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| | [No title] |
 | | The inventors propose that local, regional delivery of thiazolidinedione, such as troglitazone, to a patient who may experience or is experiencing an oxytocin-mediated action, such as uterine contractions in labor or lactation, will be a very efficient method for delivering a therapeutically effective composition to counteract the oxytocin action. | | | Such assays can be used to evaluate the efficacy of thiazolidinedione therapy; alternatively, these assays can be used with the screening methods of the present invention to identify and characterize agonists and antagonists of oxytocin. | | | thiazolidinedione effective to reduce the oxytocin-mediated action in the subject. |
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http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=00/25781.000511&ELEMENT_SET=DECL
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| | Australian Prescriber - Clinical indications for thiazolidinediones |
| | A major question is whether the glycaemic response to thiazolidinediones is maintained longer than with other oral hypoglycaemic drugs. | | | For patients in the class I or II NYHA categories, thiazolidinediones can probably be prescribed with extreme caution. | | | 7 There is no current evidence to suggest that the glucose-lowering actions of thiazolidinediones are greater than those of other oral hypoglycaemic drugs. |
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http://www.australianprescriber.com/index.php?content=/magazines/vol27no3/70_74_clinicalthiaz.htm
(2471 words)
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| | Mayo Clinic Proceedings |
| | Our data suggest that thiazolidinediones should be used with caution or avoided in patients with left ventricular dysfunction or chronic renal insufficiency. | | | Thus, these 6 cases represent 0.9% of patients being treated at our facility with thiazolidinedione therapy. | | | None of these patients had acute myocardial infarction, pronounced arrhythmia, or other conditions to explain deterioration of cardiac status. |
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http://www.mayoclinicproceedings.com/inside.asp?AID=404&UID=
(1818 words)
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| | Discovery Health :: Center Article :: Thiazolidinediones |
| | Before you take a thiazolidinedione, tell all your doctors and your pharmacist about all the medicines you take. | | | Talk with your doctor before you take a thiazolidinedione if you take any other medicines. | | | Many medicines can have harmful effects when you take them with other medicines. |
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http://health.discovery.com/centers/articles/articles.html?chrome=c10&article=LC_62¢er=p07
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| | NGC - NGC Summary |
| | Thiazolidinediones (pioglitazone, rosiglitazone): Because of the potential for hepatotoxicity, caution should be used when starting thiazolidinedione therapy if alanine transaminase levels are mildly elevated (1 to 2.5 times the upper limit of normal) and therapy should not be initiated if alanine transaminase levels are >2.5 times the upper limit of normal. | | | Discontinue thiazolidinedione therapy if alanine transaminase levels exceed three times the upper limit of normal. | | | For rosiglitazone and pioglitazone therapy, alanine transaminase levels should be determined every other month for the first year of therapy and periodically thereafter. |
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http://www.guideline.gov/summary/summary.aspx?ss=15&doc_id=4159&nbr=3187
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| | Nursing Spectrum- Career Fitness Online |
| | For patients in the early stages of CHF who take thiazolidinediones, education about the early signs of worsening heart failure is also critical. | | | The consensus statements emphasize educating patients to report any weight gain over 6.6 lbs, sudden onset of edema, or shortness of breath. | | | Nurses are aware of the importance of reminding patients with diabetes that they must not skip meals when they take anti-diabetic agents — it is crucially important to reinforce this message, especially if the patient is also taking gemfibrozil. |
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http://nsweb.nursingspectrum.com/NurseNewsEzine/DrugNews/item.cfm?ID=109
(402 words)
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| | Rosiglitazone - Wikipedia, the free encyclopedia |
| | Rosiglitazone is an anti-diabetic drug from the thiazolidinedione class. | | | Another combination drug approved by the FDA is Avandaryl® (with glimepiride). | | | Like other thiazolidinediones, its mechanism of action is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ. |
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http://en.wikipedia.org/wiki/Rosiglitazone
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| | AVANDIA |
| | Avandia is a drug in the thiazolidinedione class of medication. | | | Another drug of the thiazolidinedione class, troglitazone, has been associated with idiosyncratic hepatotoxicity, and very rare cases of liver failure, liver transplants, and death have been reported during postmarketing clinical use. | | | Lower pre-treatment hemoglobin/hematocrit levels in patients enrolled in the metformin combination clinical trials may have contributed to the higher reporting rate of anemia in these studies (see Laboratory Abnormalities, Hematologic). |
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http://www.diabetic-help.com/avandia.htm
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| | Rosiglitazone & Pioglitazone Treatment for Lipodystrophy, diabetes, effects on lipids |
| | In contrast to our study, the report by Carr and associates (2) did not demonstrate significant increases in subcutaneous fat after 48 weeks of rosiglitazone therapy compared with placebo in HIV-infected patients with lipoatrophy. | | | Consistent with these observations, clinical studies have demonstrated that thiazolidinedione therapy in type 2 diabetic patients is associated with weight gain, yet glycemic control improves. | | | Another drug of the thiazolidinedione class, troglitazone, has been associated with severe hepatotoxicity. |
