|
| Â Â |
| Â | Sufentanil (Sufenta ) as an anaesthetic |
 | | Sufentanil is effective in reducing the so-called stress responses that can occur with balanced anesthesia. | | | Although no conclusive data have shown that such reduction in stress response improves anesthetic outcome, many clinicians continue to choose sufentanil for both convenience and improved hemodynamic control. | | | his review considers a few of the controversies and most recent data pertaining to the clinical intraoperative use of the potent opioid sufentanil. |
|
http://general-anaesthesia.com/sufentanil.html
|
|
| Â Â |
| Â | ABSTRACT SUMMARY: |
| | Sufentanil provided somewhat better conditions for induction and emergence. | | | CONCLUSION: Both intranasal midazolam and sufentanil provide rapid, safe, and effective sedation in small children before anesthesia for ambulatory surgery. | | | Both drugs enabled patients to be separated from their parents with a minimum of distress. |
|
http://www.wolfetory.com/education/midazolam_for_sedation.htm
|
|
| Â Â |
| Â | MedlinePlus Drug Information: Sufentanil Citrate Injection |
| | Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue. | | | tell your doctor and pharmacist if you are allergic to sufentanil, morphine, codeine (or medications that contain codeine such as Tylenol with Codeine), hydrocodone (e.g., Vicodin), hydromorphone (e.g., Dilaudid), oxycodone (e.g., Percocet), oxymorphone (Numorphan), or any other drugs. | | | Your doctor has ordered sufentanil, a strong analgesic (painkiller), to relieve your pain. |
|
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a684066.html
|
|
| Â Â |
| Â | Dannemiller Memorial Educational Foundation |
| | In all patients that reported good pain relief, IN sufentanil was rated as much better than their usual opioid breakthrough pain medication, both in speed of onset and efficacy. | | | The use of sublingual (SL) and intranasal (IN) routes of medications to control breakthrough pain is being re-explored, to include use in the palliative care setting. | | | The authors claim no financial interest or other relationship with any manufacturer(s) of any commercial product(s) related to this article. |
|
http://www.dannemiller.com/gfile_sample.cfm
|
|
| Â Â |
| Â | sufentanil, opiate analysis - dextromethorphan - sciex 3000 |
| | sufentanil, opiate analysis - dextromethorphan - sciex 3000 | | | HFL is a GLP compliant Contract Research Organisation providing LC-MS/MS and GC-MS Bioanalysis to support Clinical Trials for Human and veterinary drug development. |
|
http://www.controlled-drugs.co.uk/sufentanil.htm
|
|
| Â Â |
| Â | Sufentanil Citrate Injection - Drugs & Vitamins - Drug Library - DrugDigest |
| | Sufentanil is used mostly during surgery or while you are recovering from surgery. | | | Occasionally, sufentanil may be given for the management of pain. | | | An anesthesiologist or specially trained health care professional will give sufentanil to you. |
|
http://www.drugdigest.com/DD/PrintablePages/Monograph/0,7765,6220,00.html
|
|
| Â Â |
| Â | Sufentanil Side Effects - Sufentanil Citrate |
| | Please note that entries here are the experiences of individual users, and in no way means that you or anyone else will experience the same side effect, since the same medication affects people in different ways. | | | This registry is a place to share positive or negative side effects of using Sufentanil. | | | If you directly experienced a side effect while using Sufentanil, then we encourage you to enter it here. |
|
http://www.medications.com/go/se/Sufentanil
|
|
| Â Â |
| Â | Obstetrics: Low Doses of Sufentanil Sufficient for Relief of Labor Pain, November 16, 2000 |
| | Obstetrics: Low Doses of Sufentanil Sufficient for Relief of Labor Pain, November 16, 2000 | | | ( NewsRx.com) -- Researchers reported in the journal Acta Anaesthesiologica Scandinavica that the effectiveness of sufentanil, an opioid used to enhance epidural analgesia for labor pain, is not improved - and is in some cases reduced - with increased dosage. | | | Low Doses of Sufentanil Sufficient for Relief of Labor Pain |
