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| | Is Bovine Thrombin Safe to Use |
 | | The use of bovine thrombin for topical applications to achieve hemostasis during surgery (for example, when using FloSeal) is safe and does not present an undue risk of bleeding resulting from an antibody-induced coagulopathy. | | | This provided a study sample of 309 patients in whom bovine thrombin was applied topically either with gelatin matrix of FloSeal or the gelatin formulated as Gelfoam sponge. | | | The safety profile of bovine thrombin demonstrated in the present study is further supported by a review of Medical Device Reports (MDRs) to the United States’ Food and Drug Administration (FDA). |
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http://service.plateletgel.net/ThrombinN.htm
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| | eMedicine - Disseminated Intravascular Coagulation : Article by Alvin H Schmaier, MD |
| | Thus, the clinical condition of DIC is summarized as follows: Too much thrombin tips the balance toward the prothrombic state, and the patient presents with thrombosis (eg, Trousseau syndrome [migratory thrombophlebitis associated with cancer]). | | | This form of DIC is the most commonly recognized and is associated with the most dramatic clinical changes. | | | The third step is to add heparin therapy. |
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http://www.emedicine.com/med/topic577.htm
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| | Thrombin-JMI - Drugs & Vitamins - Drug Library - DrugDigest |
| | Your condition will be closely monitored while you use thrombin. | | | Tell your prescriber or health care professional: about all other medicines you are taking including non-prescription medicines; if you are a frequent user of drinks with caffeine or alcohol; if you smoke; or if you use illegal drugs. | | | There are no known interactions between thrombin and other medicines. |
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http://www.drugdigest.org/DD/DVH/Uses/0,3915,8143Thrombin-JMI,00.html
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| | Desensitisation of protease-activated receptor-1 (PAR-1) in rat astrocytes: evidence for a novel mechanism for ... |
| | thrombin, after 30 min the response recovered to about 70 % of the first response and up to 2 h were required for full recovery. | | | In contrast, after an initial non-proteolytic activation of astrocyte PAR-1 by TRag, the subsequent response to thrombin, but not to an additional application of TRag, was strongly attenuated, and the time course for desensitisation was slower. | | | The concentrations of thrombin and TRag employed here induce nearly maximal responses in rat astrocytes, as assessed in our previous work (Ubl et al. |
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http://jp.physoc.org/cgi/content/full/525/2/319
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| | Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin -- Fang et al. 549 ... |
| | NMDA-induced behaviours were also not influenced by actinomycin (40.8 ± 6.4 behaviours, n = 6) or cycloheximide (36.7 ± 6.2 behaviours, n = 6) in the absence of thrombin when compared with control mice pretreated with saline only (35.7 ± 7.7 behaviours, n = 6). | | | Injection of thrombin itself did not produce any effect on von Frey fibre responses at any time over this 2 h interval. | | | It is, therefore, unlikely that PAR-1 antagonists would induce analgesia in healthy individuals in the absence of pain. |
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http://jp.physoc.org/cgi/content/full/549/3/903
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| | Thrombin |
| | In contrary, our evidences suggest that thrombin is a critical mediator of liver injury, and that its involvment closely preceeds the onset of hepatotoxicity. | | | It is our hope that this work will contribute to a better understanding of the events closely preceeding the onset of organ injury, and by doing so unmask new directions toward a better treatment of the consequences of endotoxemia. | | | From a medical viewpoint, the first exposure to LPS and the rise in TNF-alpha in the patient's circulation are not in close enough temporal apposition to the appearence of the first clinical symptomes to be considered an interesting target for therapeutic intervention. |
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http://www.msu.edu/user/moulinfr/thrombin.html
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| | Frederic Moulin |
| | Thus, despite the limitation of our research to the study of hepatotoxicity, it is reasonable to envision a broader implication of thrombin in the mechanism of endotoxin-induced multi-organ failure. | | | In both sets of experiments, the treatment of the perfusion solution prevented increase in intrahepatic pressure, suggesting the absence of fibrin clot formation in the vasculature. | | | Why are we interested in Thrombin as a possible mediator ? |
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http://www.msu.edu/user/moulinfr
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| | Blood Coagulation |
| | The inability of the body to control the circulating level of active thrombin would lead to dire consequences. | | | The intrinsic pathway requires the clotting factors VIII, IX, X, XI, and XII. | | | This effect of heparin is the basis for its clinical use as an anticoagulant. |
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http://www.med.unibs.it/~marchesi/blood.html
