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| | National Cancer Institute - Proteomics: Research for the 21st Century |
 | | A second trial will use proteomics to increase the understanding of how a cancer drug works. | | | Correlating protein patterns with clinical outcomes of treatment will allow researchers to learn more about how the drug works. | | | Interested patients can call NCI's Clinical Studies Support Center at (888) 624-1937 to learn more about both trials. |
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http://newscenter.cancer.gov/newscenter/benchmarks-vol2-issue2/page2
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| | Chemical & Engineering News: SCIENCE/TECHNOLOGY - Proteomics |
| | A number of researchers at the Proteomics conference described their groups' efforts to identify inhibitors of protein-protein interactions--both as basic research tools and for potential diagnostic and therapeutic applications. | | | Indeed, in a fundamental sense, "what we are looking at" in the field of proteomics "is a new systematic way to discover drugs," Hybrigenics' Allemand said at the conference. | | | One technique making an important contribution to proteomics is phage display. |
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http://pubs.acs.org/cen/coverstory/7831/7831scit1.html
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| | Proteomics Glossary |
| | The application of proteomics technologies to clinical research and public health in general is an immediate goal of proteomics. | | | Focuses on how researchers are applying new proteomic approaches to drug discovery and development, and how these technologies can be used most effectively and in a high- throughput capacity. | | | The reason for creating HUPO is to assist in increasing the awareness of this discipline of science across society, particularly with regard to the Human Proteome Project and to engender a broader understanding of the importance of proteomics and the opportunities it offers in the diagnosis, prognosis and therapy of disease. |
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http://www.genomicglossaries.com/content/proteomics.asp
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| | CHI's BEYOND GENOME |
| | This project required that standard analytical approaches to proteome characterization like LC/MS/MS and stable isotope labeling methods be modified. | | | These fundamental aspects will be augmented by relevant clinical proteomic and biomarker discovery applications. | | | Systems Biology affords an integrated approach to studying biological pathways and networks and involves the simultaneous analysis of mRNA, proteins, metabolites and other clinically relevant measurements. |
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http://www.beyondgenome.com/pro.asp
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| | C-202R New Developments in Therapeutic Enzyme Inhibitors and Blockers |
| | Promising inhibitors and blockers in the early stages of development are profiled, but the emphasis is strongly upon drugs that are either on the market, or will be on the market within the time frame of this study. | | | This $121 billion market is undergoing rapid change as new technologies such as genomics, proteomics, high-throughput screening, rational drug design, and combinatorial chemistry are being integrated into drug development and discovery. | | | These technologies are expanding the number of drugs in clinical testing, as well as bringing completely new classes of drugs to market. |
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http://www.bccresearch.com/biotech/C202R.html
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| | Integrated signalling group |
| | Another subject of our studies is search for antagonists and agonists of the receptor kinases. | | | This validates the architecture of the model, and defines the levels of robustness and sensitivity of the studied biological process. | | | Failure or dysregulation of the TGFß signalling is involved in development of several diseases, such as cancer, haemorragic telangiectasia, fibrotic disorders, impaired wound healing, neurodegenerative conditions, developmental disorders. |
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http://www.licr.uu.se/groups/is
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| | Proteomics Pubs |
| | Thus, the photoaffinity labeling is applied in two stages of drug discovery and development processes. | | | This review focuses on several recent impacts of photoaffinity labeling as a useful tool for drug discovery and developments. | | | Proteomic image analysis -Spotting the difference on a gel might just lead to a new drug or target. |
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http://www.altcorp.com/AffinityLabeling/proteomepubs.htm
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| | UPENN Graduate Studies in Pharmalogical Sciences Graduate Group |
