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| | About Thalassemia |
 | | Since thalassemia is not a single disorder but a group of related disorders that affect the human body in similar ways, it is important to understand the differences between the various types of thalassemia. | | | However, there is a wide range in the clinical severity of this condition, and the borderline between thalassemia intermedia and the most severe form, thalassemia major, can be confusing. |
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http://www.thalassemia.org/sections.php?sec=1
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| | Thalassemia overview |
| | Review of thalassemia is best approached by separately examining its genetic basis and clinical expression. | | | The patient then would be clinically classified as having thalassemia major. | | | The same patient then would be clinically classified as thalassemia intermedia. |
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http://sickle.bwh.harvard.edu/thalover.html
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| | Thalassemia |
| | Although there is no cure, new engineering procedures and devices are being developed to detect thalassemia in the fetus and to treat blood in babies born with the disease. | | | The only known process to treat thalassemia was to give blood transfusions, but the procedure was not performed often because of the recognized iron build up in the body. | | | This compact size pump is designed for continuous flow of Desferal® sub-cutaneously or intravenously in the home instead of at a medical clinic, so that patients have the mobility and freedom to lead normal lives. |
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http://www.bae.ncsu.edu/bae/research/blanchard/www/465/textbook/otherprojects/1999/Congenital_Anomalies/group2/project/thalassemia.dir/
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| | Division of Genetics: Thalassemia Brochure, URMC |
| | However, you may be at risk for having a child with thalassemia major. | | | If you have thalassemia trait, you need not be concerned for your own health. | | | If your partner does have thalassemia trait, you are at risk of having a child with thalassemia major. |
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http://www.urmc.rochester.edu/genetics/brochures/thal.htm
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| | Medical References: Thalassemia |
| | The drug is usually administered daily via a mechanical pump that pumps the drug underneath the skin while the child is sleeping. | | | The most severe form of alpha thalassemia, which affects mainly individuals of Southeast Asian, Chinese and Filipino ancestry, results in fetal or newborn death. | | | In addition, improved bone marrow transplantation methods may lead to wider use of the technique as a treatment for thalassemia. |
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http://www.modimes.org/professionals/681_1229.asp
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| | How Do People Get Thalassemia? |
| | Therefore, a person can change clinically from thalassemia intermedia to thalassemia major at some point during their life, while no chance occurs in their genetic makeup. | | | The child would have a severe form of thalassemia (thalassemia major or thalassemia intermedia). | | | Many considerations go into the decision to transfuse a patient chronically. |
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http://sickle.bwh.harvard.edu/thal_inheritance.html
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| | eMedicine - Thalassemia : Article by Jack P Lawson, MD |
| | Anatomy: Changes that occur in the osseous system of patients with thalassemia major are the result of marrow hypertrophy and hyperplasia in response to chronic anemia. | | | With the exception of sickle cell thalassemia, in which radiographic changes may reflect vaso-occlusive phenomena, as well as the changes of marrow hypertrophy, the radiographic appearances of these variants are solely the result of marrow proliferation and, consequently, are dependent on the degree and duration of any anemia and the type of transfusion therapy. | | | Mortality/Morbidity: Thalassemia major, the homozygous state, is a serious condition that usually becomes apparent within the first year of life. |
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http://www.emedicine.com/radio/topic686.htm
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| | Multicultural Health Clearinghouse : Disease Summary : Thalassemia |
| | By finding out if you and your spouse are carriers, you will be able to make effective decisions regarding family planning. | | | The child may even die if not treated immediately. | | | Knowing that you and your spouse do or do not carry the trait can be important when it comes to planning a family. |
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http://www.omsa.uiuc.edu/clearinghouse/diseaseSum/thalassemia.html
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| | eMedicine - Cooley Anemia : Article by Linda K Hendricks, MD |
| | This therapy appears to be a reasonable compromise that is effective in reducing ineffective erythropoiesis and the other pathophysiologic consequences of thalassemia but can reduce the incidence of iron overload. | | | With transfusion therapy, patients can survive to the fifth decade of life. | | | This results from increased dietary iron absorption (ie, to compensate for ineffective erythropoiesis) and from long-term blood transfusion therapy. |
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http://www.emedicine.com/med/topic438.htm
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| | NIH Guide: THALASSEMIA (COOLEY'S ANEMIA) CLINICAL RESEARCH NETWORK |
| | There is an urgent need to evaluate new and existing therapeutic approaches for persons with thalassemia, and to disseminate the findings to health care professionals, patients and the public. | | | There are several reasons why a thalassemia clinical research network will accelerate clinical research and meet this need. | | | This RFA, Thalassemia Clinical Research Network, is related to the priority areas of chronic disabling conditions and clinical prevention services. |
