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Topic: Respiratory depression


  
 [No title]
The authors conclude that, assuming that a mixture of analgesic techniques is used, an incidence of respiratory depression, as defined by a low ventilatory frequency, of less than 1% would be expected, and an incidence of hypotension related to analgesic technique of less than 5%.
For epidural analgesia, the mean (95% CI) reported incidence of respiratory depression varied between 1.1% (0.6% to 1.9%) and 15.1% (5.6% to 34.8%), using hypoventilation and oxygen desaturation, respectively, as indicators.
For PCA, the mean (95% CI) reported incidence of respiratory depression varied between 1.2% (0.7% to 1.9%) and 11.5% (5.6% to 22.0%), using hypoventilation and oxygen desaturation, respectively, as indicators.
http://www.frca.co.uk/JournalView.aspx?jid=66   (348 words)

  
 The Double Effect of Pain Medication
Nevertheless, these investigators pointed out that respiratory depression is a "constant concern" of practitioners, who assume respiratory symptoms in cancer patients to be opioid induced.
Bleich noted that the connection of respiratory depression with pain control is based more on myth than on medical fact, and argued that the PDE should not be applied to the risk of hastening death from pain medication.
Although this literature has clearly established that opioid use can lead to respiratory depression, much of this data may not be relevant to dying patients receiving opioids for chronic pain relief.
http://www.cpmission.com/main/double.html   (6863 words)

  
 IASP Newsletter Technical Corner: Respiratory Effects of Opioids
Depression of level of consciousness is an extremely useful guide to observing clinical effect in patients receiving opioids.
Control of respiratory rate and depth is also modulated by airway resistance, sleep state, sensation of stretch in the chest wall, and a variety of other factors and disease states.
Fear of respiratory depression, however realistic or exaggerated, represents a major barrier to the most effective use of opioids in management of pain.
http://www.iasp-pain.org/TC97JulyAug.html   (2732 words)

  
 Mechanisms regulating hypoxic respiratory depression during fetal and postnatal life -- Bissonnette 278 (6): 1391 -- ...
Maturation of the respiratory response to acute hypoxia in the newborn rat.
Foetal respiratory movements, electrocortical and cardiovascular responses to hypoxaemia and hypercapnia in sheep.
The respiratory response of healthy term infants to breath-by-breath alternations in inspired oxygen at two postnatal ages.
http://ajpregu.physiology.org/cgi/content/full/278/6/R1391   (6047 words)

  
 Opioids and Respiratory Depression
Nearly all experienced respiratory care practitioners have witnessed opioid-induced respiratory depression in the intensive care unit, or have been summoned to the postanesthesia care unit to provide support for respiratory failure caused by opioids.
The clinical observation most emphasized was the patient's level of sedation, which is closely correlated with respiratory insufficiency.
Providing adequate and satisfactory pain relief with a minimum of respiratory risk is an important adjunct to patient recovery.
http://www.rcjournal.com/contents/01.99/01.99.078.asp   (1359 words)

  
 NursingCenter - Professional Development - CE Article
The frequency of respiratory assessment varied from study to study and may not have detected all instances of respiratory depression.
Because sedation precedes respiratory depression, sedation is a vital component of assessment.
However, the risk of respiratory depression comes mainly from the action of opioids, not from surgery.
http://www.nursingcenter.com/prodev/ce_article.asp?tid=484922   (4746 words)

  
 Drug-Induced Respiratory Depression
Whenever a respiratory depressant is dispensed, it is vitally important to assess the patient’s medication profile to check for agents with alcohol in the formulation.
Unfortunately, this means that respiratory depression necessitates emergent supportive therapy when it occurs, even though the incidence of benzodiazepine-induced respiratory depression is low.
This is attributable to the respiratory stimulant effects of pain itself.
http://www.uspharmacist.com/oldformat.asp?url=newlook/files/Feat/ACF2ECE.cfm&pub_id=8&article_id=17   (3040 words)