|
http://www.obgyn.net/NewsRx/womens_health-Obstetrics-20001116-19.asp
|
|
| Â Â |
| Â | DURECT: CHRONOGESIC® |
| | The CHRONOGESIC® product delivers sufentanil continuously within the therapeutic window, at physician prescribed doses for three months of pain therapy. | | | With our CHRONOGESIC ® (sufentanil) Pain Therapy System, we intend to target patients with opioid responsive chronic pain that results from a variety of causes. | | | Sales of opioids for the treatment of moderate to severe chronic malignant and nonmalignant pain exceed $2 billion. |
|
http://www.durect.com/wt/durect/page_name/chronogesic
|
|
| Â Â |
| Â | [No title] |
| | This would conflict with earlier cat and dog studies which showed sufentanil free of any spinal cord toxicity. | | | Until further spinal cord studies have been performed, one should inject intrathecal sufentanil with caution. | | | While appropriate spinal cord toxicity studies have not been performed with meperidine, the clinical evidence supports its use in preservative-free forms. |
|
http://www.ncpainmanagement.com/InfoEpidChestAbSurgery.htm
|
|
| Â Â |
| Â | News - WIP: Chronogesic (Sufentanil) Shows Promise for Chronic Pain |
| | CUPERTINO, CA -- June 29, 2001 -- Preliminary results suggest that Chronogesic™ (sufentanil) may be effective for the long-term treatment of stable and opioid responsive chronic pain. | | | These preliminary results, from a Phase II clinical trial of three-month continuous infusion with the subcutaneous implant for the treatment of chronic pain, were presented today at the 2nd World Congress of the World Institute of Pain held June 27-30, in Istanbul, Turkey. | | | News - WIP: Chronogesic (Sufentanil) Shows Promise for Chronic Pain |
|
http://www.docguide.com/news/content.nsf/News/D448936054F9C91785256A7A00503B83?OpenDocument&id=48dde4a73e09a969852568880078c249
|
|
| Â Â |
| Â | Moskvagas |
| | A wide therapeutic index implies a greater safety margin between the effective dose and the lethal dose.The therapeutic index is derived from animal studies, not human studies, and may be based on only one animal species. | | | A better appreciation of some of the pharmacokinetic and toxicokinetic issues relating to carfentanil redistribution might have heightened concerns about recurrent toxicity. | | | Another characteristic of sufentanil, alfentanil, and remifentanil is their wide therapeutic index (Table). |
|
http://www.tjetjenien.org/Moskvagas.htm
|
|
| Â Â |
| Â | Opioide vom Typ der Anilinopiperidine - Sufentanil rec. INN |
| | (1999) Transdermal nitroglycerine enhances spinal sufentanil postoperative analgesia following orthopedic surgery. | | | (1990) Comparison of epidural sufentanil plus clonidine with sufentanil alone for postoperative pain relief. | | | (1994) Extradural sufentanil by patient-controlled analgesia or nurse-administered compared with optimal morphine in a high dependency unit: effects on oxygenation and pain relief after abdominal surgery. |
|
http://www.narcomed.com/books/opioide/literatur.html
|
|
| Â Â |
| Â | ☞ Newborns Article - Effects of sufentanil on electroencephalogram in very and extremely preterm neonates ☜ |
| | Therefore, the aims of this study were 1) to describe the effects of sufentanil on the EEG in preterm infants and 2) to evaluate the consequences of these effects on neurologic assessment in NICUs. | | | There was no significant relationship between clinical pain score and serum concentration levels of sufentanil (R = 0.185; P =.527). | | | Knowledge of the effects of drugs that may modify cerebral activity is critical for the electroencephalographer to avoid false interpretation. |
|
http://www.breastfeedinfo.com/breastfeed/bfiarticles/newborns/newborns-article-5964.html
|
|
| Â Â |
| Â | Epidural Droperidol |
| | We must be careful in caring patients suffering from chronic pain with continuous epidural administration of droperidol. | | | Phasic and tonic heat pain thresholds were increased postoperatively 1 h after sufentanil and placebo (P < 0.01 and P < 0.0005, respectively). | | | More patients were sedated with epidural droperidol than with placebo (P < 0.02). |
