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Topic: Sphingolipid

Ads by Google      United States Patent Application: 0040247603 Consequently, interfering with sphingolipid production and/or action may be beneficial in mitigating stroke, particularly in stroke casued by peripherical vascular disease, atherosclerosis and cardiac disorders. [0061] Applicants believe, without wishing to be bound by any particular theory, that the level of undesirable sphingolipids such as CER, SPH or S-1-P, and/or one or more of their metabolites, may be directly responsible for cardiac dysfunction, during or immediately after cardiac ischemia such as during reperfusion injury. http://appft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&u=/netahtml/PTO/search-adv.html&r=1&f=G&l=50&d=PG01&p=1&S1=20010041688&OS=20010041688&RS=20010041688      Membrane Sphingolipid-Ergosterol Interactions Are Important Determinants of Multidrug Resistance in Candida albicans -- ... (A) Schematic representation of the yeast sphingolipid biosynthesis pathway. and sphingolipids in the drug susceptibilities of Candida albicans. Evidence that sphingolipid content can affect the drug susceptibilities http://aac.asm.org/cgi/content/full/48/5/1778      Sphingolipid Perturbations as Mechanisms for Fumonisin Carcinogenesis Inhibition of sphingolipid biosynthesis in rat primary hepatocyte cultures by fumonisin B Methods for the diet formulation, fumonisin analysis, and sphingolipid analysis are given in Meredith et al. This balance is maintained by the relative activity of various key enzymes in the de novo and sphingolipid turnover pathways (Figure 3A). http://ehp.niehs.nih.gov/members/2001/suppl-2/301-308riley/riley-full.html      Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in ... sphingolipids and that in multicellular organisms, one consequence (A) The sphingolipid biosynthetic pathway and the metabolism of [ mutant that corrupts mutually redundant pathways of sphingolipid http://www.jcb.org/cgi/content/full/164/4/547      Roles for Sphingolipid Biosynthesis in Mediation of Specific Programs of the Heat Stress Response Determined through ... that sphingolipids are critical for the overall response. involvement of sphingolipids in the heat stress response; and Specific roles for sphingolipids in regulation of specific responses http://www.jbc.org/cgi/content/full/278/32/30328      The Organizing Potential of Sphingolipids in Intracellular Membrane Transport -- Holthuis et al. 81 (4): 1689 -- ... Eukaryotes are characterized by endomembranes that are connected by vesicular transport along secretory and endocytic pathways. The major pathway along which sphingolipids are degraded is removal of the head group and subsequent hydrolysis of ceramide breakdown and are generally (re)utilized for sphingolipid synthesis http://physrev.physiology.org/cgi/content/full/81/4/1689      Sply regulation of sphingolipid signaling molecules is essential for Drosophila development -- Herr et al. 130 (11): ... by which sphingolipids may affect animal physiology and contribute or generated that facilitate investigation of the sphingolipid Key words: Sphingosine-1-phosphate, Sphingolipids, Sphingosine phosphate lyase, Muscle, Drosophila, Serine palmitoyltransferase, Sphingolipidoses, Reproduction, Apoptosis http://dev.biologists.org/cgi/content/full/130/11/2443      A Post-genomic Approach to Understanding Sphingolipid Metabolism in Arabidopsis thaliana -- DUNN et al. 93 (5): 483 -- ... of lipids, not just a particular sub-class such as sphingolipids. many unresolved aspects of the sphingolipid pathway in plants The outcomes of such research are likely to widen http://aob.oxfordjournals.org/cgi/content/full/93/5/483      Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, ... Based upon the critical role of sphingolipids in the skin (35, Shivji, Z.M., and Ashby, P. Sympathetic skin responses in hereditary sensory and autonomic neuropathy and familial amyloid neuropathy are different. A decrease of sphingolipid synthesis in lymphoblasts from HSN1 patients. http://www.jci.org/cgi/content/full/110/9/1301      Novel Mutations That Control the Sphingolipid and Cholesterol Dependence of the Semliki Forest Virus Fusion Protein -- ... fuse with membranes deficient in either cholesterol or sphingolipid. Results from a representative example of six experiments are shown. The molecular mechanism by which cholesterol and sphingolipid http://jvi.asm.org/cgi/content/full/76/24/12712      Sphingosylphosphorylcholine Induces a Hypertrophic Growth Response Through the Mitogen-Activated Protein