Spironolactone - Medicow
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Topic: Spironolactone



  
 hirsutism / hypertrichosis - spironolactone for hirsutism
Spironolactone in combination drug therapy for unresponsive hirsutism.
Spironolactone is an effective and well tolerated systemic antiandrogen therapy for Hirsute women.
Hirsutism and the effectiveness of spironolactone in its management.
http://www.keratin.com/ah/ah022.shtml   (630 words)

  
 Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial
Despite these limitations, it is clear that spironolactone does not offer sufficient antiandrogenic coverage to sustain significant improvement of androgen-sensitive skin disorders and that long-term administration of the drug is limited because of adverse side effects.
Clinical improvement was observed in 11 of 12 patients treated with flutamide.
In agreement with the limited clinical efficacy of spironolactone are the observations of Labrie et al.
http://www.fernand.labrie.crchul.ulaval.ca/flabrie/pub/241.htm   (3154 words)

  
 Spironolactone
Immediate object of influence Spironolactone on Spironolactone should supervise the Spironolactone and through it various influences on an organism are mediated.
These problems may cause your skin to be more sensitive to sunlight than it is sharp a condition and actually many patients leave a zone of attacks of a life of the skin, or a severe sunburn.
It Spironolactone is more attractive to patients, than Spironolactone as it is important that your doctor if you have any questions about this, check with your doctor.
http://spironolactone.pillsearch.us   (2798 words)

  
 Topical Spironolactone 5%
The effect of spironolactone on genital skin 5 alpha-reductase activity.
This has led to experimentation with topical delivery of spironolactone to the scalp and skin to treat hairloss and acne, respectively, with some success being reported (2).
This has certainly not stopped individuals from experimenting on their own with topical spironolactone, with many reporting success rates comparable to finasteride.
http://www.cemproducts.com/tosp5.html   (707 words)

  
 Spironolactone for heart failure
Nowadays, the use of beta-blockers in heart failure is consistently increasing and it remains to be proved whether spironolactone adds incremental benefit beyond that of a combination of ACEI and beta-blocker to standard digitalis and diuretic therapy.
However, I'm not sure that spironolactone would be likely to have more or less of an effect in patients in fibrillation, so even if the groups were unbalanced in this regard, I don't think it would have affected the outcome.
The article referred to by Dr. Kaiser is a retrospective study of patients enrolled in SOLVD and found that use of non-potassium sparing diuretics, but not potassium-sparing diuretics, was associated with an increased risk of arrhythmic death.
http://www.journalclub.org/vol2/a72.html   (2155 words)

  
 American Family Physician: Inappropriate use of Spironolactone in heart failure - Tips - Author Abstract
Because long-term outcome data are not available, Bozkurt and associates studied the appropriateness and complications of the use of spironolactone in the treatment of heart failure in clinical practices.
The authors conclude that spironolactone is being used to treat heart failure without consideration of the NYHA class or other appropriate criteria for initiating therapy.
Secondary objectives were to determine adverse events related to hyperkalemia, incidence of hypotension, and correlation between the management index and the specialization and training of physicians.
http://www.findarticles.com/p/articles/mi_m3225/is_3_68/ai_105929626   (574 words)

  
 Odorless Topical Spiro Lotion for hair loss
chest, face, axilla, pubis, etc.) is promoted by testosterone and since Spironolactone is a potent anti-androgen, it's successfully used to eliminate unwanted hair on the body.
Using Spironolactone to treat hirsutism may sound contradictory, but body hair (e.g.
However, applied topically, Spironolactone does not have any systemic side effects.
http://www.hairlosstalk.com/newsletter/article157.htm   (2076 words)

  
 MotherNature.com - Spironolactone
The combination of spironolactone and hydrochlorothiazide would likely eliminate this problem, as hydrochlorothiazide may deplete magnesium.
People with questions about spironolactone and food should ask their prescribing doctor or pharmacist.
People taking spironolactone should talk with their prescribing doctor before severely restricting salt.
http://www.mothernature.com/Library/Ency/Index.cfm/Id/1499003   (884 words)

  
 News - Spironolactone Reduces Blood Pressure in Patients with Resistant Hypertension
A previous study indicated that combined therapy with an ACE inhibitor and spironolactone could cause hyperkalemia, especially among the elderly or those with chronic kidney disease, the researchers point out.
In their study, 2 subjects developed hyperkalemia, and both were receiving an ACE inhibitor and had chronic kidney disease, they note.
A DGReview of :"Efficacy of low-dose spironolactone in subjects with resistant hypertension"
http://www.docguide.com/news/content.nsf/news/8525697700573E1885256DCA0032EB41   (533 words)

