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| | Alpha 1-antitrypsin - Wikipedia, the free encyclopedia |
 | | A1AT is a 52 kDa serine protease inhibitor, and in medicine it is considered the most prominent one, given the fact that the words α1-antitrypsin and protease inhibitor (Pi) are often used interchangeably. | | | This disorder proves the point that the serine protease inhibitors have a closely related structure. | | | One patient with this abnormality has been described; he died of a lethal bleeding diathesis. |
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http://en.wikipedia.org/wiki/Alpha_1-antitrypsin
(670 words)
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| | HCV Protease Inhibitors-BILN 2061: a major step toward new therapeutic strategies in hepatitis C |
| | Current interferon-based therapies are suboptimal especially in patients infected with HCV genotype 1, and they are poorly tolerated, highlighting the unmet medical need for new therapeutics. | | | In the future, resistance to one drug might be sensitive to another one, and as in HIV, combination treatment (NS34A protease inhibitor and NS5 polymerase inhibitor for example) might be more efficient. | | | The same methodology is used for HCV new drug development studies. |
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http://www.natap.org/2004/HCV/080904_05.htm
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| | HCV Protease Inhibitors: Glimpses of Hope on a Distant Horizon |
| | But despite considerable research on HCV PIs over the past decade, it will require at least several more years before an HCV protease inhibitor will win FDA approval and reach the market. Only two HCV protease inhibitors are currently in human studies, and both are at the very earliest stage of clinical research. | | | The issue of whether patients and clinicians should base current treatment decisions on the future prospect of improved therapies is a critical one in the current clinical management of hepatitis C. | | | While it certainly is reasonable to offer patients the anticipation of future treatment opportunities, hope is not a particularly effective method of viral eradication.” |
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http://www.hivandhepatitis.com/hep_c/news/2004/063004_a.html
(1158 words)
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| | UCSF Craik Lab |
| | Synthesis of Haloperidol Ethanedithioketal HIV-1 Protease Inhibitors: Magnesium Chloride Facilitated Addition of Grignard Reagents. | | | Yeast Two-Hybrid Assay for Examining HIV Protease Heterodimer Foundation with Dominant Negative Inhibitors and Multidrug-Resistant Variants. | | | Crystal Structure of Rat Trypsin-S195C at -150°C. Analysis of Low Activity of Recombinant and Semi-Synthetic Thiol Proteases. |
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http://www.craiklab.ucsf.edu/pub.html
(4152 words)
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| | BILN 2061: HCV protease inhibitor |
| | Future plans for development of this drug seems uncertain but it is my understanding that the developer, Boerhinger Ingleheim, has another HCV protease inhibitor and an HCV polymerase inhibitor in earleier stages of development. | | | In previous studies, no safety issues were found in patients with minimal and advanced fibrosis who were treated with BILN 2061 for 2 days. | | | Markus Reiser and colleagues (Boerhinger Ingleheim) reported study results. |
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http://www.natap.org/2003/AASLD/day4_1.htm
(811 words)
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| | Apoptosis II: Beyond Cytochrome c; the Other Mitochondrial Proteins |
| | Collectively, these data suggest that this serine protease-specific, caspase- independent mechanism of IAP neutralization by cleavage may be the principle means of HtrA2/Omi pro-apoptotic function (Figure 1). | | | The IAP-binding motif specifically interacts with the BIR domains of IAPs to facilitate IAP/IAP inhibitor complex formation, and thereby prevent IAP/Caspase complex formation. | | | Rather, HtrA2/Omi induces apoptosis through an alternative mechanism as well that is serine protease activity-dependent and caspase-independent. |
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http://www.rndsystems.com/asp/g_sitebuilder.asp?bodyID=554
(2847 words)
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| | Serine protease inhibitor - Wikipedia, the free encyclopedia |
| | Alpha 1-antitrypsin (the most important serpin, often simply referred to as protease inhibitor); | | | Mutations in these areas may lead to dysfunction and disease ("serpinopathy"). | | | Many serpins are specific for particular proteases (most of them serine proteases), but they can show nonspecific inhibition of other serine proteases as well (e.g. |
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http://en.wikipedia.org/wiki/Serine_protease_inhibitor
(450 words)
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| | Protein gi1226313 |
