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| | NIH Guide: PROTEASE INHIBITOR RELATED ATHEROSCLEROSIS IN HIV INFECTION |
 | | Combinations of various protease inhibitors with nucleoside and non-nucleoside reverse transcriptase inhibitors usually have synergistic effects and are used effectively in clinical practice. | | | Proposed Research The known information on the dyslipidemias and lipodystrophy associated with protease inhibitor therapy for HIV-positive patients is derived from clinical observations. | | | Four protease inhibitors are currently in use: saquinavir mesylate, ritonavir, indinavir sulfate and nelfinavir. |
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http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-00-007.html
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| | SF AIDS Fdn: BETA 9/97 -- Protease Inhibitor Drug Interactions |
| | Stopping a protease inhibitor may result in the development of drug resistance and may preclude later use of that drug. | | | Much is already known about protease inhibitors and the ways they affect and are affected by other drugs. | | | Ketoconazole (Nizoral) and related drugs block the breakdown of saquinavir, indinavir and perhaps other protease inhibitors, with a resulting increase in protease inhibitor levels. |
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http://www.sfaf.org/treatment/beta/b34/b34piint.html
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| | SF AIDS Fdn: BETA Live! 8/97 -- Protease Inhibitor Drug Interactions |
| | But it’s very important that people taking protease inhibitor drugs be aware that any other drug they can take could affect the activity of their protease inhibitor. | | | We’ll be discussing with our guests how protease inhibitors interact with each other, with other classes of anti-HIV drugs and with other types of drugs that are commonly used by people living with HIV and AIDS, such as antihistamines, antinausea drugs, antidepressants and many more. | | | Included in those drug interactions are the protease inhibitors, because protease inhibitors can inhibit the breakdown of the antihistamines, leading to high serum levels. |
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http://www.sfaf.org/treatment/betalive/bl897pi.html
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| | Simple FactSheet: Protease Inhibitors |
| | Protease inhibitors can affect the absorption of other drugs by the body. | | | For anyone with HIV, a thorough medical check-up is a good idea before starting protease inhibitor treatment. | | | Your health care provider should go over any potential drug interactions with you when starting a protease inhibitor. |
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http://www.aegis.com/factshts/network/simple/protease.html
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| | USC HIV/AIDS researcher announces new protease inhibitor |
| | Lipodystrophy is a common problem linked to protease inhibitors in which a patient’s belly swells or a pad of fat may grow behind the neck, while the arms, legs and face become gaunt. | | | "Our study showed that BMS-232632 is a potent protease inhibitor that is well tolerated and can be used safely in combination with other anti-HIV therapies," said Kathleen Squires, M.D., associate professor of medicine at the Keck School of Medicine of USC. | | | About 17 percent of patients taking BMS-232632 in the study experienced diarrhea, for example, far fewer than the 55 percent of patients taking the other protease inhibitor. |
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http://www.eurekalert.org/pub_releases/2001-02/UoSC-UHra-0402101.php
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| | HIV & AIDS - JAMA study shows increased mortality from protease inhibitor use |
| | These two studies did not use a true placebo, but instead placed one group on two drugs plus a protease inhibitor and the other group just on the two other drugs. | | | For example, the first study to be reviewed found that 40% of people on any drug regimen had to change drugs, mostly due to toxic side effects. | | | The study opens with the usual claims that "Triple drug combination therapy has been shown to dramatically decrease morbidity and mortality" (page 2568), and cites the two randomized studies mentioned at the opening of this message as evidence. |
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http://www.virusmyth.net/aids/news/mijama.htm
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| | News - Data Supports Development of Investigational HIV Protease Inhibitor Brecanavir |
| | Brecanavir is an HIV protease inhibitor in Phase IIb clinical development. | | | Data Supports Development of Investigational HIV Protease Inhibitor Brecanavir | | | Preliminary Antiviral Activity and Safety of 640385/Ritonavir in HIV-infected Patients (Study HPR10006); an 8-Week Interim Analysis. |
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http://www.docguide.com/news/content.nsf/news/8525697700573E18852570EC006970F2
