Schistosoma japonicum - Medicow
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Topic: Schistosoma japonicum



  
 Three-dimensional structure of Schistosoma japonicum glutathione S-transferase fused with a six-amino acid conserved ...
Three-dimensional structure of Schistosoma japonicum glutathione S-transferase fused with a six-amino acid conserved neutralizing epitope of gp41 from HIV -- LIM et al.
http://www.proteinscience.org/cgi/reprint/3/12/2233   (23 words)

  
 Infection with Schistosomes (Schistosoma haematobium, Schistosoma mansoni and Schistosoma ...
japonicum enhanced the liver tumour incidence in mice treated with 2-acetylaminofluorene in one experiment.
japonicum have been found to be positively correlated in Japan but not consistently so in China.
japonicum in Japan and China, the estimated relative risks for the association varied from 2 to 10.
http://monographs.iarc.fr/htdocs/monographs/vol61/m61-1.htm   (1690 words)

  
 ANTIGEN-SPECIFIC ANTIBODY ISOTYPE PATTERNS TO SCHISTOSOMA JAPONICUM RECOMBINANT AND NATIVE ANTIGENS IN A DEFINED ...
Immune correlate study on human Schistosoma japonicum in a well-defined population in Leyte, Philippines: I. Assessment of ‘resistance’ versus ‘susceptibility’ to Schistosoma japonicum infection.
Cellular immune responses to Schistosoma japonicum recombinant and native antigens.
Resistance to reinfection with Schistosoma haematobium in Gambian children: analysis of their immune responses.
http://www.ajtmh.org/cgi/content/full/70/5/549   (4732 words)

  
 Schistosomiasis
No satisfactory alternative drug for S japonicum is available.
After development in the snails, cercariae emerge and penetrate the skin of humans encountered in the water.
Early stage - Initial penetration of skin by cercariae results in hypersensitivity and a transient pruritic., papular skin rash (swimmer's itch).
http://www.meddean.luc.edu/lumen/meded/mech/cases/case14/schistos.htm   (856 words)

  
 eMedicine - Schistosomiasis : Article by Michael D Nissen, BMedSc, MBBS, FRACP, FRCPA
Eggs of Schistosoma japonicum within the intestinal mucosa.
Pulmonary complications with S japonicum and S mansoni are usually only observed after the development of a collateral circulation secondary to severe hepatosplenic disease.
Abdominal pain may be observed with acute and chronic schistosomiasis secondary to liver and splenic enlargement (see Image 2).
http://www.emedicine.com/ped/topic2055.htm   (5850 words)

  
 TDRnews No.60 Meetings on Plasmodium vivax and Schistosoma japonicum in Asia
In China, the situation seems to call for a vaccine for animal use that would reduce transmission of infection to humans; but in The Philippines, a vaccine is required for human use with the aim of reducing morbidity.
Of the available antigens, Sj97 (Paramyosin) is the most advanced in development, but no consensus was reached on which of the other candidates should be progressed towards clinical trials.
The second meeting was designed to stimulate interest among Asian researchers in developing a vaccine for Schistosomiasis japonicum.
http://www.who.int/tdr/publications/tdrnews/news60/vaccine.htm   (725 words)

  
 Trematodes
The most significant trematodes from a clinical point of view are blood flukes, Schistosoma mansoni, S. japonicum and S.
Schistosoma mansoni in section of snail tissue (HandE) © Dr Peter Darben, Queensland University of Technology clinical parasitology collection.
Eggs of Schistosoma mansoni in a patient from Egypt.
http://pathmicro.med.sc.edu/parasitology/trematodes.htm   (2643 words)

  
 Bioline International Official Site (site up-dated regularly)
Considering the symptomatic form, cerebral involvement is almost always due to Schistosoma japonicum and the spinal cord disease, caused by S.
Spinal cord schistosomiasis: a report of 2 cases and review enphasizing clinical aspects.
When associated with clinical symptoms, it is one of the most severe presentations of schistosomal infection.
http://www.bioline.org.br/request?oc04087   (2489 words)

