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| | [No title] |
 | | High risk operations include handling of Shiga toxin in a syringe with a needle. | | | If use of a needle is necessary, a safety device or blunt tipped needle shall be used to decrease the possibility of inadvertent self-inoculation with Shiga toxin. | | | Mice or rats treated with Shiga toxin must be handled using BSL-2 practices. |
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http://www2.umdnj.edu/eohssweb/publications/ShigellaToxinSOP.doc
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| | Shiga-like toxin |
| | Shiga - Our Prefecture's Profile Japan Travel Bureau's information on Shiga. | | | Ricin Toxin from the Castor Bean Plant Scientific and medical article on the toxin and its effects. | | | Shiga University of Medical Science With introduction, history, organization, hospital, and research centers. |
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http://www.serebella.com/encyclopedia/article-Shiga-like_toxin.html
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| | Shiga toxin or Verotoxin: essential data |
| | The vascular endothelium has to continually renew itself, so this killing of cells leads to a breakdown of the lining and to hemorrhage. | | | Food poisoning with Shiga toxin often also has effects on the lungs and the nervous system. | | | However, there are often indirect effects on the lungs when the toxin is taken in as a food contaminant. |
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http://www.cbwinfo.com/Biological/Toxins/Verotox.html
(568 words)
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| | FDA/CFSAN FDA 2001 Food Code - Annex 7 Model Forms, Guides, and Other Aids |
| | The Food Code specifies, under Part 2-2 Employee Health Subpart 2-201 Disease or Medical Condition, that Applicants to whom a conditional offer of employment has been made and Food Employees obtain medical clearance from a physician licensed to practice medicine whenever the individual: | | | Diagnosed with illness due to Salmonella Typhi, Shigella spp. | | | This list is intended to be used as an aid to increase awareness of the person in charge that travel to some points outside the U.S. may increase the risk for acquiring foodborne illness. |
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http://www.cfsan.fda.gov/~dms/fc01-a7.html
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| | Shiga like toxin (verotoxin) |
| | Shiga like toxin 1 and shiga like toxin 2 differ in their effects on various tissues. | | | Once the shiga like toxins have been endocytosed, they are retrogradely transported through the golgi apparatus to the rough endoplasmic reticulum where they effectively target the ribosomes. | | | Shiga like toxins are very toxic and should be handled with extreme caution. |
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http://www.listlabs.com/Literature/163.htm
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| | Toxin |
| | A toxin is a substance that causes injury to the health of a living thing on contact or absorption, typically by interacting with biological macromolecules such as enzymes and receptors. | | | Ingestable toxins are also often referred to as poisons, especially when intentionally administered by a human. | | | Botulinum toxin in otolaryngology: A review of its actions and opportunities for use. |
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http://hallencyclopedia.com/Toxin
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| | Articles - Toxin |
| | Toxicity may be acute (as in a bee sting), chronic (as in the Guam cycad toxin), or both. | | | A toxin, in a scientific context, is a biologically produced substance that causes injury to the health of a living thing on contact or absorption, typically by interacting with biological macromolecules such as enzymes and receptors. | | | In the context of complementary medicine the term is often used as a broader category of any harmful substance claimed to cause ill health, though mainstream scientists argue that the nature of such substances is usually unproven. |
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http://www.fruit-center.com/articles/Toxin
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| | Shiga toxin - Wikipedia, the free encyclopedia |
| | Shiga toxins are a family of related toxins with two major groups, Stx1 and Stx2, whose genes are considered to be part of the genome of lambdoid prophages. | | | The most common sources for Shiga toxin are the bacteria Shigella dysenteriae and the O157:H7 strain of Escherichia coli. | | | The Shiga toxin found in Escherichia coli is also known as Shiga-like toxin although it is equivalent to the Shiga toxin produced by Shigella dysenteriae. |
