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Topic: Serotonin-norepinephrine reuptake inhibitor


  
 [No title]
As monoamine reuptake inhibitors, the sibutramine metabolites are active in the dopaminergic pathways.
Past studies that focused on other functions of serotonin found activity in the paracrine and endocrine systems as well as the nervous system, which implies that serotonin affects signal pathways in the digestive organs as well.
The study of serotonergic agonists began with the study of rats.
http://sulcus.berkeley.edu/mcb/165_001/papers/manuscripts/_691.html   (3141 words)

  
 Food Serotonin Norepinephrine
serotonin and norepinephrine (dopamine) in our brain seems to be directly related to how we feel.
The function of serotonin is exerted upon its interaction with...
Serotonin is derived from tryptophan whilst tyrosine is responsible for creating dopamine and norepinephrine...
http://www.serotonin-net.info/serotonin/food+serotonin+norepinephrine.html   (582 words)

  
 Tramadol, buy tramadol, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, weight loss, ...
Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: I. in vivo electrophysiological studies in the rat.
BACKGROUND: We compared patterns of medical resource utilization and costs among patients receiving a serotonin-norepinephrine reuptake inhibitor (venlafaxine), one of the selective serotonin reuptake inhibitors (SSRIs), one of the tricyclic agents (TCAs), or 1 of 3 other second-line therapies for depression.
Clinicians should evaluate the various aspects of sexual dysfunction before and during antidepressant therapy.
http://rx-drugs-usa.com/ref-effexor/effexor-research-abs3.11.html   (1094 words)

  
 biology - Selective serotonin reuptake inhibitor
SSRIs are described as 'selective' because they affect only the reuptake pumps responsible for serotonin, as opposed to earlier antidepressants, which affect other monoamine neurotransmitters as well.
Depression has been linked to a lack of stimulation of the recipient neuron at a synapse.
The arrival of these new drugs suggest that future antidepressants will not work on serotonin exclusively.
http://www.biologydaily.com/biology/Selective_serotonin_reuptake_inhibitor   (1310 words)

  
 Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in ...
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats -- Iyengar et al., 10.1124/jpet.104.070656 -- Journal of Pharmacology And Experimental Therapeutics
Efficacy of Duloxetine, a Potent and Balanced Serotonergic and Noradrenergic Reuptake Inhibitor, in Inflammatory and Acute Pain Models in Rodents
http://jpet.aspetjournals.org/cgi/content/short/jpet.104.070656v1   (351 words)

  
 Noradrenaline Reuptake Inhibitors
This is largely because of the advent of the selective serotonin reuptake inhibitors, which have facilitated clinical and experimental observation of the roles of serotonin.
Clinical experience with reboxetine challenges our current knowledge of the role of noradrenaline in depression and questions existing evidence based on studies with noradrenergic tricyclic antidepressants.
or the past decade, the role of noradrenaline in depression has been somewhat neglected in favour of serotonin.
http://www.biopsychiatry.com/rebnoradren.htm   (289 words)

  
 The Selective Norepinephrine Reuptake Inhibitor, LY368975, Reduces Food Consumption in Animal Models of Feeding -- ...
Fuller RW and Hemrick-Luecke SK (1983) Antagonism by tomoxetine of the depletion of norepinephrine and epinephrine in rat brain by
Wong DT, Horng JS and Bymaster FP (1975) dl-N-methyl-3-(p-methoxyphenoxy)-3-phenylpropylame hydrochloride, Lilly 94939, a potent inhibitor for uptake of norepinephrine into rat brain synaptosomes and heart.
inhibitors of NE uptake in presynaptic terminals of rat brains
http://www.jpet.org/cgi/content/full/287/1/122   (3882 words)

  
 Dopamine, but Not Norepinephrine or Serotonin, Reuptake Inhibition Reverses Motor Deficits in ...
reuptake inhibitors are so effective despite their potent actions
Rascol O, Brooks DJ, Korczyn AD, De Deyn PP, Clarke CE and Lang AE (2000) A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa.
Inhibition of DA reuptake may be one such approach,
http://jpet.aspetjournals.org/cgi/content/full/303/3/952   (4823 words)

