Retrovirus - Medicow
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Topic: Retrovirus



  
 The 7th Retrovirus Conference
At last year's retrovirus meeting the concept of a structured (strategic) treatment interruption (STI) was presented with much fanfare and misunderstanding.
Moreover, the fact that these complications will occur in so many of our patients is making many physicians much more conservative in deciding when to advocate starting therapy.
Further information regarding "legal drug holidays" was presented and the controversy continues.
http://www.positiveconnections.org/corkys.htm   (1133 words)

  
 The Islet Foundation - Expression of PERV by porcine endothelial cells
If transmission of PERV does occur clinically, two outcomes are possible--either the retrovirus is pathogenic but is restricted to the recipient or the virus (pathogenic or not) could infect people not participating in the xenotransplantation process.
describing the infection of human cells by a pig endogenous retrovirus (PERV) has focused attention on the fact that careful monitoring of porcine xenotransplant recipients will be necessary.
The findings, say the researchers, suggest "a serious risk of retrovirus transfer after xenotransplantaion".
http://www.islet.org/41.htm   (9153 words)

  
 Integration by Design: Potential deleterious retrovirus insertions fueled investigation into the mechanism of insertuin ...
Observation of highly specific integration in yeast helped to motivate a series of experiments to confer novel insertion specificities on retrovirus IN proteins (reviewed in refs.
What are the lessons that could be applied to better laboratory retrovirus vectors, or even make safer therapeutic vectors?
The relatively global distribution of retrovirus integration sites stands in interesting contrast to the distinctive
http://www.euchromatin.net/Sandmeyer01.htm   (2557 words)

  
 retrovirus on Encyclopedia.com
RETROVIRUS MEETING: Gut Assumes Sinister New Role in HIV Pathogenesis
Let HighBeam Research help you refine your search
Mymetics' Potent In Vitro AIDS Therapy Research Results to Be Presented at 10th Conference on Retroviruses and Opportunistic Infections.
http://www.encyclopedia.com/html/r1/retrov.asp   (365 words)

  
 Retrovirus - Wikipedia, the free encyclopedia
This enables the virus to grow resistant to antiviral pharmaceuticals quickly, and impedes, for example, the development of an effective vaccine against HIV.
A retrovirus is a virus which has a genome consisting of two RNA molecules, which may or may not be identical.
The term "retro" in retrovirus refers to this reversal of the central dogma of molecular biology.
http://en.wikipedia.org/wiki/Retrovirus   (619 words)

  
 Antibodies to a Retrovirus Etiologically Associated with Acquired Immunodeficiency Syndrome (AIDS) in Populations with ...
A morphologically similar T-lymphotropic retrovirus (HTLV-III) was isolated from lymphocytes of 26 (36%) of 72 patients with AIDS and from 18 (86%) of 21 patients with conditions thought to be related to AIDS (2).
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).
Antibodies to a Retrovirus Etiologically Associated with Acquired Immunodeficiency Syndrome (AIDS) in Populations with Increased Incidences of the Syndrome
http://www.cdc.gov/mmwr/preview/mmwrhtml/00000368.htm   (1272 words)

  
 HIV & AIDS - The HIV Virus - LGBT Health Channel - Retrovirus
HIV & AIDS - The HIV Virus - LGBT Health Channel - Retrovirus
We subscribe to the HONcode principles of the Health On the Net Foundation
RNA is a variation of DNA, which comprises the molecular make-up of most cells' genetic material.
http://www.gayhealthchannel.com/hivaids/virus.shtml   (459 words)

  
 Identification of receptors for pig endogenous retrovirus -- Ericsson et al. 100 (11): 6759 -- Proceedings of the ...
Evidence and Consequence of Porcine Endogenous Retrovirus Recombination
of porcine endogenous retrovirus (PERV) is a major concern
Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice
http://www.pnas.org/cgi/content/abstract/100/11/6759   (652 words)

  
 retrovirus - definition of retrovirus in Encyclopedia
That is one of the main reasons why an effective vaccine for HIV has not been developed yet.
A retrovirus' genome integrated into the host's genome is called a provirus.
A retrovirus is a virus which has a genome consisting of RNA.
http://encyclopedia.laborlawtalk.com/retrovirus   (334 words)