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http://en.wikipedia.org/wiki/Shiga_toxin
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| | TDL: Latest Tests |
| | E.coli 0157:H7 is the most frequently identified Shiga toxin-producing E-coli serotype and can be isolated and identified by most clinical laboratories. | | | Strains of E.coli producing these effects have now been identified: Shiga Toxin 1 (Stx1) and Shiga toxin 2 (Stx2). | | | This Shiga Toxin E.coli assay allows direct detection of Stx1 and Stx2 in stool specimens for the organism. |
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http://www.tdlplc.co.uk/testinfo/lt_shiga.htm
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| | Shiga Toxin-producing Escherichia coli |
| | Other diagnostic modalities can entail testing fecal filtrate, enrichment broth, or individual isolates for toxin by a variety of means, which include EIA, cytotoxicity, latex agglutination, and PCR techniques. | | | One or more of a family of toxins very closely related, if not identical, to the Shiga toxin (ST) of Shigella dysenteriae are produced by E. |
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http://www.idsociety.org/ein/Query_Intros/STEC_10-97.htm
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| | SHIGA LIKE TOXIN definition |
| | The disease may be treated with drugs like Alimta or Cisplatin, but it is essential for everyone to know the symptoma and get tested for Mesothelioma. | | | Examples: Shiga toxin, Shiga like toxins SLT 1 and SLT 2 of Escherichia coli. | | | Loose asbestos fibers can lodge in the surrounding tissues of the lungs and cancerous tissues can develop into Pleural Mesothelioma. |
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http://www.books.md/S/dic/Shigaliketoxin.php
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| | shiga toxin |
| | It is thought that it is the shiga toxin which is responsible for this because of the way in which it causes renal endothelial cell toxicity. | | | It is this toxin which may well be responsible for the extreme effects of an E.coli 0157:H7, which include bloody diarrhea. | | | This is caused because they have a cytotoxic effect on the intestinal epithelial cells. |
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http://homepages.strath.ac.uk/~ddu97105/webpage1.html
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| | Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives |
| | Figure 2 Crystallographic structures of ricin (A) and Shiga toxin (B). | | | Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives | | | The structures have been obtained from the PDB protein data bank (ricin: 1DMO; Shiga toxin:2AA1), and are based on work published by Rutenber et al. |
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http://www.nature.com/emboj/journal/v19/n22/fig_tab/7593408ft.html
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| | Pfam 18.0 : SLT_beta |
| | This family represents the B subunit of shiga-like toxin (SLT or verotoxin) produced by some strains of Escherichia coli associated with hemorrhagic colitis and hemolytic uremic syndrome. | | | This family represents the B subunit of shiga-like toxin (SLT or verotoxin) produced by some strains of E.coli associated with hemorrhagic colitis and hemolytic uremic syndrome. | | | A mutant Shiga-like toxin IIe bound to its receptor Gb(3): structure of a group II Shiga-like toxin with altered binding specificity. |
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http://pfam.wustl.edu/cgi-bin/getdesc?name=SLT_beta
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| | Hemolytic Uremic Syndrome Due to Shiga-like Toxin Producing Escherichia coli O48:H21 in South Australia |
| | Stool samples taken from the patient on 8 February 1994 were negative for SLT-I and SLT-II genes by PCR and were not cultured further. | | | She was well until 23 December 1993, when she had diarrhea described as very smelly and watery "like the juice of tinned crab." The diarrhea became bloody on 2 January 1994 and was associated with severe abdominal pains which made the patient draw up her legs. | | | Approximately 80% of lactose-fermenting colonies on MacConkey agar were also SLT positive. |
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http://www.cdc.gov/ncidod/EID/vol1no4/goldwat2.htm
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| | Department of Chemistry: Seminar |
| | This inhibitor has the potential to treat serious cases of the often fatal consequences of "Hamburger" disease. | | | Crystal structure data for the Type 1 Shiga like toxin (SLT-1) from E. | | | The mode of action of the inhibitor has been determined from a crystal structure of the ligand-toxin complex. |
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http://www.chemistry.mcmaster.ca/seminars/0001/chem.20001116.html