  
 Bodybuilding.com - Big Cat - In Depth Aldactone (Spironolactone) Profile!
The studies do indeed show that spironolactone can remedy some androgen-mediated conditions, and does so through other means than finasteride (proscar).
But spironolactone has been shown to work through other pathways
From estrogen first of all, through the help of clomid or Nolvadex, but also by eliminating negative feedback from androgens, and here spironolactone can help.
http://www.bodybuilding.com/fun/cataldactone.htm   (1292 words)

  
 Spironolactone Information from Drugs.com
Also, before taking spironolactone, tell your doctor if you are taking any other medicine to treat high blood pressure, water retention, heart problems, prostate problems, or another condition.
Your pharmacist has additional information about spironolactone written for health professionals that you may read.
Continue to take spironolactone and talk to your doctor if you experience
http://www.drugs.com/spironolactone.html   (1144 words)

  
 Safety of low-dose spironolactone administration in chronic haemodialysis patients -- Saudan et al. 18 (11): 2359 -- ...
Limitations of excessive extra-cellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure.
treated with spironolactone 25 mg three times/week was 13 ±
Low-dose spironolactone did not change mean serum potassium
http://ndt.oxfordjournals.org/cgi/content/full/18/11/2359   (2166 words)

  
 Rapid Effects of Aldosterone and Spironolactone in the Isolated Working Rat Heart -- Barbato et al. 40 (2): 130 -- ...
Haller C. Diuretic therapy in congestive heart failure: new views on spironolactone therapy.
*Significant spironolactone response relative to corresponding aldosterone response.
Each point represents an average of 5 separate WKY rat hearts perfused at 1 of 7 aldosterone or spironolactone concentrations.
http://hyper.ahajournals.org/cgi/content/full/40/2/130   (3222 words)

  
 Aldactone Online, Description, Chemistry, Ingredients - Spironolactone - RxList Monographs
Spironolactone is practically insoluble in water, soluble in alcohol, and freely soluble in benzene and in chloroform.
Unnecessary use of this drug should be avoided.
Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats (see PRECAUTIONS).
http://www.rxlist.com/cgi/generic/spiron.htm   (142 words)

  
 Effects of spironolactone on endothelial function, vascular angiotensin converting enzyme activity, and other ...
Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES).
Figure 2  Forearm blood flow ratio (FBFR) response to angiotensin I after spironolactone (S) or placebo (P).
Figure 1  Forearm blood flow ratio (FBFR) response to acetylcholine after spironolactone (S) or placebo (P).
http://heart.bmjjournals.com/cgi/content/full/90/7/765   (3326 words)

  
 Spironolactone and Hydrochlorothiazide - Drugs & Vitamins - Drug Library - DrugDigest
Hydrochlorothiazide; spironolactone may make your skin more sensitive to sun or ultraviolet light.
Spironolactone can make your body hold onto potassium.
Check with your health care professional before stopping or starting any of your medicines.
http://www.drugdigest.org/DD/PrintablePages/Monograph/0,7765,614,00.html   (917 words)

  
 Review - Spironolactone
Warnings: Spironolactone therapy should not be used in conjunction with any kind of potassium supplementation.
At this point, there is no clinical studies, at least not to our knowledge, that substantiates the effectiveness of topical Spironolactone as a hair loss treatment for men and women.
Sometimes Spironolactone is used in conjunction with other medications as a antihypertensive treatment.
http://www.hairsite.com/o-spironolactone.htm   (709 words)

  
 Spironolactone
How spironolactone works in acne and hair conditions is not well understood.
It does not affect the blood pressure of those whose blood pressure is normal.
Spironolactone can be a very effective treatment for women with acne, diffuse hair loss, and increased hair growth (hirsuitism.) The medication is an antiandrogen (male hormone blocking drug) that also has a mild estrogen effect on the scalp, hair, skin and body.
http://www.drsteinman.com/Content/Spironolactone.htm   (388 words)

  
 Medical Therapies: Spironolactone Therapy for recalcitrant Acne
However, if you are taking any other blood pressure medicines, spironolactone may increase their effect.
Please ask your physician about any potential problems with blood pressure medicines (or any other medication you are taking).
You may have to substitute spironolactone for one or more of your present medicines.
http://www.resderm.com/medicaltherapies/Spironolactone.html   (654 words)

  
 Spironolactone - Patient UK
It is very important to take Spironolactone exactly as directed by your doctor, and not to stop taking it without speaking to your doctor first, even if you feel quite well.
Before taking any 'over-the-counter' medicines, check with your pharmacist which medicines are safe for you to take alongside Spironolactone.
Spironolactone may cause your skin to become more sensitive to sunlight than it is usually.
http://www.patient.co.uk/showdoc/30002365   (975 words)

