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| | Human Growth Hormone for Children with Idiopathic Short Stature |
 | | Others assert that intervention for nonpathologic short stature is appropriate if the goal of therapy is to reduce the risk of psychological and social problems. | | | But, whether short stature itself (with no pathological basis) correlates with psychosocial dysfunction of any kind is debated. | | | By definition, children with short stature relative to their peers will always exist and targeting the current cohort for medical intervention will merely replace them with another cohort. |
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http://www.health.state.mn.us/htac/hgh.htm
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| | Recombinant growth hormone for idiopathic short stature in children and adolescents |
| | Idiopathic short stature (ISS) refers to children who are very short compared with their peers for unknown or hereditary reasons. | | | Increases in height are such that treated individuals remain relatively short when compared with peers of normal stature. | | | Idiopathic short stature (ISS) is the term used when children are very short compared with others of their age for unknown or hereditary reasons. |
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http://www.cochrane.org/reviews/english/ab004440.html
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| | eMedicine - Short Stature : Article by Robert J Ferry, Jr, MD |
| | In the absence of better clinical outcomes, do not use rhGH therapy to treat children with normal variant short stature. | | | Medical Care: Medical care depends on the etiology of the short stature. | | | Short stature is recognized by comparing the individual child to a large population with a similar genetic background and, more particularly, to the mid-parental target height (see History). |
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http://www.emedicine.com/ped/topic2087.htm
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| | eMedicine - Growth Failure : Article by Stephen Kemp, MD, PhD |
| | Background: Short stature may be the normal expression of genetic potential, in which case the growth rate is normal, or it may be the result of a condition causing growth failure with a lower-than-normal growth rate. | | | A child is considered short if he or she has a height that is below the fifth percentile; alternatively, some define short stature as height less than 2 standard deviations below the mean, which is near the third percentile. | | | Lacey KA, Parkin JM: Causes of short stature. |
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http://www.emedicine.com/ped/topic902.htm
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| | Short Persons Support: Health : Children |
| | When children do not demonstrate any symptoms, and test results do not indicate a problem, they are said to have idiopathic short stature. | | | The most likely reason for a child to be short is because his or her parents are short. | | | Children from short parents can be expected to reach an adult height about the same as their parents. |
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http://www.shortsupport.org/Health/Children
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| | Idiopathic short stature - Wikipedia, the free encyclopedia |
| | Idiopathic short stature (ISS) refers to extreme short stature that does not have a diagnostic explanation (idiopathic designates a condition that is unexplained or not understood) after an ordinary growth evaluation. | | | Excellent synopsis of GH use for ISS from the Minnesota Dept of Health | | | Even if treatment successfully changes height to the 5th or 10th percentile, does it actually improve the person's life in any measurable way? |
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http://en.wikipedia.org/wiki/Idiopathic_short_stature
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| | Growth Disorders - Types |
| | Conditions such as familial short stature are most often caused by an endocrine disease or a genetic condition. | | | Children with familial short stature are likely to enter puberty and have a growth spurt at a normal age; their bone age will be the same as their chronological age (age in years), meaning that there is no delay in bone maturity. | | | The term idiopathic short stature is used to describe children who do not fit into any of the "known" categories of growth failure or short stature. |
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http://www.nutropin.com/patient/3_3_types_of_gd.jsp
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| | Humatrope Approved for Very Short Kids |
| | Basis of approval: This new approval was based on two clinical trials conducted in 300 children with idiopathic short stature. | | | The safety of Humatrope in children with idiopathic short stature did not differ from that in children with other conditions for which the growth hormone is used. | | | Humatrope may be used for long-term treatment of children with abnormally short stature whose cause is unknown, called idiopathic short stature. |
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http://webmd.com/content/article/71/81426.htm?lastselectedguid={5FE84E90-B...