  
 Serotonin-norepinephrine reuptake inhibitor - Wikipedia, the free encyclopedia
Activity on norephinephine reuptake is thought necessary for an antidepressant to be effective on neuropathic pain, a property shared with the older tricyclic antidepressants but not with the SSRIs.
Serotonin norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant used in the treatment of clinical depression and other affective disorders.
This can be contrasted with the more widely-used selective serotonin reuptake inhibitors (SSRIs), which act only on serotonin.
http://en.wikipedia.org/wiki/Serotonin-norepinephrine_reuptake_inhibitor   (505 words)

  
 Cymbalta.com - Learn about Cymbalta and Depression
Scientific studies in the laboratory have shown that Cymbalta is a balanced and selective serotonin and norepinephrine reuptake inhibitor (SSNRI), and that it affects two naturally-occurring chemicals in the brain and in the spinal cord, serotonin and norepinephrine.
Research suggests that these chemicals play a role in depression and pain.
It offers relief from both the emotional and painful physical symptoms associated with depression.
http://www.cymbalta.com/depression/about/about.jsp?reqNavId=3&ccd=cymdtc757&rfr=google   (210 words)

  
 Lexapro: Glossary of terms about depression and anxiety.
Psychotherapy may take place in individual, group, or family sessions, and the process itself may take some time before it is effective.
The term used to indicate that a drug works.
Paxil is a medicine used to treat depression, panic disorder, social anxiety disorder, and premenstrual dysphoric disorder.
http://www.lexapro.com/english/resources/glossary.aspx   (1317 words)

  
 Effexor Side Effects - Effexor Drug Information - Dosage - Drug Interactions - Uses - Storage - Overdose - Precautions ...
It works by restoring the balance of natural chemicals (neurotransmitters) in the brain, thereby improving mood and feelings of well-being.
EFFEXOR DRUG INTERACTIONS: This drug should not be used with the following medications because very serious interactions may occur: MAO inhibitors (e.g., tranylcypromine, phenelzine, isocarboxazid, selegiline, linezolid, furazolidone).
EFFEXOR USES: This medication is an antidepressant (serotonin-norepinephrine reuptake inhibitor type) used in the treatment of depression in adults.
http://health-medical.infomeds.biz/drug-information/Effexor.htm   (670 words)

  
 DULOXETINE (MDXexchange)
In a large cohort study including 481,744 persons and 1487 cases of SUDDEN CARDIAC DEATH occurring in a community setting, the use of selective serotonin reuptake inhibitors was not associated with an increased risk of sudden cardiac death (rate ratio, 0.95; 95% CI, 0.42 to 2.15).
Ray WA, Meredith S, Thapa PB et al: Cyclic antidepressants and the risk of sudden cardiac death.
Abrupt discontinuation of duloxetine has lead to symptoms such as dizziness, nausea, headache, paresthesia, vomiting, irritability, and nightmare.
http://www.micromedex.com/products/updates/drugdex_updates/de/duloxetine.html   (3750 words)

  
 DepressionHurts.com - Treatment for depression
Learn about the importance of serotonin and norepinephrine in treating depression.
Print these Frequently Asked Questions About Cymbalta and discuss them with your doctor or healthcare provider.
Many researchers believe depression is caused by an imbalance of naturally occurring chemicals, serotonin and norepinephrine, in the brain and the body.
http://www.depressionhurts.com/options/options.jsp?reqNavId=4   (425 words)

  
 How AMORYN Works - HOW AMORYN WORKS - Natural Reuptake Inhibitor - Serotonin, Norepinephrine, Dopamine, GABA
By providing an all-natural boost to serotonin, dopamine, norepinephrine, and GABA, the ingredients in AMORYN can help you feel happy, calm, and confident.
A fourth neurotransmitter, called GABA, helps you relax.
Low levels of serotonin can cause excessive feelings of sadness and anxiety.
http://www.amoryn.com/howamorynworks.html   (488 words)