| | These studies utilize both biochemical and biophysical approaches to examine PRL-PRLr binding and the interaction of the PRLr with its associated transduction pathways that include JAK/Stat, Vav2/Rac, Fyn, Tec, and Bcl-2/Bag-1. | | | As such our findings present vantage points in the development of novel therapies aimed at modulating PRL action in human breast cancer and the immune system. | | | Identify pathways of prolactin receptor signaling in human breast cancer. |
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http://www.med.upenn.edu/pharmgg/bios/clevenger.html
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| | PsycPORT.com Overexpression of Serotonin(1A) Receptors Linked to Reduced Anxiety |
| | Researchers from the Netherlands have reported on the reduced anxiety-related behaviour in transgenic mice overexpressing serotonin(1A) receptors."Serotonergic neurons play a major role in the modulation of emotion and behavior," scientists writing in the journal Molecular Brain Research report. | | | The information in this article comes under the major subject areas of Anxiety, Behavior, Biotechnology, Serotonin Receptor, and Proteomics. | | | "These findings further underline the pivotal role of 5-HT1A receptors in the homeostasis of anxiety-like behavior and the crucial importance of stimulation of the 5-HT1A receptor during the early postnatal development for normal anxiety-like behaviour throughout life," concluded the researchers. |
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http://www.psycport.com/showArticle.cfm?xmlFile=newsrx_2004_12_30_eng-newsrx_eng-newsrx_133738_4469933813191902823.xml&provider=NewsRx.com
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| | NIDA - What's New - Past Meetings - Structural Biology & Structural Genomics/Proteomics |
| | Dr. Mierke spoke on receptor-protien interactions using NMR and Dr. Patel gave an overview of FRET and demonstrated the applicability of this technique for the analysis of the ligand-receptor stoichiometry and aggregation states for three receptors systems. | | | In the first session, Dr. Wlodawer reported on the determination of the crystal structure of a pepstatin-insensitive carboxyl proteinase from pseudomonas. | | | Rest of the symposium consisted of four sessions, and the sessions were on, structure determination, receptors, transporters and mechanisms, structural genomics and proteomics and, ligands and therapeutics. |
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http://www.nida.nih.gov/whatsnew/meetings/Proteomics5-8-02.html
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| | NIDA - Director's Report - September, 2004 |
| | In the present study, these researchers further demonstrated that systemic injections of SB-277011A also dose-dependently inhibits stress-induced reinstatement of cocaine-seeking behavior in animals completely extinguished from their drug-taking habits. | | | SB-277011A has also been previously shown to attenuate nicotine-triggered relapse to nicotine-seeking behavior in the reinstatement model. | | | In clinical trials, sigma-1 receptor ligands failed to improve acute psychotic symptoms of schizophrenia but, interestingly, were shown in a few studies to attenuate negative symptomatology in schizophrenic patients. |
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http://www.drugabuse.gov/DirReports/DirRep904/DirectorReport10.html
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| | Biotechnology Research Institute - Health |
| | Data collected from these studies are currently being used to design therapeutics aimed at modulating TGF-b activity that is linked to imaging and non-imaging diagnostics. | | | In order to achieve the ultimate goal of personalized cancer treatment, the group is developing linkages between molecular imaging and diagnosis and therapies based on inhibiting EGF and TGF-b signalling pathways. | | | These research activities have made the Receptors, Signalling and Proteomics Group a competitive laboratory in the field of growth-factor-related cancer research. |
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http://www.bri.nrc.gc.ca/rd/health/receptors/index_e.html
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| | Print Version |
| | Over the past ten to fifteen years [before 1987], receptor mapping has expanded from a very minor technique, besieged by problems and limited in its approach, to one that is widespread, extended beyond receptors and applied to clinical problems and populations with modern imaging and scanning techniques. | | | Genomics, proteomics, and metabolomics are being employed to investigate the effect of these changes on cellular physiology and to optimize cellular re-design. | | | This article describes attempts to construct whole cell models. |
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http://www.genomicglossaries.com/content/printpage.asp?REF=/content/molecular_modeling_gloss.asp
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| | Antisense therapy targeting GluR3 delays neurodegeneration in murine models - Genetic Disorders : Epilepsy.com |
