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 | | Selegiline has been proved to be effective in improving the conditions of PD patients in combination therapy as well. | | | Selegiline, when used alone to treat mildly affected PD patients, had little side effects, and found to be effective in improving motor control. | | | Series of research is being done on selegiline today, and more and more of positive and negative effects of selegiline are found to enhance our understanding of the role of the molecule. |
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| | Selegiline |
| | Selegiline possesses the quality of selectivity, blocking only the enzyme which destroys dopamine and allows the breakdown of other monoamines, such as tyramine, to continue. | | | Elsewhere in the body, unlike all other MAO inhibitors, Selegiline behaves in a harmless fashion. | | | The physiological working of the brain is carried out by neurotransmitters, one of which is dopamine. |
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| | Eldepryl Product Labeling |
| | ELDEPRYL is indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy. | | | The decision to prescribe selegiline should take into consideration that the MAO system of enzymes is complex and incompletely understood and there is only a limited amount of carefully documented clinical experience with selegiline. | | | There is no evidence from controlled studies that selegiline has any beneficial effect in the absence of concurrent levodopa therapy. |
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| | Treatment Options - Selegiline |
| | The main side-effects of selegiline when given as an adjunct to levodopa therapy are similar to those experienced by patients on conventional anti-parkinsonian therapy, such as bromocriptine. | | | Knoll J. The pharmacological profile of (-)-deprenyl (selegiline) and its relevance for humans: a personal view. | | | Knoll J. The facilitation of dopaminergic activity in the aged rat brain by (-)-deprenyl. |
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| | selegiline Consumer Drug Information |
| | Selegiline is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. | | | However, it is believed that selegiline prevents the breakdown of dopamine in your brain. | | | Before taking selegiline, tell your doctor if you have any other medical conditions. |
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| | Selepryl Cryprenyl L-Deprenyl selegiline citrate |
| | Selegiline turned out to be an efficient inhibitor of the uptake of dopamine in the striatum and this effect was found to play an important role in the facilitation of the activity of the nigrostriatal dopaminergic neurons in animals treated continuously with (-)Selegiline. | | | The question arose weather Selegiline, by improving the tone of the dopaminergic system, might be useful in treating other neurodegenerative diseases. | | | Studies on this medicine have been done only in adult patients and there is no specific information about its use in children. |
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| | MedlinePlus Drug Information: Selegiline |
| | Selegiline may make your skin sensitive to sunlight. | | | tell your doctor and pharmacist if you are allergic to selegiline, aspirin, tartrazine (a yellow dye in some processed foods and drugs), or any other drugs. | | | This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. |
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| | A Placebo-Controlled Study of Selegiline in the Treatment of Children With Tic Disorders and Attention Deficit ... |
| | Two subjects in the Selegiline group withdrew from the study at week 1 due to severe sedation, which required specific therapy. | | | Eleven of 22 subjects who received Selegiline were blindly rated on the Clinical Global Improvement scale as either much improved or very much improved, compared with none of 22 subjects who received placebo. | | | To evaluate the effect of Selegiline on blood pressure and pulse, we conducted a series of repeated measures ANOVAs to examine differences between groups across time and change from a lying to a standing position. |
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| | Selegiline, Carbex, Eldepryl |
| | One controlled study showed that taking selegiline at the same time as 5-HTP enhanced the antidepressant effect when compared with 5-HTP alone. | | | Though no studies have investigated whether the herb ephedra might result in similar effects, the current evidence suggests that people taking selegiline should avoid all products that contain ephedra. | | | Use of our encyclopedia will enable you to make well-informed, responsible decisions for the promotion of your own health and wellness. |
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| | Selegiline - Drugs & Vitamins - Drug Library - DrugDigest |
| | Call your prescriber or health care professional as soon as you can if you get frequent headaches or have palpitations. | | | Do not treat yourself for coughs, colds, or allergies without asking your prescriber or health care professional for advice. | | | Check with your health care professional before stopping or starting any of your medicines. |