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http://www.natap.org/2005/HIV/011005_07.htm
(4346 words)
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| | Abstract: 776 |
| | This may be a key mechanism of a secondary failure of thiazolidinedione treatment. | | | Modifying effects of vitamin A in combination with thiazolidinedione treatment | | | Vitamin A is reported to contribute to fat deposition in muscle and liver. |
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http://www.easd.org/customfiles/easd/37th/Abs01/776.html
(361 words)
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| | Triple therapy fights type 2 diabetes without weight gain |
| | It's the first study to analyze the safety and effectiveness of triple therapy using insulin, metformin and a drug in the thiazolidinedione family. | | | In the UT Southwestern study, however, all 28 patients who used triple therapy reduced their blood-sugar levels below 7 percent without increasing insulin. | | | Almost 60 percent of all patients, regardless of what order the drugs were taken, reduced HbAlc levels below 6 percent. |
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http://www.medicalnewstoday.com/medicalnews.php?newsid=9974
(610 words)
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| | News - Fluid Retention Reversible In Diabetics With Chronic Systolic Heart Failure Treated With Thiazolidinedione |
| | No differences were seen, however, in the echocardiographic severity of cardiac dysfunction or the baseline New York Heart Association functional class. | | | In this study of 111 patients treated with thiazolidinedione (TZD), the researchers found no direct link between the baseline degree of severity of HF and the risk of fluid retention, the characteristics of which they sought to define. | | | A DGReview of :"Fluid retention after initiation of thiazolidinedione therapy in diabetic patients with established chronic heart failure" |
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http://www.docguide.com/news/content.nsf/news/8525697700573E1885256D120031828C
(492 words)
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| | TPNA - Press Releases |
| | These data further support the long-term efficacy of ACTOS, the number one prescribed drug in the thiazolidinedione (TZD) class. | | | ACTOS is an oral treatment for type 2 diabetes belonging to the thiazolidinedione class of drugs. | | | It is known as an “insulin sensitizer” because it directly targets insulin resistance, a condition where the body does not produce enough insulin or does not effectively use the insulin it produces. |
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http://www.tpna.com/prdetail.asp?articleid=90
(1133 words)
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| | THIAZOLIDINEDIONE |
| | The medication class of thiazolidinedione was introduced in the late 1990s as an adjunctive therapy for diabetes mellitus and related diseases. | | | Therefore, thiazolidinediones cannot be prescribed in patients with decreased ventricular function. | | | Troglitazone was withdrawn from the market due to an increased incidence of drug-induced hepatitis in patients who were using the drug. |
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http://www.yotor.org/wiki/en/th/Thiazolidinedione.htm
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| | Diabetes Monitor - rosiglitazone (Avandia) |
| | Avandia (rosiglitazone) is a thiazolidinedione medication for the therapy of | | | When using AVANDIA in combination with other hypoglycemic agents, the risk of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and their family members. | | | Therapy with AVANDIA, like other thiazolidinediones, may result in ovulation in some premenopausal anovulatory women. |
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http://www.diabetesmonitor.com/avandia.htm
(705 words)
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| | Alzforum: News |
| | The sixth patient was also given diuretics but thiazolidinedione treatment continued. | | | In the present study, the six patients represent less than one percent of patients treated with the drugs at the Veterans Center. | | | Thirteen months later, he returned with the same symptoms, was again given diuretics and this time the thiazolidinedione treatment was halted. |
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http://www.alzforum.org/new/detail.asp?id=870
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| | Is Rosiglitazone Hepatotoxic, Too? - Journal Watch (General) |
| | Nonetheless, because these cases raise the possibility that the thiazolidinedione class may be hepatotoxic, physicians and patients should be aware of and remain alert for possible hepatic damage from this new drug. | | | Rosiglitazone -- another thiazolidinedione -- has not previously been associated with hepatotoxicity, but 2 cases of liver injury possibly due to rosiglitazone have now been reported. | | | Forman LM et al Hepatic failure in a patient taking rosiglitazone Ann Intern Med 2000 Jan 18; 132:118-121. |
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http://general-medicine.jwatch.org/cgi/content/full/2000/201/1
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| | Diabetes Scene |
| | The thiazolidinedione, which include ciglitazone and pioglitazone as well as troglitazone, have a beneficial effect on insulin resistance and may actually be useful for preventing NIDDM. | | | One of the most interesting new drugs being tested for NIDDM is troglitazone, a member of the thiazolidinedione class of anti-diabetic agents. | | | The thiazolidinedione have been shown to reduce elevated plasma glucose, triglycerides, and insulin concentrations in animals with hyperinsulinemia and to improve both fasting and postprandial hyperglycemia and hyperinsulinemia in patients with NIDDM. |
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http://www.banting.com/rcenter/thiazon.html
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| | dlife.com - Thiazolidinedione Drugs for Type 2 Diabetes |