  
 Retrovirus-Associated Heparan Sulfate Mediates Immobilization and Gene Transfer on Recombinant Fibronectin -- Lei et ...
Although the mechanism for this behavior is not known, arguments
An enzyme-linked immunosorbent assay (ELISA) for the matrix
Serum and conditioned medium do not promote retrovirus binding to FN.
http://jvi.asm.org/cgi/content/full/76/17/8722   (4913 words)

  
 Endogenous retrovirus - Wikipedia, the free encyclopedia
This family termed, HERV-K(HML2), is one of the most studied and there are indications it has even been active in the past few hundred thousand years, as some human individuals carry more copies of the virus family than others.
"The viruses in all of us: Characteristics and biological significance of human endogenous retrovirus sequences" Proceedings of the National Academy of Sciences.
Seifarth W, Frank O, Zeilfelder U, Spiess B, Greenwood AD, Hehlmann R, Leib-Mosch C. "Comprehensive analysis of human endogenous retrovirus transcriptional activity in human tissues with a retrovirus-specific microarray." Journal of Virology.
http://en.wikipedia.org/wiki/Endogenous_retrovirus   (401 words)

  
 Policy for Retrovirus Vector Research
For a review of retrovirus vectors see Gilboa et al (1986) Bio Techniques 4 504-512.
However, there are potential problems, which with care and education can be eliminated.
The hazard is not great, but individuals working with such vectors should be well educated in the use of such vectors.
http://www.fau.edu/divdept/biology/biosafety/retroviruses.html   (1026 words)

  
 Guidance for Industry - Supplemental Guidance on Testing for Replication Competent Retrovirus in Retroviral Vector ...
Evaluation of PCR and ELISA Assays for screening clinical trial subjects for replication-competent retrovirus.
Supplemental Guidance on Testing for Replication Competent Retrovirus in Retroviral Vector Based Gene Therapy Products and During Follow-up of Patients in Clinical Trials Using Retroviral Vectors
This guidance document applies to the manufacture of gene therapy retroviral vector products intended for in vivo or ex vivo use and to follow-up monitoring of patients who have received retroviral vector products.
http://www.fda.gov/cber/gdlns/retrogt1000.htm   (3713 words)

  
 Retrovirus receptors -- Sommerfelt 80 (12): 3049 -- Journal of General Virology
retrovirus that should be classified with emphasis on naming
In common with studies of other retrovirus receptors approaches
epitope of simian retrovirus serotype 1 (SRV-1), a molecule
http://vir.sgmjournals.org/cgi/content/full/80/12/3049   (8211 words)

  
 Center for Retrovirus Research OSU College of Veterinary Medicine
You are here: Home » Research » Center for Retrovirus Research
The center's mission is to facilitate interdisciplinary investigations of problems relating to prevention and treatment of retrovirus diseases of animals and man.
Retrovirus pathogenesis and prevention of infection or disease
http://www.vet.ohio-state.edu/retro.htm   (189 words)

  
 Structural analysis of membrane-bound retrovirus capsid proteins
Unfortunately, these approaches have proven difficult, since the virions do not crystallize, preparations do not appear homogeneous, and it is unclear whether mature or immature virus cores have helical or icosohedral symmetry, which would be a great help in image reconstruction (Choi et al., 1991; Fuller et al., 1995, 1996).
Ordinarily, retrovirus structure analysis might proceed by X-ray diffraction analysis of 3D crystals of virus, or by electron microscopy (EM) and image analysis of homogeneous preparations of virus particles.
We prefer the latter (ii) pathway, because purified HIV and M-MuLV capsid proteins form stable dimers in solution, and retrovirus Gag cross-linking studies have revealed dimers, tetramers and higher-order oligomers, but a relative lack of the trimers (Ehrlich et al., 1992; Hansen and Barklis, 1995) that would be expected from pathway (i).
http://www.nature.com/cgi-taf/DynaPage.taf?file=/emboj/journal/v16/n6/full/7590112a.html   (10333 words)

  
 iDevGames - Contest - Downloads - Viewing Retrovirus
Also, it would be way sweeter if the whole background and everything rotated when you rotated.
iDevGames - Contest - Downloads - Viewing Retrovirus
The more time left remaining and the bigger you combos the more points and stars you'll earn.
http://www.idevgames.com/contest/downloads/details.php?file=27   (251 words)

