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| Â | The Body: Project Inform -- Ritonavir Fact Sheet |
 | | Ritonavir is known to interact with many anti-HIV therapies and other drugs. | | | Ritonavir's potent anti-HIV activity makes it a good option for first-line therapy with other anti-HIV drugs, but its side effects and drug interactions may make it a less desirable option in this regard. | | | Ritonavir is able to increase the levels of other drugs, including other PIs, in the blood. |
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http://www.thebody.com/pinf/ritonavir.html
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| Â | MedlinePlus Drug Information: Ritonavir (Systemic) |
| | Ritonavir can be used in combination with other medicines. | | | Ritonavir will not keep you from spreading HIV to other people. | | | Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. |
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http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203528.html
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| Â | Aidsmap Ritonavir - overview |
| | Ritonavir affects the working of many other medications and recreational drugs. | | | The cholesterol-lowering drugs simvastatin ( Zocor) and lovastatin should not be co-administered with ritonavir, although atorvastatin ( Lipitor) can be used with caution. | | | Interestingly, the latter study showed equivalent effectiveness in patients treated with ritonavir plus AZT and those treated with ritonavir alone, over 48 weeks. |
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http://www.aidsmap.com/treatments/ixdata/english/3D08FB32-E5C7-4F0B-BAF8-502290079BDE.htm
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| Â | CATIE Fact Sheet : Ritonavir (Norvir) |
| | Ritonavir is known to have strong interactions with many other drugs (both prescription and non-prescription). | | | A review of low-dose ritonavir in protease inhibitor combination therapy. | | | Ritonavir is available with a prescription and is covered by all provincial formularies. |
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http://www.catie.ca/facts.nsf/9a83231f2055bda9852566b90004b064/8cc975c250db9b5b852566b90005748d?OpenDocument
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| Â | Simple Facts Sheets: ritonavir |
| | Drug interactions: Ritonavir can effect the way other drugs are absorbed by the body. | | | It is very important that anyone about to start taking ritonavir goes over all the medications they are taking with their healthcare provider. | | | These are the drugs that should NOT be co-administered with ritonavir: amiodarone, astemizole, bepridil, cisapride, flecainide, midazolam, propafenone, pimozide, quinidine, terfenadine, triazolam and a class of migraine drugs called ergot derivatives. |
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http://www.atdn.org/simple/riton.html
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| Â | Abstract 338 - Durability of Salvage Therapy with Saquinavir SGC (SQV) in Combination with Ritonavir (RTV) or ... |
| | Abstract 338 - Durability of Salvage Therapy with Saquinavir SGC (SQV) in Combination with Ritonavir (RTV) or Nelfinavir (NFV) plus Delavirdine (DLV), Adefovir Dipivoxil (ADV), or Both- --ACTG 359: 48-Week Final Results. | | | 338 Durability of Salvage Therapy with Saquinavir SGC (SQV) in Combination with Ritonavir (RTV) or Nelfinavir (NFV) plus Delavirdine (DLV), Adefovir Dipivoxil (ADV), or Both- —ACTG 359: 48-Week Final Results. |
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http://www.retroconference.org/2001/abstracts/abstracts/abstracts/338.htm
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| Â | MedlinePlus Drug Information: Ritonavir |
| | Ritonavir does not prevent the spread of HIV to other people. | | | This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. | | | Your doctor will order certain lab tests to check your response to ritonavir. |
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http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a696029.html
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| Â | Ritonavir Price Hike Materials |
| | The HIV Medicine Association (HIVMA) today called on Abbott Laboratories to rescind its recent 500 percent price hike of ritonavir (Norvir®), a drug necessary to the success of virtually all protease inhibitor combinations for treating HIV infection. | | | We are writing on behalf of the Board of Directors of the HIV Medicine Association to urge you to reconsider the recent 500 percent price increase of ritonavir (Norvir®), a drug which as you know is necessary to the success of virtually all protease inhibitor combinations for the treatment of HIV infection. | | | In addition to our particular concern about the price increase for ritonavir, we are generally concerned about continuing upward pressure on prices as each new HIV drug is approved. |
