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| | Riluzole, L3 |
 | | The deterioration of muscle strength and functional ability was significantly slower in the riluzole group than in the placebo group. | | | Discontinuation of treatment resulted in worsened chorea, indicating that riluzole was indeed associated with the improved chorea. | | | A secondary test used to examine the drug’s effectiveness was change in muscle strength. |
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http://www.stanford.edu/group/hopes/treatmts/antiglut/l3.html
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| | Rilutek , SPC from the eMC |
| | In rats, riluzole decreased the pregnancy rate and the number of implantations at exposure levels at least twice the systemic exposure of humans given clinical therapy. | | | On the basis of these data, and taking into consideration the negative studies on the carcinogenesis of riluzole in the mouse and rat, the genotoxic effect of this metabolite is not considered to be of relevance in humans. | | | Survival, as defined in the second paragraph of section 4.1, was significantly extended for patients who received riluzole as compared to patients who received placebo. |
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http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=1672
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| | Treatment of Patients with ALS: Implications for the Managed Care Pharmacist |
| | The provision of riluzole, palliative medications, and supportive care, combined with the ethical issues of mechanical ventilation and end-of-life planning, are aspects of ALS treatment to which the pharmacist and the other members of the team apply their knowledge and experience to improve patient outcomes and quality of life. | | | Participation in the optimal management of patients with ALS by encouraging early riluzole therapy and applying other pharmacotherapeutic principles is an example of how pharmacists can be proactive, aggressive, and clinically adept in meeting these challenges. | | | Most of the drugs used to treat cancer are tested in clinical trials that use survival as a primary endpoint, because surrogate markers for incurable chronic conditions are suboptimal for monitoring purposes. |
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http://www.amcp.org/data/jmcp/vol4/num6/treatment.html
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| | Bibliography: Rhone-Poulenc Rorer & Basal Gang |
| | Riluzole effect on post -traumatic spinal cord injury in the rat. | | | This study evaluated treatment with riluzole, a neuroprotective agent, following thoracic spinal cord compression in the rat. | | | Morphological studies revealed significant (53%) reduction in the degree of spinal cord infarcted after riluzole treatment. |
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http://www.sm.u-bordeaux2.fr/gross/biblio/bibrp.html
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| | PROCEEDINGS ON RILUTEK (RILUZOLE) Conference Transcript - MDA Ask the Experts |
| | First: Will be Riluzole therapy with other therapies in the future? | | | A little more than five years ago, when Rhone-Poulenc Rorer began investigating whether its novel compound, then known within the neurological community as riluzole, might be useful in ALS, experts in the medical community were already amassing a convincing body of evidence linking a buildup in glutamate, at least in part, to ALS. | | | That same hard work and persistence by so many people has brought us where we are today, introducing Rilutek, which represents an important step forward in the understanding and treatment of ALS. |
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http://www.mdausa.org/experts/tr-alsrpr.html
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| | Riluzole for Motor Neurone Disease - full guidance (html) |
| | 5.3 In the latter stages of their disease, patients may wish to review their continued use of riluzole and they should be provided with the opportunity to discontinue treatment, if after discussion with the responsible clinician, they consider it appropriate. | | | This guidance does not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patient, in consultation with the patient and/or guardian or carer. | | | Motor Neurone Disease (MND) is the name given to a group of diseases that affect the motor neurones in the brain and spinal cord. |
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http://www.nice.org.uk/page.aspx?o=14490
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| | Altered Expression and Uptake Activity of Spinal Glutamate Transporters after Nerve Injury Contribute to the ... |
| | Note that the effects of riluzole on thermal hyperalgesia and mechanical allodynia lasted at least several days after its discontinuation on postoperative day 5, indicating a significant role of regulating GT uptake activity in the development of neuropathic pain behaviors in CCI rats. | | | Effects of riluzole on the induction of neuropathic pain behaviors | | | Hammer NA, Lilleso J, Pedersen JL, Kehlet H (1999) Effect of riluzole on acute pain and hyperalgesia in humans. |
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http://www.jneurosci.org/cgi/content/full/23/7/2899
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| | Riluzole (Systemic) |
| | Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of riluzole in children with use in other age groups. | | | In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. | | | Tell your doctor and pharmacist if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. |
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http://allnutritionals.com/drugs/r/riluzole-systemic.shtml
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| | Rilutek - Drugs & Vitamins - Drug Library - DrugDigest |
| | Cigarette smoke can affect the amount of riluzole in your body. | | | Ask your prescriber or health care professional for ways to help you stop smoking or drinking. | | | Check with your health care professional before stopping or starting any of your medicines. |
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http://www.drugdigest.org/DD/DVH/Uses/0,3915,594Rilutek,00.html
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| | Drug Directory: Riluzole |
| | Riluzole affects muscles and nerves in the body. | | | Your doctor may want you to have blood tests during treatment with riluzole. | | | Your pharmacist has additional information about riluzole written for health professionals that you may read. |