Kinase ... Effect of PTX on Sphingolipid Metabolite-Induced Hypertrophic Response in Cardiac Myocytes Despite their structural relationship, the increase in total induced by exogenous sphingolipid metabolites is mediated by http://circres.ahajournals.org/cgi/content/full/85/11/1000      Effects of Membrane Potential and Sphingolipid Structures on Fusion of Semliki Forest Virus -- Samsonov et al. 76 (24): ... Experimental conditions were the same as for Fig. of all sphingolipids, but sphingosine itself does not support and sphingolipids are thought to be important not only for alphavirus http://jvi.asm.org/cgi/content/full/76/24/12691      Sphingolipid Transport: Rafts and Translocators -- van Meer and Lisman 277 (29): 25855 -- Journal of Biological ... Sphingolipids can be endocytosed via clathrin-dependent and -independent pathways. Sphingolipids have been shown to pass through each of sphingolipid rafts may be 4.5-5.5 nm thick (42). http://www.jbc.org/cgi/content/full/277/29/25855      Different Sphingolipids Show Differential Partitioning into Sphingolipid/Cholesterol-Rich Domains in Lipid Bilayers -- ... In this study we have used two approaches to monitor the association of different fluorescent phospho- and sphingolipids with TABLE 1 Relative affinities of diphenylhexatrienylpropionyl phospho- and sphingolipids for the liquid-ordered phase in sphingolipid/12SLPC/cholesterol bilayers sphingolipids for such domains may most strongly affect the intramembrane http://www.biophysj.org/cgi/content/full/79/3/1478      Identification and Characterization of a Sphingolipid Delta 4-Desaturase Family -- Ternes et al. 277 (28): 25512 -- ... De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway sphingolipids have been found in all these organisms. Sequences that have been biochemically characterized as sphingolipid http://www.jbc.org/cgi/content/full/277/28/25512      GPI anchoring leads to sphingolipid-dependent retention of endocytosed proteins in the recycling endosomal compartment ... In contrast, the change in the rate of FR-GPI internalization of cholesterol (Hannan and Edidin, 1996) and sphingolipids (Mays we have examined the role of sphingolipids in the endocytic http://embojournal.npgjournals.com/cgi/content/full/20/7/1583      Sphingolipid Mediators in Cardiovascular Cell Biology and Pathology -- Levade et al. 89 (11): 957 -- Circulation ... In response to various extracellular stimuli, sphingolipid turnover Sphingolipids have emerged as a new class of lipid mediators. Sphingolipid Mediators in Cardiovascular Cell Biology and Pathology http://circres.ahajournals.org/cgi/content/abstract/89/11/957      2002 GRC on Glycolipid & Sphingolipid Biology Structure activity relationships of psychosine and other lyso(glyco)sphingolipid ligands Sigma-2 receptors, sphingolipid signaling, and a novel pathway to apoptosis Sphingolipids in controlling cell growth and apoptosis with implications for the etiology, prevention and treatment of disease http://www.grc.uri.edu/programs/2002/glycolip.htm      Enhanced Serine Palmitoyltransferase Expression in Proliferating Fibroblasts, Transformed Cell Lines, and Human Tumors ... of flux through the sphingolipid biosynthetic pathway occurring Nagiec MM, Lester RL, Dickson RC (1996) Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase. Senchenkov A, Han TY, Wang H, Frankel AE, Kottke TJ, Kaufmann SH, Cabot MC (2001) Enhanced ceramide generation and induction of apoptosis in human leukemia cells exposed to DT388-granulocyte-macrophage colony-stimulating factor (GM-CSF), a truncated diphtheria toxin fused to human GM-CSF. http://www.jhc.org/cgi/content/full/51/6/715      NSF Grant For Sphingolipid Research Sphingolipids, lipid compounds present in all organisms except bacteria, are known to function as structural components in cells and as regulators of various biological processes. Little is known, however, about their role in plant growth and development. Lynch's research explores how and where in the cell sphingolipids are produced, transported, and degraded. http://www.eurekalert.org/pub_releases/1997-11/WC-NGFS-061197.php      2004 GRC on Glycolipid & Sphingolipid Biology "Sphingolipid synthesis mediates stress induced regulation of translation" "Sphingolipidomics: New LC-MS/MS methods to elucidate sphingolipid structure, metabolism, and cellular signaling" "Overview, Sphingolipid metabolism and trafficking: A foundation for function" http://www.grc.uri.edu/programs/2004/glycolip.htm      Regulation of sphingolipid and glycosphingolipid metabolism in extrahepatic tissues by endotoxin -- Memon et al. 42 ... Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyl transferase in rat liver microsomes. of sphingolipids and distal GSL in the liver, which may account activities were reflected in corresponding changes in sphingolipid http://www.jlr.org/cgi/content/full/42/3/452      The World's Healthiest Foods: Feeling Great A substance found in soybeans may reduce colon cancer risk, suggests animal research conducted by Alfred Merrill at Emory University and the Karmanos Cancer Institute. While other plants also contain sphingolipids, soy contains relatively high amounts of glucosylceramide, which researchers think may be one reason for the cancer-preventive effects of eating soy foods. The cancer-protective substance is a sphingolipid (a type of lipid or fat that, in the body, is primarily used as a constituent of nerve tissue) called soy glucosylceramide. http://www.whfoods.com/genpage.php?tname=foodspice&dbid=79      Sterol-dependent Regulation of Sphingolipid Metabolism in Saccharomyces cerevisiae -- Swain et al. 277 (29): 26177 -- ... Functional Analysis of CaIPT1, a Sphingolipid Biosynthetic Gene Involved in Multidrug Resistance and Morphogenesis of Candida albicans blocks in sterol biosynthesis have profound effects on sphingolipid from additional genetic studies using the sphingolipid hydroxylase http://www.jbc.org/cgi/content/abstract/277/29/26177      Sphingolipid activator proteins: proteins with complex functions in lipid degradation and skin biogenesis -- Schuette ... Using fibroblasts from these patients in cell culture feeding Burkhardt, J.K., Huttler, S., Klein, A., Mobius, W., Habermann, A., Griffiths, G., and Sandhoff, K. (1997) Accumulation of sphingolipids in SAP-precursor (prosaposin)-deficient fibroblasts occurs as intralysosomal membrane structures and can be completely reversed by treatment with human SAP-precursor. Sphingolipid activator proteins: proteins with complex functions in lipid degradation and skin biogenesis -- Schuette et al. http://glycob.oxfordjournals.org/cgi/content/full/11/6/81R      University of Cincinnati, Dept. of Biological Sciences, Publications Incorporation in vivo and in vitro of sphingolipid precursors into Paramecium tetraurelia lipids. http://www.biology.uc.edu/pubs/Publishing.htm      Aloe: Aloe Serum #1: Glycoceramides Sphingolipid Complex Rich in Glycoceramides and Sphingolipid Complex, enhances with Cyclomethicone. These fresh individual dose Serum Caps assist in renewing your skin's barrier function and essential moisture binding capacity. http://www.julietsdayspa.com/products/aloe/prod_details.php?prod=D006      Amazon.ca: Books: Sphingolipid Metabolism and Cell Signaling, Part a Look for books like Sphingolipid Metabolism and Cell Signaling, Part a by subject: Use Your Account to view or change your orders Amazon.ca: Books: Sphingolipid Metabolism and Cell Signaling, Part a http://www.amazon.ca/exec/obidos/ASIN/0121822125      Murata Lab.Kyoto University They are characteristic in their abilities to degrade a wide variety of refractory environmental pollutants, and to carry out a variety of other biotechnologically useful processes, such as the biosynthesis of valuable biopolymers. Sphingomonads are widely distributed in nature, and contain a suite of 'signature' sphingolipid components. This signature totally replaces the lipopolysaccharide (LPS) structure characteristic of conventional Gram-negative bacteria. http://www.molbiotech.kais.kyoto-u.ac.jp/bunya33e.html      Avanti Polar Lipids - The Phospholipid and Sphingolipid People Avanti Polar Lipids - The Phospholipid and Sphingolipid People http://www.avantilipids.com      OriGene - Antibodies - Sphingolipid Receptor Edg1/S1P1 EDG1, a Lysophospholipid/Lysosphingolipid Receptor, binds sphingosine-1-phosphate and may control cell proliferation, survival, and suppression of apoptosis. Homo sapiens endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 (EDG1) Researchers who bought this antibody have also purchased: http://www.origene.com/antibody/TA200026.aspx      Untitled Document Sato M, Bielawska A, Obeid L, Hannun Y, and Trojanowska M. Modulation of Transforming Growth Factor -b (TGF -b) signaling by endogenous sphingolipid mediators. Kubo M, Czuwara-Ladykowska J, Moussa O, Markiewicz M, Smith EA, Silver RM, Jablonska S, Blaszczyk M, Watson, D, and Trojanowska M. Persistent downregulation of collagen transcription suppressor Fli1 in fibrotic scleroderma skin, Am J Path, 163:571-581, 2003 http://www.musc.edu/rheumatology/current_to_2002_publications.html

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