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| | S-Adenosyl-L-Methionine (SAM) Update, Part I |
 | | I wrote an article about SAM which appeared a few years ago in Dynamic Chiropractic.1 My interest in SAM at that time was based on its ability to reduce pain in individuals with osteoarthritis. | | | The researchers found that SAM was more effective at increasing range of motion as well as decreasing pain and spasm than ibuprofen. | | | I am again writing about SAM because it is finally available from the Allergy Research Group in Hayward, California. |
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http://www.chiroweb.com/archives/16/21/07.html
(770 words)
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| | Product Abstract: Same (S-Adenosyl-L-Methionine) |
| | Chemoprevention of rat liver carcinogenesis by S-adenosyl-L- methionine: a long-term study. | | | SAMe treatment, by improving the depressive state and reducing the number of trigger points, seems to be an effective and safe therapy in the management of primary fibromyalgia. | | | Treatment with exogenous SAM prevents the development of preneoplastic and neoplastic lesions in rat liver. |
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http://www.lef.org/prod_hp/abstracts/php-ab120.html
(7971 words)
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| | Changes in GE2270 antibiotic production in Planobispora rosea through modulation of methylation metabolism -- Gastaldo and Marinelli 149 (6): 1523 -- Microbiology |
| | Haydock, S. F., Dowson, J. A., Dhillon, N., Roberts, G. A., Cortes, J. and Leadlay, P. Cloning and sequence analysis of genes involved in erythromycin biosynthesis in Saccharopolyspora erythraea: sequence similarities between EryG and a family of S-adenosylmethionine-dependent methyltransferases. | | | groups of staurosporine derived from methionine (Yang et al. | | | Application of the frit-FAB LC/MS technique to the elucidation of the pradimicin S biosynthetic pathway. |
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http://mic.sgmjournals.org/cgi/content/full/149/6/1523
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| | British Journal of Pharmacology - Influence of S-adenosyl-L-methionine on chronic mild stress-induced anhedonia in castrated rats |
| | ALGERI, S.,, CATTO, E.,, CURCIO, M.,, PONZIO, F. and, STRAMENTINOLI, G. 1979 Changes in rat brain noradrenaline and serotonin metabolism after administration of S-adenosyl-L-methionine.. | | | MANN, S. and, HILL, M.W. (1983) Activation and inactivation of striatal tyrosine hydroxylase: the effects of pH, ATP, and cyclic AMP, S-adenosylmethionine and S-adenosylhomocysteine.. | | | BERNARDI, M.,, VERGONI, A.V.,, SANDRINI, M.,, TAGLIAVINI, S. and, BERTOLINI, A. (1989b) Influence of ovariectomy, estradiol and progesterone on the behavior of mice in an experimental model of depression.. |
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http://www.nature.com/bjp/journal/v127/n3/full/0702589a.html
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| | Plant Gene Register PGR00-033 |
| | S-adenosyl-L-methionine synthetase (SAMS; EC 2.5.1.6) catalyzes the biosynthesis of S-adenosyl-L-methionine from L-methionine and ATP. | | | This research was financially supported by Academia Sinica and by a biological research grant 89-2815-C-001-011-B from the National Science Council of the Republic of China to Dr. K.Y. To. | | | Different cultivars may be the possible explanation for this observation. |
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http://www.tarweed.com/pgr/PGR00-033.html
(866 words)
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| | S-Adenosyl Methionine as a food supplement: Pros' and Cons' |
| | S-Adenosyl Methionine (SAM or SAM-e; pronounced "sammy") is an amino acid. | | | In the human body SAM is known to be essential to at least 35 biochemical processes, including maintaining the structure of cell membranes and manufacturing substances vital to transmitting nerve impulses and influencing emotions and moods. | | | If it works, it's a drug, and should be regulated and prescribed like one, as it is in Europe. |
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http://www.stoneclinic.com/sam_e.htm
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| | Health Library - |
| | Methionine has been used in connection with the following conditions (refer to the individual health concern for complete information): | | | Methionine is important in treatment of chronic pancreatitis. | | | Methionine is one of the essential amino acids (building blocks of protein), meaning that it cannot be produced by the body, and must be provided by the diet. |
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http://www.yalenewhavenhealth.org/library/healthguide/en-us/Cam/topic.asp?hwid=hn-2884008
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| | S-adenosyl methionine - Wikipedia, the free encyclopedia |
| | S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial | | | S-adenosyl methionine (SAM) is an enzymatic cofactor involved in methyl group transfers. | | | Transmethylation, transsulfuration and aminopropylation are the metabolic pathways that breakdown SAM throughout the body although most of SAM is consumed and produced in the liver (Cantoni). |
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http://en.wikipedia.org/wiki/S-adenosyl-methionine
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| | Twice the Results With One Powerful Product: SAMe (S-adenosyl-methionine) (text version) |
