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| | Receptor Workbook |
 | | Below is a hypothetical patient situation which illustrates how basic pharmacologic principles aid in the understanding of various clinical situations. | | | In a linear response relationship, 50,000 receptors would have to be occupied to give a full response. | | | Because of this hyperbolic relationship between occupancy and response, maximal responses are elicited at less than maximal receptor occupancy. |
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http://www.mc.uky.edu/pharmacology/instruction/pha824mp/PHA824mp.html
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| | Genome Biology Full text The human olfactory receptor repertoire |
| | Expression of various ORs was reported in human and murine erythroid cells [32], developing rat heart [33], avian notochord [34] and lingual epithelium [35]. | | | Whereas the amino-acid identity between a few of the most distant human ORs is as low as 20%, the average identity for a random pair of hORs is in the 35-40% range. | | | For the reasons discussed earlier, some additional functional hOR candidates are likely to be identified in the future, and will have to be accommodated by the nomenclature. |
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http://www.genomebiology.com/2001/2/6/research/0018
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| | HHMI News: Stitching Together a Receptor Reveals Plant Hormone Action |
| | Plant biologists have been hampered in their efforts to learn about plant signaling because they have had difficulty in developing techniques to obtain measurable biological responses when experimentally manipulating plant-signaling molecules. | | | We're hoping that this finding will stimulate a whole cottage industry in which researchers begin to look for the ligands for other such kinases." | | | Brassinolide is a potent growth-promoting hormone that is believed to be a key element in the plant's response to light. |
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http://www.hhmi.org/news/chory2.html
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| | NURSA Nuclear Receptor Signaling Atlas Receptors, Coactivators, Corepressors and Ligands |
| | Gene profiling of the FXR agonist fexaramine in human cultured hepatocytes | | | Please help us achieve this by citing NURSA in your research articles, reviews, grant applications and posters. | | | NURSA Angie Bookout and David Mangelsdorf A quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways full text>> |
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http://www.nursa.org
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| | Drugs - Receptor |
| | Slight changes in the molecular structure of the drug may drastically change specificity. | | | A drug must be a close "mimic" of the neurotransmitter. | | | After attachment to a receptor site, a drug may either initiate a response or prevent a response from occurring. |
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http://www.elmhurst.edu/~chm/vchembook/660drugreceptor.html
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| | Bioreagents.com: Androgen Receptor |
| | PA1-110 has been successfully used in Western blot, immunocytochemistry, immunohistochemistry and immunoprecipitation procedures. | | | Androgen receptors (AR) have been found in a variety of tissues, including reproductive organs, central nervous system and skeletal muscle. | | | PA1-110 detects androgen receptor (AR) from human, primate, rat, and mouse tissues. |
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http://www.bioreagents.com/index.cfm/fuseaction/products.detail/Product/PA1-110
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| | Angiotensin II Receptor Blockers |
| | Most likely these 3 trials reflect worse outcomes with dihydropyridine CCBs, consistent with previous evidence ( | | | Renal response to the angiotensin II receptor subtype 1 antagonist irbesartan versus enalapril in hypertensive patients. | | | Comparative effects of combination drug therapy regimens commencing with either losartan potassium, an angiotensin II receptor antagonist, or enalapril maleate for the treatment of severe hypertension. |
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http://www.ti.ubc.ca/pages/letter28.htm
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| | The Kidney |
| | Anything that dehydrates the body, such as perspiring heavily, | | | turns on the ADH → V2 receptors → aquaporin-2 pathway. | | | As little as 0.5 liter/day of urine may remain of the original 180 liters/day of nephric filtrate. |
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http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/K/Kidney.html
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| | Andogen Receptor Mutations Database Home Page |
| | Please feel free to send your feedback to bruce.gottlieb@mcgill.ca | | | Table of diseases associated with CAG tract length variation | | | This server is for all who are interested in mutations of the Androgen Receptor Gene. |
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http://ww2.mcgill.ca/androgendb
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| | MLNR - Motilin receptor |