| | "Recent proteomic analysis within our group on the copper zinc superoxide dismutase (SOD1)(G93A) transgenic mouse model of familial ALS (FALS) reveals a potentially deleterious upregulation of GluR3 in spinal cord compared to that in wild-type littermates. | | | These results suggest that interference with the GluR3 component of the AMPA receptor assembly may be a novel strategy for controlling excitotoxic destruction of motor neurons and may lead to new therapeutic opportunities for the treatment of human ALS, said Rembach and coauthors. | | | The information in this article comes under the major subject areas of Gene Therapy, Genetic Disorders, Mental Health, Neurology, Neuroscience, Pharmaceutical & Drug Development, Proteomics, and Receptor Studies. |
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http://www.epilepsy.com/newsfeed/pr_1097760612.html
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| | LICR-UCL :: Cancer Proteomics :: Members |
| | The group's research activities are focused on elucidating the mechanisms of oncogenesis using biochemical, 2D-gel and mass-spectrometry-based proteomics techniques and also the development of new proteomics strategies. | | | In 1999, I returned to the UK as a Postdoctoral Research Fellow with Professor Mike Waterfield at the Ludwig Institute, where I have mostly focused on functional proteomic studies and biochemical analysis of ErbB-2 overexpression in breast cancer. | | | My thesis project involved structural and functional studies of the EGF receptor tyrosine kinase, studies which firmly established my interests in cellular signalling. |
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http://www.ludwig.ucl.ac.uk/cprot_html/members.htm
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| | Scientists Discover New Molecule of the Immune System; a Chemokine That Binds One of The HIV Co-receptors |
| | The UCSF research was funded by the NIH, the Packard Foundation and a UCSF Molecular Medicine Training Program. | | | Although its association with a chemokine was a discovery, the receptor turned out to be one that had already been isolated by other researchers in cell studies as one of the receptors exploited by invading HIV viruses to gain entry into human cells. | | | The chemokine was identified using Compugen's LEADS algorithm-driven drug discovery platform, that uses large-scale analysis of expressed human DNA to find new sequences similar to those already known in other protein families. |
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http://www.aegis.com/news/bw/2000/BW001001.html
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| | MediChem and Neurocrine Biosciences Sign Proteomics Agreement on GPCR Drug Target for Depression, Anxiety |
| | Terms and conditions, including restrictions on redistribution, apply. | | | Preliminary studies have shown that Neurocrine's proprietary CRF-1 receptor antagonists may be effective in depression, anxiety and irritable bowel syndrome (IBS). | | | Using structural information derived through proteomics technologies such as MediChem's, scientists are able to visualize the drug compounds that will be the most effective against the target protein and have the least side effects -- a process known as structure-based drug design. |
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http://www.prnewswire.com/cgi-bin/stories.pl?ACCT=104&STORY=/www/story/06-26-2001/0001522261&EDATE=
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| | Drosophila nuclear receptor proteomics |
| | Our work has the potential to identify physiological and synthetic ligands. | | | All 16 receptors are studied in parallel in a series of complementary in vitro and in vivo approaches. | | | The importance of nuclear receptors in normal development, metabolism and oncogenesis also makes them important potential targets for drug treatment, manipulation and intervention. |
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http://www.utoronto.ca/AlEdwardsLab/nuclear_receptors_index.html
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| | The Department of Biological Chemistry, JHSOM: Links |
| | Steen, H., Ong, S. and Pandey, A. ‘Proteomic approaches to investigate phosphorylation processes,’ in, Functional proteomics: Principles and Practical Applications’ Ping, P. and Hanash, S. Eds. | | | Ibarrola, N., Molina, H., Iwahori, A. and Pandey, A. (2004) A novel proteomic approach for specific identification of tyrosine kinase substrates using 13C-labeled tyrosine. | | | Pandey, A., Duan, H. and Dixit, V.M. Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. |
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http://biolchem.bs.jhmi.edu/cv.asp?LastName=Pandey&FirstName=Akhilesh
(1561 words)
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| | Links - ePitope Informatics - epitope prediction and protein analysis |
| | spectroscopyNOW.com - proteomics portal with a spectroscopy focus, from Wiley (publishers). | | | Proteome Analysis Database (SWISS-PROT group at the EBI). | | | RIKEN Structural Genomics/Proteomics Initiative - The Institute of Physical and Chemical Research, Japan. |