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| | [Frontiers in Bioscience 2, d635-642, December 15, 1997] |
| | Louise,C.B. and T.G. Obrig: Shiga toxin-associated hemolytic uremic syndrome: combined cytotoxic effects of Shiga toxin and lipopolysaccharide (endotoxin) on human vascular endothelial cells in vitro. | | | Fontaine, A., J. Arondel, and P.J. Sansonetti: Role of Shiga toxin in the pathogenesis of bacillary dysentery, studied by using a tox | | | O'Brien, A.D., G.D. LaVeck, D.E. Griffin and M.R. Thompson: Characterization of Shigella dysenteriae 1 (Shiga) toxin purified by anti-Shiga toxin affinity chromatography. |
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http://www.bioscience.org/1997/v2/d/obrig/10.htm
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| | shiga toxin |
| | class of toxins that inhibit protein synthesis by blocking the interaction of ribosomal RNA with peptide elongation factors; includes the specific shiga toxin produced by Shigella dysenteriae and a variety of shiga-like toxins that are produced by pathologic strains of sherichia coli such as Escherichia coli O157. |
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http://crisp.cit.nih.gov/Thesaurus/00020442.htm
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| | Professor Glen D. Armstrong |
| | Paola Marcato (Graduate Student)-- Studies on the immunoprotective as well as apoptogenic activity of the Shiga toxin 2 (Stx2) B subunit. | | | 5,635,606 -- A Method of Removing Toxin A. -- Treatment of Traveller's Diarrhea. | | | Assessment in mice of the therapeutic potential of tailored, multivalent shiga toxin carbohydrate ligands. |
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http://www.ualberta.ca/~mmi/faculty/garmstrong/garmstrong.html
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| | Directory of open access journals |
| | Shiga-like toxin Escherichia coli (STEC) implicated in aqueous diarrhoea, haemorrhagic colitis and haemolytic uraemic syndrome, has become a serious health problem in various countries. | | | The five Shiga-like toxin isolates were identified as belonging to the species Hafnia alvei or Enterobacter amnigenius without any accessory virulence factors needed to cause illness. | | | Nevertheless, because of the ability of STEC to survive adverse conditions and the possibility for commensal non-pathogenic enteric bacteria to become pathogenic, raw milk cheeses are to be considered at risk for foodborne STEC contamination. |
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http://www.doaj.org/abstract?id=94219&toc=y
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| | Structure of E. coli food poisoning toxin |
| | These web pages provide some background on the disease and the role of the toxins, and show how the understanding of cell-surface binding might be exploited in the development of new therapies. | | | My laboratory has been working for a number of years on understanding the molecular basis of E. | | | Structural studies of E. coli food poisoning toxin |
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http://www-structmed.cimr.cam.ac.uk/Personal/randy/SLT
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| | W0057: Specific Binding of Shiga-Like Toxin to Its Cell Surface Receptor Gb3 |
| | Shiga-like toxin I (SLT-I) is a virulence factor of pathogenic E.coli strains, which cause 'hamburger disease' in humans. | | | The structures of the mutants in complex with a Gb analogue have been determined to resolutions ranging from 1.7 Å to 2.2 Å. | | | The B-pentamer is responsible for the entry of the toxin into the target cell. |
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http://www.hwi.buffalo.edu/ACA/ACA98/abstracts/text/W0057.html
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| | Bundle Research Group |
| | The core is a functionalized glucose molecule into which are grafted spacers and at the tips of the spacers are placed 2 identical trisaccharides that correspond to the oligosaccharide recognized by Shiga like toxin. | | | The spacers are designed to position the trisaccharide units at the correct length so that 5 trisaccharides may bind to a single toxin molecule. | | | STARFISH is the name given to a synthetic oligovalent inhibitor developed to block the binding of Shiga like toxin to cells that express GB3 (also known as CD77) at their cell surface. |
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http://www.chem.ualberta.ca/~glyco/news/starfish.htm
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| | HDCN: Review of abstract by Su et al. Escherichia coli O157:H7 infection in humans (REVIEW) AIM 10 1995 |
