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| | txt001nkg: Telomerase-directed molecular therapeutics |
 | | (2000) 2-5A antisense telomerase RNA therapy for intracranial malignant gliomas. | | | In general, the introduction of telomerase gene therapy approaches into the clinic might therefore be more straightforward than that of drugs that inhibit telomerase, as telomerase gene therapy most closely resembles existing therapeutic approaches and does not pose any major new issues in clinical trial design. | | | A study of telomerase activity in small-cell versus non-small-cell lung cancers (Ref. 40) recorded a high level of TRAP positivity in 100&; of samples from primary small-cell lung cancers and their metastases, but only 69.2–88.5% positivity, varying with histology, in primary non-small-cell samples, and only 50% positivity in metastases derived from non-small-cell lesions. |
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http://www-ermm.cbcu.cam.ac.uk/02004507h.htm
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| | How could telomerase be employed in tissue engineering |
| | Thus, clinical telomerase research is currently focused on the development of methods for the accurate diagnosis of cancer and on novel anti-telomerase cancer therapeutics. | | | After phase I trials are completed and overt toxicities are deemed not to be a problem, then randomized phase 2 and 3 clinical trials are used to test the efficacy of the new therapy. | | | Since our development of a PCR-based telomerase assays in 1994, well over 1000 clinical studies have been published on the topic of telomerase and cancer. |
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http://www.swmed.edu/home_pages/cellbio/shay/FAQ.2000.htm
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| | Telomerase - Wikipedia, the free encyclopedia |
| | Michael Fossel has suggested that telomerase therapies [1] may be used not only to combat cancer, but to actually reverse human aging and extend lifespan significantly. | | | He believes human trials of telomerase-based therapies for extending lifespan will occur within the next 10 years. | | | Telomerase.org - A blog-style discussion of telomerase and anti-aging therapies. |
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http://en.wikipedia.org/wiki/Telomerase
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| | Functional Reconstitution of Human Telomerase Expressed in Saccharomyces cerevisiae -- Bachand and Autexier 274 (53): ... |
| | Expression and affinity purification of the human telomerase catalytic subunit from S. | | | Incubation of human telomerase RNA with the S. | | | Yeast lysates were subjected to immunoprecipitation using a goat anti-GST serum, and the immunoprecipitates (IP) were analyzed for: A, telomerase activity; B, expression of GST-hTERT by Western blot (WB); and C, expression and association of hTR with hTERT by RT-PCR using hTR-specific primers. |
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http://www.jbc.org/cgi/content/full/274/53/38027
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| | Telomerase: The 'Immortalizing' Enzyme: Update On Geron Corporation |
| | Geron has developed several telomerase inhibitors, which have great promise as potential anticancer therapies and is taking steps to test these inhibitors in both animals and humans. | | | The ability to reproduce is usually not a major concern in men with cancer, who often already have children. | | | (NOTE: Geron has INFOrmed us that they are not yet engaged in clinical testing of their telomerase inhibitors.) Geron's telomerase research could lead to the development of a universal anticancer therapy based upon basic molecular engineering, which could be useful in treating all forms of cancer! |
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http://www.lef.org/anti-aging/telomer1.htm
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| | Facts about Telomeres and Telomerase |
| | In the future, their research in the area of telomerase could uncover valuable information to combat aging, fight cancer, and even improve the quality of medical treatment in other areas such as skin grafts for burn victims bone marrow transplants, and heart disease. | | | The human body is an organism formed by adding many organ systems together. | | | Telomerase has been detected in human cancer cells and is found to be 10-20 times more active than in normal body cells. |
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http://www.swmed.edu/home_pages/cellbio/shay-wright/intro/facts/sw_facts.html
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| | télomérase inhibiteur |
| | Preliminary data from a number of studies indicate telomerase levels correlate with clinical outcome in cancer patients. | | | In each of its clinical diagnostic agreements, Geron has retained significant development and commercialization rights. | | | Although Geron envisions that a telomerase inhibitor could be effective as a stand-alone treatment in certain cases, it is expected that in most cases a telomerase inhibitor will be used in conjunction with traditional anti-cancer therapies. |
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http://www.esculape.com/biologie/telomeraseinhib.html
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| | Telomerase.org |
| | This is an extremely important discovery which opens the door to using telomerase to treat many other tissue types and do in vivo tests of telomerase-based therapies. | | | Geron seems to be in a dominant position regarding telomerase, at least so they claim. | | | It was just announced that telomerase-based therapies do not cause tumors to grow in human tissues. |
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http://www.telomerase.org
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| | Telomerase, TRF1, TRF2, TP1, Tankyrase antibodies and positive controls, |
| | Recent studies examining the expression of human RNA component (hTR) showed no correlation between the hTR expression levels and telomerase activity. | | | Protein component of telomerase have only recently been cloned and characterized. | | | It is associated with telomerase activity and TP1. |
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http://www.4adi.com/flr/telomerase.html
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| | Telomerase! |
| | Telomerase Demo created by Dr. Donald F. Slish at SUNY, Plattsburgh. | | | Since this template is RNA, these should be U's | | | If you have questions or comments send me a message at slishdf@splava.cc.plattsburgh.edu |
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http://faculty.plattsburgh.edu/donald.slish/Telomerase.html
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| | Telomeres |
| | It turns out that most (85–90%) cancer cells have regained the ability to synthesize high levels of telomerase throughout the cell cycle, and thus are able to prevent further shortening of their telomeres. | | | But if cancer cells regain the ability to make telomerase, might not the reverse be true; that cells transformed with an active telomerase gene might become cancerous? | | | This should give them an unlimited life span. |
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http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/T/Telomeres.html
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