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http://www.epitope-informatics.com/Links.htm
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| | Mary T. Johnson, Ph.D. |
| | LIFS 492--Undergraduate Research in Life Sciences and LIFS 192--Undergraduate Research in Life Sciences | | | Proteomics analysis of inflammation using acute tendonitis and chronic rheumatoid arthritis models | | | Pulsed field therapy of inflammatory injury and modulation of in vivo function: biochemical and biophysical measures |
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http://www.indstate.edu/thcme/johnson
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| | Genencor: Publications |
| | Differential proteomic analysis of Bacillus subtilis nitrate respiration and fermentation in Defined medium | | | Quantitative proteome profiling during the fermentation process in pleiotropic Bacillus subtilis mutants | | | The fate of extracellular proteins tagged by the SsrA system of Bacillus subtilis. |
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http://www.genencor.com/wt/gcor/publications
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| | LICR Research Programs Biochemistry Proteomics |
| | LICR investigators are using cutting-edge proteomic technologies to identify changes that occur during cancer progression in several cancers. | | | The JPSL is involved in the development of new proteomics systems, and software and instrumentation for mass spectrometry, which increase the flexibility, speed, and sensitivity of protein identification and analysis. | | | LICR investigators are applying protein profiling technologies to analyze the signal transduction in various cancers: |
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http://www.licr.org/D_programs/d2b2_proteomics.php
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| | GO Bibliography |
| | System-based proteomic analysis of the interferon response in human liver cells. | | | Targeted cellular process profiling approach for uterine leiomyoma using cDNA microarray, proteomics and gene ontology analysis. | | | Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. |
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http://www.geneontology.org/GO.biblio.html
(8841 words)
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| | Home page of the Center for Experimental BioInformatics |
| | The goal of the group is to apply modern methods of mass spectrometry and "Proteomics" to the functional analysis of genes. | | | CEBI has been designated a Marie-Curie Training Site in the area of Mass Spectrometry and Proteomics. | | | A limited number of training fellows for three to twelve month projects may be accepted within the Center. |
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http://www.pil.sdu.dk
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| | Receptor_(proteomics) |
| | Adrenoceptors (also known as Adrenergic receptors, for adrenaline, and other structurally related hormones and drugs) | | | These receptors are either coupled to G proteins or possess enzyme or ion channel activity that allow the activation of signal transduction pathways in response to the activation by the ligand. | | | This increases the current understanding of drug action at binding sites on the receptors. |
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http://www.apawn.com/search.php?title=Receptor_(proteomics)
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| | CNC |
| | Glutamate receptors mediate the majority of excitatory neurotransmission in the central nervous system, and changes in the characteristics and cellular localization of these receptors are thought to underlie the mechanisms for synaptic plasticity. | | | Electrophysiology and imaging studies are used to test the functional relevance of the interactions. | | | We found that truncated isoforms are also generated, and that these proteins have a dominant negative effect when they are integrated in the receptor complexes. |
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http://www.uc.pt/cnc/GroupsEng/glutamate.php
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| | Genomics and Proteomics - Protein Patents: A Case Study |
| | This method takes the structural information discovered by Kendrew, and applies it in a method in which receptor binding compounds are identified. | | | One approach is to claim a computer-based method of identifying drug leads that relies on the specific set of binding site coordinates for selecting compounds from a compound database. | | | Use of this website is subject to its terms of use. |
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http://www.genpromag.com/PRArchivebyIssue.aspx?RELTYPE=EXP&YEAR=2003&MONTH=09
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| | MUSC Nephrology |
