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| | Thalidomide (Thalidomid®) : Cancerbackup |
 | | This is due to the effect of thalidomide on the nerves and is known as peripheral neuropathy. | | | Thalidomide may interact with other medicines that you are taking. | | | If you are prescribed thalidomide, your doctor will explain all about the drug, the procedures being used, and how you will be looked after while you are taking it. |
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http://www.cancerbackup.org.uk/Treatments/Biologicaltherapies/Angiogenesisinhibitors/Thalidomide
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| | thalidomide |
| | Teratogenic effects of thalidomide in the Sprague Dawley rat. | | | However, the more common response of the rat foetus to thalidomide was death and resorption in the uterus. | | | Some 40 years ago, the drug thalidomide was prescribed to women in early pregnancy to overcome the unpleasantness of morning sickness. |
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http://www.rds-online.org.uk/pages/page.asp?i_ToolbarID=5&i_PageID=1070
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| | Thalidomide Encyclopedia Article @ StylishInteriors.com (Stylish Interiors) |
| | In order for "second generation" birth defects from thalidomide to occur, thalidomide would need to behave as a mutagen, in addition to its obvious behavior as a teratogen. | | | Dark Remedy: The Impact of Thalidomide and Its Revival as a Vital Medicine. | | | There does not seem to be any convincing data showing that thalidomide acts as a mutagen. |
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http://stylishinteriors.com/encyclopedia/Thalidomide
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| | MedlinePlus Drug Information: Thalidomide (Systemic) |
| | Thalidomide (tha-LI-doe-mide) is used to treat and prevent erythema nodosum leprosum (ENL), a painful skin disease associated with leprosy. | | | Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. | | | This medicine may also be used for other problems as determined by your doctor. |
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http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202692.html
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| | Thalidomide and vivisection |
| | Thalidomide is being used to treat not only the side affects of leprosy drugs, but in Britain it is widely used to treat a condition that results in terrible mouth ulcers in AIDS and non-AIDS patients. | | | Some argue that the thalidomide tragedy was not an example of an animal-tested drug which proved disastrous for humans, but of the dishonesty and sharp practices of the pharmaceutical industry. | | | There is the further point that Thalidomide is known to be effective in treating systemic lupus erythematosus and severe forms of acne. |
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http://www.vivisection-absurd.org.uk/thalid.html
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| | Thalidomide Toxicity |
| | In the experience of the Cleveland Clinic myeloma group, the occurrence of neutropenia has not resulted in an increased incidence of infection, and consequently the thalidomide dose has not had to be changed or interrupted. | | | As additional clinical trials are conducted, the role of thalidomide alone and in combination with other drugs will become more clearly defined. | | | Stool softeners/laxatives, such as Senokot-S, psyllium, milk of magnesium, or docusate sodium, may also be started at the beginning of thalidomide therapy in order to achieve regular bowel movements. |
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http://www.clevelandclinic.org/myeloma/management_of_thalidomide_toxicity.htm
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| | Thalidomide |
| | And, as they learn more about what parts of the body and what biological processes are affected by thalidomide, they can test the drug as a treatment for other diseases and conditions. | | | Birnkrant cautions that there is still "no place in a medicine cabinet for thalidomide unless a patient has a serious, life-threatening, or unresponsive condition, where the physician, the FDA, and the patient agree that the benefits of thalidomide outweigh the risks." | | | A British physician reported that long-term use of thalidomide caused tingling, numbness,and burning pain in the fingers and toes, and he speculated that thalidomide damaged nerves in those parts of the body. |
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http://science-education.nih.gov/nihHTML/ose/snapshots/multimedia/ritn/Thalidomide/index.html
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| | Thalidomide |
| | Pharmacology: Thalidomide is being investigated for several conditions. | | | Summary: Thalidomide is currently being investigated for several different conditions. | | | The following is an article about a drug that many of us thought would never be on the market again. |
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http://alpenmic.com/pharmacy/thalidomide.htm
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| | Thalidomide (Contergan) - Annotated Collection of Links |
