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| | Journal of Family Practice: Quinolones: a practical review of clinical uses, dosing considerations, and drug ... |
 | | Quinolones are associated with several clinically significant drug interactions. | | | Indiscriminate use of quinolones has resulted in increased patterns of resistance, which is especially problematic for Pseudomonas aeruginosa and Staphylococcus aureus. | | | However, in more than 1000 pediatric patients who have received ciprofloxacin, there have been no definite arthropathies.[3] Most of these children were patients with cystic fibrosis who received ciprofloxacin because other therapeutic options were not feasible because of such problems as drug resistance to other antibiotics. |
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http://www.findarticles.com/p/articles/mi_m0689/is_n1_v42/ai_17872615
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| | The Body: Quinolones Show Promise of Much Shorter Therapy; A Match with RFP Seen |
| | Rick O'Brien, MD, head of the research and evaluation branch of the CDC's Division of TB Elimination, thinks it might be possible to use quinolone along with RFP to achieve a super-short induction phase of perhaps two weeks, followed by once-weekly therapy for six months. | | | Quinolones Show Promise of Much Shorter Therapy; A Match with RFP Seen | | | The Body: Quinolones Show Promise of Much Shorter Therapy; A Match with RFP Seen |
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http://www.thebody.com/cdc/news_updates_archive/jun11_01/quinolones.html
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| | Third Generation Quinolones |
| | There are a number of promising potent and safer quinolones in development and the study of structure activity relationships has played a major role in their development. | | | Whether these will offer the answer to a number of key problems experienced with the older drugs and fulfil their early promise remains to be seen. | | | These NFQs are reported to have a broad antibacterial spectrum with a focus on resistant Gram-positive organisms such as multidrug resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae. |
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http://www.ims-global.com/insight/news_story/news_story_000106a.htm
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| | Quinolones |
| | There are interactions that are common to antibacterial drugs in general and interactions involving a specific quinolone. | | | Each drug within the family kills specific bacteria; therefore, healthcare practitioners prescribe quinolones based on the individual’s current needs. | | | The information in this article may not necessarily apply to drugs in this class for which no separate article exists. |
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http://www.naturesbounty.com/vf/healthnotes/HN_live/Drug/Quinolones.htm
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| | [Frontiers in Bioscience 2, e63-71, August 15, 1997] |
| | Quinolones have not been successful in treating Helicobacter pylori (50). | | | A major concern of primary care practitioners is the use of quinolones in the treatment of enterococcal infections. | | | Ciprofloxacin has been successfully employed in treating MAC and has established itself as an essential drug in the treatment of multi-drug resistant tuberculosis. |
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http://www.bioscience.org/1997/v2/e/bonomo/4.htm
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| | Quinolones for the treatment and prophylaxis of tuberculosis. |
| | In the future, quinolones may emerge as first-line therapy for TB. | | | This is important considering that one of the most significant factors contributing to resistance is compliance. | | | Quinolones for the treatment and prophylaxis of tuberculosis. |
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http://www.aegis.com/aidsline/1997/mar/M9730698.html
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| | MRB: The Quinolones |
| | Quinolones are at the forefront of this research. | | | This book presents the most current information available in our continual struggle to conquer disease. | | | Quinolones are antimicrobial agents effective in the treatment of selected community-acquired and nosocomial infections. |
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http://www.medical-research-books.com/mrb-books-reviewed/0120595176.html
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| | The Fluoroquinolone Toxicity Research Foundation |
| | 2 to 20 percent of patients treated with quinolones. | | | Prolongation of the corrected QT interval (QTc) may precipitate fatal ventricular arrhythmias such as torsades de pointes. | | | Acute bronchitis may follow a viral illness, but antimicrobial therapy generally is not warranted unless the patient has underlying pulmonary disease. |
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http://www.fqresearch.org/m2.htm
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| | Structures of existing and new quinolones and relationship to bactericidal activity against Streptococcus pneumoniae -- ... |
| | Structures of existing and new quinolones and relationship to bactericidal activity against Streptococcus pneumoniae -- Mitsuyama 44 (2): 201 -- Journal of Antimicrobial Chemotherapy | | | Structures of existing and new quinolones and relationship to bactericidal activity against Streptococcus pneumoniae | | | Comparative activity of fluorinated quinolones in acute and subacute Streptococcus pneumoniae pneumonia models: efficacy of temafloxacin. |