  
 Medical Dictionary: Schistosoma - WrongDiagnosis.com
Schistosoma: Another name for Schistosomiasis (or close medical condition association).
Infection with Schistosoma mansoni, S. haematobium, and S. japonicum causes illness in humans.
Schistosoma: Schistosoma is listed as a type of (or associated with) the following medical conditions in our database: Parasitic Conditions, Fluke infections, Bladder conditions, Urinary disorders, Liver conditions
http://www.wrongdiagnosis.com/medical/schistosoma.htm   (235 words)

  
 Images of schistosome eggs
japonicum in which the small laterial spine can be seen.
A third example of a Schistosoma mansoni egg.
http://www.biosci.ohio-state.edu/~parasite/schistosome_eggs.html   (72 words)

  
 Schistosomiasis - Wikipedia, the free encyclopedia
Schistosomiasis may 'metastasize' to different parts of the body, and this does not depend on its particular clinical profile.
Rather, it is the cellular infiltration resultant from the immune response that causes the pathology classically associated with schistosomiasis.
Occasionally central nervous system lesions occur: cerebral granulomatous disease may be caused by ectopic S.
http://en.wikipedia.org/wiki/Schistosomiasis   (1593 words)

  
 Schistosomiasis in the People's Republic of China: Prospects and Challenges for the 21st Century -- Ross et al. 14 (2): ...
japonicum are round with a reduced lateral spine
The miracidium hatching test is a traditional approach to assessing S.
japonicum, is a true zoonotic organism, with a range of mammalian
http://cmr.asm.org/cgi/content/full/14/2/270   (10052 words)

  
 Profiles of Immunoglobulin M (IgM) and IgG Antibodies against Defined Carbohydrate Epitopes in Sera of ...
Using this technique, we have shown that humans infected with
A strong and early humoral immune response has been found against
Schistosoma: analysis of monoclonal antibodies reactive with the circulating antigens CCA and CAA.
http://iai.asm.org/cgi/content/full/69/4/2396   (2836 words)

  
 Specialty Laboratories ::: we help doctors help patients
Antibody isotype responses to Schistosoma japonicum antigens in subjects from a schistosomiasis area with repeated praziquantel chemotherapy compared with a new endemic zone in Hunan Province, P.R. China.
japonicum in treated and untreated populations are being defined and related to resistance to re-infection.
Differential cellular reactivity to adult worm antigens of patients with different clinical forms of schistosomiasis mansoni.
http://www.specialtylabs.com/books/display.asp?id=44   (975 words)

  
 Schistosomiasis - Microscopy Findings
The egg is typically oval and has a vestigial spine, which is better shown in Figure I.
A, B: Schistosoma mansoni eggs in a patient from Egypt.
C, D: Schistosoma mansoni eggs showing characteristic lateral spine.
http://www.dpd.cdc.gov/dpdx/html/Frames/S-Z/Schistosomiasis/body_Schistosomiasis_mic1.htm   (121 words)

  
 [No title]
A similar analysis led to the discovery in China of a separate triculine snail-transmitted S. sinensium complex (43), which may yet reveal new species of human schistosomes.
Schistosoma japonicum is also a major cause of illness in this region.
By both classical and molecular phylogenetic techniques, the Academy of Natural Sciences has provided evidence for the coevolution of S. japonicum with their snail vectors (41).
http://ftp.cdc.gov/pub/EID/vol3no3/ascii/hotez.txt   (4513 words)

  
 Brown Medical School
Estimating sensitivity and specificity of a faecal examination method for Schistosoma japonicum infection in cats, dogs, water buffaloes, pigs and rats in Western Samar and Sorsogon Provinces, The Philippines.
T-helper 2 cytokine responses to Sj97 predict resistance to reinfection with Schistosoma japonicum.
Expression, purification and human antibody response to a 67 kDa vaccine candidate for schistosomiasis japonicum.
http://www.brown.edu/Divisions/Medical_School/andera/person.php?id=1182   (1074 words)

  
 [No title]
Calcified Schistosoma haematobium eggs have been found in tissues of Egyptian mummies from as early as the 20th dynasty (1184-1087 BC).
19 Rapidly detectingSchistosoma japonicum -specific antibody in sera of Chinese patients.
The Influence of MNNG on the Proliferation of Cultured Cells from Adult Schistosoma japonicum DONG Huifen JIANG Mingsen MING Zhenping ZHONG Qinping Department of Medical Parasitology and Research Laboratory of Schistosomiasis, Medical College of Wuhan University, Wuhan 430071 AIM To study the function of MNNG on the proliferation of cultured cells from adult Schistosoma japonicum.
http://www.nhm.ac.uk/hosted_sites/schisto/prcschisto/Wuhan.doc   (8734 words)

