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Topic: Prothrombin time



  
 Home Prothrombin Time Monitor for Anticoagulation Management
Accuracy of a portable prothrombin time monitor (CoaguChek) in patients on chronic oral anticoagulant therapy: A prospective multicenter study.
No randomized controlled studies were found in the published literature to evaluate the clinical importance of home prothrombin time monitoring for other conditions or diseases.
Home prothrombin time monitoring for anticoagulation management is considered medically necessary if the medical appropriateness criteria are met.
http://www.bcbst.com/MPManual/Home_Prothrombin_Time_Monitoring.htm   (724 words)

  
 Pathology Associates Of Lexington, P.A.
In other words, to be precise in using the only the prothrombin time itself (without any ratios), one would need to adjust the therapeutic range each time these changes occur, even though the changes may be small.
There is nothing inherently wrong with using the raw prothrombin time to adjust coumadin therapy.
However, laboratories periodically acquire new instruments or change reagent manufacturers...which changes may affect clotting times.
http://www.palpath.com/coaginr.htm   (564 words)

  
 UMHS -Prothrombin Time/Anticoagulation, Pediatric
At the clinic, the prothrombin time can be done by a finger poke method.
The blood test is called a prothrombin (pro-THROM-bin) time and measures how much the clotting system has been affected by the medicine.
You should speak to your physician or make an appointment to be seen if you have questions or concerns about this information or your medical condition.
http://www.med.umich.edu/1libr/tests/testpq08.htm   (590 words)

  
 Home Prothrombin Time Monitoring
However, the clinical impact of home prothrombin time monitoring is related to improved warfarin management.
For example, Beyth and colleagues reported on a study that randomized 325 patients who started warfarin therapy in the hospital to a self-monitoring and management group or a usual care group.
As with any monitoring technology, one would ideally like to isolate the contribution of the monitored data itself from the possible impact of increased patient education or contact with health professionals that is typically associated with more intense monitoring.
http://www.regence.com/trgmedpol/dme/dme44.html   (1290 words)

  
 Warfarin Management at HomeTestProgram: Hometest Program, Prothrombin Time Home Test
The ProTime® Microcoagulation System for prothrombin time testing is designed to better monitor the clotting activity of blood and to safely manage the status of anticoagulant therapy in patients who have mechanical heart valves, atrial fibrillation, or other conditions that require such therapy.
Studies show that patients on Coumadin® therapy who self-test do so more frequently, spend more time in their therapeutic range and have fewer complications.
The consequences of falling outside one's desired therapeutic range can be dire and can quickly lead to severe health complications, such as stroke and the need for emergency care.
http://www.hometestprogram.com   (486 words)

  
 Prothrombin time - Wikipedia, the free encyclopedia
The reference range for prothrombin time is 12 - 15 seconds; the range for the INR is 0.8-1.2.
The speed of the extrinsic pathway is very affected by levels of factor VII in the body.
The prothrombin ratio is the prothrombin time for a patient, divided by the result for control plasma.
http://www.wikipedia.org/wiki/Prothrombin_time   (876 words)

  
 Bibliography: Point-of-Care Prothrombin Time Monitoring - ACF Newsletter - Spring/Summer 1998
Practicability of patient self-testing of oral anticoagulant therapy by the INR using a portable whole blood monitor.
A novel whole blood capillary technique for measuring prothrombin time.Am J Clin Pathol 1987;88:442-446.
Bedside monitoring of warfarin therapy by a whole blood capillary coagulation monitor.
http://www.acforum.org/newsletter/springsum98/valid.html   (415 words)

  
 HOME MONITORING OF THE PROTHROMBIN TIME - Journal Watch (General)
Anderson DR et al Evaluation of a portable prothrombin time monitor for home use by patients who require long-term oral anticoagulant therapy Arch Intern Med 1993 Jun 28; 153:1441-1447.
One deterrent to chronic warfarin therapy is the need to frequently monitor prothrombin time (PT) to ensure effective anticoagulation and minimize bleeding complications.
For patients requiring lifelong anticoagulation, the convenience of home monitoring might well offset its expense ($600 for the machine, plus $4 per test).
http://genmed.jwatch.org/cgi/content/full/1993/713/1   (259 words)

  
 For Patients: About Prothrombin Time/INR
is the most common way to express the clotting time of blood.
These factors require that the PT is monitored regularly so the patient stays within the desired therapeutic range.
Furthermore, several studies have shown that the more time patients spend within the desired range of INR the less likely they are to suffer serious complications of their disease or condition.
http://www.hemosense.com/patient/pt_inr.html   (186 words)