| | This may not only lead to the further characterization of motilin receptor subtypes and aid the development of safe and selective motilin receptor agonists and antagonists, useful for the treatment of GI disorders, but may also give a new dimension to the role of motilin in human physiology. | | | Motilin and EMA have direct excitatory effects on circular smooth muscle from the human colon and these effects are mediated via a smooth-muscle motilin receptor. | | | The motilin pharmacophore in CHO cells expressing the human motilin receptor. |
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http://www.pdg.cnb.uam.es/UniPub/iHOP/gg/88786.html
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| | Receptor Mediated Endocytosis |
| | Receptor mediated endocytosis is a process by which cells internalize molecules or viruses. | | | The process depends first on specific binding to the receptor, which is a subject worthy of a lecture in itself. | | | The important thing to know about adaptins is that not all are alike. |
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http://www.cytochemistry.net/Cell-biology/recend.htm
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| | RBLX > Receptor BioLogix |
| | Receptor BioLogix, Inc. is a biopharmaceutical company focused on the development and commercialization of a newly discovered class of protein therapeutics called Intron Fusion Proteins™ (IFP™) to treat cancer, autoimmune, metabolic and other diseases. | | | The company’s lead clinical product, Dimercept™, is a naturally occurring receptor modulator that blocks activation of the entire EGF family of cell receptors commonly over-expressed or otherwise activated in many cancers and predictive of a more aggressive disease state. | | | Over-expressed in a virulent form of breast cancer, the well-known HER-2 receptor is a member of this family. |
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http://www.receptorbiologix.com
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| | Receptor (biochemistry) - Wikipedia, the free encyclopedia |
| | Adrenoceptors (also known as Adrenergic receptors, for adrenaline, and other structurally related hormones and drugs) | | | This increases the current understanding of drug action at binding sites on the receptors. | | | Receptors exist in different types, dependent on their ligand and function: |
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http://en.wikipedia.org/wiki/Receptor_(biochemistry)
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| | Receptor definition - Medical Dictionary definitions of popular medical terms |
| | A receptor called PXR appears to jump-start the body's response to unfamiliar chemicals and may be involved in drug-drug interactions. | | | Receptor definition - Medical Dictionary definitions of popular medical terms | | | Article includes descriptions, uses, drug interactions, and side effects. |
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http://www.medterms.com/script/main/art.asp?articlekey=5236
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| | InterPro: IPR002231 5-Hydroxytryptamine receptor |
| | In the CNS, 5HT is believed to be involved in a wide range of functions, including the control of appetite, mood, anxiety, hallucinations, sleep, vomiting and pain perception [ 5 ] 5HT receptor ligands are of clinical use in the treatment of depression, migraine and post-operative vomiting. | | | We use the term clan to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence [ 1 ]. | | | In the periphery, 5HT contracts a number of smooth muscles, and induces endothelium-dependent vasodilation through the formation of NO. It is a mediator of peristalsis, and may be involved in platelet aggregation and homeostasis. |
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http://www.ebi.ac.uk/interpro/IEntry?ac=IPR002231
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| | Receptor-Receptor Interactions |
| | These interactions may be mediated by the extracellular divergent loop region of which a modeled structure is shown in the figure to the left. | | | Behavioral, functional, and biochemical evidence for the association of these two GPCR's in the basal ganglia was recently summarized and show that these intramembrane receptor-receptor interactions effect the pharmacology of the individual receptors. | | | This is largely a long-term research interest yet and we are still waiting for interested individual(s) to join the group who will help pursue this research. |
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http://www.ksu.edu/chem/faculty/Baures/Interactions.html~
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| | Muse Research :: Receptor Overview |
| | Keyboardists have been looking to use plug-ins in our everyday playing situations, and Receptor has come to our rescue! | | | “…this feels like a module many of us have been waiting for… a very deep and powerful device…in all ways, Receptor is a winner… Receptor may be the most testing temptation our credit cards have experienced for some time.” | | | Each source is then routed through its own inline effects matrix that allows three VST plugins to be configured in every possible parallel/series arrangement. |
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http://www.museresearch.com/receptor_overview.php
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| | Age-related changes in cardiac adenosine receptor expression. |