  
 Distribution of Schistosomiasis
japonicum, which vary considerably in their pathogenicity, drug sensitivity, morphology and infectivity.
japonicum is found in the Far East, particularly China and the Philippines, but not any longer in Japan where successful control programs have been implemented.
japonicum - like species may also exist in Thailand.
http://www.path.cam.ac.uk/~schisto/Background/Distribution.html   (669 words)

  
 Dr. B. Kalinna
This technique will be an important step towards understanding the biology of the parasite and to develop new vaccines and anthelminthics.
Donald McManus he changed fields and since then has been working with schistosomes.
Differential antigen-stimulated proliferation of human mononuclear cells by recombinant Schistosoma japonicum antigens in a Chinese population.
http://www.biologie.hu-berlin.de/~molpara/bk_en.html   (1224 words)

  
 Bio160: Development of Vaccines
Resistance to Schistosoma mansoni in humans: Influence of the IgE/IgG4 balance and IgG2 in Immunity to reinfection after chemotherapy.
This administration of IL-12 as an adjuvant has been shown to potentiate Th1-mediated immune responses and induce resistance to reinfection.
In addition to these protein candidate antigens for vaccines, another interesting approach to schistosomiasis vaccine development inivolves the irradiation of the cercariae of Schistosoma mansoni.
http://www.brown.edu/Courses/Bio_160/Projects1999/schisto/schistobody.html   (1778 words)

  
 QIMR Website - Molecular Parasitology Laboratory
Pearson, M.S., McManus, D.P., Smyth, D.J., Lewis, F.A., Loukas, A. In vitro and in silico analysis of signal peptides from the human blood fluke, Schistosoma mansoni.
We are also working on aspects of the schistosome genome and the worm surface, which may impact on vaccine and drug development.
Research projects are available within the Molecular Parasitology Laboratory for BSc Honours, MMedSci and PhD students interested in working in the schistosomiasis, hydatid and nematode biology areas.
http://www.qimr.edu.au/research/labs/donm   (2865 words)

  
 Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource - Nature Genetics
The role of glutathione-S-transferase in anti-cancer drug resistance
Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni
Schistosoma japonicum causes schistosomiasis in humans and livestock in the Asia-Pacific region.
http://www.nature.com/doifinder/10.1038/ng1236   (338 words)

  
 Glutathione Peroxidase 3 antibody (ab16799) reviews
Reacts with Schistosoma japonicum Does not react with Human, Mouse or Rat.
Reacts with Schistosoma japonicum Not yet tested in other species.
http://www.abcam.com/go.cfm?p=14&ab=16799   (775 words)

  
 Anti-interleukin-4 treatment diminishes secretion of Th2 cytokines and inhibits hepatic fibrosis in murine ...
Cheever AW; Finkelman FD; Cox TM; Laboratory of Parasitic Diseases, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; MD 20892, USA.
The number of eggs per worm pair in the tissues and feces did not differ significantly in treated and untreated mice.
Hepatic fibrosis was markedly diminished in anti-IL-4-treated-mice at ten weeks of infection while granulomas around S. japonicum eggs in the livers were slightly-to-moderately increased in size.
http://www.aegis.com/aidsline/1995/sep/M9590877.html   (370 words)

  
 Robert C. Spear
Qiu DC, Hubbard AE, Zhong B, Zhang Y, Spear RC (2005) A matched, case-control study of the association between Schistosoma japonicum and liver and colon cancers, in rural China.
Xu B, Gong P, Seto E, Liang S, Yang C, Wen S, Qiu D, Gu X, Spear RC (2005) A spatial-temporal model for assessing the effects of inter-village connectivity in Schistosomiasis transmission.
Liang S, Spear RC, Seto E, Hubbard A, Qiu D (2005) A multi-group model of Schistosoma japonicum transmission dynamics and control: model calibration and control prediction.
http://ehs.sph.berkeley.edu/superfund/about/spear.htm   (147 words)