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http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-99-016.html
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| | eMedicine - Thalassemia, Beta : Article by Kenichi Takeshita, MD |
| | Treatment for patients with thalassemia major includes chronic transfusion therapy, iron chelation, splenectomy, and allogeneic hematopoietic transplantation. | | | The severe anemia resulting from this disease, if untreated, can result in high-output cardiac failure; the intramedullary erythroid expansion may result in associated skeletal changes such as cortical bone thinning. | | | The incidence may be as high as 10% in these areas. |
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http://www.emedicine.com/med/topic2260.htm
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| | Dr. Koop - Thalassemia- Health Encyclopedia and Reference |
| | Thalassemia trait is present at birth, it remains the same for life, and it can be handed down from parents to children. | | | Additionally, splenectomy (removal of the spleen), bone marrow transplants and chelation therapy are being researched as possible treatments for thalassemia. | | | People with thalassemia major may experience the following: |
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http://www.healthscout.com/ency/43/477/main.html
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| | Texas Department of Health-Sickle Cell |
| | There are medications to help ease the pain and make your child more comfortable. | | | Your child should not be considered "sick", and you should treat him or her normally. | | | C should be taken seriously and your child taken to your family doctor or clinic IMMEDIATELY! |
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http://www.tdh.state.tx.us/newborn/beta.htm
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| | Thalassemia |
| | The fourth type of alpha thalassemia major is the most severe and affects mostly Southeast Asians, Chinese and Filipinos. | | | Nancy Ferguson is physician (MD) who is board certified in Emergency Medicine, Family Practice and Forensic Medicine. | | | Children with thalassemia major can be treated by hypertransfusion. |
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http://www.comeunity.com/adoption/health/thalessemia.html
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| | Left Ventricular Remodeling, Systolic Function, and Diastolic Function in Young Adults With {beta}-Thalassemia ... |
| | The clinical approach of thalassemia,242-255 Grune and Stratton London, UK. | | | Borow, KM, Propper, R, Bierman, FZ, et al (1982) The left ventricular end-systolic pressure-dimension relation in patients with thalassemia major: a new noninvasive method for assessing contractile state. | | | Fortini and Dr. Gamberini), Thalassemia Unit, Arcispedale S. Anna, Ferrara, Italy. |
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http://www.chestjournal.org/cgi/content/full/121/2/506
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| | A to Z Encyclopedia Topic: Beta Thalassemia |
| | A major problem is the build up of iron in the heart and other organs, resulting in heart failure for some patients in their teens or early twenties. | | | Since too much iron can be harmful, it is important to consult a hematologist regarding any treatment. | | | thalassemia minima - person has little to no symptoms |
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http://www.childrenshospital.org/cfapps/A2ZtopicDisplay.cfm?Topic=Beta%20Thalassemia
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| | Thalassemia Foundation of Canada |
| | The Thalassemia Foundation of Canada strongly encourages you to consult your health care provider with any questions or concerns you may have regarding your condition. | | | The Thalassemia Foundation of Canada is a non-profit organization dedicated to providing awareness, knowledge and support to patients and members of Thalassemia. | | | You should not use this information to diagnose or treat a health problem or disease without consulting a qualified health care provider. |
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http://www.thalassemia.ca/
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| | Thalassemia hub |
| | Thalassemia Protocol Information - new clinical trial seeks thalassemia intermedia patients for a study of butyrate plus erythropoietin sponsored by the National Institutes of Health at Boston University Medical Center, Boston, MA, USA. | | | Laboratory Diagnosis of alpha-Thalassemia - by Daniel E. Sabath, MD, PhD., Director, Hematology and Hemopathology Laboratories, University of Washington Medical Center. | | | Thalassemia Research at Mahidol University - by Khunying Pensri Pootrakul, Thalassemia Research Center, the Institute of Science and Technology for Research and Development. |
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http://www.genomelink.org/thalassemia/
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| | Beta Thalassemia - Health and medical information: diseases and conditions, medical dictionary, procedures and test, ... |
| | The clinical picture associated with thalassemia major was first described in 1925 by the American pediatrician Thomas Cooley. | | | The long-term hope is that thalassemia major will be cured by insertion of the normal beta-chain gene through gene therapy or by another modality of molecular medicine. | | | Beta Thalassemia - Health and medical information: diseases and conditions, medical dictionary, procedures and test, medications, that is reliable, relevant and produced by doctors |
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http://www.medicinenet.com/Script/Main/Art.asp?li=MNI&ArticleKey=493
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| | Head-to-Head Study Compares Early Impact of Pegasys(R) and Peg-Intron(R) on Hepatitis C Virus |
| | Benzyl alcohol has been reported to be associated with an increased incidence of neurological and other complications in neonates and infants, which are sometimes fatal. | | | Pegasys and Copegus therapy is additionally contraindicated in patients with a hypersensitivity to Copegus or any of its components, women who are pregnant, men whose female partners are pregnant, and patients with hemoglobinopathies (eg, thalassemia major, sickle-cell anemia). | | | Roche has backed Pegasys with the most extensive clinical research program ever undertaken in hepatitis C, with major studies initiated to advance treatment for hepatitis C patients with unmet needs, including patients co- infected with HIV and HCV, African Americans, patients with cirrhosis, and patients who have failed to respond to previous therapy. |