  
 EFFEXOR® XR approved for the treatment of social anxiety disorder
Serotonin and norepinephrine are thought to regulate mood and may affect motivation and sense of well-being.
EFFEXOR® XR is contraindicated in patients taking monoamine oxidase inhibitors (MAOIs).
EFFEXOR XR, already approved for the treatment of depression and generalized anxiety disorder (GAD), is the first available serotonin-norepinephrine reuptake inhibitor (SNRI), and is believed to increase the levels of two key brain chemicals thought to be deficient in individuals suffering from depression and anxiety disorders.
http://www.eurekalert.org/pub_releases/2003-02/pn-ex021103.php   (705 words)

  
 Serotonin-Norepineprine Reuptake Inhibitors: Venlafaxine (Effexor)
Many clients opt for Counselling or Therapy to complement their use of medications.
However, the medication's full mechanisms of action are not entirely understood.
Venlafaxine, a Serotonin-Norepinephrine Reuptake Inhibitor, is a structurally novel anti-depressant prescribed to treat depression, generalized anxiety disorder, and social anxiety disorder (social phobia).
http://counsellingresource.com/medications/medication-types/novel-effexor.html   (191 words)

  
 serotonin - Columbia Encyclopedia® article about serotonin
The function of serotonin in blood platelets is not clear; it seems to have no important role in the clotting mechanism.
The structural similarity of serotonin to several drugs known to cause mental aberrations, such as LSD LSD or lysergic acid diethylamide (lī'sûr`jĭk, dī'ĕth`ələmĭd, dī'ĕthəlăm`ĭd), alkaloid synthesized from lysergic acid, which is found in the fungus ergot (Claviceps purpurea).
, has prompted much speculation as to the role of serotonin in naturally occurring mental disorders such as schizophrenia or depression.
http://columbia.thefreedictionary.com/serotonin   (336 words)

  
 effexor Side Effects, Interactions and Information - Effexor on ThePills.info
Effexor - Drug Interactions Tell your doctor of any over-the-counter or prescription medication you may take especially: MAO inhibitors (e.g., tranylcypromine, phenelzine, isocarboxazid, selegiline, furazolidone), other antidepressants, cimetidine, lithium, sedatives, narcotic pain relievers (e.g., codeine, morphine), seizure medication, certain migraine medicine (e.g., sumatriptan), medicine for weight control.
IMPORTANT WARNING: Before you take Effexor, tell your doctor if you are taking or have taken within the last 2 weeks any MAO inhibitors [phenelzine (Nardil) or tranylcypromine (Parnate)].
Effexor Information from Drugs.com Prescription Drug Information for Consumers and Professionals Home New Drugs Latest News Drug Interactions Pill Identification Images Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions.
http://effexor.thepills.info   (5488 words)

  
 WebMD Health - Patient Handout for
It works by restoring the balance of natural chemicals (neurotransmitters) in the brain, thereby improving mood and feelings of well-being.
Certain medications taken with this product could result in serious, even fatal, drug interactions.
This medication is an antidepressant (serotonin-norepinephrine reuptake inhibitor type) used in the treatment of depression.
http://aolsvc.health.webmd.aol.com/drugs/mono-5047-VENLAFAXINE+-+ORAL.aspx?d...   (1339 words)

  
 Depression Hurts - Patient Resources: Glossary for Depression
Neurotransmitters are found in the brain and along pathways to the brain, such as the spinal cord.
serotonin A neurotransmitter in the brain that has been linked to a number of the emotional and physical symptoms of depression.
norepinephrine A neurotransmitter that has been linked to a number of the emotional and physical symptoms of depression.
http://www.depressionhurts.com/resources/glossary.jsp?reqNavId=3.7   (475 words)

  
 FDA Approves Cymbalta for the Treatment of Depression
Data presented at the 2003 American Psychiatric Association annual meeting showed patients whose painful physical symptoms were relieved were more likely to achieve remission of their depression than those who did not receive relief of their painful physical symptoms.i
Prozac and many other common antidepressants, in contrast, affect only serotonin.
Cymbalta is believed to affect the levels of two key neurotransmitters involved in depression - serotonin and norepinephrine - both implicated in the complex spectrum of major depression symptoms.
http://www.immunesupport.com/library/showarticle.cfm/ID/5026   (767 words)

