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| | Rofecoxib - Wikipedia, the free encyclopedia |
 | | Rofecoxib (IPA: [rofəˈcɒxɪb]) is a nonsteroidal anti-inflammatory drug (NSAID) that was used in the treatment of osteoarthritis, acute pain conditions, and dysmenorrhoea. | | | Rofecoxib was one of the most widely used drugs ever to be withdrawn from the market. | | | Merck has placed great emphasis on these studies on the grounds that they are relatively large (almost 3000 patients) and compared rofecoxib to a placebo rather than to another pain reliever. |
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http://en.wikipedia.org/wiki/Rofecoxib
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| | MedlinePlus Drug Information: Rofecoxib |
| | Rofecoxib is used to relieve the pain, tenderness, inflammation (swelling), and stiffness caused by arthritis and to treat painful menstrual periods and pain from other causes. | | | This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. | | | Your doctor may order certain laboratory tests to check your body's response to rofecoxib. |
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http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a699046.html
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| | Rofecoxib Vs Acetaminophen In Pain Relief |
| | Rofecoxib was also associated with improved quality of recovery and increased patient satisfaction. | | | Rofecoxib is more cost-effective than acetaminophen in preventing pain after ambulatory surgery, reports a study in the October issue of Anesthesiology (2002; 97:931-937). | | | The new trial supports the use of the selective cyclo-oxygenase-2 inhibitor rofecoxib over acetaminophen for pain control in patients undergoing otolaryngologic surgery. |
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http://www.indegene.com/Ort/Home/indOrt_Ind_News_10-10-2002_1.asp
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| | Single dose oral rofecoxib for postoperative pain |
| | The NNT for rofecoxib 50 mg was 2.2 (95% CI 1.9 to 2.4), ie, for every two patients treated with rofecoxib 50 mg, one patient experienced at least 50% pain relief that would not have done had they received placebo. | | | Rofecoxib is believed to be at least as effective as conventional non-steroidal anti-inflammatory drugs (NSAIDs) for postoperative pain. | | | To assess the analgesic efficacy and adverse effects of a single oral dose of rofecoxib for moderate to severe postoperative pain, and to compare its effectiveness with other analgesics used for treating acute pain. |
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http://www.cochrane.org/reviews/en/ab004604.html
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| | Rofecoxib |
| | Rofecoxib is used to treat acute painful conditions, chronic | | | Though no studies have investigated whether rofecoxib increases blood potassium levels, people taking the drug who wish to take supplemental potassium or use salt substitutes should consult with their healthcare practitioner. | | | Individuals who experience water retention, swelling, or increased blood pressure while taking rofecoxib should notify their practitioner. |
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http://www.gianteagle.com/healthnotes/Drug/Rofecoxib.htm
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| | Vioxx Pharmacology, Pharmacokinetics, Studies, Metabolism - Rofecoxib - RxList Monographs |
| | Similar to experience with other nonsteroidal anti-inflammatory drugs (NSAIDs), studies with rofecoxib suggest the potential for interaction with ACE inhibitors. | | | In vitro studies in rat hepatocytes also suggest that rofecoxib might be a mild inducer for CYP 3A4. | | | Drug interaction studies do not support the potential for clinically important interactions between antacids or cimetidine with rofecoxib. |
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http://www.rxlist.com/cgi/generic/rofecox_cp.htm
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| | MedlinePlus Drug Information: Rofecoxib (Systemic) |
| | Rofecoxib is also used to relieve other kinds of pain, such as menstrual cramps, and pain following surgery. | | | However, there is a chance that this medicine may cause unwanted effects on the heart or blood flow of the fetus or newborn baby if it is taken regularly during the last few months of pregnancy. | | | Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing the use of rofecoxib in children with use in older age groups. |
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http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203782.html
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| | Vioxx Side Effects, Interactions and Information - Drugs.com |
| | Rofecoxib should not be taken late in pregnancy (the third trimester) because it may affect the formation of the baby's heart. | | | Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. | | | Your pharmacist has additional information about rofecoxib written for health professionals that you may read. |
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http://vioxx.drugs.com
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| | News - Rofecoxib Not Associated with Increased Risk of Cardiovascular Events or Death |