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http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/10-29-2004/0002317883&EDATE=
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| | Thalassemia: Rochester Chapter: The Fight Against Thalassemia: Cooley's Anemia |
| | Let me know what you would like to see here and I will try to get it started. | | | This site was created to inform people of an inherited blood disorder called Thalassemia Major, also known as Cooley's Anemia, and to bring patients and families together for support and education on Thalassemia. | | | Usually two normal parents that both have a Thalassemia trait will pass on this disorder to their children not knowing that they were both carriers of the Thalassemia trait. |
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http://www.thalsite.com/
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| | Transfusional Hemochromatosis: Quantitative Relation of MR Imaging Pituitary Signal Intensity Reduction to ... |
| | Effect of age at the start of iron chelation therapy on gonadal function in beta-thalassemia major. | | | Insulin resistance and hyperinsulinemia in patients with thalassemia major treated by hypertransfusion. | | | Gianvincenzo Sparacia, MD Alberto Iaia, MD Aurelia Banco, MD Paolo D'Angelo, MD and Roberto Lagalla, MD From the Institute of Radiology, Università di Palermo, Italy (G.S., A.B., R.L.); the Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.I.); and the Department of Pediatrics, Thalassemia Service, Ospedale "Villa Sofia," Palermo, Italy (P.D.). |
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http://radiology.rsnajnls.org/cgi/content/full/215/3/818
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| | Thalassemia / Family Village Library |
| | Our mission is advancing the treatment and cure for this fatal blood disease, enhancing the quality of life of patients and educating the medical profession, trait carriers and the public about Cooley's anemia/thalassemia major. | | | The Cooley's Anemia Foundation is dedicated to serving people afflicted with various forms of thalassemia, most notably the major form of this genetic blood disease, Cooley's anemia/thalassemia major. | | | A support group and information site for families who have adopted children with Thalassemia |
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http://www.familyvillage.wisc.edu/lib_thal.htm
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| | Thalassemia |
| | The incidence of thalassemia trait within the ethnic groups involved ranges from 3-5% | | | Varieties unique to Southeast Asians include hemoglobin H disease ( a more severe form of alpha thalassemia) and hemoglobin E/beta thalassemia which often mimics Beta thalassemia major in its severity. | | | This leads to deficient hemoglobin accumulation, resulting in hypochromic and microcytic red cells. |
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http://www.5mcc.com/Assets/SUMMARY/TP0907.html
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| | News - European Agency Extends Marketing Authorization of Ferriprox (Deferiprone), for Thalassemia Inadequately Treated ... |
| | The new indication is "Ferriprox is indicated for the treatment of iron overload in patients with thalassemia major when deferoxamine therapy is contraindicated or inadequate". | | | "The EC's decision is a major advance in treatment options for thalassemia patients who are inadequately responsive to deferoxamine. | | | Prior to the approval of Ferriprox, an oral iron chelator, thalassemia patients had only one treatment option - daily infusions of deferoxamine, subcutaneously infused for up to twelve hours each night, resulting in local pain and compliance problems for some patients. |
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http://www.docguide.com/news/content.nsf/news/8525697700573E1885256E920066094A
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| | Berloni Foundation |
| | If up until now correct transfusion therapy has been the only available treatment for patients affected by Thalassemia Major, it is today possible to cure the disease by way of performing bone marrow transplant using a compatible donor and in this way replacing diseased cells whit healty ones. | | | It is estimed that in Italy only, the number of patients affected by Thalassemia Major flucuates between 5,000 and 8,000 individuals. | | | The term "Thalassemia" implies a genetic disorder of an extremely heterogenous group which is characterised by a reduced or erroneous production of haemoglobin, the respiratory pigment contained in the red cells. |
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http://www.abanet.it/fondazioneberloni/ing/talassem.htm
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| | Iron Disorders Institute Disorders Thalassemia Introduction |
| | Thalassemia on the other hand, is characterized by the inability to produce sufficient number of globin chains. | | | Those with thalassemia intermedia fluctuate between being asymptomatic and having symptoms as severe as those associated with thalassemia major. | | | Diagnosis of thalassemia major is confirmed by Hemoglobin electrophoresis with an increase in total hemoglobin, and analysis of lymphocyte DNA. |
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http://www.irondisorders.org/disorders/tls
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| | Beta thalassemia - Genetics Home Reference |
| | Individuals with thalassemia intermedia may have no symptoms or mild symptoms through childhood and adolescence. | | | Adolescents with the severe form may experience delayed puberty. | | | Signs and symptoms of beta thalassemia are severe in the form of the disorder known as thalassemia major and milder in the form called thalassemia intermedia. |
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http://ghr.nlm.nih.gov/condition=betathalassemia
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