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| | SRM - spermidine synthase |
 | | The specificity of rat prostatic spermidine synthase and spermine synthase with respect to the amine acceptor of the propylamine group was studied. | | | Inhibition was likewise observed in spermidine synthase activity, while spermine synthase was marginally stimulated. | | | Among the propylamine transferases tested only rat brain spermine synthase is significantly inhibited, while rat brain spermidine synthase is less sensitive. |
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http://www.ihop-net.org/UniPub/iHOP/gg/92388.html
(1486 words)
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| | Polyamines in milk JP Buts |
| | Regarding the catabolic pathway, putrescine can be catabolized by several enzymes, the much frequently analyzed being diamine oxidase (23,24). | | | Characteristics of putrescine uptake in isolated rat enterocytes. | | | These studies confirmed that for the rat as little as 500 to 600 nmol polyamines can affect the maturation of intestinal cells. |
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http://www.pediatrie.be/POLINMIL.htm
(3334 words)
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| | BIOSYNTH : Spermine, Spermidine, Putrescine |
| | This interaction is mostly based on electrostatic interactions between positively charged ammonium groups of the polyamines and the negatively charged phosphates of the nucleic acids. | | | Spermine and spermidine levels are also affected by the rate of conversion of their respective precursors, putrescine and spermine. | | | Spermidine is a triamine structure that is produced by spermidine synthase (SpdS) which catalyzes monoalkylation of putrescine (1,4-diaminobutane) with decarboxylated S-adenosylmethionine (dcAdoMet) 3-aminopropyl donor. |
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http://www.biosynth.com/index.asp?topic_id=162&g=19&m=205
(538 words)
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| | British Journal of Pharmacology - L-Arginyl-3,4-Spermidine is neuroprotective in several in vitro models of ... |
| | Inhibitors of NOS decrease neuronal death in models of both excitotoxicity and ischaemia (Dawson et al., 1991; Maiese et al., 1993), and other polyamines with structural similarities to L-Arg-3,4 such as spermine, spermidine, putrescine, arcaine, and agmatine are know inhibitors of NOS (Hu et al., 1994; Kabuto et al., 1995; Galea et al., 1996). | | | These results clearly demonstrate that one of the protective mechanisms of action of L-Arg-3,4 is to reduce the rate of superoxide production in response to injurious stimuli which could be the basis of its neuroprotective actions in the diverse injury paradigms used in these experiments. | | | Therefore, the actions of L-Arg-3,4 appear to be more robust than L-type VSCC antagonists as it was neuroprotective in more severe injury paradigms such as NMDA mediated excitotoxicity as well as ischaemia. |
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http://www.nature.com/bjp/journal/v137/n8/full/0704986a.html
(9735 words)
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| | Bergeron |
| | "A Comparison of Structure-Activity Relationships between Spermidine and Spermine Analogue Antineoplastics." R. | | | "Reagents for the Stepwise Functionalization of Spermidine, Homospermidine and Bis-(3- aminopropyl)amine." R. | | | "Spermidine Requirement for Cell Proliferation in Eukaryotic Cells: Structural Specificity and Quantitation." C. |
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http://www.cop.ufl.edu/departments/mc/bergeron.htm
(3600 words)
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| | SAT - spermidine/spermine N1-acetyltransferase |
| | Spermine levels in Hep3B cells were decreased by TGF-beta 1 treatment, although the levels of spermidine and putrescine were unchanged, probably due to compensation by remaining spermidine/spermine N1-acetyltransferase activity. | | | Interleukin-1beta induces elevation of spermidine/spermine N1-acetyltransferase activity and an increase in the amount of putrescine in synovial adherent cells from patients with rheumatoid arthritis. | | | The NAT2 substrate, sulfamethazine, inhibited spermidine acetylation with a calculated K(i) = 3.5 mM, suggesting that SSAT may be an alternate pathway for acetylation of NAT2 substrates. |