  
 Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors ...
Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors -- Cryan et al.
Dbh, were used to critically test roles for NE in mediating
The effects of the selective NE reuptake inhibitor reboxetine (10 mg/kg i.p.) and the SSRI citalopram (5 mg/kg i.p.) given individually and in combination on immobility in the TST.
http://www.pnas.org/cgi/content/full/101/21/8186   (3938 words)

  
 Obstetrics and Gynecology, December 2001
In conclusion, this study showed that venlafaxine, a selective serotonin and norepinephrine reuptake inhibitor, is effective in the treatment of PMDD.
2001;95(5):737-744

Summary

Venlafaxine, a selective serotonin and norepinephrine reuptake inhibitor, is effective in the treatment of premenstrual dysphoric disorder.
Certain somatic symptoms can be individually treated; for example, severe bloating or breast tenderness can be treated with diuretics.
http://www.medscape.com/content/2001/00/41/10/411093/411093.xml   (7474 words)

  
 Selective Serotonin Reuptake Inhibitor (SSRI) « Antidepressant Prescription Drugs & Medications « On-line Pharmacy « ...
Stop Premature Ejaculation Drug Therapy SSRI (selective serotonin reuptake inhibitors)...
Selective Serotonin Reuptake Inhibitor (SSRI) « Antidepressant Prescription Drugs & Medications « On-line Pharmacy « BoMi Health Directory
Selective Serotonin Reuptake Inhibitor (SSRI) « Prescription Drugs and Medications for depression, generalised anxiety disorder (GAD), phobias, obsessive-compulsive disorder (OCD), social anxiety disorder (social phobia), panic attack, post traumatic stress disorder (PTSD), compulsions, obsessions, premature ejaculation, shyness, etc....
http://www.bomi.info/directory/pharmacy/ssri.htm   (217 words)

  
 Cuddles 'n Kisses: Some Antidepressants in Late Pregnancy May Affect Babies
Women who take selective serotonin reuptake inhibitor (SSRI) or serotonin norepinephrine reuptake inhibitor antidepressants in the last three months of pregnancy increase the chances their babies will suffer respiratory problems, irritability and jitteriness during the first few weeks of life, a new study says.
SSRIs include Paxil and Prozac while Effexor is a serotonin norepinephrine reuptake inhibitor.
Posted by Robin at May 18, 2005 08:13 PM Comments
http://cuddlesnkisses.com/blog/archives/2005/05/some_antidepres.html   (136 words)

  
 Search Tuna Report for wellbutrin constipation
Drug Interactions: Before taking Wellbutrin tell your doctor of all nonprescription and prescription medications you may use especially: MAO inhibitors., isocarboxazid, phenelzine, tranylcypromine, pargyline, selegiline, linezolid, furazolidone, levodopa, ritonavir, corticosteroids....
WELLBUTRIN XL Is Clinically Proven To Effectively Treat...
Wellbutrin Cautions: Before taking Wellbutrin / Bupropion, tell your doctor if you have: history of seizures or head injury or brain tumor, heart disease, liver or kidney disease, eating disorder, diabetes, alcohol dependence, any allergies, the intent to quit smoking....
http://www.searchtuna.com/ftlive2/5189.html   (2517 words)

  
 Cymbalta, Duloxetine Hydrochloride Pharmacology - HealthyPlace.com
Concomitant use in patients taking monoamine oxidase inhibitors (MAOIs) is contraindicated (see WARNINGS).
Switching Patients to or from a Monoamine Oxidase Inhibitor
Preclinical studies have shown that duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake.
http://www.healthyplace.com/medications/cymbalta.asp   (4333 words)

  
 Selective norepinephrine reuptake inhibitor - Wikipedia, the free encyclopedia
Strattera is available in the United States and Canada for the treatment of ADD and ADHD, unofficial uses include the treatment of depression, and anxiety.
The abbreviation "SNRI" is also used to mean serotonin-norepinephrine reuptake inhibitor, which can be confusing.
Reboxetine, another norepinephrine reuptake inhibitor unavailable in the United States and Canada, going under the trade name Edronax in the United Kingdom, has also been found to be effective at combating depression.
http://en.wikipedia.org/wiki/Selective_norepinephrine_reuptake_inhibitor   (151 words)

