us if you would like any reassurance! | | | The human thyroglobulin (hTg) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. | | | Optimal dilutions/concentrations should be determined by the end user. |
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http://www.abcam.com/?datasheet=1983
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| | Thyroid Transcription Factor 1 Phosphorylation Is Not Required for Protein Kinase A-dependent Transcription of the ... |
| | Articles by Feliciello, A. Articles by Gottesman, M. Cancer Research | | | Pouillon V., Pichon B., Donda A., Christophe D. TTF-2 does not appear to be a key mediator of the effect of cyclic AMP on thyroglobulin gene transcription in primary cultured dog thyrocytes. | | | Thyroid Transcription Factor 1 Phosphorylation Is Not Required for Protein Kinase A-dependent Transcription of the Thyroglobulin Promoter -- Feliciello et al. |
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http://cgd.aacrjournals.org/cgi/content/full/11/12/649
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