|
http://www.csen.com/anesthesia/droperidol.htm
|
|
| Â Â |
| Â | Preemptive Analgesia |
| | Expressed pain scores over 3 days confirmed correct use of the PCEA device and that those taking less sufentanil were not in more pain. | | | Presence of presurgical pain might be responsible for the controversy over the clinical validity of PA. | | | Result: After exclusions, there were 20 patients in the study group and 21 in the control group. |
|
http://www.painstudy.ru/wcp/preemptive.htm
|
|
| Â Â |
| Â | Sufentanil ( Sufenta ) |
| | The focus of the present work was to determine the possible involvement of cross interactions between the adenylyl cyclase pathway and L-type voltage-sensitive Ca(2+)-channels, in modulating the switch from opioid tolerance into supersensitivity. | | | Tolerance to the analgesic effect of sufentanil was associated with a significant reduction in the response of adenylyl cyclase to forskolin. | | | e have previously demonstrated that chronic and simultaneous treatment of rats with the mu-opioid receptor agonist sufentanil and the Ca(2+) channel blocker nimodipine, not only prevented tolerance development, but the animals became supersensitive to the antinociceptive effect of the opioid. |
|
http://www.heroin.org/sufentanil
|
|
| Â Â |
| Â | Acute Pain Opioids |
| | Self-administering N makes our pts more aware of the need to treat itching that otherwise might go untreated. | | | METHODS : Following approval of the local University Ethics Committee and written informed consent six patients undergoing major spinal surgery received sufentanil bolus (2 mcg/ kg) followed by infusion (1 mcg/ kg/ h) intraoperatively. | | | Thus, the present study aimed to evaluate the effect of nalbuphine on respiratory depression and analgesia in patients given sufentanil infusion intraoperatively. |
|
http://www.painstudy.ru/10wcp/acutepainopioids.htm
|
|
| Â Â |
| Â | DURECT Corporation (DRRX) Initiates Phase I Trial For Its Proprietary Trans... |
| | DURECT's transdermal sufentanil product is intended to provide extended chronic pain relief for up to seven days, as compared to the three days of relief provided with currently available patches. | | | Sufentanil is a pain relief medication that is currently FDA -approved for use in hospitals as an analgesic and is the active ingredient in DURECT's CHRONOGESIC(R) product under development. | | | The objectives of the clinical study are to determine the safety and tolerability of DURECT's transdermal sufentanil patch as well as evaluate the pharmacokinetics of sufentanil following transdermal administration. |
|
http://www.biospace.com/news_story.cfm?StoryId=17804820
|
|
| Â Â |
| Â | Choice of epidural agent |
| | PCEA is associated with an overall reduction in the amount of drug used when compared with other techniques. | | | Fentanyl 100mcg may be indicated in certain circumstances (14, 15). | | | Success has also been reported a with combination of 0.01% bupivacaine, sufentanil and epinephrine (20). |
|
http://www.manbit.com/oa/C60.htm
|
|
| Â Â |
| Â | Inadvertent Administration of Sufentanil Instead of Fentanyl during Sedation/Analgesia in a Community Hospital ... |
| | Frank Klanduch, MD From the Department of Emergency Medicine, Indiana University School of Medicine and the Emergency Medicine and Trauma Center, Methodist Hospital, Clarian Health Partners, Indianapolis, IN (CDC, FK). | | | Key words : sufentanil; fentanyl; medication error; adverse drug events | | | Inadvertent Administration of Sufentanil Instead of Fentanyl during Sedation/Analgesia in a Community Hospital Emergency Department: A Report of Two Cases -- Chisholm and Klanduch 7 (11): 1282 -- Academic Emergency Medicine |
|
http://www.aemj.org/cgi/content/abstract/7/11/1282
|
|
| Â Â |
| Â | Palliative Care Incident Pain and Incident Dyspnea Protocol |
