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Topic: Restenosis



  
 Troubleshooting Coronary In-Stent Restenosis: Endovascular Brachytherapy: Currents: UI Health Care
Several clinical trials have been carried out worldwide to examine the safety and effectiveness of beta-radiation therapy for the prevention of restenosis.
New facts: However, in-stent restenosis remains a major problem in percutaneous coronary intervention, requiring patients to undergo repeated procedures and surgery.
This problem prompted a search for interventional techniques that would minimize the risk of restenosis.
http://www.uihealthcare.com/news/currents/vol2issue4/4brachy.html

  
 Amazon.ca: Books: Arterial Remodeling: A Critical Factor in Restenosis
Recently the mechanisms of restenosis have been reappraised with an enriched understanding that the original concept of neointimal hyperplasia may not be accounting for the bulk of the problem.
However, the enthusiasm for angioplasty is shadowed by restenosis, which remains a critical problem after the procedure, resulting in clinical recurrence in over a third of patients.
Enthusiasm for angioplasty is shadowed by restenosis, which results in clinical recurrence in over a third of patients.
http://www.amazon.ca/exec/obidos/ASIN/0792380088

  
 [No title]
Despite this development, restenosis has remained the "bugaboo" of the interventional cardiologist, and has limited the long-term effectiveness of this technique.
Stenting has been associated with a significant reduction in the incidence of restenosis.
Initial pilot studies have yielded very encouraging results, and lead one to conclude that the threat of restenosis may appreciably recede in the future.
http://public.csusm.edu/guests/hhv/ask1101.txt

  
 Intracoronary brachytherapy
Therefore, clinical researchers, trying to reduce restenosis, are interested in identifying a method, such as radiation therapy to use in conjunction with angioplasty and stenting.
This multi-center registry will include data from patients with in-stent restenosis who underwent brachytherapy with the Galileo™ system for the development of restenosis following a successful interventional cardiology procedure, including PTCA, stent, atherectomy, or laser angioplasty.
Catheter-based ionizing radiation and radioactive stents, which deliver either gamma (g) or beta (b) radiation to the affected vessels, are the two intra-coronary radiation therapy techniques currently used or being clinically investigated to reduce restenosis.
http://www.health.state.mn.us/htac/brachydr.htm

  
 New recipes for in-stent restenosis: cut, grate, roast, or sandwich the neointima? -- Di Mario et al. 84 (5): 471 -- ...
In-stent restenosis is set to become a large part of our interventional practice in the new millennium.
Improved angiographic results following excimer laser debulking for in-stent restenosis are not associated with improved clinical outcome [abstract].
Management of restenosis within the Palmaz Schatz coronary stent (The US Multicentre Experience).
http://www.heartjnl.com/cgi/content/full/84/5/471

  
 Comparative Genetics of Atherosclerosis and Restenosis: Exploration With Mouse Models -- Wang and Paigen 22 (6): 884 -- ...
Genetic aspects of restenosis after percutaneous coronary interventions: towards more tailored therapy.
Recent clinical trials that use local radiation to the treated
Complex trait analysis in the mouse: the strengths, the limitations and the promise yet to come.
http://atvb.ahajournals.org/cgi/content/full/22/6/884

  
 Endothelial Recovery: The Next Target in Restenosis Prevention -- Losordo et al. 107 (21): 2635 -- Circulation
First clinical experience with a paclitaxel derivate–eluting polymer stent system implantation for in-stent restenosis: immediate and long-term clinical and angiographic outcome.
Histopathologic phenomena at the site of percutaneous transluminal coronary angioplasty: the problem of restenosis.
Endothelial Recovery: The Next Target in Restenosis Prevention -- Losordo et al.
http://circ.ahajournals.org/cgi/content/full/107/21/2635

  
 [No title]
Approximately 400,000 angioplasty procedures are performed each year in the U.S. Restenosis occurs in 20 to 50 percent of patients who have undergone a revascularization procedure.
"This study also raises the possibility of new therapeutic approaches involving antiviral strategies to prevent restenosis," added Dr. Lenfant.
Most cases of restenosis involve hyperplasia and remodeling and, according to Dr. Epstein, CMV may play a role in the devlopment of these responses to injury.
http://www.nhlbi.nih.gov/new/press/prcmv.txt