  
 [No title]
Feasibility study towards effectiveness of health education intervention for reducing the risk of porcine cysticercosis in Mbulu district, Tanzania.
Part I: A Bayesian cumulative logit modeling approach.
Carabin H, Guyatt HL, Engels D. A comparative analysis of the cost-effectiveness of treatment based on parasitological and symptomatic screening for Schistosoma mansoni in Burundi.
http://w3.ouhsc.edu/biostat/carabin_pubs.html   (821 words)

  
 Vaccination with Calpain Induces a Th1-Biased Protective Immune Response against Schistosoma japonicum -- Zhang et al. ...
japonicum isolated in Yamanashi Prefecture, Japan, has been maintained in our laboratory by using Onchomelania
Vaccination with Calpain Induces a Th1-Biased Protective Immune Response against Schistosoma japonicum
Vaccination with Calpain Induces a Th1-Biased Protective Immune Response against Schistosoma japonicum -- Zhang et al.
http://iai.asm.org/cgi/content/full/69/1/386   (3471 words)

  
 STAC Member: Dr Niels Ornjberg Christensen
Chandiwana, S., Ørnbjerg, N. Review of North-South and South-South cooperation and conditions necessary to sustain research capability in developing countries.
Schistosoma japonicum infection in the pig as a model for human Schistosomiasis japonica, Acta Tropica, 2000, 76, 85-99
Johansen, M.V., Ørnbjerg, N. Prenatal Schistosoma Japonicum infection in piglets: effect of repeated exposure of the dams on treatment efficacy and susceptibility to challenge infections.
http://www.who.int/tdr/about/governance/ornbjerg.htm   (485 words)

  
 Emerging Foodborne Trematodiasis CDC EID
Third, it is important to juxtapose these observations with trends observed over the same period, but with an emphasis on soil-transmitted helminthiasis and schistosomiasis.
These decreases are the result of socioeconomic development and chemotherapy-based illness control programs that largely depend on treatment with praziquantel, albendazole, and mebendazole.
In many parts of Southeast Asia, including China, the number of people infected with Schistosoma japonicum and the major soil-transmitted helminths (i.e., Ascaris lumbricoides, hookworms, and Trichuris trichiura) has decreased (38,39).
http://www.cdc.gov/ncidod/eid/vol11no10/05-0614.htm   (4667 words)

  
 EHS Center at UC Berkeley
Spear RC, Hubbard A, Liang S, Seto E (2002) Disease transmission models for public Health decision-making: towards an approach for designing intervention strategies for Schistosomiasis japonicum.
Liang S, Maszle D, Spear RC (2002) A quantitative framework for a multi-group model of Schistosomiasis japonicum transmission dynamics and control in Sichuan, China.
Hurshman AR, Marletta MA (2002) Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer.
http://ehscenter.berkeley.edu/publications/default.htm   (8329 words)

  
 [No title]
Kinetic studies of a quantitative single-tube enzyme-linked immunosorbent assay.
Schistosoma haematobium infection despite multiple courses of therapy with praziquantel.
Enzyme-linked immunoelectrotransfer blot techniques (EITB) for studying the specificities of antigens and antibodies separated by gel electrophoresis.
http://www.ctegd.uga.edu/people_pages/tsang.html   (1790 words)

  
 WHO Schisto Data
Schistosoma haematobium is responsible for urinary symptoms and disease in Africa and the Middle East.
Intestinal symptoms and disease are due to S. intercalatum, S. japonicum, S. mansoni and S. mekongi infections.
As an example, S. japonicum which accounted for most of the transmission among the three major schistosome species and was the most difficult to control, due to its zoonotic nature, has now been effectively controlled in many areas.
http://www.geog.umn.edu/courses/1403/whoschisto.htm   (1038 words)

  
 Snails as intermediate hosts of Schistosoma mansoni
Picture left: Schistosoma mansoni — one of the pathogen causes responsible for the illness Bilharziosis or Schistosomiasis.
Bilharziosis or Bilharzias is a tropical illness named after the German doctor Theodor Bilharz, who found it in 1852.
The most important species are Schistosoma mansoni, Schistosoma haematobium and Schistosoma japonicum.
http://www.weichtiere.at/Mollusks/Schnecken/parasitismus/schistosoma.html   (465 words)