| | about the comeback of thalidomide in cancer therapy. | | | Program and abstracts of an open public scientific workshop, sponsored by by the National Institutes of Health and the Food and Drug Administration, September 9-10, 1997, Bethesda, MD. The workshop was designed to assess the benefits and risks and to guide further investigation and clinical use of thalidomide. | | | Different political conditions in the United States and Germany resulted in very different situations regarding the risk assessment and clearance for the sale of thalidomide containing drugs. |
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http://www.k-faktor.com/thalidomide
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| | News in Science - Thalidomide returns to respectability - 12/09/2003 |
| | The body that regulates medicines in Australia, the Therapeutic Goods Administration (TGA), is expected to give its approval soon for thalidomide to be prescribed for the treatment of leprosy and for multiple myeloma - a form of blood cancer. | | | One of modern medicine's most infamous drugs - thalidomide - is making a return to respectability, with Australia soon expected to become only the second country after the U.S. to re-register it for use. | | | Despite McBride being later deregistered for scientific fraud in relation to other work, his alert on thalidomide resulted in evaluation, safety standards and monitoring procedures for new drugs becoming far more rigorous. |
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http://www.abc.net.au/science/news/stories/s944491.htm
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| | Giving Thalidomide a Second Chance |
| | Although there are risks involved in an investigational program with a teratogenic drug like thalidomide, Birnkrant points out that it is important to explain to the public and to the patients just how the drug should be used. | | | Female patients are also reminded that no method of birth control is completely reliable except for abstinence, and that if the patient does not practice abstinence or has not had a hysterectomy, she must use birth control even if she believes that she cannot become pregnant. | | | Long honored for her role in blocking the approval of the drug, Kelsey, who still works for FDA as deputy for medical and scientific affairs in the agency's Center for Drug Evaluation and Research, points out that thalidomide was the first drug application to which she was assigned after joining the agency in 1960. |
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http://www.fda.gov/fdac/features/1997/697_thal.html
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| | CNN - FDA gives restricted approval to thalidomide - January 12, 1999 |
| | Narcessian, a doctor who specializes in rehabilitation medicine, said taking the drug makes her feel that she is actively fighting the cancer even after completing six weeks of radiation therapy. | | | When combined with chemotherapy or radiation therapy, the cancer cells, in theory, die of starvation. | | | A growing number of doctors are prescribing it for deadly cancers even though tests have yet to definitively prove it works. |
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http://www.cnn.com/HEALTH/9901/12/thalidomide.01/index.html
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| | Home |
| | Isotretinoin is derived from vitamin A. In 1985 when the world discovered that the drug thalidomide was being used in the treatment of leprosy and that babies were still being born in countries like Brazil, our immediate response was to call for the drug to be banned. | | | Thalidomide UK will bring you the latest news summaries regarding TGN1412 ASAP and we will highlight the procedures for testing medicines in the UK, before a drug can be licensed. | | | One function of Thalidomide UK will be as an Advisory and a Monitoring Group regarding the use of thalidomide and similar drugs. |
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http://www.thalidomideuk.com
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| | MedlinePlus Drug Information: Thalidomide |
| | Thalidomide is used to treat and prevent skin conditions caused by erythema nodosum leprosum (ENL). | | | Thalidomide may make your skin sensitive to sunlight. | | | Talk to your doctor about the possible risks of using this drug for your condition. |
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http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a699032.html
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| | Medical References: Thalidomide |
| | Thalidomide (tha-LID-o-mide) was first prescribed in the late 1950s in Europe to treat anxiety, insomnia and, in pregnant women, morning sickness and was marketed in numerous countries including Japan, Australia, and Canada. | | | One for which there is proven effectiveness is severe ulcers of the mouth and throat in individuals with AIDS and ulcers of the mouth and genitals in individuals with Behchet disease. | | | Although being studied, there is, thus far, no conclusive evidence of the effectiveness of thalidomide treatment for these conditions. |
