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| | Protein phosphatases |
 | | Phosphatases that inactivate other kinases associated with the Ras-Raf-MAP kinase pathway are thought to exist, although their activities are poorly characterized. | | | This somewhat paradoxical finding was intriguing since phosphatases were largely considered to be negative regulators of growth-promoting pathways characterized by extensive protein tyrosine phosphorylation. | | | Similar DA and CS mutants for several phosphatases have also been used as dominant negatives to determine what pathways may recruit the activity of a particular phosphatase. |
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http://neurobio.mcphu.edu/GalloWeb/Loudonprotein_phosphatases.htm
(1839 words)
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| | Phosphatases in the Nervous System |
| | There were 6 speakers in the session who discussed various aspects of serine/threonine and tyrosine protein phosphatases in neuronal development, synaptic plasticity, and neuronal disease. | | | The mechanisms of such vulnerability are not well understood but it is recognized that brain ischemia can lead to the induction of pathological forms of synaptic plasticity causing delayed neuronal death, and also to changes in plasticity during recovery. | | | One notable feature of the presentation of given by Paul Lombroso that is not included in the summary, is that he gave a translational presentation that bridged his clinical work in child psychiatric illness (autism and Tourette's) and basic research into the protein tyrosine phosphatase, STEP, in learning processes related to these psychiatric illnesses. |
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http://www.neurochem.org/newsletter/Dec2004/PhosphatasesNervousSystem.htm
(1924 words)
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| | Protein Phosphatases |
| | The physiological significance of this heterogeneity is not known; however, recent studies suggest that the variable subunits regulate substrate specificity and catalytic activity in vitro. | | | Normal signal transduction from the cell surface to the nucleus in response to an external stimulus requires pathways which are acutely regulated by the reversible phosphorylation of specific proteins. | | | Several genes have been identified which encode the phosphatase catalytic subunits, and many of these proteins have been purified from a variety of tissues; including: skeletal muscle, heart, liver, kidney, and brain. |
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http://www.oxfordbiomed.com/mi85protphos.html
(417 words)
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| | EMD Biosciences: Protein Phosphatases / Inhibitors |
| | Protein Phosphatase Inhibitor 2, Rabbit Muscle, Recombinant, E. | | | When products are displayed, click on the catalog number hyperlink to view the products detail page. |
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http://www.emdbiosciences.com/Products/BrowseProductsByCategory.asp?catid=840
(86 words)
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| | Honkanen - Department of Biochemistry and Molecular Biology Homepage - University of South Alabama |
| | Such insight should aid in the development of new and improved methods for the medical management of an acute myocardial infarction. | | | A major goal of our cancer research is to identify and clone novel protein phosphatases that may play a role in the aberrant proliferative behavior of neoplastic cells. | | | Therefore, the interference of the "normal" activity of certain PPases may contribute to the aberrant proliferative behavior of neoplastic cells. |
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http://southmed.usouthal.edu/com/biochem/honkanen.html
(1970 words)
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| | [Frontiers in Bioscience 3, d961-972, September 1, 1998] |
| | A number of mechanisms have been analyzed with an eye on their potential for coordinating kinases and phosphatases. | | | Thus, hormones via the modulation of phosphatase inhibitors may control many different pathways, and phosphatase inhibitors become conduits for crosstalk between multiple signaling pathways or important devices for integrating and orchestrating the physiological response. | | | This was confirmed by the pharmacological treatment of cells with the phosphatase inhibitor, okadaic acid, which leads to a robust and prolonged phosphorylation of CREB and may in part account for the cytotoxic effects of this toxin. |
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http://www.bioscience.org/1998/V3/d/oliver/2.htm
(2332 words)
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| | Protein phosphatase - Wikipedia, the free encyclopedia |
| | This occurs on its own by hydrolysis or is mediated by protein phosphatases. | | | Serine and threonine phosphates are stable under physiological conditions, so a phosphatase has to remove the phosphate to reverse the regulation. | | | Ser/Thr-specific protein phosphatases are regulated by their location within the cell and by specific inhibitor proteins. |
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http://en.wikipedia.org/wiki/Protein_phosphatase
(155 words)
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| | Protein Phosphatases |
| | The processes involved in the binding of microcystins to protein phosphatases is the subject of some research. | | | Protein phosphatases are a group of enzymes, found ubiquitously, which are responsible for the dephosphorylation of various proteins and enzymes in a cell. | | | This role is an extremely important one since protein phosphorylation and dephosphorylation is required for the regulation of a large number of cellular activities. |
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http://www-cyanosite.bio.purdue.edu/cyanotox/toxins/ppase.html
(132 words)
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| | [No title] |
| | This process is dependent on the antagonistic interplay between protein kinases and phosphatases. | | | Consequently, it is generally observed that a substrate specific kinase is matched by a corresponding phosphatase. | | | Our new SignalScout™ Phosphatase Profiling System enables you to study dephosphorylation by protein tyrosine phosphatases. |
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http://www.stratagene.com/products/displayProduct.aspx?pid=696
(239 words)
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| | Signal Transduction Cascades |
| | is a general mechanism by which activity of many proteins is regulated, in eukaryotes (including mammals) as well as in prokaryotes. | | | is a mechanism by which some proteins (e.g., transcription factors) may be retained in the cytosol, and prevented from entering the cell nucleus. | | | Scaffold proteins often interact also with membrane constituents, elements of the cytoskeleton, and adaptors mediating recruitment into clathrin-coated vesicles. |
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http://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/part2/signals.htm
(1521 words)
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| | Protein Tyrosine Phosphatases |
| | This website aims to provide a peer-reviewed compendium on Protein Tyrosine Phosphatases (PTPs) that integrates sequence and structure information with cellular and biological function. | | | The cysteine phosphatases utilize a conserved 'C[X] R’ sequence motif to hydrolyze phosphoester bonds in proteins and in non-protein substrates. | | | They belong to a larger family of cysteine-dependent phosphatases that comprises 106 genes in humans and numerous pseudogenes. |
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http://ptp.cshl.edu
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| | Phosphoregulators: Protein kinases and Protein phosphatases of mouse |
| | This approach allowed us to 1) distinguish between true members of the protein kinase and phosphatase families and enzymes of related biochemistry 2) determine the structure of the families and 3) suggest functions for previously uncharacterized members. | | | The classifications obtained by this approach were in good agreement with previous schemes and allowed us to demonstrate domain associations with a number of clusters. | | | This cohort was then analysed using TribeMCL protein sequence similarity clustering followed by CLUSTALV alignment and hierarchical tree generation. |
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http://www.iscb.org/ismb2003/posters/a.forrestATimb.uq.edu.au_413.html
(214 words)
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| | Metaplastic Protein Phosphatases -- Klann 9 (4): 153 -- Learning & Memory |
| | Long-term depression in the hippocampus in vivo is associated with protein phosphatase-dependent alterations in extracellular signal-regulated kinase. | | | Metaplastic Protein Phosphatases -- Klann 9 (4): 153 -- Learning & Memory | | | An essential role for protein phosphatases in hippocampal long-term depression. |
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http://www.learnmem.org/cgi/content/full/9/4/153
(1677 words)
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