  
 NetDoctor.co.uk - Information about drugs for Patients
Spironolactone is commonly used in conditions such as heart failure, where the pumping mechanism of the heart is less effective.
Spironolactone increases the levels of cardiac glycosides such as digoxin in the blood and should be monitored carefully when these medicines are used together.
Spironolactone does not increase the loss of potassium from the body in the urine, therefore there is less risk of developing low potassium levels in the blood (hypokalaemia).
http://www.netdoctor.co.uk/medicines/showpreparation.asp?id=2448   (846 words)

  
 Spironolactone - IntenseMuscle.com
Spironolactone is a potent anti-androgen and it is effective applied topically.
Spironolactone is also an antiandrogen and aldosterone antagonist used to treat hirsutism...
The opinions presented do not encourage the use of illegal substances nor take the place of professional medical advice.
http://www.intensemuscle.com/showthread.php?t=3197   (545 words)

  
 Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne (Cochrane Review)
Its value in clinical practice is difficult to assess from currently available research.
Spironolactone is an antiandrogen and aldosterone antagonist used to treat hirsutism.
Two trials investigated spironolactone versus placebo; one trial was a dosage studies of spironolactone; one trial compared spironolactone with spironolactone in combination with dexamethasone; one trial used topical spironolactone for the treatment of acne, one trial compared three treatments; spironolactone, finasteride, cyproterone acetate.
http://www.cochrane.org/cochrane/revabstr/AB000194.htm   (660 words)

  
 Spironolactone (Aldactone®) - PetPlace.com
Consult with your veterinarian to determine if other drugs your pet is receiving could interact with spironolactone.
Spironolactone also blocks the effects of aldosterone on the heart muscle.
The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects.
http://petplace.netscape.com/articles/artShow.asp?artID=1578   (472 words)

  
 Spironolactone for polycystic ovary syndrome (PCOS)
Your health professional may not recommend spironolactone if you have kidney problems because it affects potassium excretion.
Spironolactone has been reported to cause a change in the genitals of a male fetus, though this is rare.
Spironolactone is a diuretic, which eliminates excess salt and water in the body.
http://www.webmd.com/hw/womens_conditions/tw9658.asp   (232 words)

  
 Spironolactone
If you have an allergy to spironolactone or any other part of the medicine.
These were long-term studies using larger doses than would be used in humans.
It may be used in some people with heart failure.
http://www.umm.edu/altmed/ConsDrugs/Spironolactonecd.html   (671 words)

  
 Inhouse Drugstore Spironolactone (Aldactone, Spirotone)
It may take six or more months to see improvement in the skin condition.
Spironolactone (Aldactone) is a potassium-sparing medication used as a diuretic medication for heart failure, liver disease and high blood pressure.
It may also be used to treat other conditions as determined by your doctor.
http://www.inhousedrugstore.com/bcp-hormones/spironolactone.html   (253 words)

  
 Buy Spironolactone online in 25mg, 50mg, 100mg tablets; cheap drug prices and information
Click on a drug in the list below to view prices and information.
Spironolactone may also be used to treat other conditions as determined by your doctor.
Spironolactone is a potassium-sparing diuretic used to treat congestive heart failure or high blood pressure.
http://www.drugstore.com/qxdSpironolactone_332828_sespider/spironolactone/spironolactone.htm   (404 words)

  
 Hair loss question about spironolactone
If you are willing to discipline yourself to applying these medications twice/day, you may find that you will have positive results in your battle against MPB."
Dr Richard Lee, MD answered: "I would not recommend oral spironolactone for the treatment of MPB in a male patient.
In general how much testosterone in a male's body (percentage wise) would 25 mg a day of spironolactone inhibit?
http://www.hairlosshelp.com/qna/Detail.Cfm?FAQID=1337&ExpertID=8&Keyword=spiro   (251 words)

  
 Potassium-Sparing Diuretics
Potassium-sparing diuretics include drugs such as amiloride hydrochloride (Midamor), spironolactone (Aldactone), and triamterene (Dyrenium) among others.
This family of diuretics was invented to avoid the potassium loss common with loop and thiazide diuretics.
Potassium-sparing diuretics cause the kidneys to hold potassium in the body.
http://healthlibrary.epnet.com/GetContent.aspx?token=e0498803-7f62-4563-8d47-5fe33da65dd4&chunkiid=21463   (427 words)

  
 NEJM -- Rates of Hyperkalemia after Publication of the Randomized Aldactone Evaluation Study
Buck, M. Clinical Experience with Spironolactone in Pediatrics.
increases in the rate of prescriptions for spironolactone and
Conclusions The publication of RALES was associated with abrupt
http://content.nejm.org/cgi/content/abstract/351/6/543   (851 words)