| | Subsequently, relative analysis of the adenosine receptor subtypes using 18S rRNA found a significant age-related reduction in the expression of the adenosine A(1) receptor (5.5-fold), with no changes in the expression of the adenosine A(2A), A(2B) and A(3) receptors. | | | Absolute quantification showed that no age-related changes occurred in the expression of 18S rRNA or adenosine A(2B) receptor internal control genes. | | | In this study we determined the effect of age on cardiac adenosine receptor expression using the housekeeping gene 18S rRNA versus the adenosine A(2B) receptor gene as internal controls. |
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http://www.arclab.org/medlineupdates/abstract_15013665.html
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| | Receptor - Wikipedia, the free encyclopedia |
| | In physiology, a sensory receptor is any structure which, on receiving environmental stimuli, produces an informative nerve impulse. | | | In biochemistry, a receptor is a protein molecule that receives and responds to a specific neurotransmitter, hormone, or other substance. | | | This is a disambiguation page, a list of pages that otherwise might share the same title. |
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http://en.wikipedia.org/wiki/Receptor
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| | Chen, Qijun - Activation and regulation of the alpha-factor receptor. |
| | Our studies have shown that receptors are regulated by phosphorylation (Mol. | | | Nine candidates have been isolated as being more sensitive to *alpha*-factor. | | | The role of TMD6 was explored further by mutating polar residues in TMD6 to leucine. |
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http://www.yeastgenome.org/yeast96/f2326.html
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| | InterPro: IPR001320 Ionotropic glutamate receptor |
| | The ability of synapses to modify their synaptic strength in response to activity is a fundamental property of the nervous system and may be an essential component of learning and memory. | | | They are believed to play critical roles in synaptic plasticity. | | | At many synapses in the brain, transient activation of NMDA receptors leads to a persistent modification in the strength of synaptic transmission mediated by AMPA receptors and kainate receptors can act as the induction trigger for long-term changes in synaptic transmission [ 1 ]. |
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http://www.ebi.ac.uk/interpro/IEntry?ac=IPR001320
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| | ECCO Receptor - powered by Receptor Technology |
| | A Three-Finger Propulsion Plate and Dual Axis Flex Channels Replicate the natural flex pattern of the human foot to allow ease of flexion and provide additional strength during the push-off phase. | | | The placement of each 'finger' is based on the biomechanics of the foot's natural geometry while encountering ascending, descending and horizontal surfaces. | | | Walking is science - pure design modern technology and quality"> |
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http://www.ecco-receptor.com
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| | A Brief Introduction to the Brain:Neurotransmitters |
| | Neurotransmitters act on receptors, which are transmembrane proteins that have an extracellular site that binds the neurotransmitter and suffers some conformational change. | | | Acetylcholine, for instance can act as an excitator when it binds to one type of receptor, and as an inhibitor when bound on another kind, even if both types of receptors are present in the same cell. | | | The following is a list of several known and well studied neurotransmitters, although some others have been proposed, along with bioactive peptides, such as substance P and neuropeptide Y. Neurotransmitter: |
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http://ifcsun1.ifisiol.unam.mx/Brain/trnsmt.htm
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| | Trophic factors |
| | Binding to Trk receptors by neurotrophis activates different pathways than p75 | | | Receptors: Transduce intracellular signals through serine-threonine kinase subunits | | | Each neurotrophin also binds to a specific Trk receptor |
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http://www.neuro.wustl.edu/neuromuscular/lab/trophic.htm
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| | The Nuclear Receptor Resource |
| | For a general overview of nuclear receptors, the drug industry and the NRR see Jeanne McAdara's article in The Scientist. | | | The NRR itself integrates the separate databases and allows an interactive forum for the dissemination of information about the superfamily. | | | Although the databases are located on different servers and are managed individually, they each form a node of the NRR. |
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http://biochem1.basic-sci.georgetown.edu/nrr/NRR1.html
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| | LICR-Brussels Signal Transduction Group |
| | Ghaffari, S. and Constantinescu, S. (2003) Human erythropoietin and the erythropoietin receptor. | | | Colamonici, O.R., Porterfield, B., Domanski, P., Constantinescu, S.N., and Pfeffer, L.M. Complementation of the interferon a response in resistant cells by expression of the cloned subunit of the interferon a receptor: A central role of this subunit in IFN-a signaling. | | | and Pfeffer, L.M. Role of the IFN-a/b receptor chain 1 in structure and transmembrane signaling of the IFN a/b receptor complex. |
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http://www.bru.licr.org/stg/stefan.html
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| | MedlinePlus Medical Encyclopedia: H2 Receptor antagonists |