  
 Psychiatric Times
The safety of iloperidone was evaluated for psychotic and behavioral symptoms in elderly patients with dementia in flexible daily doses of 0.5 mg to 6 mg in a placebo-controlled study sponsored by Novartis Pharmaceuticals.
Another noradrenergic agent, reboxetine (Vestra), which is a selective norepinephrine reuptake inhibitor now under review by the U.S. Food and Drug Administration for treating depression, was evaluated for depression, anxiety and panic disorder in three separate studies.
Safety monitoring revealed "no clinically meaningful increases" in QT prolongation, and the extrapyramidal symptoms (EPS) in patients receiving aripiprazole were comparable to those in patients receiving placebo.
http://www.psychiatrictimes.com/p011136.html   (1918 words)

  
 Nutrition Research Newsletter: Treating binge eating disorder with sibutramine - Eating Disorders - serotonin and ...
Binge-eating disorder (BED) is a common diagnosis among those who are overweight or obese and who are candidates for sibutramine therapy.
Sibutramine, a serotonin and norepinephrine reuptake inhibitor, commonly used for the treatment of obesity, has been shown to be consistently effective in weight loss across a variety of studies.
Nutrition Research Newsletter: Treating binge eating disorder with sibutramine - Eating Disorders - serotonin and norepinephrine reuptake inhibitor - Author Abstract
http://www.findarticles.com/p/articles/mi_m0887/is_6_22/ai_104439017   (739 words)

  
 Company News On Call
That I'm able to have fun with my friends and family and that I can live a productive life." Duloxetine hydrochloride also is being studied for the treatment of stress urinary incontinence and diabetic neuropathic pain, conditions believed to respond to treatment with both serotonin and norepinephrine.
The U.S. Food and Drug Administration has approved Cymbalta, a balanced and potent selective serotonin and norepinephrine reuptake inhibitor (SSNRI), for the treatment of major depression.
http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=105&STORY=/www/story/08-26-2004/0002239191   (986 words)

  
 Medical Question - Norepinephrine Antidepressant
Serotonin and Norepinephrine Antidepressant Effects* CME Atomoxetine andreboxetine are specific norepinephrine reuptake inhibitors that have not yet
Serotonin and Norepinephrine Antidepressant Effects - American Psychiatric Association 155th Annual Meeting, 5/23/02 Neurotransmitters in Various Disorders: Major Depressive Disorder Generalized Anxiety
Selective serotonin reuptake inhibitors (SSRIs) specifically prevent the reuptake of
http://www.scalextricincardiff.com/norepinephrine-antidepressant.htm   (203 words)

  
 Outpatient Management of Depression: The Rational Basis for the Development and Use of Newer Antidepressants
For example, under usual dosing conditions, amitriptyline achieves concentrations that engage the norepinephrine uptake pump.
The clinician can also use Tables 6.2 and 6.3 to anticipate what type of pharmacodynamically mediated drug interactions are likely to occur when a specific type of antidepressant is used in combination with other agents.
Fluoxetine, fluvoxamine and paroxetine all inhibit one or more CYP enzymes to a clinically significant degree at their usually effective antidepressant dose, whereas citalopram and sertraline do not.
http://www.preskorn.com/books/omd_s6.html   (4269 words)

  
 Boston.com / Your Life / Health & Fitness / British Warn on Antidepressants for Adults
It said treatment with the drug, which is a selective serotonin and norepinephrine reuptake inhibitor, "should only be initiated by specialist mental health practitioners" and "there should be arrangements in place for continuing supervision of the patient." The drug should not be used in patients with heart disease, it said.
Efexor accounted for $2.7 billion in sales last year and is Wyeth's top-selling drug.
The authority took particular issue with an antidepressant that is not an S.S.R.I., Efexor, which is made by Wyeth and marketed in the United States as Effexor, because of its concerns about heart damage and a heightened danger from overdose.
http://www.boston.com/yourlife/health/other/articles/2004/12/07/british_warn_on_antidepressants_for_adults   (525 words)

