|
| Â Â |
| Â | The Scientist - Inner Sanctum |
 | | Says Dani, "It all comes down to time, and whether people are willing to keep it up." Nevertheless, the NRR currently has a wealth of information useful for researchers studying these proteins and their consequences for human health and disease. | | | Evolution of complex life forms required intricate methods for responding to environmental changes, maintaining homeostasis, and controlling health and development. | | | A related question is how local perturbations in structure, such as the ligand-induced conformational change in the LBD, affect the global structure of the NHR and, in turn, its functional specificity. |
|
http://www.the-scientist.com/yr2000/may/profile_000529.html
|
|
| Â Â |
| Â | Pharmacy : UT Austin : Faculty |
| | Neural mechanisms for reproductive senescence : The mechanisms for reproductive senescence are poorly understood, particularly whether the brain (as opposed to the gonad) plays a role in this process. | | | Increased expression of forebrain GnRH mRNA and changes in testosterone negative feedback following pubertal maturation. | | | Neuroendocrine aging in the female rat: the changing relationship of GnRH neurons and NMDA receptors. |
|
http://www.utexas.edu/pharmacy/divisions/pharmtox/faculty/gore.html
|
|
| Â Â |
| Â | Steroid hormones and receptors |
| | This line of thinking, possible only since the early 1990's (so don't look for it in the earlier literature) adds another level at which to think about drug regulation of cellular processes. | | | The response takes 24 hours to become effective. | | | Such information can be used to facilitate computer modeling and "rational" drug design. |
|
http://www.neurosci.pharm.utoledo.edu/MBC3320/steroids.htm
|
|
| Â Â |
| Â | Nuclear Receptor Full text Stat3 enhances transactivation of steroid hormone receptors |
| | We studied if active Stat3 could be responsible for this behavior of AR. | | | This work was supported by the National Institutes of Health grant RO1 CA90271; and US Army Medical Research and Materiel Command AMRMC Prostate Cancer Research Program grant DAMD17-01-1-0089. | | | The JAK/STAT signaling pathway is involved in many cytokines, hormones, and growth factors mediated signaling pathways to regulate a variety of biological responses, including development, cell differentiation, proliferation and survival [ 7, 8 ]. |
|
http://www.nuclear-receptor.com/content/1/1/3
|
|
| Â Â |
| Â | Steroid Hormones |
| | Although there is the commonly observed effect of altered transcriptional activity in response to hormone-receptor interaction, there are family member-specific effects with ligand-receptor interaction. | | | Adrenal insufficiency is known as Addison disease, and in the absence of steroid hormone replacement therapy can rapidly cause death (in 1--2 weeks). | | | Several receptors are induced to interact with other transcriptional mediators in response to ligand binding. |
|
http://web.indstate.edu/thcme/mwking/steroid-hormones.html
|
|
| Â Â |
| Â | Nuclear Hormone Receptors |
| | Can the hormone use one pathway for binding and another pathway for unbinding? | | | These switches control the development and differentiation of skin, bone and behavioral centers in the brain, as well as the continual regulation of reproductive tissues. | | | The identity of a response element resides in three features: the sequence of the base pairs in the half-site, the number of base pairs between the half-sites and the relative orientation of the two half-sites. |
|
http://www.ks.uiuc.edu/Research/pro_DNA/ster_horm_rec/
|
|
| Â Â |
| Â | Thyroid Hormone Receptors |
| | Such experiments are beginning to allow determination of which functions of the different receptor isoforms are redundant and which are not. | | | Receptor alpha-1 is the first isoform expressed in the conceptus, and there is a profound increase in expression of beta receptors in brain shortly after birth. | | | More than half of affected children show attention-deficit disorder, which is intriguing considering the role of thyroid hormones in brain development. |
|
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/thyroid/receptors.html
|
|
| Â Â |
| Â | Encyclopedia4U - Testosterone - Encyclopedia Article |
| | The sequence of actions is needed for the hormone to exert its physiological role. | | | These receptors are ligand-activated and in effect they undergo structural change that renders them capable of binding to specific nucleotide sequences in the DNA called hormone response elements (HREs). | | | While bound they influence transcriptional activity of certain genes. |
|
http://www.encyclopedia4u.com/t/testosterone.html
|
|
| Â Â |
| Â | Nancy H. Ing |
| | Ing's research focuses on the effects of steroid hormones on the sheep uterus. | | | Her studies specifically address changes in gene regulation that make the uterus able to support embryo growth and development. | | | Currently, the focus is on finding out how estrogen up-regulates the expression of estrogen receptor gene. |
|
http://animalscience.tamu.edu/ansc/FACULTY/ingvita.htm
|
|
| Â Â |
| Â | Hess publications |
| | Estrogen receptor function in the adult male rat: short and long-term effects of the antiestrogen ICI 182,780 on the testis and efferent ductules, without changes in testosterone. | | | Thyroid hormone regulation of Sertoli cell proliferation may be mediated through the cell cycle inhibitors p27Kip1 AND p21Cip1. | | | 1992 Hormonal correlates of the neonatal hypothyroidism induced increase in adult testis size and sperm production in the rat. |
|
http://www.cvm.uiuc.edu/~rexhess/Pubs.html
|
|
| Â Â |
| Â | Steroid Hormone Receptors |
| | liver cells or lymphocytes) show no accumulation of female sex hormones. | | | a domain needed for the receptor to activate the promoters of the genes being controlled | | | The zinc-finger proteins that serve as receptors for glucocorticoids and progesterone are members of a large family of similar proteins that serve as receptors for |
|
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/SteroidREs.html
|
|
| Â Â |
| Â | Current Research Focusing on Euchromatin Within the Cell Nucleus. |
| | Wang G, Cantin GT, Stevens JL, and Berk AJ, "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". | | | Remboutsika E, Lutz Y, Gansmuller A, Vonesch JL, Losson R, Chambon P, "The Putative Nuclear Receptor Mediator TIF1alpha is Tightly Associated with Euchromatin". | | | Cantile M, Cindolo L, Napodano G, Altieri V, and Cillo C, "Hyperexpression of locus C genes in the HOX network is strongly associated in vivo with human bladder transitional cell carcinomas". |
|
http://www.euchromatin.net/current1.html
|
|
| Â Â |
| Â | Inactivation of the Phloem-Specific Dof Zinc Finger Gene DAG1 Affects Response to Light and Integrity of the Testa of ... |
| | Karssen C, M., Laçka E (1986) A revision of the hormone balance theory of seed dormancy: studies on gibberellin and/or abscisic acid-deficient mutants of Arabidopsis thaliana. | | | Kisu Y, Esaka M, Suzuki M (1995) Putative zinc binding domain of plant transcription factor AOBP is related to DNA binding domains of steroid hormone receptors and GATA1. | | | Kisu Y, Ono T, Shimofurutani N, Suzuki M, Esaka M (1998) Characterization and expression of a new class of zinc finger protein that binds to silencer region of ascorbate oxidase gene. |
|
http://www.plantphysiol.org/cgi/content/full/128/2/411
|
|
|