  
 Reversal of Morphine-Induced Apnea in the Anesthetized Rat by Drugs that Activate 5-Hydroxytryptamine1A Receptors -- ...
Opioid-resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat
rats, and respiratory activity was monitored with diaphragm electromyography.
Removal of the rat from the ventilator for periods of 20 s was ineffective in generating respiratory activity.
http://jpet.aspetjournals.org/cgi/content/full/292/2/704   (5410 words)

  
 [No title]
Even if a patient were eligible for PCA treatment with prior art systems, these systems do not allow the patient to receive a more aggressive treatment because of the risk of inadvertent respiratory depression and thus the patient would not be able to obtain quicker and more effective pain relief from a more aggressive treatment.
In particular, clinical error associated with programming of PCA unit 150A would be reduced, thereby reducing the risks of respiratory depression associated with the administration of narcotic analgesics from use of PCA unit 150A.
Because of disadvantages associated with existing PCA systems, certain patients who might otherwise benefit from the PCA method of therapy may not be PCA candidates because of concerns about respiratory depression.
http://www.wipo.int/cgi-pct/guest/getbykey5?KEY=98/19734.980827&ELEMENT_SET=DECL   (4293 words)

  
 Respiratory depression from neuraxial opioids
This has been done successfully on surgical wards provided that nursing staff are well trained and monitoring includes respiratory rate and degree of sedation (10).
This has been recently questioned (2, 3) as the incidence of 0.6% is similar to that of morphine (4).
Rawal N, Wattwil M. Respiratory depression following epidural morphine: an experimental and clinical study.
http://www.manbit.com/oa/C90.htm   (504 words)

  
 Data Sheet
analgesia, euphoria, miosis, bradycardia, respiratory depression, bronchoconstriction, muscle rigidity and suppression of cough reflexes.
Premedication (To be appropriately modified in the elderly, debilitated and those who have received other depressant medicines) 50 to 100 micrograms (1 to 2 mL) may be administered intramuscularly 30 to 60 minutes prior to surgery.
The onset of action of fentanyl is almost immediate when the medicine is given intravenously.
http://www.medsafe.govt.nz/Profs/Datasheet/f/FentanylcitrateinjUSP.htm   (2968 words)

  
 eMedicine - Respiratory Acidosis : Article by Jackie A Hayes, MD, FCCP
Findings on chest radiography that may help determine an etiology of respiratory acidosis include hyperinflation and diaphragm flattening secondary to severe obstructive airway disease, infiltrates secondary to pneumonias, elevated diaphragm related to diaphragmatic weakness or paralysis, pneumothorax, and atelectasis.
This study is useful in documenting respiratory muscle weakness but is difficult to perform and usually is carried out in specialized pulmonary function laboratories.
Hoo GW, Hakimian N, Santiago SM: Hypercapnic respiratory failure in COPD patients: response to therapy.
http://www.emedicine.com/med/topic2008.htm   (3737 words)

  
 ARCHI - Helping Nurses to Recognise and Manage Respiratory Depression
Nurses are the principal health professionals responsible for the care of post-operative patients with epidural analgesia.
Results show that the nurses improved their knowledge and found the experience and feedback beneficial.
Results show that nurses improved their knowledge and found the experience and feedback beneficial.
http://www.archi.net.au/content/index.phtml/itemId/119138/fromItemId/117541   (910 words)

  
 Definitions of "respiratory depression" with intrathecal morphine postoperative analgesia: a review of the literature: ...
Respiratory depression after epidural morphine–an experimental and clinical study.
Definitions of "respiratory depression" with intrathecal morphine postoperative analgesia: a review of the literature
Decreased chemosensitivity of the respiratory centres to hypercapnia
http://www.cja-jca.org/cgi/content/full/50/7/679   (3698 words)