  
 Treatments: Spironolactone - CureResearch.com
Count: Spironolactone is listed as a: treatment for 2 conditions; alternative treatment for 2 conditions; preventive treatment for 0 conditions; research treatment for 0 conditions.
Spironolactone as a treatment: The following list of conditions have 'Spironolactone' or similar listed as a treatment in our database:
Use of this site is subject to our TERMS OF USE.
http://www.cureresearch.com/treat/spironolactone.htm   (239 words)

  
 IngentaConnect The spironolactone renaissance
Spironolactone may also be useful in the treatment of left ventricular hypertrophy, portal hypertension and cirrhosis.
Spironolactone reduces vascular fibrosis and injury, inhibits angiogenesis, reduces vascular tone and reduces portal hypertension.
The RALES clinical trial was stopped early when it was shown that there was a 30% reduction in risk of death among the spironolactone patients.
http://www.ingentaconnect.com/content/apl/eid/2001/00000010/00000005/art00012   (298 words)

  
 spironolactone: Definition and Much More From Answers.com
Due to its anti-androgen effect, it can also be used to treat hirsutism, and is a common component in hormone therapy for male-to-female transgendered people.
It can also be used to treat elevated blood pressure in combination with other drugs and in resistant cases of low potassium (hypokalemia).
Therefore, spironolactone is classified as a potassium-sparing medication that promotes the output of urine (diuretic).
http://www.answers.com/topic/spironolactone   (745 words)

  
 Cell-Specific, Promoter-Dependent Mineralocorticoid Agonist Activity of Spironolactone -- Massaad et al. 51 (2): 285 -- ...
The mechanism by which spironolactone antagonizes the aldosterone effect is still unclear.
this question is to define conditions under which spironolactone
the treatment period did not prevent the agonist activity of spironolactone
http://molpharm.aspetjournals.org/cgi/content/full/51/2/285   (3986 words)

  
 SPIRONOLACTONE - ORAL (Aldactone) side effects, medical uses, and drug interactions.
SPIRONOLACTONE - ORAL (Aldactone) side effects, medical uses, and drug interactions.
MedicineNet Home > Medications A-Z List > SPIRONOLACTONE-ORAL
Please consult your healthcare provider before beginning any course of supplementation or treatment.
http://www.medicinenet.com/spironolactone-oral/article.htm   (392 words)

  
 Effect of spironolactone on the renal clearance of digoxin in dogs -- O'Brien et al. 234 (1): 190 -- Journal of ...
conclude that spironolactone inhibits renal CDIG by a mechanism that may be
changes in digoxin handling with spironolactone appeared to be temporally
Effect of spironolactone on the renal clearance of digoxin in dogs -- O'Brien et al.
http://jpet.aspetjournals.org/cgi/content/abstract/234/1/190   (242 words)

  
 Spironolactone Pharmacology
The most important of these receptors are situated in the distal portion of the renal tubules.
The optimal effect is dependent on a sufficient sodium supply in the distal portion of the renal tubules, as it can be observed in thiazide treatments.
Spironolactone is a synthetic steroid with an aldosterone-like structure; it acts as a competitive antagonist at aldosterone receptors.
http://www.infomed.org/100drugs/spiphar.html   (84 words)

  
 Medication instructions for SPIRONOLACTONE
Potassium-sparing diuretics are used to help the body lose water.  Amiloride and spironolactone are also used to treat high blood pressure (hypertension).  Spironolactone may also be used to increase the amount of potassium in the body.  These medicines may also be used for other conditions. 
For spironolactone and triamterene only (in addition to effects listed above) - cough or hoarseness; fever or chills; lower back or side pain; pain or trouble in urinating 
Tell your doctor if you notice any of these possible side effects: 
http://www1.va.gov/visn10/CincyMedSheets/Spironlactone.htm   (476 words)

  
 Mechanisms for Aldosterone and Spironolactone-Induced Positive Inotropic Actions in the Rat Heart -- Barbato et al. 44 ...
the effects of aldosterone and spironolactone on isolated cardiac
actions of aldosterone and spironolactone are caused by different
http://hyper.ahajournals.org/cgi/content/abstract/44/5/751   (303 words)

  
 spironolactone - OneLook Dictionary Search
spironolactone : The On-line Medical Dictionary [home, info]
Spironolactone : RxList The Internet Drug Index [home, info]
spironolactone : Dorland's Illustrated Medical Dictionary [home, info]
http://www.onelook.com/?w=spironolactone&ls=a   (129 words)

  
 Mott Health Topics: Aldactone Brand Name: Aldactone/Generic Name: Spironolactone
Mott Health Topics: Aldactone Brand Name: Aldactone/Generic Name: Spironolactone
In order to capture all information when printing please set your printer page setup to landscape before printing.
http://www.med.umich.edu/1libr/chheart/meds01.htm   (415 words)

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