  
 Cahaba GBA - 217 - PROTHROMBIN TIME
Diagnostic tests may only be ordered by a treating physician (or other treating practitioner acting within the scope of their license and Medicare requirements).
Plasma coagulation function is readily assessed with a few simple laboratory tests: the partial thromboplastin time (PTT), prothrombin time (PT), thrombin time (TT), or a quantitative fibrinogen determination.
The prothrombin time (PT) test is one in-vitro laboratory test used to assess coagulation.
http://www.gamedicare.com/policies/217.htm   (1013 words)

  
 Method for preparing from cultured cells a thromboplastic reagent suitable for use in the prothrombin time test - ...
There are several methods for producing thromboplastins from animal tissues: The classical acetone extraction/dehydration procedure of Quick et al.
In the past, many laboratories manufactured their own thromboplastins from human or animal tissues.
The prothrombin time (PT) test is one of several clinical hematology assays of plasma in which the result is based on the time required to form a fibrin clot.
http://www.freepatentsonline.com/5413919.html   (4895 words)

  
 Medicare Newsroom: [Home Prothrombin Time International Normalized Ratio (INR) Monitoring for Anticoagulation ...
For services furnished on or after July 1, 2002, Medicare will cover the use of home prothrombin time INR monitoring for anticoagulation management for patients with mechanical heart valves on warfarin (ICD-9 V43.3, Organ or tissue replaced by other means; heart valve, applies.)
NOTE: Porcine valves are not covered so Medicare will not make payment on Home INR Monitoring for patients with porcine valves.
The INR is the ratio of the patient's prothrombin time compared to the mean prothrombin time for a group of normal individuals.
http://www.hgsa.com/newsroom/news05062002.shtml   (395 words)

  
 Arch Intern Med -- Abstract: Evaluation of a portable prothrombin time monitor for home use by patients who require ...
Evaluation of a portable prothrombin time monitor for home use by patients who require long-term oral anticoagulant therapy
Arch Intern Med -- Abstract: Evaluation of a portable prothrombin time monitor for home use by patients who require long-term oral anticoagulant therapy, June 28, 1993, Anderson et al.
Systematic review of near patient test evaluations in primary care
http://dx.doi.org/10.1001/archinte.153.12.1441   (514 words)

  
 WHO Hepatitis D
The test is basic to any study of the coagulation process, and it helps in establishing and maintaining anticoagulant therapy.
prothrombin time a test used to measure the activity of clotting factors I, II, V, VII, and X. Deficiency of any of these factors leads to a prolongation of the prothrombin time.
http://www.who.int/csr/disease/hepatitis/whocdscsrncs20011/en/index7.html   (2065 words)

  
 Medical Encyclopedia: Prothrombin time (PT) (Print Version)
For a person on full anticoagulant therapy, the PT should be 2 to 3 times the laboratory "control" value.
This test may be performed under many conditions in the evaluation of a wide variety of disorders.
Note: This test is often performed on people who may have bleeding problems; if so, the risk of bleeding and hematoma are slightly greater than for people without bleeding problems.
http://www.nlm.nih.gov/medlineplus/print/ency/article/003652.htm   (818 words)

  
 Prothrombin time
Using the INR system, treatment to prevent blood clots (anticoagulant therapy) remains consistent even if a person has the test done at different labs.
A prothrombin time test may also be used to monitor treatment with medication that prevents the formation of blood clots.
A long prothrombin time can be caused by treatment with certain medications, such as heparin or warfarin (Coumadin), that are used to prevent the formation of blood clots.
http://www.online-ambulance.com/articles/doc/0/grp/Testdescription/art/ProthrombinTime.htm   (485 words)

  
 FAQ: Prothrombin Time
The "protime" (or "prothrombin time") is a method of measuring how well the body clots.
Generally a protime is considered to be prolonged if it is more than 1.2 times the control time.
When the protime is 22 seconds, it is said to be "twice control".
http://www.transweb.org/qa/qa_txp/faq_protime.html   (151 words)

  
 reference range (prothrombin time) - General Practice Notebook
reference range (prothrombin time) - General Practice Notebook
The information provided herein should not be used for diagnosis or treatment of any medical condition.
http://www.gpnotebook.co.uk/static/590676035.htm   (64 words)

  
 HGSA Medical Policy: L-57D - Prothrombin Time
The Prothrombin Time (PT) is used to evaluate the adequacy of the extrinsic system and common pathway in the clotting mechanism.
Many diseases and drugs are associated with decreased levels of these factors.
Title XVIII of the Social Security Act, Section 1833(e) states that no payment shall be made to any provider for any claim that lacks the necessary information to process the claim.
http://www.hgsa.com/professionals/retiredpolicy/l57d.html   (653 words)