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http://www.ihop-net.org/UniPub/iHOP/gg/91995.html
(2654 words)
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| | BSAS The effects of intradermal injections of spermidine on the growth rate of fibres and mitosis of wool follicles in ... |
| | Spermidine injection did not result in a significant change in fibre diameter during the treatment period. | | | The results suggest that injecting extra spermidine into the skin altered spermidine homeostasis in the skin, stimulated cell proliferation and resulted in increased fibre growth. | | | The concentration of spermidine in the skin patch 3 h after injection on day 7 increased by proportionately 0•18, 0•33 or 0•41 (P < 0•001) respectively. |
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http://www.bsas.org.uk/Publications/Animal_Science/2002/Volume_75_Part_1/33
(410 words)
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| | Spermidine and spermine synthesis - Polyamines, nonprotein amino acids and alkaloids - HORT640 - Metabolic Plant ... |
| | The putrescine aminopropyltransferase of alfalfa may be responsible not only for spermidine and spermine synthesis, but also the synthesis of the uncommon polyamines, thermospermine, homocaldopentamine and homocaldohexamine (Bagga et al, 1997). | | | Recently, the assumption that spermidine synthase and spermine synthase are two separate enzymes in plants, has been questioned (Bagga et al, 1997). | | | Bagga S, Rochford J, Klaene Z, Kuehn GD, Phillips GC 1997 Putrescine aminopropyltransferase is responsible for biosynthesis of spermidine, spermine, and multiple uncommon polyamines in osmotic stress-tolerant alfalfa. |
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http://www.hort.purdue.edu/rhodcv/hort640c/polyam/po00002.htm
(339 words)
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| | Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin ... |
| | Putrescine, spermidine and spermine are the natural polyamines | | | Bergeron,R.J., Feng,Y., Weimer,W.R., McManis,J.S., Dimova,H., Porter,C., Raisler,B. and Phanstiel,O. (1997) A comparison of structure–activity relationships between spermidine and spermine analogue antineoplastics. | | | putrescine and spermidine levels, SSAT mediated elevations in |
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http://carcin.oxfordjournals.org/cgi/content/full/23/2/359
(4437 words)
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| | [No title] |
| | Spermidine [n-(2-amino-propyl)-1,4-diaminobutane] is a widely occurring hetero compound found in plants and have been recently reported to have mammary tumor controlling abilities in rats. | | | The protein trypanothione reductase is a “flavoenzyme that has been found only in parasitic protozoa” and has been linked to the cause of Chagas' disease, African sleeping sickness. | | | Spermidine has also been found to reside within the protein trypanothione reductase. |
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http://classweb.gmu.edu/ssok1/chem350/assignments/protein.doc
(1809 words)
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| | Spermidine antibody (ab7318) datasheet |
| | But please do contact us if you would like any reassurance! | | | Spermidine is a polyamine compound was originally isolated from semen. | | | It is found ribosomes and living tissues and has various metabolic functions. |
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http://www.abcam.com/?datasheet=7318
(210 words)
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| | References |
| | Putrescine and spermine concentrations decreased and spermidine increased 3 days after S-allylmercaptocysteine treatment. | | | Both S-allylmercaptocysteine and S-allylcysteine caused an increase in LNCaP cell reduced glutathione concentrations. |
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http://www.garlicure.com/reference.htm
(1547 words)
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| | Pfam 18.0 : Spermine_synth |
| | This family includes spermidine synthase that catalyses the fifth (last) step in the biosynthesis of spermidine from arginine, and spermine synthase. | | | A group of polyamine biosynthetic enzymes involved in the fifth (last) step in the biosynthesis of spermidine from arginine and methionine which includes; spermidine synthase (EC:2.5.1.16), spermine synthase (EC:2.5.1.22) and putrescine N-methyltransferase (EC:2.1.1.53) MEDLINE:9517003. |