  
 PlA Polymorphism of Platelet Glycoprotein IIIa and Risk of Restenosis After Coronary Stent Placement -- Kastrati et al. ...
Stent restenosis: can effective antithrombotic therapy be protective?
The primary end point of the study was the angiographic restenosis.
Comparison of incidence of restenosis between patients with and those without Pl allele (left) and according to allelic genotype (right).
http://circ.ahajournals.org/cgi/content/full/99/8/1005

  
 New approaches to preventing restenosis -- Bhargava et al. 327 (7409): 274 -- BMJ
New approaches to preventing restenosis -- Bhargava et al.
http://bmj.com/cgi/reprint/327/7409/274

  
 Intracoronary {beta}-Irradiation With Liquid Rhenium-188: Results of the Taiwan Radiation in Prevention of Post-Pure ...
Waksman, R, White, RL, Chan, RC, et al Intracoronary gamma-radiation therapy after angioplasty inhibits recurrence in patients with in-stent restenosis.
Verin, V, Popowski, Y, de Bruyne, B, et al Endoluminal beta-radiation therapy for prevention of coronary restenosis after balloon angioplastya; the Dose-Finding Study Group.
patients had undergone stent implantation and that the restenosis
http://www.chestjournal.org/cgi/content/full/124/4/1284

  
 Mutated p21/WAF/CIP transgene overexpression reduces smooth muscle cell proliferation, macrophage deposition, ...
Therefore, antioxidants may have a therapeutic role in the prevention
The goal of the present study was to determine
A critical event underlying restenosis is smooth muscle
http://www.fasebj.org/cgi/content/full/15/12/2162

  
 Carotid Recurrent Stenosis and Risk of Ipsilateral Stroke : A Systematic Review of the Literature -- Frericks et al. 29 ...
Carotid endarterectomy: relationship of outcome to early restenosis.
Summary of 10 Studies Reporting Incidence of Ipsilateral and Contralateral Stroke in Relation to Restenosis After Carotid Endarterectomy
Long-term follow-up and clinical outcome of carotid restenosis.
http://stroke.ahajournals.org/cgi/content/full/29/1/244

  
 Gene Therapy for Restenosis : Are We Ready? -- DeYoung and Dichek 82 (3): 306 -- Circulation Research
approaches to prevent restenosis: (1) Is gene therapy a rational
improved therapies that would further decrease restenosis or
Is the disease pathogenesis sufficiently understood that an
http://circres.ahajournals.org/cgi/content/full/82/3/306

  
 Effects of nitric oxide-releasing aspirin versus aspirin on restenosis in hypercholesterolemic mice -- Napoli et al. 98 ...
Animal studies were carried out according to the Guidelines of the American Heart Association for Accreditation of Laboratory
NO production was able to reduce clinical, angiographic, and intravascular
the development of restenosis after PTCA continues to be a clinical
http://www.pnas.org/cgi/content/full/98/5/2860

  
 American Family Physician: Treating Coronary Artery Stent Restenosis
The authors conclude that debulking techniques such as rotational atherectomy, laser coronary angioplasty and directional atherectomy have been believed to be more efficacious than balloon angioplasty and have been increasingly used for in-stent restenosis, but the ability to assess any notable difference is limited by small numbers of rotational atherectomies and clinical events on follow-up.
Of this group, 116 patients underwent PTCA, 30 patients underwent rotational atherectomy and 14 patients had repeat stenting.
Between January 1993 and December 1996 at one site, 160 patients were treated for in-stent restenosis with percutaneous transluminal coronary angioplasty (PTCA).
http://www.findarticles.com/cf_dls/m3225/7_60/57062719/p1/article.jhtml

  
 Percutaneous coronary interventions in patients with renal failure: overcoming in-stent restenosis? -- Haller 17 (5): ...
Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study.
are being used for the treatment of recurrent in-stent restenosis.
The effect of intracoronary radiation for the treatment of recurrent in-stent restenosis in patients with chronic renal failure.
http://ndt.oupjournals.org/cgi/content/full/17/5/701

  
 A central role of interferon regulatory factor-1 for the limitation of neointimal hyperplasia -- Wessely et al. 12 (2): ...
develop restenosis despite reasonable therapy of treatable risk
in the positive or negative regulation of vascular restenosis.
of restenosis, but may also be important for clinical risk stratification
http://hmg.oupjournals.org/cgi/content/full/12/2/177