  
 Randomized prospective trial comparing the native prothrombin antigen with the prothrombin time for monitoring oral ...
antigen (therapeutic range, 12 to 24 micrograms/mL) or the prothrombin time
the prothrombin time in patients anticoagulated with warfarin sodium, we
rate in warfarin-treated patients monitored with the native prothrombin
http://www.bloodjournal.org/cgi/content/short/75/2/344   (512 words)

  
 European Concerted Action on Anticoagulation (ECAA). An assessment of lyophilised plasmas for ISI calibration of ...
A monitor system is defined as a combination of a brand of monitor
Point of care testing (POCT) whole blood monitors are being
POCT monitor systems, performed at the same time at the same
http://jcp.bmjjournals.com/cgi/content/full/56/2/114   (3137 words)

  
 Prothrombin Time Home Test, ProTime Microcoagulation System, INR
The ProTime ensures patients and physicians that Coumadin therapy is at optimal therapeutic prothrombin time levels and is ideal for:
Medicare will cover and reimburse for home prothrombin time (INR) monitoring for anticoagulation management for certain patients.
Prothrombin Time Home Test, ProTime Microcoagulation System, INR
http://www.hometestprogram.com/provider.html   (389 words)

  
 Prothrombin Time
PT shorter than the reference range is not associated with any clinical condition and is usually related to improper procedure.
Monitor oral anticoagulant therapy with warfarin, which decreases the activity of VII, IX, X and prothrombin.
Collect blood from the patient into a citrated tube
http://medinfo.ufl.edu/year2/coag/pt.html   (195 words)

  
 The role of augmented Hageman factor ( factor XII) titers in the cold-promoted activation of factor VII and spontaneous ...
These data indicate that a high titer of HF, such as that observed in OCA users, is needed for the spontaneous CPA and add support to evidence linking the extrinsic and intrinsic pathways of clotting.
The prothrombin time was inversely related to factor VII activity and HF coagulant titer, whereas factor VII activity was strongly associated with the titer of HF.
The relationship of this in vitro phenomenon to the pathogenesis of thrombosis in women using OCAs is presently unclear.
http://www.pdg.cnb.uam.es/UniPub/iHOP/gp/3995279.html   (277 words)

  
 Prothrombin Time - [Medical Test]
For more information, see the medical tests Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT).
Prothrombin levels are monitored along with other tests, such as aspartate aminotransferase and alanine aminotransferase, to help evaluate liver function.
Discuss the use of a home test with your health professional.
http://www.peacehealth.org/kbase/topic/medtest/hw203083/consider.htm   (175 words)

  
 RATE-EXCHANGE.org - Currency Resources and Exchange-Rates
A thorough understanding of the different types of exchange rates is essential to becoming a successful participant in this dynamic market, and will help you develop an appreciation of the various tools that are available to aid in your decision making.
Occasionally, these rates are fixed values that can be relied upon not to change over periods of time.
While this antiquated system could be cumbersome at times, it sufficed for decades and successfully handled millions of individual transactions.
http://rate-exchange.org   (1313 words)

  
 Prolonged Prothrombin Time Profile
Avoid warfarin (Coumadin®) therapy for 2 weeks and heparin therapy for 2 days prior to the test.
To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Carefully remove the plasma from cells without disturbing the cells.
http://www.labcorp.com/datasets/labcorp/html/chapter/mono/cf003200.htm   (307 words)

  
 Fat emulsion effects on prothrombin time in warfarin anticoagulated patients: an in vitro study -- Cotto et al. 14 (2): ...
Fat emulsion effects on prothrombin time in warfarin anticoagulated patients: an in vitro study
The effect of lipid emulsions on prothrombin time in blood from anticoagulated patients was determined.
Fat emulsion effects on prothrombin time in warfarin anticoagulated patients: an in vitro study -- Cotto et al.
http://jpen.aspenjournals.org/cgi/content/abstract/14/2/201   (252 words)

  
 prothrombin time
clotting time of plasma recalcified in the presence of excess tissue thromboplastin; used for monitoring anticoagulant therapy with coumarins.
http://crisp.cit.nih.gov/Thesaurus/00006719.htm   (19 words)

  
 Results of a Survey of Prothrombin Time Testing Practices in the Pacific Northwest, 2004
See more of The 2005 Institute for Quality in Laboratory Medicine Conference
Coagulation and bleeding problems are associated with substantial morbidity and mortality, and certain inappropriate prothrombin time (PT) testing practices may lead to such complications.
Results of a Survey of Prothrombin Time Testing Practices in the Pacific Northwest, 2004
http://cdc.confex.com/cdc/qlm2005/techprogram/paper_8624.htm   (334 words)