| | Consequently, they must be used with appropriate clinical assessment and monitoring, particularly when first initiating use on a patient. | | | If the maximum number of doses (three) has been given, and the patient remains in discomfort with activity that must be undertaken presently, the physician should be contacted for consideration of immediately proceeding to the next step of the Incident Pain and Incident Dyspnea Protocol. | | | This can be very useful for in-home care, where the preparation of pre-drawn syringes for sublingual administration can be tedious. |
|
http://palliative.info/IncidentPain.htm
|
|
| Â Â |
| Â | University of Iowa Anesthesia Publications |
| | Fentanyl and sufentanil were associated with a more rapid return of mental function than morphine and meperidine. | | | Meperidine caused deleterious effects on objective tests of psychomotor and cognitive skills that were not reflected by subjective evaluation of rate of recovery from anesthesia. | | | The hemodynamic changes, plasma norepinephrine levels, pupil size, and rapidity of postoperative mental recovery were measured and compared in 72 patients randomly assigned in a double-blind manner to receive either morphine, meperidine, fentanyl, or sufentanil as supplements to nitrous oxide anesthesia. |
|
http://www.uianesthesia.com/readabstract.asp?PMID=0006230953
|
|
| Â Â |
| Â | MedicineHouse.com |
| | NSAIDs, antidepressant agents (see front matter for drug combinations) and use of non-drug therapies e.g. | | | Sufentanil may produce a dose dependent bradycardia probably by stimulation of the vagal nucleus in the medulla. | | | (3) Sufentanil may produce a dose-related rigidity of skeletal muscles (4) The drug crosses the placental barrier and usage in labor may produce depression of respiration in the neonate. |
|
http://www.medicinehouse.com/cgi-bin/drug.php?drug=sufentanil
|
|
| Â Â |
| Â | Anestesiologia.com.br |
| | Interaction of Morphine, Fentanyl, Sufentanil, Alfentanil, and Loperamide with the Efflux Drug Transporter P-glycoprotein | | | Fentanyl, sufentanil, and alfentanil did not behave as P-glycoprotein substrates, whereas the morphine glucuronides did not cross the cell monolayers at all, whether P-glycoprotein was present or not. | | | In this study, the authors examined whether other opioids of importance to anesthesiologists such as fentanyl, sufentanil, and alfentanil, and also morphine-6-glucuronide and morphine-3-glucuronide, are P-glycoprotein substrates and whether, in turn, these opioids act also as P-glycoprotein inhibitors. |
|
http://www.anestesiologia.com.br/resumos.php?itm=13&anestesiologia_secao=8a8641bb5fc2f5f4cea276c60d8da527
|
|
| Â Â |
| Â | Pain.com |
| | When using other opioids, especially when changing from one to another, it is incumbent upon the clinician to understand not only the concept of equianalgesic dosing, but also of lipid solubility to avoid side effects, such as respiratory depression. | | | With chronic intraspinal infusions of such drugs, patients become tolerant to the side effects and may have their 24-hour dose increased substantially to cover pain outside the immediate segments where the drug is being delivered, usually at low lumbar level for implanted systems (due to concerns of catheter-tip fibrosis). | | | The hydrophilicity (or lipophilicity) of a drug is a significant determinant of duration of action (and onset of action) when the drug is delivered intrathecally. |
|
http://www.pain.com/articles/onepage.cfm?chapter_id=65
|
|
| Â Â |
| Â | (S-48) DIRECT MYOCARDIAL EFFECTS OF REMIFENTANIL, SUFENTANIL, FENTANYL, AND ALFENTANIL ON ISOLATED HUMAN RIGHT ATRIA IN ... |
| | METHODS: With approval of the local medical ethics comittee, human right atrial tissue was obtain from patients scheduled for coronary artery bypass surgery. | | | M. At clinically relevant concentations, remifentanil, sufentanil, alfentanil, and fentanyl did not modified inotropic parameters of isolated human right atrial trabeculae. | | | Never- theless, alfentanil induced a dose dependent negative inotropic effect significantly greater than that induced by remifentanil, sufentanil, and fentanyl. |
|
http://www.iars.com/abstracts/abstracts/S25/s48.htm
|
|
|