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http://netpediatrics.com/drugs/r-17.htm
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| | Riluzole |
| | The deterioration of the muscles governing crucial body functions--especially swallowing and breathing--eventually proves fatal. | | | Consult your doctor for specific advice if you are taking any other prescription or over-the-counter medication. | | | Do not drive or engage in hazardous work until you determine how this medication affects you. |
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http://www.wholehealthmd.com/print/view/1,1560,DR_546,00.html
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| | MedlinePlus Drug Information: Riluzole |
| | tell your doctor and pharmacist if you are allergic to riluzole or any other drugs. | | | This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. | | | Your doctor will order certain lab tests to check your response to riluzole. |
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http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a696013.html
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| | Families of SMA: Riluzole and SMA |
| | A Phase I therapeutic trial should be first carried out to determine whether riluzole is well tolerated in infants. | | | "Our goal was to know whether riluzole, a drug able to protect neurons, might have a therapeutic benefit in SMA. | | | No significant improvement of motor behavior was however observed. |
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http://www.fsma.org/melki2003-2.shtml
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| | The Use of Riluzole in the Treatment of Amyotrophic Lateral Sclerosis (Motor Neurone Disease) |
| | However, further work should be undertaken to identify sub-groups of patients who would benefit significantly from treatment, either on the basis of a further analysis of the clinical trial data, or from other on-going primary research. | | | Prior to the introduction of riluzole, only symptomatic and supportive care has been available. | | | The cost of treatment is about £3,700 per patient year. |
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http://www.shef.ac.uk/uni/academic/R-Z/tiwgap/summs/GN9703.htm
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| | Riluzole appears to minimally improve survival in ALS |
| | The patient has read about anti-glutamatergic and anti-excitotoxicity therapy and wishes to pursue this avenue. | | | Paper 2 : A 155 patient 12 month multicentred double-blinded placebo-controlled trial of riluzole 100mg/day. | | | Riluzole does not appear to slow rate of decline of patient functional assessments |
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http://www.uwo.ca/cns/ebn/CATs/nm-als-therapy.htm
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| | riluzole |
| | The imaging will allow researchers to see the condition of the nerve terminals in the brain that release dopamine. | | | Early-stage patients taking L-dopa or other Parkinson's drugs can be considered for the study if they stop their medication one month prior to entering the study. | | | In a pilot study at Baylor, riluzole appeared to be well tolerated by Parkinson's patients. |
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http://www.bcm.edu/pa/riluzole.htm
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| | FDA APPROVES FIRST DRUG FOR LOU GEHRIG'S DISEASE |
| | "This is a modest effect, but before riluzole there was no therapy for ALS at all," the Secretary said. | | | Adverse effects of riluzole observed in clinical tests include weakness, nausea, vomiting and elevated liver enzymes. | | | Commenting on the approval, Secretary of Health and Human Services Donna E. Shalala noted that when tested in two placebo- controlled studies on more than 1,000 patients, riluzole prolonged survival on average by about three months. |
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http://www.fda.gov/bbs/topics/NEWS/NEW00522.html
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| | RILUZOLE (By mouth) |
| | Your doctor will tell you how much medicine to use and how often. | | | There may be other brand names for this medicine. | | | You should not use this medicine if you have had an allergic reaction to riluzole. |
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http://www.medformation.com/ac/mm_qd.nsf/qd/dnx0873.htm
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| | Weeks of June 14, 21 and 28, 1998 |
| | While a cure for this devastating disease seems distant, the hope is that eventually a combination of drugs will be effective in halting the progression of the condition. | | | It is being studied both as single treatment and in combination with an existing medication for ALS, riluzole. | | | The other, known at this point by its experimental compound designation SR57746A, appears to enhance the body's nerve growth factors, thereby theoretically improving the survival of the remaining motor neurons and promoting nerve cell regeneration. |
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http://www.breakthroughtv.com/program19.htm
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| | The ALS Newsletter 4-3 MDA |
| | The article, however, became a "shot heard 'round the world!" ALS Web sites and on-line publications quickly picked up the story, alarming readers with messages such as "Anyone taking riluzole should be aware of the following" and "ALS Medical Alert," followed by a summary of the French story. | | | Williams said RPR is well aware of the drug's potential to cause liver damage and that this is reflected in the labeling for the drug, which all physicians should have. | | | In reality, Rhone-Poulenc Rorer, maker of riluzole (brand name Rilutek), and most doctors who prescribe it for people with ALS, have been aware of riluzole's potential to cause liver damage ever since the drug was first approved by the Food and Drug Administration in late 1995. |
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http://www.mdausa.org/publications/als/als4_3.html
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| | Hereditary Disease Foundation Riluzole Dosing in HD (RID HD) |
| | The RID-HD study is currently enrolling subjects who have early HD at sites in the US and Canada. | | | The Riluzole Dosing in HD (RID-HD) study is designed to access riluzole's short term impact on motor, cognitive and behavioral symptoms of HD and to gather information on the safety and tolerability of Riluzole. | | | Hereditary Disease Foundation Riluzole Dosing in HD (RID HD) |
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http://www.hdfoundation.org/clinical/rid.html
