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| | Evaluation of New Oral Hypoglycemic Agents |
 | | Of the 2,287 patients in the 6-year cohort, 676 were allocated to conventional therapy with 1,611 to intensive therapy (922 allocated to sulfonylurea and 689 to insulin therapy). | | | Additionally, 685 obese subjects were allocated to intensive therapy (consisting of 393 allocated to sulfonylurea and 302 allocated to insulin therapy). | | | Long-term, well-designed trials are necessary to determine if metformin should replace sulfonylureas as first-line therapy in nonobese patients, especially in the absence of hyperlipidemia. |
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http://daccx.bsd.uchicago.edu/drug/Bulletins/n0896.html
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| | MedlinePlus Drug Information: Antidiabetic Agents, Sulfonylurea (Systemic) |
| | Until your thyroid condition is controlled, the amount of sulfonylurea you need may change. | | | Instead of taking more of this medicine, your doctor may change you to another sulfonylurea. | | | For sulfonylurea medicines, the following should be considered: |
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http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202742.html
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| | United States Patent: 6,693,094 |
| | There are various pharmacological approaches to improving glucose homeostasis, but those currently used in clinical practice, either do not succeed in restoring normoglycemia in most patients, fail after a variable period of time or have side effects that ultimately preclude their use in many patients. | | | (Surprisingly, the dose-response relationships of the sulfonylureas have been poorly investigated.) By complementing and efficiently optimizing the therapeutic action of sulfonylurea, the formulations of this invention permit the use of minimal doses of sulfonylureas, thereby lowering the risks of sulfonylurea therapy, including hypoglycemia. | | | The formulations of this invention provide appropriate therapeutic levels of a sulfonylurea and will enhance and/or extend the beneficial effect of the sulfonylureas upon plasma lipids, coagulopathy and microvascular permeability. |
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http://spore.patentmatrix.com/Projects/WNCCTC/BOS/6693094.html
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| | p990915a - Myocardial Infarction, Diabetes, Sulfonylurea Drugs |
| | Congestive heart failure, but not sulfonylurea drug use, was associated with an increased incidence of in-hospital ventricular arrhythmias. | | | Univariate analysis identified sulfonylurea drug, age, ventricular function, ejection fraction less than 40%, prior bypass surgery and congestive heart failure as correlates of increased in-hospital mortality. | | | Whether sulfonylurea drugs affect outcome adversely in diabetic patients undergoing direct angioplasty for acute myocardial infarction is unknown. |
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http://www.emory.edu/WHSCL/grady/amreport/litsrch99/p990915a.html
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| | AACE: Pioglitazone/Sulfonylurea and Pioglitazone/Metformin Combinations Both Effective for Reducing Very Low Density ... |
| | The objectives of the pioglitazone plus sulfonylurea study, and the pioglitazone plus metformin study, were to determine the effects of both 30 mg and 45 mg of pioglitazone, plus the combination of either sulfonylurea or metformin on subjects poorly controlled by either drug alone | | | "These trials are among the first to demonstrate that pioglitazone, in combination with either sulfonylurea or metaformin, is clearly effective in clearing the dyslipidemia picture, and decreasing the cardiovascular risk which is what 75% of all diabetic patients die from, either heart disease or stroke," said Dr. Murray, an author on each of the studies. | | | There were 2 groups of 351 patients, 1 group received 30 mg of pioglitazone plus sulfonylurea, and the other received 45 mg of pioglitazone plus sulfonylurea. |
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http://www.docguide.com/dg.nsf/PrintPrint/CB895B55108D1BBD85256D2D0056E345
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| | Sulfonylurea herbicide alert, PTFE fumes kill birds, teflon |
| | Our intent in looking at such incidents in hindsight is not to assign blame, but rather to bring the incident to light in order to protect our farmers and wildlife populations from future occurrences of the unintended consequences of herbicide applications. | | | They attributed the problem to the sulfonylurea herbicide, sulfometuron methyl that had been applied to approximately 17,000 acres of land adjacent to their fields. | | | This land had been scorched by wildfire in August 2000. |
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http://members.aol.com/rccouncil/ourpage/rccalert.htm
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| | Title of Invention: Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase |
| | The in vitro constructed Pro 197 to Ser and Pro 197 to Ala mutations both confer resistance to the sulfonylurea herbicide chlorsulfuron without affecting sensitivity to an imidazolinone. | | | Although not wishing to be bound by theory, binding of sulfonylurea herbicides to ALS during acetolactate synthesis is believed to be facilitated by the binding of a first pyruvate molecule to the enzyme. | | | Plasmid pSBALS216 has been deposited at the ATCC, Rockville, Md. under accession number 67425. |
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http://www.nal.usda.gov/bic/Biotech_Patents/1995patents/05378824.html
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| | Diabetes Monitor - troglitazone (Rezulin) |
| | These actions, taken with the full cooperation of the drug's manufacturer, re-emphasize for health care providers and patients the importance of monitoring patients taking Rezulin to ensure that it is used in the safest manner. | | | The FDA said about 600,000 patients in the United States and 200,000 in Japan had taken Rezulin, which is prescribed with insulin or older drugs known as sulfonylureas for patients whose blood sugar levels are not being controlled by the other treatment. | | | The manufacturer of the diabetes drug Rezulin (troglitazone) is changing prescribing information for the product and adding new warning information to the labeling, in response to reports of liver injury associated with use of the drug. |
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http://www.diabetesmonitor.com/rezulin.htm
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| | Zabrze on Encyclopedia.com |
| | Repaglinide versus sulfonylurea in combination with bedtime NPH insulin in patients with type 2 diabetes with secondary failure to oral treatment. |
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http://www.encyclopedia.com/html/Z/Zabrze.asp
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| | Increase in cardiovascular mortality in Type 2 Diabetics |
| | Alternatively type 2 diabetic patients can be screened periodically for cardiovascular disease and risk factors, and sulfonylurea drugs can be used only in those at low risk
. | | | In Light of current understanding of the cardiovascular effects of sulfonylurea drugs especially on preconditioning, more cautious use of these agents in patient at risk for cardiovascular disease seems warranted.” | | | In the UGDP* (University Group Diabetes Program) conducted 1970, the study found that patients treated for 5 to 8 years with SU had an increased incidence of cardiovascular death compared with those treated with diet alone, and the study was terminated by the monitoring committee. |
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http://www.diabetes-eg.com/cardio.htm
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| | Sulfonylurea |
| | ...treatment with metformin was compared to sulfonylurea treatment, study showed a 24.7.....metformin, alone or in combination with sulfonylurea, was associated with a decreased.....risk of... | | | Date: Friday, March 15.....The effect of insulin addition when maximal sulfonylurea therapy was inadequate in.....the... | | | Sulfonylurea: Information on Sulfonylurea Agents - Diabetes Treatment |
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http://onlinediabetesinfo.com/sulfonylurea
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| | Pharmacology |
| | androgen, antiandrogen, gonadotropin, corticosteroid, growth hormone, insulin, antidiabetic ( sulfonylurea, biguanide/ metformin, thiazolidinedione, insulin), thyroid hormones, antithyroid drugs, calcitonin, diphosponate, vasopressin analogues |
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http://www.sciencedaily.com/encyclopedia/pharmacology
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