  
 AccessMedicine - Harrison's Internal Medicine: Blood Flukes: Schistosomiasis
Topics Discussed: schistosoma haematobium infection; schistosoma intercalatum; schistosoma japonicum; schistosoma mansoni; schistosoma mekongi; schistosomal hepatomegaly; schistosomatidae; schistosomiasis; schistosomiasis, cutaneous; schistosomiasis, hepatic, chronic; schistosomiasis, pulmonary.
Infection may cause considerable morbidity in the intestines, liver, and urinary tract, and a proportion of affected individuals die.
"Human schistosomiasis is caused by five species of this parasitic trematode: the intestinal species Schistosoma mansoni, S. japonicum, S. mekongi, and S. intercalatum and the urinary species S. haematobium.
http://www.accessmedicine.com/content.aspx?aID=78532   (291 words)

  
 Schistosoma - Wikipedia, the free encyclopedia
A genus of trematodes, Schistosoma spp., commonly known as blood-flukes and bilharzia, cause the most important human helminth infection (schistosomiasis) from a world health perspective, and are considered by the World Health Organization as second in importance only to malaria, with hundreds of millions infected worldwide.
Eggs are passed through urine or feces to fresh water, where larval stages can infect a new host by penetrating the skin.
japonicum whose common name is simply blood fluke is found widely spread in Eastern Asia and the southwestern Pacific region.
http://en.wikipedia.org/wiki/Schistosoma   (431 words)

  
 Schistosomiasis
The life cycle of the parasite is outlined here and common therapies for the disease are presented.
One mated pair of S. japonicum produces about 3000 eggs per day, some of which pass through the membranes of the bowels and are excreted in stool.
At least 37 vertebrate hosts have been identified in China for S. japonicum including humans, pigs, cattle, dogs, cats, ducks, and rodents.
http://ehs.sph.berkeley.edu/china/e/disease.htm   (1404 words)

  
 Tropeduweb / Factsheets: Parasital Classification Trematodes
Schistosoma mekongi resembling to Schistosoma japonicum is responsible for the most cases reported from Indochina.
Schistosoma japonicum infections are similar to that of Schistosoma mansoni.
Humans are the only important host of the urinary schistosomiasis caused by Schistosoma haematobium.
http://www.tropeduweb.ch/factsheets/fs_parasital_class_trematodes.html   (167 words)

  
 [No title]
To the present moment, the use of PCR as a method for diagnosing human Schistosomiasis has never been related.
Each primer of the pair is, preferentially, constructed in a manner as to be substantially complementary to a different strand of the sequence that flanks the specific sequence of the Schistosoma sp.
The disease has been recorded for 4000 years and still constitutes an important problem for public health, affecting more than 200 million people in undeveloped countries.
http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=01/75148.011011&ELEMENT_SET=DECL   (4276 words)

  
 Antigenic variation
Larval forms of the parasites (known as cercariae), released by the snails, penetrate the skin of people in the water.
mansoni, S. japonicum), but some eggs are trapped in body tissues.
Immune reactions to eggs lodged in tissues are the cause of disease.
http://www.icp.ucl.ac.be/~opperd/parasites/schisto1.html   (625 words)

  
 Schistosoma japonicum definition - Medical Dictionary definitions of popular medical terms
Schistosoma japonicum definition - Medical Dictionary definitions of popular medical terms
Schistosoma japonicum: A species of trematode worm that parasitizes humans and that (like S. mansoni) causes liver and gastrointestinal tract disease.
MedicineNet Home > MedTerms medical dictionary A-Z List > Schistosoma japonicum
http://www.medterms.com/script/main/art.asp?articlekey=5414   (146 words)