| | similar to the DPTI/Kunitz family of inhibitors; most similar to tissue factor pathway inhibitor precursor | | | similar to the BPTI/Kunitz family of inhibitors; most similar to tissue factor pathway inhibitor precursor (TFPI) | | | strong similarity to homeobox proteins; similar to inhibitor domain of tissue factor pathway inhibitor (TFPI) |
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http://www.sbc.su.se/PhylProM/CELE/gi1226313.html
(472 words)
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| | EID Vol. 4 No.1: Proteases of Malaria Parasites: New Targets for Chemotherapy |
| | Work in the author's laboratory was supported by grants from the National Institutes of Health, the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, and the American Heart Association. | | | However, other studies have shown that native hemoglobin is cleaved by plasmepsin I, but not falcipain, in nonreducing conditions that may be present in the food vacuole (53,59,72). | | | Synthesis and antimalarial effects of phenothiazine inhibitors of a Plasmodium falciparum cysteine protease. |
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http://www.cdc.gov/ncidod/eid/vol4no1/rosenth.htm
(4136 words)
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| | M&I • Xuanyong Lu, PhD |
| | My researches focus on the study of hepatitis B virus (HBV), a major human pathogen responsible for acute and chronic liver disease. | | | The up-regulation of the IAPs and SPI has also been identified in the other cancers such as breast cancer, lung cancer, pancreatic cancer and prostate cancer. | | | If it were true, down regulation of over-expressed apoptosis inhibitor, consequently reinstating the apoptosis of cancer cell, probably could be used to control the cancer development. |
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http://www.drexel.edu/med/microbiology_immunology/faculty/lu.html
(1082 words)
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| | OUTPUT from blastx for SL2-0055 |
| | 80 1e-14 pirS08102 serine proteinase inhibitor 1 - rat >gi57231e... | | | >spP01009A1AT_HUMAN ALPHA-1-ANTITRYPSIN PRECURSOR (ALPHA-1 PROTEASE INHIBITOR) (ALPHA-1-ANTIPROTEINASE) pirITHU alpha-1-antitrypsin precursor - human embCAA25838.1 | | | 80 2e-14 pirA26423 serine proteinase inhibitor 2.1 - rat (fragment) 80 2e-14 spP23775CBG_RABIT CORTICOSTEROID-BINDING GLOBULIN (CBG) (... |
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http://cbr-rbc.nrc-cnrc.gc.ca/reith/salmon/liver/SL2-0055.html
(618 words)
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| | Directory of open access journals |
| | METHODS: We constructed pCI-neo-NS3/4A-SEAP chimeric plasmid, in which the secreted alkaline phosphatase (SEAP) was fused in-frame to the downstream of NS4A/4B cleavage site. | | | Pefabloc SC, a potent irreversible serine protease inhibitor, was used to treat the stably expressing cell lines to assess the system for screening NS3 inhibitors. | | | To compare the activity of serine proteases from 1b and 1a, two chimeric clones were constructed and introduced into both transient and stable expression systems. |
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http://www.doaj.org/abstract?id=90900&toc=y
(268 words)
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| | BILN 2061 HCV Protease Inhibitor Development Held Due to Toxicity |
| | In the meantime several HCV drugs are in early study in patients or about to begin study in patients. | | | BILN 2061 is a potent and specific inhibitor of HCV serine protease in vitro. | | | Vertex's HCV protease inhibitor is just starting its first study in patients at the end of 2004. |
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http://www.natap.org/2004/HCV/113004_01.htm
(3793 words)
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| | OUTPUT from blastx for SL3-0032 |
| | >spP00995IPST_HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR PRECURSOR (TUMOR-ASSOCIATED TRYPSIN INHIBITOR) (TATI) pirTIHUA pancreatic secretory trypsin inhibitor precursor - human gbAAA36521.1 | | | serine protease inhibitor, kanzal type 1/ Trypsin inhibitor-like protein, pancreatic [Rattus norvegicus] spP09655IPS1_RAT PANCREATIC SECRETORY TRYPSIN INHIBITOR I PRECURSOR (PSTI-I) (CHOLECYSTOKININ-RELEASING PEPTIDE) (MONITOR PEPTIDE) pirTIRT1 pancreatic secretory trypsin inhibitor I precursor - rat embCAA42217.1 | | | >pdb1CGII Chain I, Alpha-Chymotrypsinogen Complex With Human Pancreatic Secretory Trypsin Inhibitor Variant 3 pdb1HPT |
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http://cbr-rbc.nrc-cnrc.gc.ca/reith/salmon/liver/SL3-0032.html
(2600 words)
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| | Serine protease - encyclopedia article about Serine protease. |
| | Determination of serine protease levels may be useful in the context of particular diseases. | | | Coagulation factor levels may be required in the diagnosis of hemorrhagic or thrombotic conditions. | | | Serine proteases participate in a wide range of functions in the body, including blood clotting coagulation of blood is a complex process during which blood forms solid clots. |