| | Or you may take a thiazolidinedione as your only diabetes medicine. | | | Yes, your health care provider may ask you to take another diabetes medicine along with a thiazolidinedione. | | | Call your doctor right away if you have any signs of liver disease: nausea, vomiting, stomach pain, lack of appetite, tiredness, yellowing of the skin or whites of the eyes, or dark-colored urine. |
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http://www.dlife.com/dLife/do/ShowContent/about_diabetes/type_2/treatment/oral_medication/thiazolidinedione
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| | FDA Approves Rosiglitazone to Treat Type II Diabetes |
| | Mild to moderate edema, an increase in blood cholesterol and anemia were also reported in patients treated with rosiglitazone, but did not usually require discontinuation of treatment. | | | FDA has approved rosiglitazone (Avandia), a new drug in the thiazolidinedione class of drugs to treat type II diabetes. | | | Another drug of the thiazolidinedione class, Rezulin (troglitazone, manufactured by Parke-Davis), has been associated with idiosyncratic hepatotoxicity, or liver failure. |
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http://www.fda.gov/bbs/topics/ANSWERS/ANS00957.html
(474 words)
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| | The Diabetes Educator -- Sign In Page |
| | Early Combination Therapy With a Thiazolidinedione for the Treatment of Type 2 Diabetes | | | CONTACT US Copyright © 2003 by American Association of Diabetes Educators; Published by SAGE Publications Privacy Policy |
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http://tde.sagepub.com/cgi/reprint/29/6/954
(229 words)
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| | BioCarta - Charting Pathways of Life |
| | The natural ligand 15-deoxy prostaglandin J2 stimulated PPAR-gamma interaction with SRC-1, TIF2, TRAP220, and p300, while the synthetic PPAR-gamma ligand troglitazone, an antidiabetic thiazolidinedione drug, did not promote these interactions, indicating that other distinct coactivators may mediate the response to PPAR-gamma when it binds this ligand. | | | PPAR-gamma is a member of this gene family that is activated by fatty acids and thiazolidinedione drugs that plays a role in insulin sensitivity and adipogenesis (See Visceral Fat Deposits and the Metabolic Syndrome pathway). | | | Some PPAR-gamma ligands induce the specific recruitment of coactivators, and might evoke different functional responses based on the interactions they favor. |
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http://www.biocarta.com/pathfiles/h_ppargPathway.asp
(566 words)
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| | Starlix - Press Release |
| | Novartis Pharmaceuticals Corporation researches, develops, manufacturers and markets leading innovative prescription drugs used to treat a number of diseases and conditions, including diabetes, central nervous system disorders, organ transplantation, cardiovascular diseases, dermatological diseases, respiratory disorders, cancer and arthritis. | | | Combination therapy with a thiazolidinedione provides new option for controlling and maintaining blood sugar levels in type 2 diabetes | | | Research has shown that improved glycemic control, as measured by a reduction of HbA1c levels, may lead to a dramatic lowering of deaths and complications from diabetes. |
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http://www.pharma.us.novartis.com/newsroom/pressReleases/releaseDetail.jsp?PRID=1063
(375 words)
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| | Ohyama et al., January 1998 |
| | These results showed that the thiazolidinedione stimulated adipocyte differentiation and the retinoids blocked the adipogenesis induced by the thiazolidinedione in primary culture of bovine SV cells. | | | Peroxisome proliferator-activated receptor gamma may play an important role in adipocyte differentiation, and retinoids may interfere with the action of PPARgamma in cattle. | | | Understanding the action of PPARgamma ligand and retinoids in bovine adipocytes will contribute to our understanding of adipose development in meat animals and meat production. |
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http://www.asas.org/jas/abs/1998/jan61abs.html
(347 words)
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| | Process Development and Scale-Up of the Potential Thiazolidinedione Antidiabetic Candidate PNU-91325 |
| | This process involves a novel epoxide ring opening with a deactivated phenol under phase-transfer conditions. | | | An efficient six-step synthesis has been developed for the preparation of the thiazolidinedione analogue PNU-91325 (3) from the commercially available olefin 12. | | | Process Development and Scale-Up of the Potential Thiazolidinedione Antidiabetic Candidate PNU-91325 |
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http://pubs.acs.org/cgi-bin/abstract.cgi/oprdfk/2002/6/i05/abs/op025549s.html
(145 words)
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| | TPNA - Press Releases |
| | Takeda is the originator of thiazolidinedione derivatives and Actos | | | Metformin acts primarily by reducing the amount of glucose produced by the liver. | | | is a member of the thiazolidinedione class of "insulin-sensitizing" agents, and it directly targets insulin resistance. |
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http://www.tpna.com/prdetail.asp?articleid=104
(353 words)
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| | PAT5A: A Partial Agonist of Peroxisome Proliferator-Activated Receptor {gamma} Is a Potent Antidiabetic ... |
| | role of this novel thiazolidinedione in the treatment of type-2 | | | Is a Potent Antidiabetic Thiazolidinedione Yet Weakly Adipogenic | | | Berger J, Bailey P, Biswas C, Cullinan CA, Doebber TW, Hayes NS, Saperstein R, Smith RG, and Leibowitz MD (1996) Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: binding and activation correlate with antidiabetic actions in db/db mice. |
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http://jpet.aspetjournals.org/cgi/content/full/306/2/763
(4019 words)
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