  
 [No title]
Feasibility of personal prothrombin time measurement in anticoagulant treatment follow-up.
http://journals.biohealthmatics.com/articles/0012537925.aspx   (388 words)

  
 News - Prothrombin Time Should Be Monitored In Cancer Patients Receiving Both Warfarin, Fluorouracil
Prothrombin time should be monitored in cancer patients who are receiving both prophylactic warfarin and fluorouracil, Italian researchers report.
Prothrombin Time Should Be Monitored In Cancer Patients Receiving Both Warfarin, Fluorouracil
A DGReview of :"Minidose warfarin prophylaxis for catheter-associated thrombosis in cancer patients: can it be safely associated with Fluorouracil-based chemotherapy?"
http://www.docguide.com/news/content.nsf/news/8525697700573E1885256CCF00360E4A   (452 words)

  
 Monitoring "mini-intensity" anticoagulation with warfarin: comparison of the prothrombin time using a sensitive ...
Prothrombin Fragment 1+2 Is Associated With Carotid Intima-Media Thickness in Subjects Free of Clinical Cardiovascular Disease
A mean reduction of 65% was observed for those patients with
F1+2, a marker of factor Xa action on prothrombin in vivo, were also
http://www.bloodjournal.org/cgi/content/abstract/79/8/2034   (544 words)

  
 DealWest.com - Western Canada classifieds - Free classifieds - pet classifieds auto, motorcycle, Canadian classifieds ...
The prothrombin time is commonly used as a method of monitoring the accuracy of blood thinning treatment (anticoagulation) with COUMADIN.
Because prothrombin comes before thrombin, it is called prothrombin.
Prothrombin time: A clotting test, the prothrombin time is done to test the integrity of part of the clotting scheme.
http://www.medicaldictionary.dealwest.com/p/Pp-Pt/Prothrombin_time.html   (205 words)

  
 Prothrombin Time
This test measures the integrity of the extrinsic and common pathways of coagulation, whereas the activated partial thromboplastin time (PTT) measures the integrity of the intrinsic and common pathways of coagulation.
During warfarin initiation, the PT/INR is typically checked daily or at least 4-5 times per week until the dose and INR are therapeutic and stable.
It is added to patient plasma, and the time until clot formation is measured in seconds.
http://www.mgh.harvard.edu/labmed/lab/coag/handbook/co004400.htm   (2167 words)

  
 Healthopedia.com - Prothrombin Time (PT)
You are here : Healthopedia.com > Medical Encyclopedia > Tests and Exams > Prothrombin Time
The prothrombin time test, also called PT, helps measure how well your blood is able to clot.
It is much like the partial thromboplastin time test, which is also called PTT.
http://www.healthopedia.com/prothrombin-time   (334 words)

  
 Influence of Lepirudin, Argatroban, and Melagatran on Prothrombin Time and Additional Effect of Oral Anticoagulation -- ...
International standardization of laboratory control of oral anticoagulant therapy: a survey of thromboplastin reagents used for prothrombin time testing.
Effect of melagatran, the active form of the oral direct thrombin inhibitor, ximelagatran (pINN, formerly H 376/95), on activated partial thromboplastin time in orthopedic surgery patients treated to prevent deep vein thrombosis and pulmonary embolism [Abstract P 3093].
were 10%, 8.7%, and 9.9% at clotting times of 10, 50, and 300
http://www.clinchem.org/cgi/content/full/48/10/1791   (2071 words)

  
 OIVD: Home-Use Tests - Prothrombin Time
If you take blood-thinning drugs such as Coumadin or Warfarin, you may need to test you blood regularly to make sure it clots properly.
Your doctor may want to take a sample of your blood and compare the clotting time of that sample with the time your meter gives.
This is a quantitative test -- you find out the length of time it takes your blood to clot.
http://www.fda.gov/cdrh/oivd/homeuse-prothombin.html   (345 words)

  
 Use of EDTA samples for prothrombin time measurement in patients receiving oral anticoagulants
Horsti J. Use of EDTA samples for prothrombin time measurement in patients receiving oral anticoagulants.
Use of EDTA samples for prothrombin time measurement in patients receiving oral anticoagulants
http://www.hytti.uku.fi/tays/julkaisut/2001/200100271.html   (28 words)