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http://encyclopedia.thefreedictionary.com/Serine%20protease
(3250 words)
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| | Coagulation - Wikipedia, the free encyclopedia |
| | The system in humans is the most extensively researched and therefore the best known. | | | It is now known that the primary pathway for the initiation of blood coagulation is the Tissue Factor pathway. | | | The pathways are a series of reactions, in which a zymogen of a serine protease and its glycoprotein co-factor are activated to become active components that then catalyze the next reaction in the cascade. |
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http://en.wikipedia.org/wiki/Blood_clotting
(2222 words)
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| | Bowman Birk Inhibitor (soybean-derived serine protease) |
| | Detection of Bowman-Birk Inhibitor and Anti-Bowman-Birk Inhibitor Antibodies in Sera of Humans and Animals Treated With Bowman-Birk Inhibitor Concentrate | | | BBI, in the form of BBI concentrate (BBIC), is currently being evaluated in clinical trials as a human cancer-preventive agent. | | | Abstract: The Bowman-Birk inhibitor (BBI) is a soybean-derived serine protease inhibitor with anticarcinogenic activities. |
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http://www.annieappleseedproject.org/bowbirinsoys.html
(292 words)
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| | PHRI :: Richard Pine, Ph.D. |
| | A serine protease on the cytoplasmic surface of an organelle or vesicle in the "lysosomal/mitochondrial" fraction from undifferentiated cells was responsible for the modification of IRF-1. | | | It is likely that induction of both IRF-1 and the serine protease inhibitor in response to infection by M. tuberculosis represent host defense mechanisms. | | | Recovery of intact IRF-1 correlated with induction of a serine protease inhibitor that was able to significantly reduce the modification of IRF-1. |
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http://www.phri.org/research/res_abs_pine01.asp
(238 words)
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| | Mailgate: sci.life-extension: Serine protease inhibitor 2A increases memory T-cells |
| | The finding could help scientists create more effective vaccines and may lead to potent immune system-based therapies against diseases that have previously eluded vaccines, such as cancer or AIDS. | | | Mailgate: sci.life-extension: Serine protease inhibitor 2A increases memory T-cells | | | Subject: Serine protease inhibitor 2A increases memory T-cells |
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http://mailgate.supereva.it/sci/sci.life-extension/msg11942.html
(499 words)
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| | Serpine2 identified as novel candidate gene for COPD |
| | But no significant study of this protease inhibitor's expression in normal or diseased lungs had been undertaken previously. | | | Serpine2 is a major tissue and cell-associated inhibitor of thrombin and plasmin, but not elastase. | | | Researchers have identified a serine protease inhibitor as a novel candidate susceptibility gene for chronic obstructive pulmonary disease (COPD). |
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http://www.drugresearcher.com/news/news-ng.asp?n=59167-serpine-identified-as
(824 words)
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| | 109_Serine Proteases |
| | Ecotin is a serine protease inhibitor that is found in the periplasm of Escherichia coli. | | | It has a very broad range of inhibition including the pancreatic serine proteases trypsin and chymotrypsin, human leukocyte, porcine elastase, and rat mast cell chymase. | | | Ecotin is regarded as a potent, tight-binding, reversible inhibitor of Factor Xa. |
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http://www.oxfordbiomed.com/vb109serpro.html
(188 words)
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| | PDB Molecule of the Month: Serpins |
| | Several control the process of blood clotting: antithrombin limits the action of thrombin when a clot is forming, and antiplasmin limits the action of plasmin when blood clots are being disassembled. | | | Over thirty different human serpins (a number of which are available in the PDB) have been studied, each with a different essential job. | | | The serpins are one class of these molecules, designed to seek out and destroy specific serine proteases. |
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http://nist.rcsb.org/pdb/molecules/pdb53_1.html
(565 words)
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| | Pfam 18.0 : Kazal_1 |
| | Kazal inhibitors, which inhibit a number of serine proteases (such as trypsin and elastase), belong to family of proteins that includes pancreatic secretory trypsin inhibitor; avian ovomucoid; acrosin inhibitor; and elastase inhibitor. | | | The presence of this Pfam domain is usually indicative of serine protease inhibitors, however, Kazal-like domains are also seen in the extracellular part of agrins which are not known to be proteinase inhibitors. | | | However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. |