| | Not a prescription drug or an herb, SAMe (S-adenosyl- methionine) is a synthetic replication of a compound that the body makes naturally from methionine, an amino acid found in protein-rich foods. | | | This all-natural product may just replace even the most popular treatments currently being used for joint pain and depression, without many of the negative side-effects they usually bring. |
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http://www.immunesupport.com/articles/same/same003txt.htm
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| | Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations |
| | 550601 -- Medicine-- Unsealed Radionuclides in Diagnostics; METHIONINE-- RADIOENZYMATIC ASSAY; BLOOD PLASMA;BODY FLUIDS;CARBON 14 COMPOUNDS;CENTRAL NERVOUS SYSTEM;CEREBROSPINAL FLUID;CHEMICAL PREPARATION;COMPARATIVE EVALUATIONS;LABELLED COMPOUNDS;TRITIUM COMPOUNDS |
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http://www.osti.gov/energycitations/product.biblio.jsp?osti_id=5696320
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| | S-adenosyl-L-methionine Information |
| | Loss of activity in the enzyme methionine adenosyltransferase (MAT) results in decreased concentrations of SAMe and depletion of glutathione. | | | SAMe is present only in minute amounts in the diet, and its principle source in the body is through methionine metabolism. | | | Up to half of the daily intake of methionine is metabolized into SAMe in the liver. |
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http://www.vitaminherbuniversity.com/topic.asp?categoryid=3&topicid=1045
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| | S-Adenosyl-L-Methionine, SAM-e |
| | - SAM S-Adenosyl-L-Methionine alleviates Major Depression [scientific research - humans]. | | | - SAM S-Adenosyl-L-Methionine is especially effective in treating Postpartum Depression. | | | - Supplemental SAM is presently under investigation as a potential treatment for Parkinson’s Disease [scientific research - humans: Parkinson’s Disease patients have endogenous levels of SAM that are only 60% of the levels of those of healthy subjects]. |
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http://www.thevitaminoutlet.com/Info_Pages/details/sam_details.htm
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| | Sam-e - Antidepressant Supplement Remedy Depression Symptoms Stress Relief Anxiety Health |
| | In young, healthy people SAM-e is well distributed throughout the body as a result of its synthesis from methionine by enzymes using ATP. | | | However, in sickness and in age, system levels may become depleted. | | | SAM-e is used by the body in three important pathways: methylation (contributing methyl groups to activate certain molecules); the synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.); and trans-sulfuration (synthesis of cysteine, glutathione and other sulfate chemicals). |
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http://www.health-marketplace.com/SAM-e-400mg.htm
(319 words)
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| | SAMe (S-Adenosyl L-Methionine) on NutritionOnline.com |
| | SAMe, made from the amino acid methionine, is a naturally occurring molecule distributed throughout most body tissues and fluids. | | | Additional benefits include promoting liver health, as well as being very effective in soothing joints. | | | Many people are finding SAMe to be a side-effect free best solution for healthy mood and attitude as well as joint health. |
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http://www.nutritiononline.com/item.jsp?item=583
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| | S-Adenosyl Methionine (SAMe) |
| | SAMe, or S-adenosyl-l-methionine, is an activated from of the essential amino acid methionine. | | | SAMe is formed when ATP and methionine are combined. | | | SAMe is present in most living cells and is not found abundantly in the diet, although methionine can be. |
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http://www.webvitamins.com/nutrient.aspx?ID=1924
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| | News - S-Adenosyl Methionine May Be As Efficacious As Celecoxib in Management of Knee Osteoarthritis, But Onset of Action Is Slower |
| | A DGReview of :"S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial. | | | BMC Musculoskeletal Disorders 2004 Feb. 26;5:1:6 "S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial. | | | S-Adenosyl Methionine May Be As Efficacious As Celecoxib in Management of Knee Osteoarthritis, But Onset of Action Is Slower |
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http://www.docguide.com/news/content.nsf/news/8525697700573E1885256E80002925F1
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| | Methionine - Wikipedia, the free encyclopedia |
| | Methionine plays a role in cysteine, carnitine and taurine synthesis by the transsulfuration pathway, lecithin production, the synthesis of phosphatidylcholine and other phospholipids. | | | Methionine can also occur at other positions in the protein. | | | As a consequence, methionine is incorporated into the N-terminal position of all proteins in eukaryotes and archaea during translation, although it is usually removed by post-translational modification. |
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http://en.wikipedia.org/wiki/Methionine
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| | Spec Sheet Display |