  
 Retroviruses
1981: Human T-cell leukaemia virus discovered, the first pathogenic human retrovirus.
~11% of the mammalian genome is composed of retrovirus-like retrotransposons: "transposable elements in which transposition involves a process of reverse transcription with an RNA intermediate similar to that of a retrovirus".
There is considerable diversity between various types of retrovirus; the following is a generalized description of the particle.
http://www-micro.msb.le.ac.uk/3035/Retroviruses.html   (2206 words)

  
 Alveolar Type II Cells Expressing Jaagsiekte Sheep Retrovirus Capsid Protein and Surfactant Proteins Are the ...
DeMartini JC, Rosadio RH, Sharp JM, Russell HI, Lairmore MD: Experimental coinduction of type D retrovirus-associated pulmonary carcinoma and lentivirus-associated lymphoid interstitial pneumonia in lambs.
Analysis of Integration Sites of Jaagsiekte Sheep Retrovirus in Ovine Pulmonary Adenocarcinoma
Palmarini M, Sharp JM, De las Heras M, Fan H: Jaagsiekte sheep retrovirus is necessary and sufficient to induce a contagious lung cancer in sheep.
http://www.vetpathology.org/cgi/content/full/39/3/341   (4494 words)

  
 Evidence of Retrovirus in Blood of ALS Patients - The ALS Association
Evidence of Retrovirus in Blood of ALS Patients
Evidence of Retrovirus in Blood of ALS Patients - The ALS Association
[QUICK SUMMARY: Footprints of Retrovirus Found in ALS Patient Samples Leaves Researchers Unsure of Role of Retrovirus in the Disease]
http://www.alsa.org/news/article.cfm?id=610&CFID=544070&CFTOKEN=43868217   (668 words)

  
 Improved Amphotropic Retrovirus-Mediated Gene Transfer into Hematopoietic Stem Cells -- BODINE et al. 850 (1): 139 -- ...
HSC or retroviruses will be required for human gene therapy
that retrovirus transduction of HSC correlates with ampho R
The level of ß-2 microblobulin mRNA was measured to quantify the amount of c-DNA analyzed in each reaction.
http://www.annalsnyas.org/cgi/content/full/850/1/139   (3938 words)

  
 Retrovirus definition - Medical Dictionary definitions of popular medical terms
Primary Biliary Cirrhosis - Learn more about Primary Biliary Cirrhosis (PBC), including a description, scope of the problem, causes, symptoms, risk factors, diagnosis, natural progression (course of disease), medications, and treatments associated with different symptoms, complications, and diseases related to PBC.
The human immunodeficiency virus (HIV), the cause of AIDS, is a retrovirus.
Retrovirus definition - Medical Dictionary definitions of popular medical terms
http://www.medterms.com/script/main/art.asp?articlekey=5344   (243 words)

  
 The Retrovirus Laboratory
Research in the Retrovirus Laboratory focuses on the molecular virology and pathogenesis of lentivirus infections.
In particular, we study the simian immunodeficiency virus (SIV) to determine the molecular basis for the development of HIV CNS, pulmonary and cardiac disease.
Current research is examining the role of these innate immune responses on restricting viral RNA transcription and gene expression.
http://www.hopkinsmedicine.org/comparativemedicine/virus   (337 words)

  
 Study Shows Link Between Retrovirus and Schizophrenia
The retrovirus Yolken and his colleagues studied is called "endogenous retrovirus," and worked its way into the human genetic code millions of years ago, he says.
Yolken, whose work focuses on how mental disorders may be caused by germs, genetics or environmental triggers, will continue to study what might be causing the activation of the retrovirus.
While 29 percent of those with acute schizophrenia showed the most evidence of the activated retrovirus, just 7 percent of those with chronic schizophrenia showed signs of the activated retrovirus.
http://www.namiscc.org/newsletters/May01/virualcause.htm   (1110 words)

  
 Inhibition of Human Endogenous Retrovirus-K10 Protease in Cell-free and Cell-based Assays -- Kuhelj et al. 276 (20): ...
Molecular and Enzymatic Characterization of the Porcine Endogenous Retrovirus Protease
A full-length and C-terminally truncated version of human endogenous retrovirus (HERV)-K10 protease were expressed in Escherichia
pattern observed after exogenous retrovirus infection with, for
http://www.jbc.org/cgi/content/full/276/20/16674   (6394 words)