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| | MEDSTUDENTS-INTENSIVE CARE |
| | They may be treated with blood components to replace depleted coagulation factors ( although, in theory, it may temporarily " feed the fire "), platelets and natural inhibitors of plasmin and thrombin in an attempt to reduce bleeding while the underlying problem is being corrected ( antibiotics, fetal delivery, aneurysm surgery... | | | Localized chronic DIC occurs in patients with aortic aneurysms, hemangiomas ( Kasabach-Merrit syndrome) or empyema. | | | Direct thrombin inhibitors may be more effective as they do not require antithrombin. |
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http://www.medstudents.com.br/terin/terin2.htm
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| | thrombin |
| | ZymoGenetics Announces Results of Phase 2 Clinical Trials with Recombinant Human Thrombin; Company Reaffirms Plans to Move Forward with Phase 3 Clinical Program. | | | Additional search results provided by HighBeam Research, LLC. | | | Thrombin *: can't live without it; probably die from it. |
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http://www.infoplease.com/ce6/sci/A0919574.html
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| | Glycoprotein Receptor Yields Clues to Platelet "Stickiness" |
| | Understanding the precise molecular mechanism by which the binding occurs offers opportunities for developing drugs to treat coronary artery and related diseases by controlling overzealous clotting. | | | The structure reveals that both the GpIbα and thrombin molecules are bivalent. | | | Direct interaction between GpIbα and thrombin is essential for initiation of platelet procoagulant activity, and exposure to very small concentrations (<1 nM) of thrombin is sufficient to induce aggregation and activation at sites of vascular injury. |
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http://www-als.lbl.gov/als/science/sci_archive/69platelet.html
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| | Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and ... |
| | is increased after treatment with thrombin or Cit-NH when compared to treatment with the vehicle, HEPES. | | | Ricketts, W. A., Brown, J. H., Olefsky, J. (1999) Pertussis toxin-sensitive and -insensitive thrombin stimulation of Shc phosphorylation and mitogenesis are mediated through distinct pathways. | | | B) Densitometry of Western blots reveals that phosphorylation of tyrosine residues on the EGF receptor is significantly increased after treatment with thrombin, Cit-NH, or EGF compared to treatment with the vehicle, HEPES. |
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http://www.fasebj.org/cgi/content/full/16/12/1515
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| | CND: Hypercoagulation: The CFS/FM Plot Thickens |
| | Testing of many patients diagnosed with CFS, FM, MPS shows that the thrombin-SFM-fibrin process is not working properly. | | | The first is thrombinphilia, "thrombin loving", where the body keeps producing thrombin because the normal control that would prevent excessive or inappropriate thrombin generation fail, do not exist, or have somehow been overridden so the body keeps producing thrombin at low levels. | | | Fibrin production is the last stage in a complex clotting process. |
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http://www.anapsid.org/cnd/diffdx/hypercoagulation.html
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| | KDD Cup 2001 |
| | Dataset 1: Prediction of Molecular Bioactivity for Drug Design -- Binding to Thrombin | | | Description of Dataset 1: Prediction of Molecular Bioactivity for Drug Design -- Binding to Thrombin | | | Such a determination can then be used in the design of new compounds that not only bind, but also have all the other properties required for a drug (solubility, oral absorption, lack of side effects, appropriate duration of action, toxicity, etc.). |
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http://www.cs.wisc.edu/~dpage/kddcup2001
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| | Haematologic Technologies - Beta Thrombin, Gamma Thrombin |
| | Another form of proteolyzed thrombin, termed β '-thrombin is formed by the single cleavage of thrombin at Arg-154. | | | These proteolyzed forms of thrombin retain their ability to cleave small synthetic substrates (6,7) and some protein substrates such as factor XIII (8), antithrombin III (9) and prothrombin (10). | | | Similar inactivation was observed upon limited digestion of a-thrombin with trypsin (5). |
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http://www.haemtech.com/Enzymes/BetaGammaThrombin.htm
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| | Thrombostat Online, Description, Chemistry, Ingredients - Thrombin Topical - RxList Monographs |
| | RxList only refers patients to online pharmacies certified by VIPPS, Verified Internet Pharmacy Practice Sites, a program administered by the National Association of Boards of Pharmacy which ensures that member pharmacies offering online prescription services are bona fide, fully licensed, and demonstrate "competent Internet/interstate pharmacy practices." | | | The thrombin in Thrombin, Topical (Bovine Origin) THROMBIN-JMI | | | Thrombostat Online, Description, Chemistry, Ingredients - Thrombin Topical - RxList Monographs |
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http://www.rxlist.com/cgi/generic3/thrombin.htm
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