  
 The Insulin-Like Growth Factor Axis : A Review of Atherosclerosis and Restenosis -- Bayes-Genis et al. 86 (2): 125 -- ...
In conclusion, this review of experimental and clinical studies supports
Coronary restenosis remains a major clinical problem after all
Long-term effects of angiopeptin treatment in coronary angioplasty: reduction of clinical events but not angiographic restenosis.
http://www.circresaha.org/cgi/content/full/86/2/125

  
 Restenosis -- Angioplasty.Org
The use of stents has lowered this rate of recurrence or restenosis, and new types of devices that release clot-deterring medicine or even certain forms of radiation have been developed in the hopes of reducing this problem even further.
It is thought that the mechanism of this phenomenon, called "restenosis", is not the progression of coronary artery disease, but rather the body's immune system response to the "injury" of the angioplasty.
Several investigational clinical studies have been in progress to determine the effective dose levels and optimum delivery systems of gamma or beta radiation (brachytherapy) but the most recent results (five year data) are not encouraging.
http://www.ptca.org/devices6.html

  
 Elevated Circulating Levels of Monocyte Chemoattractant Protein-1 in Patients With Restenosis After Coronary ...
from patients who developed restenosis after PTCA had enhancing
of monocytes; however, its role in the pathophysiology of restenosis
generation after culturing for 20 hours in medium supplemented with either 20% serum from 50 healthy subjects (control), 20% serum from 36 patients without restenosis, or 20% serum from 14 patients with restenosis after PTCA.
http://atvb.ahajournals.org/cgi/content/full/21/3/327

  
 Stenosis and Restenosis of Coronary Arteries
Studies are under way using stents covered with drugs that show promise for improving the long-term success of this procedure.
One way to help prevent restenosis is by using stents.  A stent is a wire mesh tube used to prop open an artery after angioplasty.&; Restenosis is less common in stented arteries.
Restenosed arteries may have to undergo another angioplasty.
http://www.americanheart.org/presenter.jhtml?identifier=4706

  
 tipsofallsorts/vitamins
Patients who were given 1 mg of folate, 400 mcg of B12 & 10 mg of B6 experienced lesser chest pains, had clear arteries & fewer heart attacks after 6 months compared to others who did not.
Those with high levels of homocysteine are more likely to develop this disease.
risk of restenosis, the re-clogging of arteries after successful coronary angioplasty.
http://www.tipsofallsorts.com/vitamins.html

  
 New Books
Drug Eluting Stents: Anti-Inflammatory Approach to Prevent Restenosis After Stent Implantation
Effect of Calcium Channel Blockers on the Incidence of Restenosis after
http://www.coronetbooks.com/new.html

  
 MedlinePlus Medical Encyclopedia: Coronary heart disease
This new treatment is reserved for patients who have undergone stent implantation in a coronary artery and but developed problems, such as diffuse in-stent restenosis.
http://www.nlm.nih.gov/medlineplus/ency/article/007115.htm

  
 Nutritional Gangrene Control - Complement Angioplasy, Reduce Restenosis
For this reason, doctors tend to treat angioplasty patients with higher doses of cholesterol-lowering drugs, such as lovastatin and cholestyramine, in order to reduce restenosis (reclogging).
However, there are potential risks associated with radiation treatment.
Reclogging, or reblockage, is the Achilles’ heel of the standard therapies to open up blocked leg (or heart) arteries.
http://www.reversegangrene.com/Aangioplasty.htm

  
 Restenosis After Angioplasty in Patients with Left Ventricular Dysfunction -- Magdy et al. 7 (3): 209 -- Asian ...
Restenosis After Angioplasty in Patients with Left Ventricular Dysfunction
Restenosis After Angioplasty in Patients with Left Ventricular Dysfunction -- Magdy et al.
the higher rate of restenosis in patients with low ejection
http://asianannals.ctsnetjournals.org/cgi/content/abstract/7/3/209

  
 Restenosis
Nitric Oxide Stents for the Treatment of Restenosis
Balloon angioplasty is a procedure to widen blocked arteries that have resulted from certain conditions such as high cholesterol.
We have entered into a development and license agreement with Boston Scientific in which we have granted Boston Scientific an exclusive worldwide license to develop and commercialize products for restenosis which incorporate these nitric oxide-releasing compounds.
http://www.nitromed.com/restenosis.html