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http://www.marchofdimes.com/professionals/681_1172.asp
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| | BBC NEWS Health 'They just didn't know what it would do' |
| | However, even if he had realised this, the tragedy would probably not have been averted, as it is believed that the safe version is converted into the dangerous one within the body. | | | He said: "Thalidomide is a very controversial drug. | | | He added: "We do have a lot of stringent controls to ensure women who are, or might be, pregnant do not take the drug - even though most of our patients are past child-bearing age. |
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http://news.bbc.co.uk/1/hi/health/3589173.stm
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| | Richland College - Thalidomide History |
| | In light of the horror this drug has caused, the future of thalidomide is still looking bright. | | | It was then implemented in a trial to develop new antihistamines for allergy treatment. | | | As a Food and Drug Administration drug evaluator, she repeatedly stalled numerous efforts by a U.S. based licensee of Chemie Gruenenthal, the William S. |
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http://www.rlc.dcccd.edu/MATHSCI/reynolds/thalidomide/history/history.html
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| | Thalomid (thalidomide) |
| | For this reason, some physicians recommend that thyroid function be monitored during thalidomide therapy. | | | Based on recently reported results and a review of key clinical trials, the panel of investigators developed general dosing and monitoring recommendations to optimize thalidomide therapy, which are summarized in the box below. | | | If DVT develops, it is treated with full-dose anticoagulation while thal-dex therapy is continued. |
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http://www.multiplemyeloma.org/treatments/3.04.html
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| | Thalidomide Fetopathy |
| | The Thalidomide Victims Association of Canada (TVAC) is an organization representing approximately 125 Canadians born disabled as a consequence of the drug Thalidomide. | | | there are no studies on pregnancy outcome in women who only used thalidomide prior to conception... | | | Always seek the advice of your local health care provider. |
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http://ibis-birthdefects.org/start/thalfact.htm
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| | The Body: Thalidomide: Important Patient Information |
| | However, the Food and Drug Administration allows it to be used in studies (such as this one). | | | The tests should be done and interpreted by your doctor. | | | Check with your doctor before taking any other prescription or over-the-counter medication. |
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http://www.thebody.com/fda/thal0997.html
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| | Thalidomide. DermNet NZ |
| | In New Zealand thalidomide has not been approved for use for any condition, however special application to the Ministry of Health may allow its use in exceptional circumstances. | | | However, its use is strictly monitored and many precautions are taken to ensure its safe and correct use by both prescriber and patient. | | | With this in mind any use of thalidomide is under strict supervision. |
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http://www.dermnet.org.nz/treatments/thalidomide.html
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| | BBC - Radio 4 - The Archive Hour |
| | Presented by Geoff Adams-Spink, who was himself directly affected by the drug, this programme tells the moving human story of Thalidomide and investigates how this powerful medication is currently being used in the fight against disease. | | | Around ten thousand babies were born with disabilities as a result of their mothers taking the Thalidomide drug. | | | The programme also asks why scientists have once again started using the drug to treat leprosy, AIDS patients and people with certain types of cancer. |
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http://www.bbc.co.uk/radio4/factual/thalidomide.shtml
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| | University of Chicago Hospitals: Thalidomide effective against refractory Crohn's disease |
| | "We were impressed by the number of patients with truly difficult-to-manage Crohn's disease who responded to thalidomide and with the speed of the drug's effect in some of these patients," said Eli Ehrenpreis, MD, assistant professor of clinical medicine at the University of Chicago and director of the study. | | | All patients in this study had to practice reliable birth control to prevent any risk of birth defects. | | | A study in the December issue of Gastroenterology shows that thalidomide, a drug that became infamous in the 1960s for causing thousands of severe birth defects, can be an effective short-term treatment for Crohn's disease--even for patients whose disease has not responded to other therapies. |