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http://pfam.wustl.edu/cgi-bin/getdesc?acc=PF00050
(307 words)
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| | Directory of open access journals |
| | We have studied the effects of proteases and their inhibitors on the extracellular matrix and the consequences to the migration of gonadotropin releasing hormone (GnRH) neurons in the embryonic chick. | | | The accessibility of this coherent cell group make it amenable for studying protease/inhibitor roles in migratory processes. | | | Moreover, the data suggest, for the first time, that aspects of GnRH neuronal migration may be cell autonomous but modulated by ECM alterations. |
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http://www.doaj.org/abstract?id=80846&toc=y
(236 words)
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| | Alpha-1-Antitrypsin Deficiency |
| | This is a very efficient mechanism for controlling serine protease activity. | | | Alpha-1-antitrypsin (AAT), also referred to as SERPIN A1, is the most abundant serine protease inhibitor (PI; serpin) in human plasma. | | | The three-dimensional structure of AAT and other serpins has provided major insights into the mechanism of inhibition of cognate proteases. |
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http://www.dekker.com/sdek/4696497-33621364/abstract~content=a713544902~db=enc
(352 words)
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| | antithrombin / heparin system - General Practice Notebook |
| | Deficiency of heparin cofactor II may cause thrombophilia. | | | Binding of heparin to antithrombin improves the speed with which antithrombin can neutralise these prothrombotic factors. | | | Antithrombin is a serine protease inhibitor which inhibits the following coagulation factors: |
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http://www.gpnotebook.co.uk/cache/-771358677.htm
(143 words)
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| | SERINE PROTEASE INHIBITOR definition |
| | A class of highly polymorphic inhibitors of trypsin, elastase, and certain other proteases synthesised by hepatocytes and macrophages |
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http://www.books.md/S/dic/serineproteaseinhibitor.php
(159 words)
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| | Recent Publications: Fornace lab |
| | p38 MAP kinase inhibitor protects the epidermis against the acute damaging effects of UV irradiation by blocking apoptosis and inflammatory responses. | | | Zhang, H., Cooney, D.A., Sreenath, A., Zhan, Q., Agbaria, R., Stowe, E.E., Fornace, A.J., Jr., and Johns, D.G.: Quantitation of mitochondrial DNA in human lymphoblasts by a competitive polymerase chain reaction method: application to the study of inhibitors of mitochondrial DNA content. | | | Huang, Y., Sheikh, M.S., Fornace, A.J., Jr., and Holbrook, N.J. Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells. |
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http://rex.nci.nih.gov/RESEARCH/basic/lbc/recent.htm
(4219 words)
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| | Biomolecular Modelling Group at ICRF : FTDock : Test System : SERINE PROTEASE/INHIBITOR COMPLEX |
| | These are not exactly the same as the original PDB files in that they have been run through our PDB parser, which does various things such as remove alternative atoms. | | | Biomolecular Modelling Group at ICRF : FTDock : Test System : SERINE PROTEASE/INHIBITOR COMPLEX | | | ALPHA-CHYMOTRYPSINOGEN COMPLEX WITH HUMAN PANCREATIC SECRETORY TRYPSIN INHIBITOR VARIANT 3 |
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http://www.bmm.icnet.uk/docking/systems/1CGI.html
(80 words)
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| | At2g26390 - serpin, putative / serine protease inhibitor, putative |
| | At2g26390 is a homologue of At2g25240 (serpin, putative / serine protease inhibitor, putative) from Arabidopsis thaliana. | | | At2g26390 - serpin, putative / serine protease inhibitor, putative | | | These synonyms are used for gene At2g26390 (serpin, putative / serine protease inhibitor, putative): T9J22.6. |
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http://www.ihop-net.org/UniPub/iHOP/gg/2560.html
(106 words)
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| | Calbiochem: 565000: Serine Protease Inhibitor Cocktail Set I |
| | Calbiochem: 565000: Serine Protease Inhibitor Cocktail Set I | | | A cocktail of four protease inhibitors that is useful for inhibition of a broad range of serine proteases. | | | Proteomics, Tools for Protein Expression, Purification, & Analysis » Protein Extraction » Protease Inhibitor Cocktails |
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http://www.merckbiosciences.com/product/565000
(130 words)
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