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| | British Journal of Pharmacology - Somatostatin receptor-mediated arachidonic acid mobilization: evidence for partial ... |
 | | Assuming this to be the case, the effects of specific inhibitory compounds, such as PD 98059 or PP1, would be more readily observed against a somatostatin rather than an angiopeptin response, which was indeed found to be so. | | | Intriguingly, the MEK and Src inhibitors reduced the responses to somatostatin but not those to angiopeptin. | | | Both of these analogues have generated recent interest concerning their potential use therapeutically for the prevention of angiogenesis (Woltering et al., 1997; Albini et al., 1999) and restenosis following balloon angioplasty (Emanuelsson et al., 1995; von Essen et al., 1997). |
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http://www.nature.com/bjp/journal/v132/n3/full/0703862a.html
(4134 words)
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| | American Family Physician: Octreotide: a somatostatin analog |
| | Octreotide is a synthetic octapeptide with pharmacologic actions of somatostatin, but the drug has been rendered more resistant to the action of serum peptidases (Figure 1). | | | This drug is currently the most promising therapy for inoperable thyrotropinomas.16 | | | Finally, it can behave as a "lumone," acting on the gut after secretion into the intestinal lumen. |
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http://www.findarticles.com/p/articles/mi_m3225/is_n6_v39/ai_7689235
(1291 words)
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| | SSTR3 - Somatostatin receptor type 3 |
| | Therefore, SSTR scintigraphy of human primary tumours and their metastases presumably visualizes SSTR2-expressing tumours, although it is reasonable to assume that SSTR5, and to a lesser extent SSTR3, when expressed simultaneously with SSTR2, also contribute to the visualization of tumours. | | | Interestingly, SSTR3 mRNA, which is highly expressed in rat pancreatic islets, is not expressed in normal human pancreatic islets, while SSTR1, SSTR2, and SSTR4 mRNAs are expressed. | | | Binding experiments on HEK cells transfected with either SSTR3 or 4 indicated that this difference is not attributable to slow dissociation of the agonist from the receptor, suggesting that SSTR4 mediates long-lasting signalling, a property which may be relevant for clinical therapy. |
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http://www.pdg.cnb.uam.es/UniPub/iHOP/gg/92418.html
(4358 words)
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| | Somatostatin Receptor Imaging |
| | However, it is not clear how this technique compares to traditional gallium imaging. | | | Somatostatin receptor scintigraphy with [111In-DTPA-D-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients. | | | Normal tracer uptake in surrounding tissues may be responsible for eight false negative studies of medullary thryroid cancer metastatic to the liver in seven patients as well as one lesion in the thyroid. |
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http://brighamrad.harvard.edu/Cases/jpnm/hcache/1009/full.html
(960 words)
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| | OCD and Somatostatin -- Neurotransmitter.net |
| | The exact sites and mechanisms of this action, however, are poorly understood, and the physiological context in which somatostatin acts is unknown. | | | The high levels of CSF somatostatin reported here in a patient subgroup whose predominant symptoms consisted of overly focused, perseverative thought processes are in contrast to the consistently low levels of CSF somatostatin seen in patients with a spectrum of disorders characterized by substantial cognitive deficits." [Abstract] | | | RESULTS: The mean CSF somatostatin level was significantly higher in the patients with obsessive-compulsive disorder than in the normal subjects. |
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http://www.neurotransmitter.net/ocdsomatostatin.html
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| | Increased pituitary response to somatostatin in aging male rats: relationship to somatostatin receptor number and ... |
| | Increased pituitary response to somatostatin in aging male rats: relationship to somatostatin receptor number and affinity. | | | The purpose of this study was to determine whether this decline is associated with (1) increased pituitary response to somatostatin, and/or (2) increased number or affinity of pituitary somatostatin receptors. | | | Two pituitaries from each age group were superfused simultaneously and the experiment replicated 4 times. |
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http://www.arclab.org/medlineupdates/abstract_2575235.html
(211 words)
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| | S W J LAMBERTS et al.: Somatostatin analogs (European Journal of Endocrinology) |
| | Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity [see comments]. | | | Effect of long-acting somatostatin analog (Somatulin) on renal hyperfiltration in patients with IDDM. | | | The role of somatostatin in the regulation of anterior pituitary hormone secretion and the use of its analogs in the treatment of human pituitary tumors. |
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http://www.eje.org/eje/146/0701/eje1460701.htm
(822 words)
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| | Somatostatin |
| | Somatostatin and its synthetic analogs are used clinically to treat a variety of neoplasms. | | | Somatostatin acts by both endocrine and paracrine pathways to affect its target cells. | | | Injection of somatostatin into the brain of rodents leads to such things as increased arousal and decreased sleep, and impairment of some motor responses. |
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http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/otherendo/somatostatin.html
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| | Somatostatin - Wikipedia, the free encyclopedia |
| | The FDA has approved the usage of a salt form of this peptide, octreotide acetate, as an injectable depot formulation for the treatment of acromegaly, the treatment of diarrhea and flushing episodes associated with carcinoid syndrome, and treatment of diarrhea in patients with vasoactive intestinal peptide-secreting tumors (VIPomas). | | | Somatostatin is secreted not only by cells of the hypothalamus but also by so called delta cells of stomach, intestine and pancreas. | | | Octreotide (brand name Sandostatin, Novartis Pharmaceuticals) is an octopeptide that mimics natural somatostatin pharmacologically, though is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone. |
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http://en.wikipedia.org/wiki/Somatostatin
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| | SSTR2 - Somatostatin receptor 2 - Cancer GeneticsWeb |
| | High expression of somatostatin receptor subtype 2 (sst2) in medulloblastoma: implications for diagnosis and therapy. | | | Disclaimer: This site is for educational purposes only; it can not be used in diagnosis or treatment. | | | Somatostatin receptor type 2 gene expression in neuroblastoma, measured by competitive RT-PCR, is related to patient survival and to somatostatin receptor imaging by indium -111-pentetreotide. |
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http://www.cancerindex.org/geneweb/SSTR2.htm
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| | Somatostatin Receptor 1 antibody (ab479) datasheet |
| | Somatostatin receptors have been implicated in numerous diseases ranging from Alzheimer's to cancers of the gastrointestinal tract, breast, prostate, and pituitary. | | | Customer reviews (feedback) regarding Somatostatin Receptor 1 antibody | | | Somatostatin acts to regulate numerous physiological processes by binding to and activating specific receptors in target tissues. |
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http://www.abcam.com/?datasheet=479
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| | Somatostatin Activation of Mitogen-Activated Protein Kinase via Somatostatin Receptor 1 (SSTR1) -- Florio et al. 13 ... |
| | Somatostatin Receptor Subtype-Dependent Regulation of Nitric Oxide Release: Involvement of Different Intracellular Pathways | | | Quantitative and Functional Expression of Somatostatin Receptor Subtypes in Human Prolactinomas | | | Prolonged Activation of Extracellular Signal-regulated Kinase by a Protein Kinase C-dependent and N17Ras-insensitive Mechanism Mediates the Proliferative Response of Gi/o-coupled Somatostatin sst4 Receptors |
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http://mend.endojournals.org/cgi/content/abstract/13/1/24
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