  
 Differential Effects of Naltrindole on Morphine-Induced Tolerance and Physical Dependence in Rats -- Hepburn et al. 281 ...
The respiratory depression experiments were conducted on rats that were exposed to the two-pellet chronic morphine regimen
Pazos, A. and Florez, J.: A comparative study in rats of the respiratory depression and analgesia induced by mu and delta agonists.
Our experiments have demonstrated a significant tolerance to the morphine-induced respiratory depression in rats treated with
http://jpet.aspetjournals.org/cgi/content/full/281/3/1350   (4427 words)

  
 NMDA Receptor Activity In Utero Averts Respiratory Depression and Anomalous Long-Term Depression in Newborn Mice -- ...
This is in contrast to the depressed respiratory rhythm in the NR1
Schwartz PJ Southall DP Valders-Dapena M editors (1988) In: The sudden infant death syndrome: cardiac and respiratory mechanisms and interventions.
Because respiratory rhythm is reportedly the same in the isolated
http://www.jneurosci.org/cgi/content/full/20/9/RC73   (3846 words)

  
 Glycyl-glutamine inhibits the respiratory depression, but not the antinociception, produced by morphine -- Owen et al. ...
drugs are the mainstay of pain therapy, but the respiratory depression they produce can be a serious
but does not influence respiratory or cardiovascular homeostasis
Gly-Gln administration to conscious rats will prevent the respiratory
http://ajpregu.physiology.org/cgi/content/full/279/5/R1944   (2408 words)

  
 [No title]
Deep anesthesia depresses renal blood flow and urine flow by circulatory depression and reflex vasoconstriction, stimulates release of ADH
Dissociative anesthetic agents induce and anesthetic state by interruption of ascending transmission from the unconscious to conscious parts of the brain rather than by generalized depression of all brain centers
Unconsciousness with progressive depression of reflexes, divided into 3 planes
http://www.neamc.com/anesthesia_cvt.htm   (2561 words)

  
 Tramadol
Tramadol: pain relief by an opioid without depression of respiration.
Houmes M, Voets MA, Verkaaik A, Erdmann W, Lachmann B. Efficacy and safety of tramadol versus morphine for moderate and severe postoperative pain with special regard to respiratory depression.
Proven efficacy in a broad range of painful conditions
http://www.medsafe.govt.nz/Profs/PUarticles/tramadol.htm   (1556 words)

  
 The effects of a nonsteroidal antiinflammatory drug (ketoprofen) on morphine respiratory depression: a double-blind, ...
The effects of a nonsteroidal antiinflammatory drug (ketoprofen) on morphine respiratory depression: a double-blind, randomized study in volunteers -- Moren et al.
respiratory depression was less marked with the combination of drugs than
The effects of a nonsteroidal antiinflammatory drug (ketoprofen) on morphine respiratory depression: a double-blind, randomized study in volunteers
http://www.anesthesia-analgesia.org/cgi/content/abstract/85/2/400   (322 words)

  
 Physostigmine antagonizes morphine-induced respiratory depression but not analgesia in dogs and rabbits -- Weinstock et ...
Physostigmine antagonizes morphine-induced respiratory depression but not analgesia in dogs and rabbits -- Weinstock et al.
Physostigmine antagonizes morphine-induced respiratory depression but not analgesia in dogs and rabbits
The ability of physostigmine to antagonize the respiratory depressant
http://bja.oxfordjournals.org/cgi/content/abstract/52/12/1171   (241 words)

  
 Go Seek It respiratory depression
Our work was endless in order to find the best information we could on respiratory depression to decide on the top sites for you.
You won't believe the depth of our online investigations for information on respiratory depression and guide you to the best site to click to.
Finding the most useful respiratory depression sites is often difficult.
http://www.go-seekit.com/depression/respiratory-depression.htm   (158 words)

  
 Respiratory Depression
Occasionally, respiratory depression occurs when pain is abruptly relieved and the sedative effects of opioids are no longer opposed by the stimulating effects of pain.
The dose of naloxone should be titrated to the patient's respiratory rate.
Because many patients in the terminal phase have been receiving opioid pain medications for a significant period of time, the fear of shortening life by medication is usually unfounded.
http://www.hivpositive.com/f-PainHIV/Pain/LS3.3.4.4.html   (545 words)