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| | publications |
| | Kalra S, Cashman N, Genge A, Arnold DL: Recovery of N-acetylaspartate in Corticomotor Neurons of Patients with ALS after Riluzole Therapy. |
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http://www.mrs.mni.mcgill.ca/mrs/publications.html
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| | Riluzole |
| | Riluzole - Familydoctor.org - Information for patients in English and Spanish. |
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http://www.iseekhealth.com/pharmacy/riluzole-5715.htm
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| | Neurosciences Report - Riluzole |
| | Researchers at the Maxine Dunitz Neurosurgical Institute are performing preclinical studies on the effect of Riluzole in an animal xenograft GBM model. | | | The MDNSI team is developing a clinical protocol to administer Riluzole to patients with recurrent GBM and anaplastic astrocytoma (AA) to determine its effects on tumor growth and survival among patients with AA or GBM. | | | One such glutamate antagonist candidate for brain tumor treatment is Riluzole, which has been approved by the U.S. Food and Drug Administration for the treatment of amyotrophic lateral sclerosis (ALS), that acts by inhibiting voltage-activated sodium channel to block glutamate release. |
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http://www.csmc.edu/3987.html
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| | MSN Encarta - Search Results - riluzole |
| | Two medications may provide some relief to people with ALS. | | | In 1995 the Food and Drug Administration (FDA) approved riluzole, the first drug shown to... | | | Search Amazon.com for books about your topic, "riluzole" |
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http://encarta.msn.com/riluzole.html
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| | Re: riluzole |
| | Riluzole is a new treatment that was recently approved by the FDA for the treatment of some forms of Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig's disease). | | | It has been shown to delay the deterioration of the neurological condition due to the ALS process. | | | : If they have not ruled out ALS, possibly Lymes disease, would riluzole be a proper medication to try? |
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http://www.medhelp.org/perl6/neuro/archive/4803.html
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| | e-solutions for health - The Health Network Company © 2003 |
| | Several therapeutic agents have recently been tested in clinical trials in patients with ALS. | | | Anti-glutamate agents - Riluzole, which is a sodium channel blocker that inhibits the release of glutamate and has several other potentially neuro-protective effects; it had a modest effect in prolonging survival of patients. | | | Antioxidant agents - no significant positive effects have been found. |
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http://www.thnc.com/healthguide/article.asp?id=173
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| | MedlinePlus Medical Encyclopedia: Amyotrophic lateral sclerosis |
| | Blood tests can exclude other conditions that may cause similar symptoms. | | | Riluzole may prolong life, but does not reverse or stop disease progression. | | | Baclofen or diazepam may be used to control spasticity that interferes with activities of daily living. |
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http://www.nlm.nih.gov/medlineplus/ency/article/000688.htm
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| | Riluzole Dosage, Interactions, Side Effects, How to Use |
| | Clearance of riluzole in Japanese clients is 50% lower compared with Caucasians; clearance may also be lower in women. | | | Use with caution in the elderly, as age-related changes in renal and hepatic function may cause a decreased clearance. | | | Safety and efficacy have not been determined in children. |
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http://www.healthdigest.org/drugs/nursing/riluzole.php
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| | Riluzole |
| | Riluzole and she has been feeling much better over the past 4 months no more nausea etc. I was | | | wondering if anyone else was experiencing these symptoms of nausea who are on the Riluzole | | | I have only been taking it for 2 months and have had no nausea but some gas and indigestion. |
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http://www.als.ca/_forum/alstopic.php?t=158
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| | Rilutek ALS Info: Rilutek® Fact Sheet |
| | Now that you and your physician have chosen Rilutek® (Riluzole) Tablets, you may have some questions about your treatment. | | | Although researchers don’t fully understand how Rilutek works, one explanation is that Rilutek may protect nerve cells from overexposure to glutamate. | | | For any questions about Rilutek that are not answered here, contact the Aventis Pharmaceuticals Drug Information Center at (610)454-8110 or 1 (800) 340-7502. |
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http://www.alsinfo.com/patients/RilutekPatientFactSheet.jsp
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| | riluzole |
| | I think that my question would be concerning riluzole, That if no diagnosis can be obtained confirming ALS, but the symptoms are prevelant; fisiculations, weakness, etc., why can't a gp prescribe the medication; or can they?? | | | When drug are released by the FDA they are to be used for specific disease entities. |
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http://www.medhelp.org/perl6/neuro/archive/4873.html
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| | API Synonym... RILUZOLE |
| | Compare Internet Pharmacies - We recommend that you check with each pharmacy to see if they do business in your country and state. | | | If you do not see the VIPPS seal, contact the pharmacy and ask if they are taking steps to receive the VIPPS certification. | | | Riluzole Tablets, 50 mg, Impax, ANDA 76-173 7/17/02 Riluzole Tablets, 50 mg, Impax, ANDA 76-173 |
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http://www.betterchem.com/drugs/RILUZOLE
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| | [Brainlife] Riluzole |
| | , PhD, and Asha Das, MD Riluzole: A Potent Anti-Brain Tumor Agent? | | | Summer 2003 issue of Neurosciences Report (Review Article, HTML Full Text) |
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http://www.brainlife.org/treatment/riluzole.htm
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