  
 Osborne's publication
Sharp, J.G., W.R. Hanson, and J.W. Osborne, The relationship between the compensatory response in the stomach and colon and the extent of small bowel resection in the rat.
Hsü, S.Y., H.F. Hsü, L.F. Burmeister, and J.W. Osborne, Evaluation of lung recovery assayed for schistosomula in mice immunized with X-irradiated cercariae of Schistosoma mansoni.
Hsü, H.F., S.Y. Li Hsü, and J.W. Osborne, Further studies on Rhesus monkeys immunized against Schistosoma japonicum by administration of X-irradiated cercariae.
http://www.medicine.uiowa.edu/frrb/completeplublications/osbornejamescompletepub.htm   (1924 words)

  
 schistosomiasis - Columbia Encyclopedia® article about schistosomiasis
This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.
schistosomiasis (shĭs`təsōmī`əsĭs), bilharziasis, or snail fever, parasitic disease caused by blood flukes, trematode worms of the genus Schistosoma.
http://columbia.thefreedictionary.com/schistosomiasis   (295 words)

  
 Schistosomiasis
japonicum is limited to China and the Philippines and can infect other mammals, in addition to humans, such as pigs, dogs, and water buffalos.
Intestinal schistosomiasis, caused by Schistosoma japonicum, S. mekongi, mansoni, and S.
There are five species of schistosomes that are prevalent in different areas of the world and produce somewhat different symptoms:
http://www.lifesteps.com/gm/Atoz/ency/schistosomiasis.jsp   (1808 words)

  
 Schistosoma spp. (schistosomiasis, blood flukes)
There are a number of species of schistosomes that can infect humans, but most human infections are caused by one of the three following species: Schistosoma mansoni; S.
The schistosomes are unusual trematodes in that the sexes are separate (they are dioecious), they reside in the blood vessels of the definitive host, and there are no second intermediate hosts in their life cycles.
http://www.biosci.ohio-state.edu/~parasite/schistosoma.html   (454 words)

  
 Glutathione-S-Transferase [GST-tag] , S. japonicum form : AB3282
Reacts with Schistosoma japonicum, Most common vertebrate species tested..
Reactivity with other species has not been confirmed.
The anti-GST antibody can be used to detect GST fusion proteins in Western blot analysis and ELISA studies.
http://www.chemicon.com/Product/ProductDatasheet.asp?ProductItem=AB3282   (295 words)

  
 Queen's University Belfast - Professor A.G. Maule: Publications
Structure and bioactivity of neuropeptide F from the human parasites Schistosoma mansoni and Schistosoma japonicum.
Skelly, P.J., Dougan, P.M., Maule, A.G., Day, T.A. and Shoemaker, C.B. Cloning and characterization of a muscle isoform of a sodium potassium ATPase alpha subunit (SnaK1) from Schistosoma mansoni.
McCarthy, E., Stack, C., Donnelly, S.M., Doyle, S., Mann, V.H., Brindley, P.J., Stewart, M., Day, T.A., Maule, A.G. and Dalton, J.P. Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum.
http://www.qub.ac.uk/bb/people/maule/pubs.html   (918 words)

  
 List of identified uniques
Contig1830 - Similar to Schistosoma mansoni NADH dehydrogenase subunit 2
Contig1507 - Similar to Schistosoma mansoni 14-3-3 epsilon 2
Contig648 - Similar to Schistosoma mansoni purine-nucleoside phosphorylase
http://www.icb.ufmg.br/~lgb/schisto/inf/list.htm   (13189 words)

  
 Parasitology: SchistoSim main page
The major causes of the disease are Schistosoma mansoni, Schistosoma japonicum and Schistosoma haematobium.
Transmission of the schistosomes to humans is via contact with fresh water that contains the parasite's intermediate snail host and that has been contaminated by urine or faecal material from infected individuals.
It is thought to infect some 200 to 300 million people across Africa, South America, the Caribbean, the Middle East, China and Southeast Asia.
http://www.aber.ac.uk/~mpgwww/Schisto/Schisto.html   (1530 words)

  
 Schistosomiasis: Parasitic Infections: Merck Manual Home Edition
The eggs of Schistosoma mansoni and Schistosoma japonicum typically lodge in the intestine and liver, whereas those of Schistosoma hematobium typically lodge in the bladder.
Three species cause most of the cases of schistosomiasis in people: Schistosoma hematobium infects the urinary tract and bladder, and Schistosoma mansoni and Schistosoma japonicum infect the intestine.
The resulting inflammation can lead to scarring, and increased pressure in the veins that carry blood between the digestive tract and the liver (portal vessels).
http://www.merck.com/mmhe/print/sec17/ch196/ch196j.html   (491 words)

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