  
 SIMIAN RETROVIRUS
Animal Models of Retrovirus Infection and Their Relationship to AIDS.
Type D retrovirus could play an important role in the pathogenesis of the disease without being primarily responsible for the immunodeficiency.
Type D retrovirus has been readily isolated from macaques that had a spontaneous immunodeficiency syndrome; however, experimental infection of naive macaques with D/New England has not induced the immunodeficiency syndrome.
http://www.aegis.com/aidsline/1987/may/M8750353.html   (401 words)

  
 Retrovirus marker identified in motor neuron disease
The new study, conducted with 30 US patients, identified a marker of retrovirus activity in the blood of 47 per cent of the patients.
Dr Al-Chalabi adds: “What we have identified in the serum of some MND patients is reverse transcriptase, an enzyme associated with retroviruses.
The study, led by Dr Jeremy Garson of University College London (UCL) and Dr Ammar Al-Chalabi of King's College London (KCL), confirms their earlier work which revealed evidence of retroviral involvement in a group of 56 UK patients with MND, 59 per cent of whom were found to carry the marker.
http://www.medicalnewstoday.com/medicalnews.php?newsid=19714&nfid=rssfeeds   (881 words)

  
 UCSD Researchers Discover Gene Able to Suppress Retrovirus Insertion Mutations
The researchers studied vibrator mice, which have severe tremors, progressive degeneration of the brain stem and spinal cord, and die early.
In further experiments, the researchers showed that Mbv1 also modifies an Eya1 mutation that is a mouse model of human branchiootorenal syndrome, which is also caused by an IAP retrovirus.
As a result, the host gene may be poorly expressed and depending upon the gene and how it is affected, this can cause disease.
http://health.ucsd.edu/news/2003/09_28_Hamilton.html   (751 words)

  
 Retroviruses
This is troublesome because of the efforts that are being made to transplant pig tissue into humans (e.g., fetal pig cells into the brains of patients with Parkinson's disease).
View an animation of the life cycle of a retrovirus at this Molecular Medicine in Action site.
Several cancers in animals are caused by retroviruses that have, at some earlier time, picked up a proto-oncogene from their mammalian host and converted it into an oncogene.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/R/Retroviruses.html   (501 words)

  
 Retrovirus silencer blocking by the cHS4 insulator is CTCF independent -- Yao et al. 31 (18): 5317 -- Nucleic Acids ...
The transgene constructs are derived from BGT32 (16).
One but not two internal dimer cHS4 cores can be transmitted through a retrovirus vector.
retrovirus sequences and is not solely a position effect of
http://nar.oxfordjournals.org/cgi/content/full/31/18/5317   (4502 words)

  
 Constructing primate phylogenies from ancient retrovirus sequences -- Johnson and Coffin 96 (18): 10254 -- Proceedings ...
human endogenous retrovirus (HERV) sequences to phylogenetic analysis
Endogenous retrovirus loci provide no less than three sources of phylogenetic signal, which can be used in complementary fashion
HERVs can be organized into at least a dozen distinct groups, which vary in size from one to thousands of members (1, 12).
http://www.pnas.org/cgi/content/full/96/18/10254   (5188 words)

  
 Human endogenous retrovirus glycoprotein−mediated induction of redox reactants causes oligodendrocyte death and ...
Thus, syncytin's proinflammatory properties in the nervous system demonstrate a novel role for an endogenous retrovirus protein, which may be a target for therapeutic intervention.
Human endogenous retrovirus glycoprotein−mediated induction of redox reactants causes oligodendrocyte death and demyelination - Nature Neuroscience
Human endogenous retrovirus glycoprotein−mediated induction of redox reactants causes oligodendrocyte death and demyelination
http://www.nature.com/cgi-taf/DynaPage.taf?file=/neuro/journal/v7/n10/abs/nn1319.html   (286 words)

  
 DNA and RNA (Retrovirus) Tumor Viruses
Typical retrovirus structure and the structure of a retrovirus with an oncogene (Rous Sarcoma Virus)
These cellular homologs are often genes involved in growth control and development/differentiation (as might be expected) and have important non-transforming functions in the cell; some can cause cancer under certain circumstances and, presumably, those not shown to cause cancer have the ability to do so under the correct conditions.
A seminal observation was made: Just as any other retrovirus does, ALV can integrate into the cell genome at many different sites but, in ALV-induced tumors, the virus is ALWAYS found in a similar position (very important!).
http://pathmicro.med.sc.edu/lecture/RETRO.HTM   (7197 words)