| | Such studies indicate that these RNA-binding proteins play significant role in regulating receptor expression under normal conditions as well as in response to a challenge with agonist. | | | Both ectopic expression and RNAi mediated suppression of these proteins are used to study their role in receptor regulation. | | | Work in the laboratory is focused on the post-transcriptional mechanisms that regulate receptor expression or how receptor expression is controlled by proteins that bind to the adenine- and uridine-rich elements (AREs) present in the 3'-untranslated region of the receptor mRNA. |
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http://www.musc.edu/nephrology/BGT1.html
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| | CCR - In the Journals |
| | Future research will focus on optimizing the selectivity and potency of these promising new lead compounds in the treatment of breast cancer and determining whether they complement existing antiestrogen therapy. | | | Current breast-cancer therapies designed to prevent the binding of estrogen compounds to the estrogen receptor have met with limited success. | | | Previous research suggests that electrophilic compounds may attack these zinc fingers, thereby destabilizing the estrogen receptor-DNA complex. |
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http://ccr.nci.nih.gov/news/inthejournals/3_18_04.asp
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| | BioCarta - Charting Pathways of Life |
| | Friedmann, M.C., Migone, T.S., Russell, S.M., Leonard, W.J. (1996) Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. | | | br>Different regions of the cytoplasmic domain of the IL-2 receptor beta chain interact and couple with distinct signaling pathways and cellular responses. | | | The polypeptides of the IL-2 receptor do not themselves have intrinsic catalytic activity, but interact with cytoplasmic signaling proteins to transduce signals. |
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http://www.biocarta.com/pathfiles/h_il2rbPathway.asp
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| | Receptors LLC - Pioneering the development and commercialization of artificial receptor products. |
| | RECEPTORS LLC is pioneering the development and commercialization of Artificial Receptor products for proteomics research, pharmaceutical development, bioterrorism/emerging disease defense, as well as veterinary and clinical diagnostics. | | | Artificial Receptors are optimized **BY DESIGN** to any application and environment. | | | Receptors LLC - Pioneering the development and commercialization of artificial receptor products. |
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http://www.receptorsllc.com
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| | The University of Melbourne - Department of Medicine (RMH) HOMEPAGE |
| | Project Title: Investigation of the signalling pathways governed by the CSF-1 receptor – a proteomics approach | | | A novel enrichment strategy for the specific study of the CSF-1R signalosome has been developed. | | | Our goal is to understand the cellular signalling networks within the macrophage that are associated specifically with the CSF-1 receptor (CSF-1R) upon activation, the signalosome. |
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http://www.medrmhwh.unimelb.edu.au/rmh-staffLC.htm
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| | Steven T. Lund, Ph.D. Research |
| | Never ripe, to study the role of ethylene-induced signaling in response to pathogen infection. | | | Reduced expression of the tomato ethylene receptor gene LeETR4 enhances the hypersensitive response to Xanthomonas campestris pv. | | | In my first two years, I was part of team involved in cloning Arabidopsis receptor-like kinases, expressing tagged fusion proteins and developing various proteomics approaches for isolating cognate ligands for the orphan receptor fusions. |
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http://www.agsci.ubc.ca/wine/lund5.htm
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| | COLL 424 - Self-assembly of oligomeric structures on gold |
| | A few examples describing their applications in the evergrowing fields of proteomics and receptor mimicking are highlighted | | | Finally I describe a new class of helix-loop-helix polypeptides that can be used as a scaffold for site-selective attachment of, in principle, any type of ligand. |
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http://membership.acs.org/c/coll/neworleans/P626221.HTM
(211 words)
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| | Nuclea Biomarkers Antibodies |
| | Nuclea has developed a proprietary technology which helps to identify protein or peptide biomarkers of disease directly from whole tissue samples, a process that is still highly valuable despite significant advances in both genomics and proteomics. | | | Thus, it makes possible the rapid identification of proteins that play significant roles in disease, many of which will become novel drug targets or diagnostic markers. | | | By combining proteomics methodologies with high-throughout genomic analysis, this technology eliminates the need for protein purification and greatly increases efficiency. |