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http://jac.oxfordjournals.org/cgi/content/full/44/2/201
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| | QUINOLONES |
| | Although data exists to demonstrate their effectiveness, quinolones are not the drugs of choice because of their moderate activity against Staphylococci, and tendency for resistance to develop. | | | Some quinolones are used in combination with other antimycobacterial drugs for the treatment of Mycobacterium tuberculosis and Mycobacterium-avium-intracellulare. | | | Should not be used alone as empiric therapy because of their inadequate activity against Streptococcus pneumoniae, one of the common pathogens in these infections. |
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http://www.uic.edu/pharmacy/courses/pmpr342/itokazu/quinolones.html
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| | Fact Sheet: Quinolones and the Clinical Laboratory |
| | Reporting susceptibilities to various quinolones provides the information necessary to choose an appropriate therapy that will minimize the selection of mutations leading to resistance. | | | Quinolones are antimicrobial agents effective in the treatment of selected community-acquired and nosocomial infections. | | | Resistance to quinolones limits drug selection for treatment of many infections. |
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http://www.cdc.gov/ncidod/hip/Lab/FactSheet/quinlolones.htm
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| | Quinolones and Tendon Ruptures |
| | We also review the literature describing the association between fluoroquinolones and tendon rupture and discuss the mechanisms explaining the heightened risk of tendon rupture associated with these drugs. | | | Online databases and journal websites can be searched to find papers about quinolone drugs. |
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http://www.drugvictims.org/papers/00smjquin.html
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| | The Fluoroquinolone Toxicity Research Foundation |
| | Histopathological changes were observed in the retina of dogs. | | | Moxifloxacin should be discontinued if the patient experiences pain, inflammation, or rupture of a tendon. | | | Quinolones have been reported to have proconvulsant activity that is exacerbated with concomitant use of non-steroidal anti-inflammatory drugs (NSAIDS). |
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http://www.fqresearch.org/moxifloxacin.htm
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| | Re: Neurotoxic Effects from Quinolones |
| | As you probably know already, the quinolones are also a GABA inhibitor (a neurotransmitter that balances the excitatory stimuli with a negative influence), in addition to it's antibiotic property. | | | Since quinolones are GABA inhibitors they probably should not be taken with other CNS stimulants like large doses of caffeine or theophylline. | | | The company recommends that this medication not be given to anyone with a pre-existing neurological problem such as seizures. |
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http://www.medhelp.org/perl6/neuro/archive/10232.html
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| | The Quinolones - New Discoveries, January 22, 2005 |
| | But it virtually does increase with all of the other drugs other than the two that are no longer available. | | | The quinolones we'll talk about today are fluoroquinolones and are very, very different in terms of their activity from what Nalidixic acid, or NegGram, was. | | | This was an important consideration because originally, ciprofloxacin was thought to be adequate therapy for pneumococcal and staphylococcal infection, but it became obvious that the sensitivities were borderline and then I told you about that slow, small step-type of resistance which occurs over time, and that happened with ciprofloxacin. |
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http://www.ccspublishing.com/journals5a/quinolones.htm
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| | How Quinolones Work... |
| | Much is known about the structure activity relationships of the quinolones: | | | This carboxy group may also be responsible for chondrotoxicity as the same part of the molecule chelates cations like Mg2+. | | | Quinolones bind to DNA gyrase via the carboxy group at C3 in the 4-quinolone ring so these are essential for activity. |
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http://www.ims-global.com/insight/news_story/news_story_000106b.htm
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| | Medindia.net |
| | the following quinolones are undergoing various phases of clinical trials viz., | | | Quinolones primary target is DNA Gyrase(Topoisomerase II) in many of the gram-ve organisms whereas in the case of gram+ve organisms Topoisomerase IV appears to be the primary target as is the case of Ciprofloxacin, Norfloxacin, and Sparfloxacin. | | | Longer plasma half life and o/d drug regimen |
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http://medindia.org/doctors/Epharma/december.asp
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| | Merck Vet. Edition - Pharmacokinetic Features |