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http://www.uchospitals.edu/news/thalidomide.html
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| | Thalomid Online, Description, Chemistry, Ingredients - Thalidomide - RxList Monographs |
| | she acknowledges, in writing, her understanding of these warnings and of the need for using two reliable methods of contraception for 4 weeks prior to beginning thalidomide therapy, during thalidomide therapy, and for 4 weeks after discontinuation of thalidomide therapy. | | | The test should be performed within the 24 hours prior to beginning thalidomide therapy. | | | Thalidomide is contraindicated in WOMEN of childbearing potential unless alternative therapies are considered inappropriate AND the patient MEETS ALL OF THE FOLLOWING CONDITIONS (i.e., she is essentially unable to become pregnant while on thalidomide therapy): |
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http://www.rxlist.com/cgi/generic2/thalidom.htm
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| | Simple Facts Sheets: thalidomide |
| | Thalidomide works in lab experiments against HIV by suppressing a natural substance produced in the body. | | | The technical name for this condition is aphthous ulcers. | | | Thalidomid is now approved for the treatment of a condition associated with leprosy. |
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http://www.atdn.org/simple/thalid.html
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| | Thalidomide Victims Association of Canada - What is Thalidomide? |
| | Around the world, in the late 1960's and into the early 1970's, the victims of the drug Thalidomide and their families entered into class action legal suits, or threatened actions, against the various drug companies who manufactured and/or distributed the drug, and they were eventually awarded settlements. | | | Thalidomiders are now in their late fourties and they are experiencing physical deterioration due to stress placed on their different body structures, further limiting their abilities, often resulting in new disabilities (see degeneration), and therefore compounding the tragedy. | | | Thalidomide was a sedative that was found to be effective when given to pregnant women to combat many of the symptoms associated with morning sickness. |
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http://www.thalidomide.ca/en/information/what_is_thalidomide.html
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| | Thalidomide For Brain Tumors |
| | All women receiving this drug require monthly pregnancy tests (unless not medically necessary). | | | Thalidomide is currently being tested in combination with a chemotheraputic agent active in malignant gliomas (carboplatin), and single-agent clinical trials are being initiated in the treatment of recurrent brain metastases and in the treatment of recurrent atypical or malignant meningiomas. | | | Clinical trials of thalidomide as a single agent in malignant gliomas that have recurred following radiation therapy have shown evidence of that this drug is active and can produce responses. |
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http://www.virtualtrials.com/thalidomide.cfm
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| | Thalidomide Isomerism and Optical Isomerism |
| | Despite this, the drug may be set for a come back treating a whole new catalogue of conditions. | | | For a long time the name Thalidomide has been associated with one of the most horrific medical accidents in history. | | | Looking forward, we see the events which have lead to the possibility of its reintroduction. |
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http://www.chm.bris.ac.uk/motm/thalidomide/start.html
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| | thalidomide - Hutchinson encyclopedia article about thalidomide |
| | In 1995 US researchers announced trials using thalidomide derivatives for a variety of immune disorders, including AIDS, cancer, and graft-versus-host disease – it was already used routinely in the treatment of leprosy. | | | When taken in early pregnancy, it caused malformation of the fetus (such as abnormalities in the limbs) in over 5,000 recognized cases, and the drug was withdrawn. | | | In 1997 it was approved for that purpose by the US Food and Drug Administration. |
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http://encyclopedia.farlex.com/thalidomide
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| | Thalidomide Trust - Home |
| | The aim of the Trust is to provide relief and assistance for those people born, in the United Kingdom, damaged as a result of their mothers having taken the drug Thalidomide (as manufactured by Distillers Biochemicals Limited) during their pregnancy. | | | We currently are supporting 455 individuals, each in the main between 42 and 46 years of age who, for the most part, have two or four limbs missing. | | | The Library is where you will be able to view and download documents, articles and files relating to Thalidomide and the Trust. |
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http://www.thalidomide.org.uk
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