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http://www.nucleabiomarkers.com/Microfluidic.asp
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| | Mechanism by which soy intake reduces cholesterol levels investigated in new study |
| | This article was prepared by Health and Medicine Week editors from staff and other reports. | | | "When HepG2 cells were transiently transfected with HMG CoA synthase and LDL receptor reporter plasmids there was an increase in expression in response to soy extract or isoflavone treatment from both of these promoters, but this induction was blunted in the presence of sterols (P<0.05). | | | The mechanism responsible for this effect may be via a statin-like inhibition of HMG CoA reductase enzyme activity or by enhanced SREBP processing via the SREBP cleavage activating protein, they observed. |
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http://www.talksoy.com/media/rRelease050131-NewsRx.htm
(422 words)
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| | ExPASy Proteomics Server |
| | You may not see all the information available for this page (More information). | | | The ExPASy (Expert Protein Analysis System) proteomics server of the Swiss Institute of Bioinformatics (SIB) is dedicated to the analysis of protein sequences and structures as well as 2-D PAGE (Disclaimer / References). | | | SPS'05: Expanding Proteomics - New directions in Biology, Chemistry, Pharmaceutical Sciences and Medicine - December, 5-7, 2005 - Zurich, Switzerland |
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http://www.expasy.org
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| | NRC's Biotechnology Research Institute - Cell Surface Receptors Group |
| | interactions with the EGF receptor extracellular domain: A real time kinetic study fits a conformational change model. | | | through NMR Analysis of the Receptor Bound Ligand: Design, Solution Structure and Activity of TGF- | | | Receptor and Increased Nuclear Accumulation after Growth Arrest, Experimental Cell Research, |
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http://cbr-rbc.nrc-cnrc.gc.ca/receptor/pubs.html
(413 words)
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| | AmProx-dependable proteomics services |
| | Wingless-type MMTV integration site family, member 10A; FLJ14301, mature form | | | Thyroid hormone receptor interactor 10; salt tolerator; CDC42-interacting protein; thyroid receptor interacting protein 10; CIP4; STOT | | | Toll-like receptor 2; toll/interleukin 1 receptor-like 4; TIL4 |
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http://www.amprox.com
(460 words)
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| | Job Review |
| | Desirable Selection Criteria: Experience specifically in protein expression and purification, bacteriophage T7, phage display, ligand receptor interactions; proteomics analysis. | | | Essential Selection Criteria: PhD (or equivalent) in biology; an outstanding academic record and experience in cDNA library construction and bacteriophage. | | | The appointee will construct genomic and cDNA libraries; T7-phage display libraries; study ligand receptor interactions; screen geromic/cDNA libraries for small molecular binding partners. |
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http://jobreview.camrev.com.au/Jobs/addtohitlist.asp?adid=240954
(249 words)
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| | ExPASy's Life Sciences Directory |
| | BIOMDB - Db of mutations causing tetrahydrobiopterin deficiencies | | | This list contains almost exclusively pointers to information sources for life scientists with an interest in biological macromolecules. | | | ADB - Albinism db (Mutations in human genes causing albinism) |
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http://www.expasy.org/links.html
(3830 words)
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| | Kinetics of G-protein-coupled receptor signallingand desensitization |
| | The kinetics of G-protein-coupled receptor activation and deactivation has, so far, been measured only | | | methods based on fluorescence resonance energy transfer to quantify the kinetics of receptor activation by | | | Post Signal transduction methods related comment or question in troubleshooting forum |
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http://www.biowww.net/detail-646.html
(151 words)
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| | Usage Statistics for metallo.scripps.edu - February 2004 - Search String |
| | coli alkaline phosphatase 1 0.02% mutation mung protein 1 0.02% mutational analysis structual interaction 1 0.02% myc nmr pdb 1 0.02% myc nmr pdb chime 1 0.02% mycbacterium 1 0.02% mycbacterium tuberculosis 1 0.02% mycobacterium srp signal receptor 1 0.02% myobacterium tuberculosis 1 0.02% myoglobin. |
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http://metallo.scripps.edu/stats/search_200402.html
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