| | Bioavailability is often >80% for most quinolones, except in ruminants with functional forestomachs, in which bioavailability may be as low as 20%. | | | Among the few quinolones that have been studied to any degree in domestic animals, pharmacokinetic differences are significant. | | | Characteristically, phase I reactions produce a number of primary metabolites (up to six have been described for some quinolones) that retain some antibacterial action. |
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http://www.merckvetmanual.com/mvm/htm/bc/191127.htm
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| | Quinolones |
| | The quinolones are a group of drugs known as broad-spectrum anti-infectives; that is, they are effective against many different bacteria. | | | One quinolone, ciprofloxacin, has been making headlines lately: it was used to treat the recent anthrax scare in the United States. | | | Names of the quinolones often end in “-oxacin.” Here are some examples: |
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http://www.infectionspotlight.com/resistance/Quinolones.jsp?id=20022
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| | Levofloxacin Infections Pharmatia Pharmacy: drugs & medicines |
| | Quinolone antibiotics have been known to cause tendon rupture during and after therapy. | | | It is also prescribed for flare-ups of chronic bronchitis, acute kidney infections, certain urinary infections, and skin infections. | | | The first sign of a developing problem is often a rash; so you should stop taking Levaquin and check with your doctor when any type of skin disorder appears. |
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http://pharmatia.net/infections/levofloxacin.php
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| | Neurotoxic Effects from Quinolones |
| | It is recommended in the package insert not to take the quinolones in a patient with a neurological disorder. | | | I hope this helps, it may be that you were looking up information that just described the reaction and not the pathophysiology of how the quinolones may work on the nervous system. | | | It has been reported that a very rare patient might experience status epilepticus. |
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http://www.medhelp.org/perl6/neuro/archive/10265.html
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| | quinolones |
| | My husband has been effected by Cipro,my Mother by Tequin and from her symptoms, I believe that my daughter has taken one of these drugs.The damage that they do seems to be harmful for years. | | | My husband has been > effected by Cipro,my Mother by Tequin and > from her symptoms, I believe that my > daughter has taken one of these drugs.The > damage that they do seems to be harmful for > years. | | | Can anyone give me a complete list of all the quinolone drugs? |
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http://www.rxlist.com/rxboard/levaquin.pl?read=1585
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| | Re: quinolones |
| | > is a complete list of all the quinolone drugs and further down you will |
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http://www.rxlist.com/rxboard/levaquin.pl?read=1587
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| | Quinolones - definition of Quinolones in Encyclopedia |
| | For example, case reports have implicated their use in rare instances of tendon damage, especially when administered with a systemic corticosteroid. | | | Quinolones or fluoroquinolones are a group of broad-spectrum antibiotics. | | | Embed a dictionary search in your own web page |
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http://encyclopedia.laborlawtalk.com/Quinolones
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| | Pharmaceutical Consulting Services |
| | Responsible for microbiological and clinical development of new quinolone antiinfective in the international marketplace for the Company. | | | Cox, C., Siporin, C. et al., A Multicenter, Double Blind Trimethoprim/Sulfamethoxazole Controlled Study of Enoxacin in the Treatment of Patients with Complicated Urinary Tract Infection. | | | Siporin, C., The Evolution of Fluorinated Quinolones: Pharmacology, Microbiological Activity, Clinical Uses and Toxicities. |
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http://www.greystoneconsult.com/about.cfm
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| | MedlinePlus Medical Encyclopedia: Legionnaire's disease |
| | Supportive treatment includes hospitalization for fluid and electrolyte replacement and oxygen administration by mask or by mechanical ventilation, if the respiratory system becomes severely compromised by the infection. | | | The antibiotics commonly used are quinolones (ciprofloxacin, levofloxacin, moxifloxacin, or gatifloxacin) or macrolides (azithromycin, clarithromycin, or erythromycin). |
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http://www.nlm.nih.gov/medlineplus/ency/article/000616.htm
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| | Pharmacology - Wikipedia, the free encyclopedia |
| | antifungal, alkalising agent, quinolones, antibiotic, cholinergic, anticholinergic, anticholinesterase, antispasmodic, 5-alpha reductase inhibitor, selective alpha-1 blocker, sildenafil |
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http://en.wikipedia.org/wiki/Pharmacology
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