| | Secondary person-to-person contact may be an important method of spread in institutions and day care centers. | | | Other strains of Shiga-like toxin producing E.Coli may be more common in other countries, e.g., Argentina. | | | No treatment has been shown to be effective, and antibiotics may worsen the course by eliminating competing bowel flora or to sublethal damage to the bacteria, causing liberation of Shiga-like toxins. |
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http://www.hdcn.com/5/511aimsu.htm
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| | Certificate of Analysis Shiga-like toxin 2 |
| | This shiga like toxin is very toxic and should be handled with extreme caution. | | | Since the toxicity varies with the cell type, a range of concentrations should be tested to determine optimal concentrations for specific studies. | | | Shiga like toxin 2 has an LD of 0.26 µg in mice when measured by intraperitoneal injection. |
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http://www.listlabs.com/Certificates%20of%20Analysis/164.htm
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| | Shiga on Encyclopedia.com |
| | Shiga toxin-producing Escherichia coli infections associated with hemolytic uremic syndrome, Italy, 1988-2000. | | | Toxin Gene Expression by Shiga Toxin-Producing Escherichia coli: the Role of Antibiotics and the Bacterial SOS Response. | | | Shiga includes part of Biwa, Japan's largest lake. |
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http://www.encyclopedia.com/html/S/Shiga.asp
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| | ARS Publication request: Shiga-Like Toxin Induces Decreased Expression of the Anti-Apoptotic Protein Mel-1 Concomitant ... |
| | Understanding the mechanism by which SLT-induces injury maylead to the development of therapeutic interventions that can block these deleterious effects and confer protection to the host organism. | | | Technical Abstract: Shiga-like toxin (SLT)-1 has been implicated in the pathogenesis of several human and animal disease states. | | | Consumption of STEC-contaminated food products can result in diarrhea and the development ofhemorrhagic colitis and hemolytic uremic syndrome, the latter of which is a leading cause of acute renal failure in children. |
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http://www.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=145761&pf=1
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| | World J Gastroenterol |
| | The shiga-like toxins have been demonstrated as the virulence factors for E.coli strain, which could cause HC and HUS | | | The toxin producing ability of E.coli F171 was studied with Vero cell assay, which was originally used for study SLTs since E.coli F171 was hybridized with SLT2 probe. | | | All of the EHEC strains are believed to be pathogenic. |
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http://www.wjgnet.com/1007-9327/5/191.asp
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| | IDSA Shiga Toxin-Producing Escherichia coli |
| | coli O157:H7, little is known about the experience of ID consultants with patients who have bloody diarrhea caused by this organism or the many other strains of Shiga toxin-producing E. | | | Accordingly, in the fall of 1997 the IDSA Emerging Infections Network (EIN) queried its members about their experiences. |
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http://www.idsociety.org/Template.cfm?Section=Home&CONTENTID=9074&TEMPLATE=/ContentManagement/ContentDisplay.cfm
(334 words)
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| | Shiga Toxin-producing Escherichia coli Fact Sheet |
| | Person-to- person spread, via fecal->oral transmission, may occur in high-risk settings like day care centers and nursing homes. | | | Further studies are being done to better understand the modes of transmission. | | | Shiga toxin-producing Escherichia coli is a type of enterohemorrhagic E. |
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http://www.cdphe.state.co.us/dc/Epidemiology/stec_fs.html
(334 words)
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| | Tetracycline, buy tetracycline, Ultram, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, ... |
| | The study showed that Shiga-like toxin-II variant was primarily cell associated and that strain TB1 (pCG6) produced as much as 100 times more toxin than did strain 412. | | | Culture conditions that resulted in the greatest yield of Shiga-like toxin-II variant were incubation at 37 degrees C for 24 h with shaking in syncase broth initially adjusted to pH 8.5. | | | Aerobic culture with shaking resulted in higher yields of Shiga-like toxin-II variant than did static aerobic or anaerobic culture. |
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http://www.darwinpharmacy.com/ref-tetracycline/tetracycline-research-abs3.1106.html
(563 words)
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| | BMCD v2.0 |