  
 Doxapram Hydrochloride, Dopram, Respiratory Stimulants, Respiratory Depression Reversal Prescription Drugs, Medications
Purchase Doxapram Hydrochloride, Dopram, Respiratory Stimulants, Respiratory Depression Reversal Prescription Drugs, Medications at Discount Pharmacies Online:"The Discount Pharmacies Online gives consumers the chance to buy prescription drugs at discount prices from the privacy of their homes.
Doxapram Hydrochloride, Clinical Pharmacology, RXlist:"Doxapram hydrochloride produces respiratory stimulation mediated through the peripheral carotid chemoreceptors.
Doxapram Hydrochloride(Dopram), Description, Drugs.com:"Doxapram is indicated to stimulate deep breathing in postoperative patients and to stimulate respiration in patients with drug-induced postanesthesia respiratory depression or apnea not associated with muscle relaxants."
http://www.lopez1.com/lopez/drugs/respiratory/doxapram.hydrochloride.dopram.htm   (1370 words)

  
 Untitled Document
In the first few days of opioid therapy, patients should be monitored closely.
Opioid naive patients in acute pain are far more susceptible to respiratory depression than patients who have been receiving regularly scheduled opioid therapy for 5 days or more.
Respiratory depression occurs before a patient becomes sedated.
http://www.rnceus.com/ages/side.htm   (569 words)

  
 Nursing: Treating oversedation and respiratory depression
Continue the infusion until her respiratory status stabilizes.
Withholding opioids from a surgical patient for 24 hours will cause needless suffering and may delay her recovery.
Administering naloxone, an opioid antagonist, will reverse morphine-induced oversedation and respiratory depression.
http://www.findarticles.com/p/articles/mi_qa3689/is_199812/ai_n8821043   (533 words)

  
 Promethazine and Fatal Respiratory Depression In Children Under Age 2 - Use Contraindicated
Clinicians should use promethazine with caution in any pediatric patient.
The FDA and Wyeth are warning clinicians that promethazine (Phenergan®) is contraindicated in children less than 2 years of age because fatal respiratory depression may occur.
Promethazine and Fatal Respiratory Depression In Children Under Age 2 - Use Contraindicated
http://uuhsc.utah.edu/pharmacy/alerts/70.html   (93 words)

  
 AllRefer Health - Opioid Intoxication (Intoxication - Opioids)
Reviewed By : Todd Severson, M.D., Department of Emergency Medicine, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
An abnormal mental state, generally of excessive sleepiness or unconsciousness (depending on the degree of intoxication), and usually associated with respiratory depression and small pupils, that is caused by opium or its derivatives (which include: morphine, heroin, oxycodone, and the synthetic opioid narcotics).
http://health.allrefer.com/health/opioid-intoxication-info.html   (278 words)

  
 Severe respiratory depression after epidural morphine in a patient with myotonic dystrophy -- Ogawa et al. 40 (10): 968 ...
Severe respiratory depression after epidural morphine in a patient with myotonic dystrophy
the sensitivity of the respiratory centre to morphine in patients with
Severe respiratory depression after epidural morphine in a patient with myotonic dystrophy -- Ogawa et al.
http://www.cja-jca.org/cgi/content/abstract/40/10/968   (200 words)

  
 Leptin Prevents Respiratory Depression in Obesity -- O'DONNELL et al. 159 (5): 1477 -- American Journal of Respiratory ...
159 (5): 1477 -- American Journal of Respiratory and Critical Care Medicine
to involve depression of central respiratory control mechanisms.
of hypoventilation by stimulation of central respiratory control
http://ajrccm.atsjournals.org/cgi/content/abstract/159/5/1477   (1618 words)

