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| | Aidsmap Saquinavir - overview |
 | | A small study has shown that ritonavir-boosted saquinavir alone may be an effective induction treatment in induction and maintenance therapy of patients with advanced HIV infection. | | | Saquinavir is cleared from the body more slowly by women than men, so the drug reaches higher levels in the blood and brings about better virological responses in women (Fletcher 2004). | | | For research into saquinavir plus the NNRTIs, see the relevant NNRTI entry in Drugs used by people with HIV. |
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http://www.aidsmap.org.uk/en/docs/33B06321-7CE1-47C2-B15A-F901843D7060.asp
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| | Sex-Based Differences in Saquinavir Pharmacology and Virologic Response in ACTG Study 359 |
| | The objective of the present study was to investigate relationships among concentrations of saquinavir, saquinavir inhibitory quotient (IQ), characteristics of patients, and virologic response. | | | ACTG 359 was designed such that the protease inhibitor saquinavir was the common drug in all 6 arms of the study. | | | Females had significantly higher concentrations of saquinavir than did males, and, consistent with the relationship between exposure to saquinavir and virologic response, a greater proportion of females than males had HIV RNA values ≤500 copies/mL at week 16. |
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http://www.hivandhepatitis.com/recent/inter/032904a.html
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| | TAG: Ten texts on saquinavir |
| | Saquinavir, like ddC, is the most potent drug of its class – in vitro. | | | We believe the initial labeling for Saquinavir should include a prominent box warning that use of Saquinavir may limit the clinical and virological utility of future protease inhibitors, and that physicians and patients must be educated about this possibility in Roche promotional materials. | | | Examples of such behavior are legion, from the fiasco that was ddC to the joke that is the current formulation of saquinavir to the curious decision by the Basel-based pharmaceutical giant to drastically curtail development of valganciclovir, the oral ganciclovir prodrug which offered the hope for finally being an effective prophylaxis for cytomegalovirus (CMV) disease. |
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http://www.aidsinfonyc.org/tag/tx/saquinavirten.html
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| | MedlinePlus Drug Information: Saquinavir |
| | Saquinavir does not cure HIV and may not prevent you from developing HIV-related illnesses.Saquinavir does not prevent the spread of HIV to other people. | | | Take only the brand of saquinavir that was prescribed by your doctor and do not switch to the other brand of saquinavir unless your doctor tells you that you should. | | | tell your doctor and pharmacist if you are allergic to saquinavir, any other medications, or any of the ingredients in saquinavir. |
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http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a696001.html
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| | Invirase - Drugs & Vitamins - Drug Library - DrugDigest |
| | Saquinavir is used in combination with other drugs to treat the HIV virus. | | | Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. | | | Check with your health care professional before stopping or starting any of your medicines. |
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http://www.drugdigest.org/DD/DVH/Uses/0,3915,600Invirase,00.html
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| | AEGiS-ATN: Garlic Reduces Saquinavir Blood Levels 50%; May Affect Other Drugs |
| | A study at the U.S. National Institute of Allergy and Infectious Diseases found that garlic supplements reduced blood levels of the protease inhibitor saquinavir by 51%. | | | It is not clear how other drugs besides saquinavir will be affected. | | | Other findings of this study are complex, and the mechanism of this interaction is not clear. |
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http://www.aegis.com/pubs/atn/2001/ATN37501.html
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| | Saquinavir (Systemic) - MayoClinic.com |
| | Saquinavir will not keep you from spreading HIV to other people. | | | People who receive this medicine may continue to have other problems usually related to AIDS or HIV disease. | | | When you are taking saquinavir, it is especially important that your health care professional know if you are taking any of the following: |
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http://www.mayoclinic.com/health/drug-information/DR203529
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| | The Body: HIV Inhibitor: Boosted Saquinavir Shows Significant Safety Benefit Over Boosted Crixivan |
| | Fifty-seven percent of patients who received at least one dose of the saquinavir therapy had undetectable HIV levels (less than 50 copies/mL) at 48 weeks, compared to 46 percent in the boosted indinavir arm of the study at 48 weeks. | | | Among patients who completed 48 weeks of therapy, HIV blood levels were suppressed to less than 50 copies/mL in 79 percent of patients on boosted saquinavir and in 77 percent of patients on boosted indinavir. | | | One hundred patients had at least one severe and/or life threatening adverse event: 65 (41 percent) in the boosted indinavir arm vs. 35 (24 percent) in the boosted saquinavir arm. |