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| | NEWS FLASH |
| | There has been some concern that because children with idiopathic short stature already produce their own growth hormone they may eventually develop cancer because the drug stimulates additional cell growth. | | | Naturally, parents worry about how short stature will affect their children’s lives. | | | The approval of idiopathic short stature as a criterion for growth hormone treatment has caused some apprehension that it will be misused by overanxious parents who simply want taller children in a culture that typically prizes height. |
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http://www.hgfound.org/growth_with_rGH.htm
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| | References |
| | Ranke, M.B. (1996) Towards a consensus on the definition of idiopathic short stature. | | | Chatelain, P.G. (1999) Trends in the diagnosis and treatment of short stature as revealed by KIGS. | | | Jorge, A., Souza, S.C., Arnold, I.J. and Mendonca, B.B. (2002) Poor reproducibility of IGF-I and IGF binding protein-3 generation test in children with short stature and normal coding region of the GH receptor gene. |
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http://www.medscape.com/content/2004/00/46/73/467351/467351_ref.html
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| | Nature Genetics |
| | Our data suggest an involvement of SHOX in idiopathic growth retardation and in the short stature phenotype of Turner syndrome patients. | | | Growth retardation resulting in short stature is a major concern for parents and due to its great variety of causes, a complex diagnostic challenge for clinicians. | | | We have determined an interval of 170 kb of DNA within PAR1 which was deleted in 36 individuals with short stature and different rearrangements on Xp22 or Yp11.3. |
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http://www.nature.com/ng/wilma/05-97.862415599.html
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| | Pediatric Academic Societies |
| | Data demonstrating the efficacy and safety of GH therapy for children with idiopathic short stature will be reviewed. | | | Although "idiopathic" short stature has often been held synonymous with "normal" short stature, cases in which the underlying molecular defect(s) have recently been elucidated will be presented. | | | Chairs: Marsha L. Davenport, University of North Carolina, Chapel Hill, NC; and Leona Cuttler, Case Western Reserve University, Cleveland, OH In July of 2003, the FDA approved the use of growth hormone for the long-term treatment of children with idiopathic short stature, also called non-growth hormone deficient short stature. |
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http://www.pas-meeting.org/2004SanFran/Daily/0503.htm
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| | American Family Physician: Use of Human Growth Hormone in Children |
| | * Health care professionals should help parents and children address the problems that stem from idiopathic short stature. | | | The use of rhGH to treat children with idiopathic short stature appears to have little risk of serious short-term harm, but long-term risks are not yet known. | | | According to the report, idiopathic short stature results when children are short, compared with others in their age group, for unknown or hereditary reasons. |
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http://www.findarticles.com/p/articles/mi_m3225/is_4_62/ai_65106154
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| | Growth Delay, Constitutional |
| | Short stature may be the result of a growth pattern inherited from a parent (familial) or occur for no apparent reason (idiopathic). | | | CGD is the most common cause of short stature and delayed puberty. | | | Constitutional growth delay (CGD) is a term describing a temporary delay in the skeletal growth and height of a child with no other physical abnormalities causing the delay. |
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http://my.webmd.com/hw/parenting_and_pregnancy/nord865.asp
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| | Welcome to AJC! ajc.com |
| | Growth hormone has been used for 16 years to treat children who are extremely short because their bodies don't naturally produce the substance or because of a few other growth-stunting diseases. | | | The drug, called Humatrope, is only for the shortest 1.2 percent of children, which manufacturer Eli Lilly says includes 400,000 such children between the ages 7 to 15. | | | Some 200,000 children worldwide have taken it; the cost range is between $10,000 and $25,000 a year for the drug. |
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http://www.ajc.com/health/content/shared-auto/healthnews/kids/514381.html
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| | FDA Approves Humatrope for Short Stature |
| | The safety profile of Humatrope in children with idiopathic short stature did not differ from that in children with other conditions for which growth hormone is indicated. | | | "Short stature" has been defined by the American Association of Clinical Endocrinologists and the Growth Hormone Research Society as height more than 2 standard deviations (SD) below the mean for age and sex. | | | Today's approval was based on 2 randomized, multicenter trials, conducted in approximately 300 children with idiopathic short stature. |
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http://www.fda.gov/bbs/topics/ANSWERS/2003/ANS01242.html
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| | UpToDate Other indications for growth hormone treatment in children |
| | This "disorder" has been called idiopathic short stature (ISS) and includes children with familial (genetic) short stature, constitutional delay of growth, and other less well characterized disorders. | | | — There are many children with short stature who have peak stimulated serum growth hormone concentrations above the usual cut-off values for the diagnosis of growth hormone deficiency, but who have the same auxological findings as those with growth hormone deficiency. | | | The indications for and efficacy of exogenous growth hormone treatment in children with idiopathic short stature, intrauterine growth retardation, Prader-Willi syndrome, and chondrodysplasia are reviewed here. |
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http://patients.uptodate.com/topic.asp?file=pediendo/8765
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| | Human Growth Hormone for Children with Idiopathic Short Stature |
| | Prediction of the outcome of growth hormone therapy in children with idiopathic short stature. | | | Immunologic studies in children with idiopathic short stature before and during growth hormone therapy. | | | Idiopathic short stature (ISS) results when children are short, compared to others in their age cohort, for unknown or hereditary reasons. |
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http://www.health.state.mn.us/htac/hgh.htm
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| | Kids.net.au Dictionary - Definitions of the word: short-tailed_shrew |
| | 302315620 # low in stature; not tall; "his was short and stocky"; "short in stature"; "a short smokestack". | | | low in stature; not tall; "his was short and stocky"; "short in stature"; "a short smokestack". | | | 301400351 # cut short in duration; "the abbreviated speech"; "a curtailed visit"; "her shortened life was clearly the result of smoking"; "an unsatisfactory truncated conversation". |
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http://www.kids.net.au/dictionary-definition/short-tailed_shrew
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| | SHORT CHILDREN TOO OFTEN VIEWED AS HANDICAPPED, UF RESEARCHERS SAY |
| | Previous studies indicating short stature is related to poor achievement have led to short stature being treated as a disorder. | | | Short stature can be an indication of problems with the child's endocrine glands, which secrete hormones necessary for normal growth and development, or other serious problems. | | | There is a question, however, whether these studies are biased; the children in the studies may have been referred to clinics because of behavior problems thought to be related to their short stature. |
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http://www.napa.ufl.edu/oldnews/short.htm
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