| | Similar rates of thrombotic events (myocardial infarctions, cerebrovascular accidents, transient ischaemic attacks, angina, deep vein thromboses, and peripheral thromboses) were observed with rofecoxib, placebo, and nonselective NSAIDs (ibuprofen, diclofenac, and nabumetone) in a retrospective analysis of 8 clinical trials consisting of 5435 patients with osteoarthritis. | | | The above results were supported by a pooled analysis of 23 studies (including the VIGOR study) that represented over 14,000 patients years from patients with osteoarthritis, rheumatoid arthritis, Alzheimer's disease, and chronic low back pain. | | | Furthermore, similar risk of cardiovascular, haemorrhagic, and unknown deaths, nonfatal myocardial infarctions, and nonfatal strokes was also found between the groups. |
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http://www.docguide.com/news/content.nsf/news/8525697700573E1885256DC40033EBFF
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| | National Cancer Institute - Celecoxib, Rofecoxib: Cardiovascular Risk |
| | After an average of two-and-a-half years of treatment, 46 out of 1,287 patients taking rofecoxib (3.5 percent) had had a “thrombotic event” (that is, a blood clot, unstable chest pain, a heart attack, a stroke or transient ischemic attack, or sudden cardiac death). | | | By contrast, 26 out of 1,299 patients taking a placebo (2 percent) had had such an event. | | | Some earlier studies had suggested that taking certain COX-2 inhibitors might increase patients’ risk for heart attacks and strokes, while other studies had found no increased risk. |
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http://www.cancer.gov/clinicaltrials/results/cox-inhibitor-trials0205
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| | Rofecoxib (Vioxx) voluntarily withdrawn from market |
| | The study's external safety monitoring board recommended that the trial be halted, but “because of the nature of the events and the availability of other drugs, we decided the right thing was to discontinue [the drug],” said Bertrand. | | | Patients who want to dispose of the drug should bring it to their pharmacy. | | | However, the Vioxx Gastrointestinal Outcomes Research (VIGOR) study, released in March 2000, did indicate an increased risk compared to naproxen. |
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http://www.cmaj.ca/news/30_09_04.shtml
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| | Rofecoxib for rheumatoid arthritis |
| | Rofecoxib was associated with a greater risk for MI, but the exact significance and pathophysiology of this possible relationship is unclear. | | | The reason for the heart problems is not clear at this time. | | | It cannot therefore be prescribed and therefore there are no implications for practice concerning its use. |
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http://www.cochrane.org/reviews/en/ab003685.html
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| | Rofecoxib |
| | If you have an allergy to aspirin, aspirin-like products, another nonsteroidal anti-inflammatory drug (NSAID), rofecoxib, or any other part of the medicine. |
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http://www.umm.edu/altmed/ConsDrugs/Rofecoxibcd.html
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| | Pharmacy Times: Rofecoxib (Vioxx) |
| | Until further study can indicate the safety of rofe-coxib in patients at risk for cardiovascular complications, caution should be employed when rofecoxib is used for the treatment of arthritis. | | | Patients were ³50 years old (or ³40 years old if receiving long-term glucocorticoid therapy) and were expected to require chronic NSAID therapy for ³1 year. | | | However, clinicians should avoid the use of rofecoxib in patients with ischemic heart disease. |
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http://www.pharmacytimes.com/article.cfm?ID=297
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| | ASHP News: Merck Withdraws Rofecoxib From Worldwide Market |
| | Abrupt replacement of rofecoxib with another medication should not pose a problem, he said, except in patients also receiving warfarin therapy. | | | The increased risk of cardiovascular events, according to Merck, was discovered in an analysis of data from patients who had completed three years in the Adenomatous Polyp Prevention on VIOXX study, which sought to determine whether long-term rofecoxib therapy can prevent the recurrence of colorectal adenoma. | | | Patients with a chronic pain disorder, he said, may be candidates for propoxyphene or tramadol at a low dosage. |
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http://www.ashp.org/news/ShowArticle.cfm?cfid=17971017&CFToken=64418711&id=7854
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| | Hotline - Rofecoxib (Vioxx) |
| | Lower extremity edema (3.7%) and hypertension (3.5%) occurred at similar rates in those treated with rofecoxib and with traditional NSAIDs, which was higher than in those taking placebo. | | | Upper endoscopy at 12 weeks revealed comparable incidence of ulcers for placebo (7.3%), rofecoxib 25 mg q.d. | | | Unlike celecoxib, rofecoxib is a sulfone, not a sulfonamide, and should not cause reactions in patients allergic to sulfonamides. |
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http://rheumatology.org/publications/hotline/archive/0799rofecoxib.asp?...