| | H2 receptor antagonists are medications available by prescription and over-the-counter for reducing stomach acid. | | | Note: This list may not be all inclusive. | | | Call Poison Control or your local emergency number if an overdose of an H2 receptor antagonist has occured. |
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http://www.nlm.nih.gov/medlineplus/ency/article/002585.htm
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| | Vitamin D Nuclear Receptor (VDR) |
| | VDR has a domain structure homologous to that of the other nuclear receptors (see next section). | | | These are effected in two ways: (1) at the level of the plasma membrane (by a vitamin D membrane receptor) and (2) at the level of gene transcription. |
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http://vdr.bu.edu
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| | Olfactory Receptor DataBase (ORDB) |
| | Olfactory receptors (ORs) are the largest family in the genome, and the first of a widening range of chemosensory receptors (CRs) in other chemosensory organs. | | | It also provides links to a local cluster of databases of related information in SenseLab, and to other relevant databases worldwide. | | | ORDB began as a database of vertebrate OR genes and proteins and continues to support sequencing and analysis of these receptors by providing a comprehensive archive with search tools for this expanding family. |
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http://senselab.med.yale.edu/senselab/ORDB
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| | GPCRDB home page |
| | The numbering system have been modified for class A GPCRs: it describes now the helices location instead of transmembrane domains. | | | GPCRDB: Information system for G protein-coupled receptors (GPCRs) |
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http://www.gpcr.org/7tm
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| | IUPHAR RECEPTOR DATABASE - HOME |
| | Welcome to the official database of the IUPHAR Committee on Receptor Nomenclature and Drug Classification. |
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http://www.iuphar-db.org/iuphar-rd
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| | McArdle Faculty - Christopher A. Bradfield |
| | Chan, W. K., Yao, G., Gu, Y.-Z., and Bradfield, C. Cross-talk between the Aryl Hydrocarbon Receptor and Hypoxia Inducible Factor Signaling Pathways. | | | Walisser, J. A., and Bradfield, C. The Aryl Hydrocarbon Receptor: A Model of Gene-Environment Interactions. | | | Carver, L. A., and Bradfield, C. Ligand-dependent Interaction of the Aryl Hydrocarbon Receptor with a Novel Immunophilin Homologue in Vivo. |
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http://www.mcardle.wisc.edu/faculty/bio/bradfield_c.html
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| | Endocrine Disruptor BRD Page (Final) |
| | Notice to Reader: The BRDs contain data, a proposed list of substances, and minimum procedural standards that were reviewed by an independent Expert Panel in May 2002. | | | B4 - Standard Operating Procedure for the Rat Estrogen Receptor Equilibrium Exchange Assay | | | Please refer to the final report, ICCVAM Evaluation of In Vitro Test Methods For Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays, (NIH Publication No. 03-4503), for the final ICCVAM recommended substances and minimum procedural standards. |
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http://iccvam.niehs.nih.gov/methods/endodocs/ed_brd.htm
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| | Nuclear Receptor Home page |
| | Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing PPAR isoforms | | | Nuclear Receptor is ready to receive papers on all aspects of the molecular features of nuclear receptor biology | | | The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals |
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http://www.nuclear-receptor.com/home
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| | Pain Receptor |
| | Sylva leaves for Vegas, but not until Pain Receptor does a crazy show in NJ | | | First Live Show was at Duvel's in Clifton, NJ opening for KILLBOX on November 21st, 2001 (Thursday). | | | Record Label Crazy Enough to have me...okay I pay them |
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http://www.painreceptor.com
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| | AllRefer.com - angiotensin receptor blocker (Pharmacology) - Encyclopedia |
| | More articles from AllRefer Reference on angiotensin receptor blocker | | | You are here : AllRefer.com > Reference > Encyclopedia > Pharmacology > angiotensin receptor blocker | | | AllRefer.com - angiotensin receptor blocker (Pharmacology) - Encyclopedia |
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http://reference.allrefer.com/encyclopedia/X/X-angtnsnrcp.html
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| | 1998 Research Publications |
| | Karlen, S., De Boer, M.L., Lipscombe, R.J., Lutz, W., Mordinov, V.A. and Sanderson, C.J. (Review)Biological and molecular characteristics of interleukin-5 and its receptor, 16: pp 227-247, Amsterdam, Netherlands(1998) | | | Sanderson, C.J. Interleukin-5 and its Receptor, Encyclopedia of Immunology, 3: pp 1456-1458, London (1998) |
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http://www.publishing.uwa.edu.au/research/1998/Microbiology.asp
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