  
 Retrovirus-mediated HO gene transfer into endothelial cells protects against oxidant-induced injury -- Yang et al. 277 ...
The hHO1-expressing replication-deficient retrovirus vector LSN-hHO was constructed
plaque-forming units/ml, which is much higher than that of retrovirus
and tested for their potential to produce retrovirus in culture
http://ajplung.physiology.org/cgi/content/full/277/1/L127   (4212 words)

  
 Retrovirus - EvoWiki
A retrovirus is an RNA virus which integrates itself into a host genome by reverse transcription, to form a provirus.
There are four known human retroviruses, classified as HIVs and HTLVs, all of them attack T-helper cells.
This page was last modified 00:06, 25 November 2004.
http://wiki.cotch.net/index.php/Retrovirus   (197 words)

  
 Diagram of a Retrovirus
The virus that causes AIDS (acquired immune deficiency syndrome) is a retrovirus.
Retroviruses contain RNA as the hereditary material in place of the more common DNA.
In addition to RNA, retrovirus particles also contain the enzyme reverse transcriptase (or RTase), which causes synthesis of a complementary DNA molecule (cDNA) using virus RNA as a template.
http://www.accessexcellence.org/AB/GG/diagram.html   (151 words)

  
 retrovirus - Columbia Encyclopedia article about retrovirus
Retroviruses sometimes destroy the cells whose DNA they alter, as with HIV, the virus that causes AIDS AIDS or acquired immunodeficiency syndrome, fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections, malignancies, and neurological disorders.
Viruses usually are too small (100–2,000 Angstrom units) to be seen with the light microscope and thus must be studied by electron microscopes.
retrovirus, type of RNA virus virus, parasite with a noncellular structure composed mainly of nucleic acid within a protein coat.
http://columbia.thefreedictionary.com/retrovirus   (343 words)

  
 MSN Encarta - Retrovirus
Human Immunodeficiency Virus (HIV), retrovirus that causes AIDS
Retrovirus, any virus belonging to the family Retroviridae, whose members share a unique method of replicating (copying) themselves when they infect...
Become a subscriber today and gain access to:
http://encarta.msn.com/encyclopedia_761561203/Retrovirus.html   (83 words)

  
 National Cancer Institute - Dictionary of Cancer Terms
The virus that causes AIDS, the human immunodeficiency virus (HIV), is a type of retrovirus.
This allows many copies of the virus to be made in the host cells.
http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=306514   (92 words)

  
 Retrovirus Replication
An example of this process is illustrated in the replication of the retrovirus, HIV (human immunodeficiency virus).
New viral particles are assembled, bud from the plasma membrane, and are released.
http://www.accessexcellence.org/RC/VL/GG/retrovirus.html   (143 words)

  
 Retrovirus - Compare Prices & Reviews at Smarter
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Retrovirus - Compare Prices & Reviews at Smarter
http://www.smarter.com/sm-retrovirus--ch-1_pi-1448231.html   (225 words)

  
 Retrovirus Life Cycle
The specificity of the virus-cell interaction is determined largely by the envelope protein(s) of the retrovirus.
Infection leads to injection of the virus nucleoprotein core (consisting mostly of gag-derived proteins, full-length genomic RNA, and the reverse transcriptase protein).
Full-length genomic mRNA is made initiating at the beginning ofthe R (repeat) at the 5' LTR (Long Terminal Repeat).The free particle can infect new cells by binding to a cell surface receptor.
http://www.stanford.edu/group/nolan/tutorials/ret_2_lifecyc.html   (210 words)

  
 Definition of retrovirus - Merriam-Webster Online Dictionary
For More Information on "retrovirus" go to Britannica.com
Get the Top 10 Search Results for "retrovirus"
http://www.m-w.com/cgi-bin/dictionary?book=Dictionary&va=retrovirus   (113 words)

  
 Retrovirus
Society for General Microbiology (Download Article on Retrovirus Mutation Rates)
http://www.whfreeman.com/kuby/content/anm/kb03an01.htm   (191 words)

  
 Current Research Focusing on Euchromatin Within the Cell Nucleus.
Yu X, Zhu X, Pi W, Ling J, Ko L, Takeda Y, and Tuan D, "The LTR of ERV-9 human endogenous retrovirus binds to NF-Y in the assembly of an active LTR enhancer complex NF-Y/MZF1/GATA-2".
http://www.euchromatin.net/current1.html   (10425 words)

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