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| | Ranbaxy Discontinues Rofecoxib |
| | All patients who are currently taking Ranbaxy's Rofecoxib formulations should consult their physicians for alternate medications. | | | In quick response, Ranbaxy had earlier issued a statement, advising only short term use of Rofecoxib, whilst data was being reviewed. | | | Ranbaxy Laboratories Limited (Ranbaxy) has decided to discontinue all its Rofecoxib formulations with immediate effect from India. |
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http://www.medicalnewstoday.com/medicalnews.php?newsid=14964&nfid=rssfeeds
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| | Study analyzed Celecoxib (Celebrex) and Rofecoxib (Vioxx) |
| | The VIGOR trial demonstrated a 220 percent increase in cardiovascular event rates with rofecoxib compared with naproxen, but the absolute incidence was low at 1.3 percent and 0.67 percent for the two groups, respectively. | | | Recent clinical studies demonstrate that the coxibs raise blood pressure, which may contribute to the tendency toward increased heart attack risk. | | | established coronary artery disease or are at high risk of coronary obstruction use caution when prescribing the so-called coxib drugs celecoxib (Celebrex) and rofecoxib (Vioxx). |
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http://www.clevelandclinic.org/heartcenter/pub/news/archive/2001/cox2events_8_21.asp
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| | Vioxx - Drugs & Vitamins - Drug Library - DrugDigest |
| | Patients currently taking Rofecoxib should contact their prescriber regarding discontinuation and alternative therapies. | | | Check with your health care professional before stopping or starting any of your medicines. | | | ROFECOXIB (Vioxx®) is a drug used to reduce inflammation and ease mild to moderate pain for such conditions as arthritis, painful menstrual cycles, or pain after dental or surgical procedures. |
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http://www.drugdigest.org/DD/DVH/Uses/0,3915,6278Vioxx,00.html
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| | Rofecoxib - information on Rofecoxib and Cheap prices no prescriptions needed |
| | You're being unfair, Rofecoxib you know Generic Vioxx You're being unreasonable, just like when we were Floxin just like in my dream." Jane pulled her hair back again, sighing deeply, pondering what to say, what she could say to counter Kate's finger-pointing. | | | With a quick movement of Rofecoxib head she threw her Phenergan back and away Rofecoxib dream?" "Because you were crying... | | | She looked Propranolol and gaped at the sight of his erection, and then at the touch of his hands on her bottom. |
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http://www.metformin.biz/Rofecoxib.html
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| | WorstPills.org - Search Results for rofecoxib (VIOXX) |
| | This is the first of a two part series on drug induced psychiatric symptoms that is based on the July 8, 2002 issue of The Medical Letter on Drugs and Therapeutics. | | | Search results below include drug profiles where your selected drug is a primary subject of discussion | | | We list these drugs as Do Not Use drugs because they are no more effective than related drugs, most have not been shown to have a lower rate of ulcers than related drugs and some have been shown to cause heart disease. |
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http://www.worstpills.org/results.cfm?drug_id=713
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| | Rofecoxib: Vioxx litigation information. Who is responsible for Vioxx heart attacks and strokes? |
| | Who is Responsible for Vioxx (Rofecoxib) Heart Attacks and Strokes? | | | The manufacturers of the drugs may have believed that they would be competing with older NSAIDs like Ibuprofen. | | | In fact, the FDA ordered Merck to tone down their advertised claims about the benefits of Vioxx (Rofecoxib), saying that the ads and promotional material for the drug were "false, lacking in fair balance, or otherwise in violation of the Federal Food, Drug, and Cosmetic Act and applicable regulations". |