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| | Selegiline - Patient UK |
| | Before taking any 'over-the-counter' medicines, check with your pharmacist which medicines are safe for you to take alongside selegiline. | | | Never give it to others, even if their condition appears to be the same as yours. | | | This belongs to the group of medicines known as dopaminergic drugs. |
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| | Selegiline news articles |
| | Prior to this, Dr. Clarke was Worldwide Clinical Operations Manager at RP Scherer, where he was co-inventor of Zelapar, a novel form of selegiline for the... | | | Psychopharmacologic Drugs has issued a revised Prescription Drug User Fee Act (PDUFA) goal date of February 26, 2006 for EMSAM® (selegiline transdermal system... | | | PET DOCTOR Easing life of older dogs Apr 1, 2005 |
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| | Deprenyl (Selegiline, Eprenyl, etc.) |
| | FDA Panel Backs Selegiline Patch For Depression: Majority view 20-mg formulation as safe - Clinical Psychiatry News, 12/05 - "Unlike the transdermal formulation, the oral formulation does not achieve antidepressant levels in the central nervous system" | | | The striatal dopamine dependency of life span in male rats. | | | Fast-dissolving Selegiline (Zelapar Zydis) Reduces "Off-Time" in Up to 4 Years of Follow-Up - Doctor's Guide, 10/3/05 |
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| | SELEGILINE |
| | Hypertension: headache at the base of the of the neck (occipital headache), neck stiffness or soreness, nausea, vomiting, sweating, light sensitivity, tight throat or chest pain, changes in heart rhythm (heart is beating fast or slow) | | | It is a good idea to always check with your study clinician before taking any other medications, prescription or otherwise, to be sure it will not interact with Selegiline Transdermal System. | | | Selegiline is a medication that is used in combination with other medications to treat people with Parkinson’s Disease, a disease characterized by difficulty with movement and muscle control. |
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http://depts.washington.edu/actu/drugs/selegiline.htm
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| | HighBeam Research: Library Search: Results |
| | This article reviews the pharmacology and clinical use of selegiline. | | | our position in bringing generic selegiline to market, says Gunter. | | | Chain Drug Review; February 17, 1997; 442 Words |
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http://www.highbeam.com/library/search.asp?q=Selegiline&refid=healthcyclopedia
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| | Selegiline for Alzheimer's disease (Cochrane Review) |
| | Reasons for this uncertainty involve the modest overall effects observed in some trials, the lack of benefit observed in several trials, the use of cross-over designs which harbour methodological problems in a disease like dementia and the difficulty in interpreting results from trials when a variety of measurement scales are used to assess outcomes. | | | Data collection and analysis: An individual patient data meta-analysis of selegiline, Wilcock 2002 provides much of the data that are available for this review. | | | Objectives: The objective of this review is to assess whether or not selegiline improves the well-being of patients with Alzheimer's disease. |
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http://www.cochrane.org/cochrane/revabstr/ab000442.htm
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| | Selegiline for Parkinson's disease |
| | However, if you experience severe headache or chest pain while taking selegiline, you should seek medical care immediately. | | | Selegiline prolongs the effects of dopamine in the brain by preventing its breakdown. | | | Selegiline may be used in the early stages of Parkinson's disease to treat very mild symptoms (such as resting tremor) and delay the need for levodopa. |
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http://www.webmd.com/hw/parkinsons/hw91653.asp
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| | Selegiline HCl (Anipryl®) - PetPlace.com |
| | Consult with your veterinarian to determine if other drugs your pet is receiving could interact with selegiline. | | | Selegiline is a complex drug that affects brain function. | | | Selegiline is used primarily to treat canine cognitive dysfunction syndrome (senility in older dogs). |
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http://www.petplace.com/article.aspx?id=1531
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| | Clinical Trial: Safety and Effectiveness of the Selegiline "Patch" for Decreased Mental Function in HIV ... |
| | An adjunctive therapy that interferes with the cascade of events triggered by the virus is likely to play an important role. | | | Further study details as provided by National Institute of Allergy and Infectious Diseases (NIAID): | | | The purpose of this study is to evaluate the use of selegiline transdermal system (STS) in the treatment of decreased mental function in patients with HIV. |