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http://www.atac-usa.org/Abbott%20price%20hike.html
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| Â | RITONAVIR |
| | Prescribers are advised that combinations with other nucleoside analogues should be guided by cautious therapeutic and safety monitoring. | | | Prolongation of Life and Prevention of AIDS in Advanced HIV Immunodeficiency with Ritonavir. | | | Hypertriglyceridaemia, hypercholesterolaemia and hyperuricaemia have also been clearly related to ritonavir therapy. |
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http://www.keele.ac.uk/depts/mm/MTRAC/ProductInfo/summaries/R/RITONAVIRs.html
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| Â | Ritonavir (Norvir) |
| | The addition of low-dose ritonavir may boost amprenavir( 3), atazanavir ( 4), fosamprenavir ( 5), or saquinavir ( 6) to therapeutic levels when any of these protease inhibitors is used in combination with efavirenz. | | | Ritonavir interacts with many other medications; dose adjustment of certain interacting medications is recommended when they are combined with ritonavir. | | | Pharmacokinetics of the Triple Combination of Saquinavir, Ritonavir, and Efavirenz in HIV-Positive Patients. |
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http://hivinsite.ucsf.edu/InSite.jsp?page=ar-drugs&doc=ar-03-02
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| Â | Aidsmap Ritonavir liquid |
| | The information in this Factsheet is based on current knowledge and practice and does not necessarily reflect the views of Abbott Laboratories. | | | Both preparations are equally effective and have similar potential side-effects and drug interactions. | | | Don’t forget to read the manufacturer’s information for patients on ritonavir liquid and to discuss this Factsheet with your doctor. |
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http://www.aidsmap.com/publications/factsheets/fs27.htm
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| Â | 450-W. The Interim Analysis of a Phase IV Randomised, Open-Label, Multicentre Trial to Evaluate Safety and Efficacy of ... |
| | Conclusions: In the interim analysis at 24 weeks of this randomised trial no differences were observed in virological or immunological response to the 2 ritonavir -boosted study PIs nor in the proportion of patients with grade 3/4 AEs. | | | Background: The MaxCmin1 trial is the first head-to-head comparison of ritonavir (r)-boosted PI treatments. | | | No changes are warranted in the conduct of the trial following the Data and Safety Monitoring Board’s evaluation of the week 24 data. |
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http://63.126.3.84/2002/Abstract/12784.htm
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| Â | 794-W. Pharmacokinetic and Virologic Response to Ritonavir (RTV) in Combination with Zidovudine (ZDV) and Lamivudine ... |
| | Background: Final results from an open-label, dose-finding phase 1 study of RTV in combination with ZDV/3TC in pregnant women and their infants are presented. | | | 794-W. Pharmacokinetic and Virologic Response to Ritonavir (RTV) in Combination with Zidovudine (ZDV) and Lamivudine (3TC) in HIV-1 Infected Pregnant Women and Their Infants | | | Women developed increased viral load in the 12 weeks PP, but with no detectable primary resistance mutations to RTV. |
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http://63.126.3.84/2002/Abstract/13702.htm
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| Â | RITONAVIR a Commonly Used Medication |
| | The following drugs may have 3-fold increases if given with ritonavir; use with caution: alfentanil, amlodipine, carbamezepine, clonazepam, coumadin, cyclosporine, dexamethasone, diltiazem, disopyramide, dronabinol, erythromycin, ethosuximide, etoposide, fentanyl, felodipine, isradipine, lidocaine, lovastatin, nefazodone, nicardipine, nifedipine, nimodipine, nisoldipine, ondansetron, paclitaxel, pravastatin, prednisone, quinine, sertraline, tamoxifen, trazodone, verapamil, vinblastine, vincristine. | | | The following drugs have 1.5-3-fold increases when given with ritonavir: amitriptyline, chlorpromazine, clomipramine, desipramine, fluoxetine, haloperidol, hydrocodone, imipramine, maprotiline, methamphetamine, metoprolol, mexiletine, nortriptyline, oxycodone, paroxetine, perphenazine, pindolol, propranolol, risperidone, thioridazine, timolol, tramadol, venlafaxine. |
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http://www.hivdent.org/drugs/RITONAVIR.htm
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| Â | Ritonavir; Norvir®; ABT-538 |
| | Ritonavir is also a potent inhibitor of a primary liver drug metabolizing enzyme, CYP-3A4. | | | *Isolate from patient after 21 days of ritonavir therapy; first mutation seen was at position 82 in 20/21 patients; sequence from pcr population sequencing of plasma viral rna; wild type pr assumed at pretreatment. | | | ^Isolate from patient after 200 days of ritonavir therapy; first mutation seen was at position 82 in 20/21 patients; sequence from pcr population sequencing of plasma viral rna; mixtures denoted by /; wild type pr assumed at pretreatment. |