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http://www.monheit.com/vioxx_celebrex/responsible.shtml
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| | Rofecoxib. Order from the comfort of your home. |
| | The doctors in aspect of body may get near them when accumulated in mind rofecoxib is included. | | | On the subject of the rofecoxib, It is awesome to know these guys who try their best to provide a comprehensive service, all that you need to properly treat your medical problem! | | | The resemblance which in recognizing a public domain in medical schools in preference rofecoxib to win the century, the elder langenbeck, father of body, which, however, if nature but heterogenesis became much so much rofecoxib so long after. |
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http://rofecoxib.themediconline.com
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| | Vioxx Drug Description - Rofecoxib - HealthScout |
| | To find more information on specific conditions, please visit our partner sites: | | | Please be aware that the information below is provided only for reference. | | | VIOXX * (rofecoxib) is described chemically as 4-[ 4-(methylsulfonyl) phenyl]-3-phenyl-2(5H)-furanone. |
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http://www.healthscout.com/rxdetail/1/73/1/main.html
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| | Alzforum: Drugs In Clinical Trials - Rofecoxib |
| | VIOXX is contraindicated in patients with known hypersensitivity to rofecoxib or any other component of VIOXX. | | | VIOXX should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. | | | Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study. |
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http://www.alzforum.org/dis/tre/drc/detail.asp?id=57
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| | Asthma: Use with caution in patients with preexisting asthma. | | | Lithium, methotrexate: Rofecoxib may increase plasma levels of these drugs, which may increase activity and adverse effects. | | | Loop diuretics, thiazide diuretics: Diuretic effects may be decreased. |
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http://www.reutershealth.com/atoz/html/Rofecoxib.htm
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| | Definition of rofecoxib - NCI Dictionary of Cancer Terms |
| | Definition of rofecoxib - NCI Dictionary of Cancer Terms | | | The Nation's Investment in Cancer Research FY 2007 | | | Rofecoxib was taken off the market in the U.S. because of safety concerns. |
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http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=45083
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| | Cardio risks of rofecoxib quantified |
| | Merck withdrew rofecoxib from the worldwide market when clear evidence became available during a colon cancer prevention trial that long-term use of high doses of the drug significantly increased patients’ risk for serious MI or stroke. | | | FDA advisors will have an opportunity to provide input about this and other studies on this drug class. | | | The authors concluded: “Rofecoxib use increases the risk of serious coronary heart disease compared with celecoxib use. |
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http://www.pharmacist.com/articles/h_ts_0719.cfm
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| | Medicine recall - Vioxx (Rofecoxib) |
| | Reason: The company has decided to recall VIOXX based on new information from a recent clinical study which showed that there was an increased risk of cardiovascular events such as heart attack and stroke beginning after 18 months of treatment, in the patients taking Vioxx at a dose of 25 mg once daily. | | | Home > Recalls and alerts > Medicines 2004 > Vioxx (Rofecoxib) | | | VIOXX (Rofecoxib) oral suspension 25mg/5mL (AUST R 69869) |
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http://www.tga.gov.au/recalls/2004/vioxx.htm
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