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http://pfam.wustl.edu/cgi-bin/getdesc?acc=PF01564
(71 words)
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| | V.A. Engelhardt Institute of Molecular Biology 1996 report |
| | To prepare 3H-labelled analogues of spermidine and spermine corresponding w-[[(1'-ethoxyethylidene)amino]oxy]-polyiminomethylene nitriles were reduced by NaBT4 /CoCl2 complex, which had no effect on N-O and C=N bonds of ethoxyethylidene group removed at the final step of the synthesis by mild acidic hydrolysis. | | | Four earlier unknown mono-acetylated derivatives of two aminooxy spermidines were also synthesized. | | | Novel analogs of spermine and spermidine with terminal aminomethylene group replaced with aminooxy one were prepared starting from N-hydroxyacetimidate. |
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http://www.imb.ac.ru/2kolbas.htm
(15895 words)
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| | EC 2.5.1.16 |
| | Hannonen, P., Janne, J. and Raina, A. Partial purification and characterization of spermine synthase from rat brain. | | | Tabor, H. and Tabor, C.W. Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. | | | Pegg, A.E., Shuttleworth, K. and Hibasami, H. Specificity of mammalian spermidine synthase and spermine synthase. |
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http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/5/1/16.html
(97 words)
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| | Pfam: domain structure of proteins in the Spermine_synth Seed alignment |
| | SPEE_METJA Q57761 Probable spermidine synthase (EC 2.5.1.16) (Putrescine aminopropyltransferase) (SPDSY). | | | SPEE_MYCTU O33279 Probable spermidine synthase (EC 2.5.1.16) (Putrescine aminopropyltransferase) (SPDSY). | | | SPEE_PYRHO O57950 Probable spermidine synthase (EC 2.5.1.16) (Putrescine aminopropyltransferase) (SPDSY). |
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http://pfam.wustl.edu/cgi-bin/getdomainview?name=Spermine_synth
(242 words)
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| | OUTPUT from blastx for SK1-0025 |
| | 161 4e-39 pirS13037 spermidine N-acetyltransferase - human (fragments) 57 1e-07 gbAAF75760.1AF262218_2 (AF262218) putative acetyltransfer... |
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http://cbr-rbc.nrc-cnrc.gc.ca/reith/salmon/kidney/SK1-0025.html
(132 words)
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| | MPI for Chemical Ecology - Biochemistry - Publications |
| | Graser G; Schneider B; Oldham NJ; Gershenzon J (2000): The methionine chain elongation pathway in the biosynthesis of glucosinolates in Eruca sativa (Brassicaceae). | | | Tholl D; Harms R; Ludwig A; Kaiser A (1998): Retarded growth of an Escherichia coli mutant deficient in spermidine synthase can be unspecifically repaired by addition of various polyamines. | | | Steele CL; Katoh S; Bohlmann J; Croteau RB (1998): Regulation of oleoresinosis in grand fir (Abies grandis) - Differential transcriptional control of monoterpene, sesquiterpene, and diterpene synthase genes in response to wounding. |
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http://www.ice.mpg.de/ger/publ/publ.htm
(3879 words)
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| | WAHRI: Western Australian Herbicide Resistance Initiative |
| | Soar, C.J., Karotam, J., Preston, C., Powles, S.B. (2005) Paraquat translocation is inhibited by cadaverine and spermidine in paraquat susceptible Arctotheca calendula but not in the resistant biotype, suggesting a possible role for a polyamine transporter in the paraquat resistance mechanism. | | | Steadman KJ, Eaton DM, Plummer JA, Ferrris DG and Powles SB (2005) Late season non-selective herbicide application reduces Lolium rigidum seed dormancy and seed fitness as well as seed numbers. |
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http://wahri.agric.uwa.edu.au/Publications/publications.htm
(4752 words)
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| | Synthesis of Macrocyclic Spermidine Alkaloid |
| | have isolated several novel hydroxylated spermidine alkaloids from the leaves of a New Caledonian Celastraceae, Pleurostylia opposita (Wall.) Merrill-Metcalf [3][4]. |
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http://www.mdpi.net/ecsoc-5/c0024/c0024.htm
(1070 words)
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