  
 Cahaba Government Benefit Administrators: Prothrombin Time
In addition, prothrombin time testing performed for indications other than those listed above will be considered not medically necessary or reasonable and will result in denial of coverage.
This test is performed to evaluate the extrinsic coagulation system, evaluate deficiency of prothrombin, dysfibrinogenemia, afibrinogenemia (complete), heparin effect, coumadin or wafarin effect, liver failure, disseminated intravascular coagulation (DIC), and vitamin K deficiency.
Documentation supporting the medical necessity of this item, such as ICD-9-CM codes, must be submitted with each claim.
http://www.almedicare.com/provider/LMRPBRetired/R_Prothrombin%20Time.htm   (360 words)

  
 [No title]
Accuracy and precision of point-of-care testing for glucose and prothrombin time at the critical care units.
http://journals.biohealthmatics.com/articles/0011369346.aspx   (144 words)

  
 NICL Laboratories: Customer Resources - Prothrombin Time with International Normalized Ratio (INR)
Prothrombin Time with International Normalized Ratio (INR) for Monitoring Anticoagulated Patients
The World Health Organization along with the International Committee on Thrombosis and Haemostasis recommend that reporting of PT results for patients on oral anticoagulant therapy include the use of INR (International Normalized Ratio) values.
NICL Laboratories: Customer Resources - Prothrombin Time with International Normalized Ratio (INR)
http://www.nicl.com/customer/prothrombin.html   (211 words)

  
 Cold-induced contact surface activation of the prothrombin time in whole blood.
Cold-induced contact surface activation of the prothrombin time in whole blood.This shortening is related to the activation of the contact phase of blood coagulation.
These studies indicate the pivotal roles of the contact phase of coagulation in initiating activation of the PT and of CI INH in inhibiting the activation of the coagulation factor(s) responsible for the cold-promoted activation of factor VII.
Shortening of the PT correlated directly with increased levels of factor VII.
http://www.pdg.cnb.uam.es/UniPub/iHOP/gp/4142430.html   (214 words)

  
 Hemostasis Reference Laboratory Prothrombin Time
The PT assesses the extrinsic pathway of coagulation that includes factors VII, X, V, prothrombin, and fibrinogen.
The prothrombin time (PT) is a kinetic screening test performed by adding a sensitive tissue thromboplastin reagent and calcium chloride to plasma using an automated method.
See Sample Requirements when ordered with other tests.
http://www.psbc.org/lab_hemostasis/test05.htm   (128 words)

  
 CiteULike: Expression of recombinant rabbit tissue factor in Pichia pastoris, and its application in a prothrombin time ...
Expression of recombinant rabbit tissue factor in Pichia pastoris, and its application in a prothrombin time reagent
CiteULike: Expression of recombinant rabbit tissue factor in Pichia pastoris, and its application in a prothrombin time reagent
http://www.citeulike.org/article/15816   (80 words)

  
 STUDIES ON THE HEMORRHAGIC SWEET CLOVER DISEASE. VII. THE EFFECT OF 3,3'-METHYLENEBIS(4-HYDROXYCOUMARIN) ON THE ...
THE EFFECT OF 3,3'-METHYLENEBIS(4-HYDROXYCOUMARIN) ON THE PROTHROMBIN TIME OF THE PLASMA OF VARIOUS ANIMALS -- Overman et al.
http://www.jbc.org/cgi/reprint/142/2/941   (26 words)

  
 Provider Information: CMS Notice - Home Prothrombin Time International Normalized Ratio (INR) Monitoring for ...
Claims should be processed in accordance with §4020, Review of Health Insurance Claim Form – HCFA-1500, of Part 3, Chapter IV of the Medicare Carriers Manual.
Provider Information: CMS Notice - Home Prothrombin Time International Normalized Ratio (INR) Monitoring for Anticoagulation Management
http://www.momedicare.com/provider/CRS/cr2532abb.htm   (495 words)

  
 PREGNANCY-BIRTH Messages for April, 2000: Re: Prothrombin time?
This is for educational purposes only, and is not intended to be replacement or substitute for consultation and examination by an appropriate medical professional.
>Can anyone tell me what a prothrombin time is? My time was low normal,
Due to time constraints, private e-mails cannot be answered.
http://forums.obgyn.net/pregnancy-birth/P-B.0004/0180.html   (180 words)

  
 NEJM -- Effect of Laboratory Variation in the Prothrombin-Time Ratio on the Results of Oral Anticoagulant Therapy
to determine prothrombin time and consequent uncertainty about
the ratio of costs to effectiveness to almost five times the
Methods We explored the effect of this uncertainty on the benefits
http://content.nejm.org/cgi/content/short/329/10/696   (552 words)

  
 Prothrombin Time: Evaluation of Determination Methods
Horsti J. Prothrombin Time: Evaluation of Determination Methods.
http://www.hytti.uku.fi/tays/julkaisut/2002/200200411.html   (8 words)

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