  
 Randomized, Double-Blind, Placebo-Controlled Trial of Oral Sirolimus for Restenosis Prevention in Patients With ...
the prevention of recurrent restenosis in patients with ISR.
Randomized, Double-Blind, Placebo-Controlled Trial of Oral Sirolimus for Restenosis Prevention in Patients With In-Stent Restenosis
for de novo coronary lesions, the treatment of in-stent restenosis
http://www.circulationaha.org/cgi/content/abstract/110/7/790

  
 Early Experiences and Clinical Implications of Drug-Eluting Stents: Part 1 -- Chong and Cheng 38 (4): 661 -- The Annals ...
Early Experiences and Clinical Implications of Restenosis and Drug-Eluting Stents: Part 2
of patients undergoing stent placement develop restenosis 6
This article has been cited by other articles:
http://www.theannals.com/cgi/content/abstract/38/4/661

  
 Biocompatibility and Performance of the Wallstent and the Wallgraft, Jostent, and Hemobahn Stent-Grafts in a Sheep ...
Index terms: Endovascular stent-grafts • Intimal hyperplasia • Restenosis • Stents and prostheses
http://www.jvir.org/cgi/content/abstract/13/8/823

  
 Restenosis after Angioplasty
A study by Wang and Zhao measured the
stenosis and restenosis has been studied by scientists
control group 57 percent had severe restenosis, but in
http://www.drbylenok.com/restenosis_after_angioplasty.htm

  
 Drug eluting coronary stents -- Jenkins et al. 325 (7376): 1315 -- BMJ
no instances of restenosis in 61 randomised patients at nine months,
to patients at high risk of restenosis or those presenting with
of coronary stents is associated with lower rates of restenosis
http://bmj.bmjjournals.com/cgi/content/full/325/7376/1315

  
 Ann Intern Med -- Sign In Page
Restenosis After Arterial Injury Caused by Coronary Stenting in Patients With Diabetes...
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http://www.annals.org/cgi/content/full/118/5/344

  
 Catalytic Oligonucleotides Targeting EGR-1 As Potential Inhibitors of In-Stent Restenosis -- KHACHIGIAN 947 (1): 412 -- ...
Key Words: catalytic oligonucleotides • early growth response factor-I • restenosis
Catalytic Oligonucleotides Targeting EGR-1 As Potential Inhibitors of In-Stent Restenosis -- KHACHIGIAN 947 (1): 412 -- Annals of the New York Academy of Sciences
LEVON M. Centre for Thrombosis and Vascular Research, The University of New South Wales, Sydney, Australia
http://www.annalsnyas.org/cgi/content/abstract/947/1/412

  
 Preprocedural C-Reactive Protein Is Not Associated with Angiographic Restenosis or Target Lesion Revascularization ...
Clinical Chemistry, Academic Medical Center, University of Amsterdam, The Netherlands.
Preprocedural C-Reactive Protein Is Not Associated with Angiographic Restenosis or Target Lesion Revascularization after Coronary Artery Stent Placement -- Rittersma et al.
Preprocedural C-Reactive Protein Is Not Associated with Angiographic Restenosis or Target Lesion Revascularization after Coronary Artery Stent Placement
http://www.clinchem.org/cgi/content/abstract/50/9/1589

  
 Histopathology of coronary in-stent restenosis following {gamma} brachytherapy -- Lowe et al. 89 (1): 11 -- Heart
Histopathology of coronary in-stent restenosis following {gamma} brachytherapy -- Lowe et al.
Human coronary morphology after {beta} radiation brachytherapy of in-stent restenosis
http://heart.bmjjournals.com/cgi/content/abstract/89/1/11

  
 Stent-based Controlled Release of Intravascular Angiostatin to Limit Plaque Progression and In-Stent Restenosis -- ...
Stent-based Controlled Release of Intravascular Angiostatin to Limit Plaque Progression and In-Stent Restenosis -- Ganaha et al.
after arterial implantation, offer insight into in-stent restenosis,
Stent-based Controlled Release of Intravascular Angiostatin to Limit Plaque Progression and In-Stent Restenosis
http://www.jvir.org/cgi/content/abstract/15/6/601

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