  
 EFFEXOR XR: Approved for Treatment of Depression, Generalized Anxiety Disorder, and Social Anxiety Disorder
EFFEXOR XR is believed to work by affecting the levels of 2 naturally occurring chemicals in the brain — serotonin and norepinephrine.
Because EFFEXOR XR works on these 2 chemicals, it is known as an SNRI, or serotonin-norepinephrine reuptake inhibitor.
The information on this site should not take the place of your doctor's advice or instructions.
http://www.effexorxr.com   (401 words)

  
 The antidepressant duloxetine ( Cymbalta ) a dual serotonin-noradrenaline reuptake inhibitor
Duloxetine: a dual serotonin-norepinephrine reuptake inhibitor for treatment of major depressive disorder
Duloxetine, approved by the U.S. Food and Drug Administration for the treatment of MDD, is a reuptake inhibitor at serotonergic and noradrenergic neurons and appears to have low affinity for other neurotransmitter systems.
The antidepressant duloxetine (Cymbalta) a dual serotonin-noradrenaline reuptake inhibitor
http://psychiatry.co.uk/duloxetine-cymbalta.html   (275 words)

  
 Duloxetine: A Dual Reuptake Inhibitor -- Dugan and Fuller 38 (12): 2078 -- The Annals of Pharmacotherapy
inhibitor being considered for treatment of MDD and stress urinary incontinence.
Key Words: duloxetine, major depressive disorder, serotonin–norepinephrine reuptake inhibitor
While approved dosing ranges have not yet been determined, studies
http://www.theannals.com/cgi/content/abstract/38/12/2078   (297 words)

  
 SSRI and SNRI antidepressants unfit for pediatric use: EMEA
The European Medicines Agency (EMEA), after a review of two classes of antidepressants — serotonin-selective reuptake inhibitor (SSRI) and serotonin norepinephrine reuptake inhibitor (SNRI) — said that they are unfit for use on children and adolescents except in ‘their approved indications’.
http://www.earthtimes.org/articles/show/2576.html   (438 words)

  
 Venlafaxine Consulting Mental Health News Articles
It works by blocking the transporter "reuptake" proteins for key neurotransmitters affecting mood, thereby leaving more active in the synapse.
Effexor is chemically unrelated to other antidepressants, but is sometimes catagorized as a serotonin-norepinephrine reuptake inhibitor (SNRI).
At medium dosages, Effexor blocks the reuptake of norepinephrine as well as serotonin.
http://psych.consultinghealth.com/article_89.html   (275 words)

  
 BehaveNet® Clinical Capsule™: selective serotonin norepinephrine reuptake inhibitor (SNRI)
This class of drugs probably acts by limiting the reabsorption of serotonin and norepinephrine by neurons (nerve cells) in the brain where they meet (the synapse).
BehaveNet® Clinical Capsule™: selective serotonin norepinephrine reuptake inhibitor (SNRI)
Also: dual reuptake inhibitor, norepinephrine serotonin reuptake inhibitor (NSRI)
http://www.behavenet.com/capsules/treatments/drugs/snri.htm   (44 words)

  
 Charlotte.com - Your Guide to Charlotte
The royalty payments are based on Lilly's United States sales of Cymbalta(R) (duloxetine hydrochloride), a selective serotonin and norepinephrine reuptake inhibitor approved by the U.S. Food and Drug Administration for the treatment of major depressive disorder and the management of diabetic peripheral neuropathic pain in adults.
Quintiles will sell its rights to the royalty and certain other payments under the agreement to Royalty Sub, which will purchase the rights using the net proceeds from the sale of the notes.
Payments of principal and interest on the notes will be made solely out of royalty and other payments to be made under an existing agreement between Quintiles and Eli Lilly and Company (NYSE: LLY) ("Lilly").
http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=ncharlotte.story&STORY=/www/story/08-19-2005/0004091228&EDATE=Aug+19,+2005   (521 words)

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