| | The toxin is composed of one 32,217 dalton A subunit and multiple copies of the 7691 dalton B subunit. | | | Remarks : Shiga-like toxin I is produced by several pathogenic strains of E. coli. | | | Molecule Name : shiga-like toxin I, B chain |
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http://wwwbmcd.nist.gov:8080/cgi-bin/query/bmcd/schema/molecule?MO_ID=M15J
(82 words)
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| | Bacterial Infections and Mycoses |
| | Revival of the Use of Botulinum Toxin: Application in Dermatology [Kreyden and Burg] - Dermatology, 200/4, 2000 | | | Foodborne Pathogenic Microorganisms and Natural Toxins, Handbook from FDA (US) | | | Botulism: cause, diagnosis, treatment - Centers for Disease Control and Prevention (US) |
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http://www.mic.ki.se/Diseases/C01.html
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| | Shiga-Like Toxin I : on Medical Dictionary Online |
| | A toxin produced by certain pathogenic strains of ESCHERICHIA COLI such as ESCHERICHIA COLI O157. | | | Shiga-Like Toxin I : on Medical Dictionary Online | | | It is closely related to SHIGA TOXIN produced by SHIGELLA DYSENTERIAE. |
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http://www.online-medical-dictionary.org/?q=Shiga%2DLike+Toxin+I
(133 words)
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| | [No title] |
| | USDA's Animal and Plant Health Inspection Service recently released the results of two surveys conducted in U.S. feedlots, one examining the prevalence of salmonella and the other the prevalence of E. coli O157:H7, based on a positive test for shiga-like toxin, or STEC. | | | Samples from southern operations were more likely to test positive for salmonella than samples from northern operations. | | | : : Samples from southern operations were more likely to test : positive for salmonella than samples from northern operati : ons. |
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http://www.foodhaccp.com/msgboard.mv?parm_func=showmsg+parm_msgnum=1000763
(376 words)
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| | [No title] |
| | All E. coli cultures will be tested for the ability to produce Shiga-like toxins (STX 1 and STX 2). | | | All E. coli isolates positive for STX 1 and/or STX 2 will be serotyped. | | | Prior consultation with the Microbiology Section is necessary in order to arrange more frequent testing. 2. |
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http://www.michigan.gov/documents/LSGEnteric_Pathogen_Serotyping_of_Cultures_8246_7.doc
(115 words)
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| | Pharmainfo.net - Home |
| | If you have some pharma information that you would like to share with the community, please email us your short story, article, announcement or review at pharmaarticles @ gmail.com |
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http://www.pharmainfo.net/displayarticle10106.html
(383 words)
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| | Molecules To Go (Formerly known as Molecules R Us) |
| | First 100 lines from the PDB structure record... | | | HEADER TOXIN 20-OCT-98 2BOS TITLE A MUTANT SHIGA-LIKE TOXIN IIE BOUND TO ITS RECEPTOR COMPND MOL_ID: 1; COMPND 2 MOLECULE: SHIGA-LIKE TOXIN IIE B SUBUNIT; COMPND 3 CHAIN: A, B, C, D, E; |
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http://molbio.info.nih.gov/cgi-bin/moldraw?2BOS
(102 words)
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| | Neurotrophins & Neurochemicals-codon optimized expression ready clones |
| | Prion Protein; a full-length codon-optimized cDNA, encoding a 220-aa Prion Protein recombinant protein, fused to His-Tag | | | Pasteurella Multocida Toxin; a full-length codon-optimized DNA, encoding a 1285-aa recombinant protein of Pasteurella Multocida Toxin | | | Receptor Associated Protein; a synthetic full-length codon-optimized cDNA, encoding a 322-aa recombinant protein of Receptor Associated Protein |
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http://www.bioclon.com/expression-ready-Neurotrophins-Neurochemicals.html
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| | (WO 00/66714) SHIGA-LIKE TOXIN AS AN ENRICHING AND PURGING AGENT [Repub: 15.02.2001] |
| | (57) Methods for enriching hematopoietic progenitor cells in a culture with a Shiga-like toxin, and for purging of shiga-like toxin sensitive cells of normal or malignant origin that lack CD77 or SLTB subunit receptors, are disclosed. | | | (WO 00/66714) SHIGA-LIKE TOXIN AS AN ENRICHING AND PURGING AGENT [Repub: 15.02.2001] | | | SHIGA-LIKE TOXIN AS AN ENRICHING AND PURGING AGENT |
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http://www.wipo.int/ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=00/66714.010215
(176 words)
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