| | A new process has been developed which utilizes an engineered strain of yeast that eliminates the need to provide a source of methionine, an expensive nucleic acid, in the production of S-adenosyl methionine (SAM). | | | In young, healthy people, SAM is well distributed throughout the body as a result of its synthesis from methionine by enzymes using ATP. | | | SAM is available as an over-the-counter dietary supplement, and has been used in the treatment of depression, osteoarthritis, fibromyalgia, liver disease, chronic fatigue syndrome, and migraine headaches. |
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http://www.otc.utexas.edu/Technologies/Display.jsp?&ip_info_id=1204
(301 words)
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| | S-Adenosyl-L-Methionine (SAMe) |
| | A randomized double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAMe therapy in patients with knee osteoarthritis. | | | Bottiglieri T, Hyland K. S-adenosylmethionine levels in psychiatric and neurological disorders: a review. | | | Cofactors for the metabolism of homocysteine to methionine are folic acid, vitamin B12 and trimethylglycine (betaine). |
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http://www.gettingwell.com/drug_info/nmdrugprofiles/nutsupdrugs/sad_0231.shtml
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| | News - S-Adenosyl-L-Methionine Results Similar to Imipramine in Major Depression |
| | A DGReview of :"A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S -adenosyl- L -methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder" | | | "A double-blind, randomized parallel-group, efficacy and safety study of intramuscular S -adenosyl- L -methionine 1,4-butanedisulphonate (SAMe) versus imipramine in patients with major depressive disorder" | | | Intramuscular S-adenosyl-l-methionine (SAMe) appears to be comparable to oral imipramine for the treatment of major depression, Italian researchers have found in a short-term trial. |
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http://docguide.com/news/content.nsf/news/8525697700573E1885256C8B005CF1C4
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| | LifeLink - SAM-e |
| | SAMe (often mispronounced unless spelled SAM-e) is an acronym for S-adenosyl methionine — i.e, the amino acid methionine linked to the DNA base adenosine. | | | SAMe deficiencies would result from deficiencies of the factors or cofactors required to make it — methionine, choline, or B-vitamins. | | | SAMe has also been shown to be beneficial in treating osteoarthritis, depression, and liver disease. |
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http://www.lifelinknet.com/siteResources/Products/SAM-e.asp
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| | Methylcycle, AdoMetDC, and O-Methyltransferases (OMTs) |
| | The methyl group of methionine is transferred to the substrate, and the demethylated AdoMet is released, | | | Thanks for invaluable help: We would like to stress here that the enzymatic characterization of the plant methionine synthase was only possible because of the generous help by Rowena Matthews at the University of Michigan (USA). | | | There was a long-standing puzzle with respect to the biosynthesis of methionine: all of the enzymes were located to the plastids (chloroplasts), except for the final enzyme, the methionine synthase. |
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http://www.biologie.uni-freiburg.de/data/bio2/schroeder/Methylcycle_General.html
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| | Holistic Health Encyclopedia - S |
| | Sulfur has a vital relationship with protein, since sulfur is found in the amino acids methionine, cystine, and cysteine. | | | Sulfur has been found to be a structural component of connective tissues, skin, hair, nails, antibodies (which fight disease) and other proteins. | | | Disinfestation of the skin is accomplished by applying creams or ointments containing gamma benzene hexachloride or benzyl benzoate. |
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http://www.findhealer.com/glossary/S.php3
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| | - SHOP.COM |
| | Jarrow Formulas’ SAMe 200 contains pharmaceutical grade stabilized S-Adenosyl Methionine (SAMe), a naturally occuring compound produced by the body. | | | SAMe is formed when the body combines the amino acid L-methionine with ATP (adenosine triphosphate), the primary energy molecule found in physiologic processes. | | | When you buy from more than one store, we pay any additional shipping - our Holiday gift to you. |
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http://www.shop.com/op/aprod-p27167225
(262 words)
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| | NIH Guide: S-ADENOSYL-L-METHIONINE (SAME) AND LIVER DISEASE |
| | 2) Chronic ethanol intake depletes hepatic SAMe levels that are associated with impaired metabolism of methionine, a precursor of SAMe. | | | Possible topics responsive to this RFA include, but are not limited to: o Investigation of the mechanisms by which hepatotoxic agents, including alcohol, impair methionine (SAMe precursor) metabolism and its impact on hepatic SAMe and glutathione levels? | | | o Identification of the role of folate deficiency in methionine metabolism, and ultimately SAMe and glutathione levels. |
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http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-02-011.html
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