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| | ScienceMatters @ Berkeley. Mapping Cellular Signals |
 | | "The ability to understand how a specific kinase regulates signaling pathways would permit the development of new drugs and new strategies to control almost all disorders including cancer, neurological disorders, autoimmunity, and tissue rejection," he says. | | | "Kinases are involved in almost every aspect of physiology," he says. | | | Pharmacologists could then consult that map to determine the best drug therapy to fight a particular disease. |
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http://sciencematters.berkeley.edu/archives/volume2/issue14/story2.php
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| | CHI's Kinase |
| | Case studies will be presented where novel chemotypes were identified against Abl Kinase which is a commercially important target at this time due to the clinical resistance to Gleevec™ observed in patients with chronic myeloid leukemia (CML). | | | Ambit has developed a new, quantitative method to experimentally determine the specificity of kinase inhibitors. | | | 2:15 GPC286199: A Novel Cyclin-Dependent Kinase Inhibitor with Therapeutic Potential in Oncology |
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http://www.healthtech.com/2003/kin
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| | protein kinase substrates |
| | The phosphorylated peptide, in turn, is an effective substrate for phosphoprotein phosphatase. | | | The synthetic heptapeptide LRRWSLG (W4-Kemptide) is readily phosphorylated by the cAMP-dependent protein kinase (PKA). | | | The synthetic peptide LRRASVA is a very effective substrate for the cAMP dependent protein kinase (PKA) in in vitro kinase assays and represents a part of the phosphorylation site of rat liver pyruvate kinase. |
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http://www.proteinkinase.de/html/protein_kinase_substrates.html
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| | Protein Tyrosine Kinase |
| | This will entail making deletion constructs of both Csk and Lck, overproducing the proteins, and studying their behavior in pure form. | | | Another general puzzle in the protein kinase field is defining which particular substrates are subject to phosphorylation by specific kinases in the cell. | | | They are involved in immune, endocrine, and nervous system physiology and pathology and thought to be important in the development of many cancers. |
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http://www.rockefeller.edu/labheads/cole/cole-ptk.html
(599 words)
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| | Protein Kinase |
| | c-raf-1 is the first upstream kinase in the MAPK signal transduction pathway. | | | AK is involved in cytoskeleton organization and other signal transduction processes. | | | Distinct insulin-stimulated cytosolic protein kinase which phosphorylates eIF-4E (GLO118, kinase substrates) at physiological sites. |
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http://www.gentaur.com/new_page_80.htm
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| | Mitogen-activated protein kinase - Wikipedia, the free encyclopedia |
| | The JNKs (also known as stress-activated protein kinases; SAPKs) and p38 signaling pathways are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation and apoptosis. | | | The ERKs (also known as classical MAPKs) signaling pathway is preferentially activated in response to growth factors and phorbol ester (a tumor promoter), and regulates cell proliferation and cell differentiation. | | | And ERK5, which has been found recently, is activated both by growth factors and by stress stimuli, and it participates in cell proliferation. |
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http://en.wikipedia.org/wiki/MAP_kinase
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| | Protein Kinase C |
| | Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis. | | | In the future, the same or similar drugs probably will be tested as treatments for neovascularizations caused by age related macular degeneration. | | | Drugs which inhibit protein kinase C may be able to block this neovascularization pathway. |
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http://www.eyesight.org/Research/Research-Kinase/research-kinase.html
(561 words)
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| | OriGene - cDNA Clones - Protein Kinase Family CloneSet |
| | Because dysfunction of kinase genes results in a variety of diseases, such as cancer, diabetes and heart disease, this family of genes has captured academic and pharmaceutical research interest. | | | Protein kinases play key roles in most aspects of cellular process, including cell division, signal transduction, apoptosis and cell mobility. | | | According to a recent survey (Manning, G. et al., Science 298:1912, 2002), the human "kinome" (complete kinase collection) contains 518 gene loci, with multiple alternative splicing variants for some of the loci, and represents 1.7% of human gene repertoire. |
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http://www.origene.com/cdna/gene_family/kinase.mspx
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| | Amazon.com: Protein Kinase Protocols (Methods in Molecular Biology): Books: Alastair D. Reith |
| | Presents a range of techniques and tools for understanding the roles of specific protein kinases within signalling cascades and for identification and evaluation of novel therapeutic targets. | | | ...provides the methods and techniques utilized by experts to identify proteins according to their interactive relationship with other components of signaling cascades and protocols for analysis of functional properties. | | | Customers interested in this title may also be interested in: |
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http://www.amazon.com/exec/obidos/tg/detail/-/0896037002?v=glance
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| | Kinase.com |
| | kinase.com explores the the functions, evolution and diversity of protein kinases through analysis of kinomes - the full complement of protein kinases of any sequenced organism. | | | We have also carried out kinome analyses of three important model organisms: the nematode Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and the yeast Saccharomyces cerevisiae. | | | HyperTree is a tool we developed to visualize large phylogenetic trees. |
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http://www.kinase.com
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| | Kinase Assays |
| | The phosphorylated molecule can be another protein, the kinase itself (autophosphorylation) or any other molecule. | | | P transferred to the substrate over time would indicate the rate of activity for each kinase. | | | There is no way of knowing in advance whether a kinase will activate or inactivate its substrate. |
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http://www.bio.davidson.edu/courses/genomics/method/kinaseassay.html
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| | Pfam 19.0 : Pkinase |
| | Eukaryotic protein kinases PUBMED:12734000, PUBMED:7768349, PUBMED:1835513, PUBMED:1956325, PUBMED:3291115 are enzymesthat belong to a very extensive family of proteins which share a conserved catalytic core common withboth serine/threonine and tyrosine protein kinases. | | | This entry includes protein kinases from eukaryotes and viruses and may include some bacterial hits too. | | | Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. |
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http://pfam.wustl.edu/cgi-bin/getdesc?acc=PF00069
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