  
 Respiratory depression - definition of Respiratory depression in Encyclopedia
It can be caused by medical conditions, or by holding the breath.
Respiratory depression - definition of Respiratory depression in Encyclopedia
It generally causes increased carbon dioxide concentration (hypercapnia) and respiratory acidosis.
http://encyclopedia.laborlawtalk.com/Respiratory_depression   (80 words)

  
 [No title]
Benzodiazepines cause CNS and respiratory depression; administration with other drugs* which also have these effects increases the risk of these effects; monitor clinical effects and reduce benzodiazepine dose if appropriate.
–inhibits metabolism of midazolam prolonging its sedative and respiratory depressant effects; reduce midazolam dose (possibly to one-quarter) and monitor clinical effect.
–may inhibit metabolism of alprazolam; may enhance sedation and cause respiratory depression; consider an alternative benzodiazepine, eg lorazepam or oxazepam, or monitor clinical effects and reduce alprazolam dose if necessary.
http://amh.hcn.net.au/interactions/iddi521c0d.htm   (1547 words)

  
 Respiratory depression in the acute management of seizures -- Stewart et al. 87 (3): 225 -- Archives of Disease in ...
with respiratory depression in this study received doses at
doses of benzodiazepines increase the risk of respiratory depression.
Respiratory depression in children receiving diazepam for acute seizures: a prospective study.
http://adc.bmjjournals.com/cgi/content/full/87/3/225   (727 words)

  
 Effects of morphine and respiratory depression on sulfobromophthalein disposition in rats.
Effects of morphine and respiratory depression on sulfobromophthalein disposition in rats.
Since narcotics depress respiration, effects of hypoxia, hypercapnia, and acidosis on BSP disposition were studied.
Ambient gases breathed by rats were adjusted to achieve blood gas levels identical to those of morphine-induced respiratory depression.
http://www.ihop-net.org/UniPub/iHOP/gp/4804863.html   (333 words)

  
 AAN: Diastat (Diazepam Rectal Gel) Does Not Produce Respiratory Depression In Epileptics
Two patients reported adverse events (lethargy in both cases) however, no change in the respiratory status of these patients was noted.
No episodes of clinical respiratory depression were associated with the use of diazepam rectal gel.
She added that additional research regarding the effect of diazepam rectal gel on respiratory response is warranted.
http://www.docguide.com/dg.nsf/PrintPrint/69E8B4D1F9E047FC85256A480043C5BE   (373 words)

  
 Famvir Category
The patient has entered into a field of a lesion Attributes a dyspnea, depression of duration of the respiratory certificate.
http://cheap-famvir.hdanet.com/famvir_category.html   (1012 words)

  
 MedlinePlus Medical Encyclopedia: Opioid intoxication
Opium and its derivatives (which include morphine, heroin, oxycodone, and the synthetic opioid narcotics) generate an abnormal mental state, generally characterized by excessive sleepiness or unconsciousness (depending on the degree of intoxication), and usually associated with respiratory depression and small pupils.
http://www.nlm.nih.gov/medlineplus/ency/article/000948.htm   (202 words)

  
 Anesthesia
Neuraxial blockade reduces the risk of deep vein thrombosis, pulmonary embolism, transfusion, pneumonia, respiratory depression, myocardial infarction and renal failure[1].
Conquering surgical pain: Four men stake their claim
http://www.sciencedaily.com/encyclopedia/anesthesia   (845 words)

  
 Diazepam Inhibits Organophosphate-induced Central Respiratory Depression -- Dickson et al. 10 (12): 1303 -- Academic ...
and respiratory arrest (0% 10-minute survival in all cohorts).
Diazepam Inhibits Organophosphate-induced Central Respiratory Depression -- Dickson et al.
OP-induced CRD is the result of overstimulation of CNS respiratory
http://www.aemj.org/cgi/content/abstract/10/12/1303?etoc   (265 words)

  
 respiratory depression morphine - OneLook Dictionary Search
You can look up the words in the phrase individually using these links: respiratory depression morphine
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http://www.onelook.com/?w=respiratory+depression+morphine&ls=a   (90 words)

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