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http://www.clinicaltrials.gov/ct/show/NCT00013585
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| | Selegiline (MAO inhibitor) |
| | Monoamine oxidase type B is responsible for the oxidative deamination of dopamine in the brain. | | | In controlled clinical trials, selegiline caused slight improvement in motor performance at the start of therapy and worsening at its discontinuance; it also delayed the development of disability that requires the addition of levodopa. | | | Selegiline's duration of action depends on the time required to regenerate MAO type B. At higher selegiline doses (e.g., 20÷40 mg/day), brain MAO is blocked nonselectively, predisposing patients to the risks of traditional MAOIs that block MOA type A (e.g., hypertension). |
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http://www.rockford.uic.edu/jc/selegil.htm
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| | Selegiline |
| | If you have an allergy to selegiline or any other part of the medicine. | | | There may be low amounts of dopamine in the system. | | | Selegiline increases a chemical in the brain called dopamine. |
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http://www.umm.edu/altmed/ConsDrugs/Selegilinecd.html
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| | Selegiline - Wikipedia, the free encyclopedia |
| | Selegiline (l-deprenyl, Eldepryl® or Anipryl® [veterinary]) is a drug used for the treatment of early-stage Parkinson's disease and senile dementia. | | | Selegiline is also used (at extremely high dosages relative to humans) in veterinary medicine to treat the symptoms of Cushing's disease and so-called "cognitive dysfunction" in dogs. | | | However, due to this selegiline can cause false positives for amphetamine/methamphetamine on drug tests. |
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http://en.wikipedia.org/wiki/Selegiline
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| | CAN DEPRENYL (SELEGILINE) EXTEND HUMAN LIFESPAN? |
| | [*9] "Selegiline in Treatment of Behavioral and Cognitive Symptoms | | | of levodopa and levodopa combined with selegiline in patients | | | [*5] "Chronic Treatment of Syrian Hamsters with Low-Dose Selegiline |
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http://www.benbest.com/lifeext/deprenyl.html
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| | Selegiline - Compare Prices, Reviews and Buy at NexTag - Price - Review |
| | Anipryl (selegiline), also known as L-Deprenyl, is a monoamine oxidase inhibitor (MAOI) used in the treatment of Cushing& and canine cognitive dysfunction (senility). | | | Selegiline, a generic form of Anipryl, is used to treat some types of Cushing& and cognitive dysfunction (senility) in dogs. | | | Anipryl (selegiline) is used to treat canine cognitive dysfunction and a type of Cushing& caused by a pituitary tumor. |
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http://www.nextag.com/selegiline/search-html
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| | Selegiline Hydrochloride (L-Deprenyl) |
| | Children: This drug should not be used by children. | | | Without levodopa/carbidopa, this drug has no known benefit. | | | MAO, which is found in the brain and intestinal tract, acts to break down certain chemicals that play a role in the initiation and control of muscle movement. |
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http://www.wholehealthmd.com/refshelf/drugs_view/1,1524,559,00.html
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| | ARS Publication request: Transdermal Selegiline and Dietary Tyramine: Is There a Concern? |
| | Preliminary studies suggest that as much as 200 mg of dietary tyramine may be required to produce an effect with the transdermal form. | | | Technical Abstract: The interaction of dietary tyramine and monoamine oxidase inhibitor (MAOI) drugs has been a major barrier to the use of these effective antidepressants. | | | Low dose selegiline has been used in Parkinson Disease with little or no adverse effects, but higher doses of this selective Type B MAOI produced a pressor response to as little as 10 mg of tyramine. |
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http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=155373
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| | SELEGILINE WITH EFFEXOR |
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| | New Application: BiDil 16 June 2005 - NitroMed, Inc. announced today that the FDA's Cardiovascular and Renal Drugs Advisory Committee voted to recommend approval of its product candidate BiDil for the treatment of heart failure in black patients... | | | New Application: Emsam 16 June 2005 - Mylan Laboratories Inc. and Watson Pharmaceuticals, Inc., announced that Somerset Pharmaceuticals, Inc. has submitted a response to the FDA's Action letter related to Emsam (selegiline transdermal system)... | | | New Application: Arcoxia 17 June 2005 - As previously announced, on Oct. |
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