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http://www.thebody.com/cdc/news_updates_archive/2003/nov12_03/sqv_safety.html
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| | Saquinavir (Invirase): First Protease Inhibitor Approved -- Reimbursement, Information Hotline Numbers - AIDS Treatment ... |
| | Also, as our last issue suggested, grapefruit juice may increase blood levels of saquinavir -- although there is no blood-level test available to tell if this is working for you. | | | Hoffmann-La Roche has suggested that no one will fall through the cracks: "To ensure that every patient in the U.S. who can benefit from Invirase(TM) gets immediate and sustained access to the drug, irrespective of their financial situation, Roche has established the Roche HIV Therapy Assistance Program. | | | AIDS TREATMENT NEWS already covered some technical aspects of this drug in two articles in issue #235, November 17, 1995: "Protease Inhibitors: Drug Resistance and Cross Resistance," and "Grapefruit Juice and Saquinavir." |
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http://www.aids.org/atn/a-237-01.html
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| | Clinical Trial: The Anti-HIV Effects of Saquinavir Soft Gelatin Capsules Versus Indinavir in Patients Who Have Used ... |
| | Patients on the other two arms will remain on their assigned regimen for the entire 24 weeks unless they have no virologic response by week 8, in which case they will be crossed-over to open-label therapy with the alternative drug (i.e., either soft gelatin capsule saquinavir or indinavir). | | | Patients currently enrolled may stop their participation in the trial and seek other anti-retroviral therapies or may continue on study. | | | Methods for investigation of the relationship between drug-susceptibility phenotype and human immunodeficiency virus type 1 genotype with applications to AIDS clinical trials group 333. |
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http://clinicaltrials.gov/ct/show/NCT00000848
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| | SAQUINAVIR |
| | Inform your doctor and pharmacist of all prescribed and non-prescribed drugs you are taking. As well, you should inform them of natural products you are taking. | | | Why should you not forget to take this drug? | | | Also, saquinavir might influence the effect of other drugs you are taking. |
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http://www.tthhivclinic.com/FactSheets/html/SAQUINAVIR.html
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| | Saquinavir |
| | If you have an allergy to saquinavir or any other part of the medicine. | | | If you have direct sun exposure without the use of sunscreen or protective clothing. |
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http://www.umm.edu/altmed/ConsDrugs/Saquinavircd.html
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| | Simple Facts Sheets: saquinavir (Invirase) |
| | Hoffman-La Roche, the company that makes Fortovase, has an assistance program for people that need help getting the drug. | | | The Invirase version of saquinavir wasn't well absorbed by the body and had a very weak anti-HIV effect compared to other protease inhibitors. | | | Because the level is higher than usual, the dose of both drugs is lowered. |
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http://www.atdn.org/simple/saqu.html
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| | SAQUINAVIR a Commonly Used Medication |
| | Providers should use alternatives to astemizole and terfenadine while Patients are on fortovase. | | | Although saquinavir does not act as strongly as keta or itra, the combinations have not been studied. | | | Other compounds, such as calcium channel blockers, clindamycin, dapsone, quinidine or triazolam (that are substrates of CYP3A4) may have increased plasma concentrations when given with fortovase; therefore, patients should be monitored for toxicities with these drugs. |
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http://www.hivdent.org/drugs/SAQUINAVIR.htm
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| | Fortovase Online, Description, Chemistry, Ingredients - Saquinavir Mesylate - RxList Monographs |
| | When using saquinavir as the sole protease inhibitor in an antiviral regimen, FORTOVASE is the recommended formulation (see CLINICAL PHARMACOLOGY: Drug Interactions). | | | INVIRASE brand of saquinavir mesylate is an inhibitor of the human immunodeficiency virus (HIV) protease. | | | INVIRASE may be used only if it is combined with ritonavir, which significantly inhibits saquinavir's metabolism to provide plasma saquinavir levels at least equal to those achieved with FORTOVASE. |
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http://www.rxlist.com/cgi/generic/saquin.htm
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| | The Body: Saquinavir (Fortovase, Invirase) |
| | Correction: Fortovase Information Number for Patients in Washington D.C. Area (December 5, 1997) | | | The Body is a service of Body Health Resources Corporation, 250 West 57th Street, New York, NY 10107. | | | Efavirenz (Sustiva, DMP 266) and Saquinavir (Fortovase) Combination: Pharmacologic Interaction (June 5, 1998) |
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http://www.thebody.com/treat/saquinavir.html
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