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http://www.niaid.nih.gov/daids/dtpdb/028478.htm
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| Â | Ritonavir (Norvir®) |
| | KALETRA® is a combination of two antiretroviral drugs: LOPINAVIR and RITONAVIR. | | | For questions about KALETRA ®, please contact the clinic pharmacist at 234-2388. | | | Both of these agents belong to the class of drugs called “protease inhibitors” or “PIs”. |
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http://www.crha-health.ab.ca/clin/sac/ritonavi.htm
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| Â | Norvir Online, Description, Chemistry, Ingredients - Ritonavir - RxList Monographs |
| | NORVIR (ritonavir) is an inhibitor of HIV protease with activity against the Human Immunodeficiency Virus (HIV). | | | RxList only refers patients to online pharmacies certified by VIPPS, Verified Internet Pharmacy Practice Sites, a program administered by the National Association of Boards of Pharmacy which ensures that member pharmacies offering online prescription services are bona fide, fully licensed, and demonstrate "competent Internet/interstate pharmacy practices." | | | Get the latest health information from leading experts, delivered direct to your email box! |
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http://www.rxlist.com/cgi/generic2/ritonavirsol.htm
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| Â | Ritonavir price hike – the protests continue Treatment HIV Life Gay.com UK |
| | They also applied to the government for a licence to manufacture generic versions of ritonavir and a Pfizer drug they also regard as overpriced, under the WTO agreement that allows companies to make their own versions of patented drugs in a public health emergency. | | | Abbott did not increase the price of its other protease inhibitor (PI) Kaletra ®, which contains ritonavir, leading to accusations it is trying to corner the market and crowd out competitors such as Roche’s saquinavir, which has just been licensed to be dosed with ritonavir. | | | Protests from doctors and Aids activists continue to mount in the US over the fivefold increase in the price of the HIV drug Norvir ® (ritonavir) made by Abbott Laboratories. |
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http://uk.gay.com/article/hiv/treatment/2449
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| Â | Lopinavir + Ritonavir (Kaletra) |
| | The ritonavir component of lopinavir/r is a potent inhibitor of cytochrome P450 3A (CYP3A) and CYP2D6, as well as an inducer of other hepatic enzyme systems. | | | Approval was based on a study( 1) showing comparable rates of viral suppression at 24 weeks of initial treatment in individuals receiving lopinavir/r + stavudine + lamivudine compared with those receiving nelfinavir + stavudine + lamivudine. | | | The co-formulation of lopinavir + ritonavir (lopinavir/r) received FDA approval in 2000 for treatment of HIV in adults and children age 6 months or older. |
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http://hivinsite.ucsf.edu/InSite.jsp?page=ar-drugs&doc=ar-03-06
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| Â | PUBPAT News > PUBPAT Testifies to NIH Regarding Key AIDS Drug Patents |
| | If they are not, the government may "march-in" by exercising a license on any resulting patent rights so that the results of publicly funded research are made available to the public. | | | Essential Inventions, the consumer group that filed the request, argues that Abbott's raising of the per capsule price of Norvir from $1.71 to $8.57 was unreasonable and that the government should exercise its Bayh-Doyle march-in rights so that generic pharmaceutical companies can make a ritonavir capsule without being threatened by Abbott's patents. | | | "We have accepted the NIH's invitation to testify during the ritonavir march-in hearing in order to ensure that a clear analysis of the patent issues relevant to the march-in request are presented," said Mr. |
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http://www.pubpat.org/NIH_Ritonavir_Testimony.htm
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| Â | Simple Facts Sheets: lopinavir (Kaletra) |
| | If you're taking Kaletra at the recommended dose, it's important to know that you'll also be taking a total of 200mg of Norvir each day. | | | The standard dose of Kaletra is three pills taken twice a day with food. | | | Each Kaletra pill contains 133mg of Kaletra and 33mg of the protease inhibitor Norvir (ritonavir). |
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http://www.atdn.org/simple/lopi.html
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