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| | Eight Years of HIV Protease Inhibitor Therapy: |
| | The assumptions underlying this change are worth re-examining in light of improvements in protease inhibitors that have made them both simpler and more efficacious. | | | For example, data from ACTG 5095 as well as the recently discontinued ESS30009 study indicate that triple nucleoside therapy may not be sufficiently potent to be recommended as stand-alone treatment. Moreover, the resistance consequences of failing some triple nucleosides regimens can be particularly problematic. | | | Thus, there has been a resurgence of interest in the proper role of PIs in HIV treatment, and the remainder of this essay will focus on how the more recently developed drugs appear to fit into current HIV treatment approaches. |
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http://www.hivandhepatitis.com/recent/protease/112403_essay.html
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| | CRISP - Computer Retrieval of Information on Scientific Projects, Abstract Display |
| | Further, intervention experiments will be initiated to abrogate protease inhibitor-induced hyperlipidemia using genetic approaches. | | | The investigators expect that the synergisms and interactions between the three collaborating R01 applications will provide a framework for development of new approaches to correct metabolic derangements in HIV-infected subjects treated with protease inhibitors, will impact on future drug development and reduce the risk of cardiovascular disease. | | | Abstract: DESCRIPTION (Adapted from the applicant's abstract) In this collaborative series of projects, the investigators will characterize the underlying mechanisms for the metabolic complications (hyperlipidemia/body fat redistribution/insulin resistance) associated with protease inhibitors in HIV-infected subjects. |
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http://crisp.cit.nih.gov/crisp/CRISP_LIB.getdoc?textkey=6818763&p_grant_num=5R01HL065953-05&p_query=(atherosclerosis)&ticket=16289214&p_audit_session_id=76645215&p_audit_score=26&p_audit_numfound=276&p_keywords=atherosclerosis
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| | Science & Medicine Long-Term Protease Inhibitor Treatment Increases Men's Risk for Heart Attack, Study Says - ... |
| | Long-term antiretroviral drug treatment including protease inhibitors increases HIV-positive men's risk for heart attack, according to a study published in the Nov. 21 issue of the journal | | | In an accompanying editorial, Dr. Peter Reiss of the University of Amsterdam, writes, "It seems prudent to at least consider individually managing patients with respect to their risk of developing coronary artery disease," adding that doctors should encourage HIV-positive patients to stop smoking and appropriately modify diet and exercise ( | | | Although the life expectancy gained by taking antiretroviral treatments that include protease inhibitors "far outweighs" the increased heart attack risk, physicians should consider patients' cardiovascular disease risk factors when deciding whether to prescribe protease inhibitors, the researchers concluded. |
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http://www.kaisernetwork.org/daily_reports/rep_index.cfm?DR_ID=21427
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| | Bugs in the News - Protease Inhibitor and HIV |
| | In many instances, such combined therapy has led to the inability to any longer detect the virus within treated patients. | | | Before I begin, if you first wish to learn a bit about HIV and AIDS, please see: HIV, AIDS and The Immune System. | | | Further, the research which led to the use of protease inhibitors for treatment of HIV infection has provided further information as to the mechanism of HIV infection, and may perhaps lead to other treatment therapies. |
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http://people.ku.edu/~jbrown/protease.html
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| | Protease inhibitor (pharmacology) - Wikipedia, the free encyclopedia |
| | Protease inhibitors were the second class of antiretroviral drugs developed. | | | Protease inhibitors (PIs) are a class of medication used to treat or prevent infection by viruses, including HIV and Hepatitis C. | | | Protease inhibitors have been developed or are presently undergoing testing for treating various viruses: |
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http://en.wikipedia.org/wiki/Protease_inhibitor_(pharmacology)
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| | The Body: NIH Clinical Center Study Demonstrates Dangerous Interaction Between St. John's Wort and an HIV Protease ... |
| | "When St. John's wort and the protease inhibitor indinavir are taken together, the levels of indinavir in the blood drop dramatically," explained the study's principal investigator, clinical pharmacokineticist Dr. Stephen Piscitelli of the NIH Clinical Center's Pharmacy Department. | | | The Body: NIH Clinical Center Study Demonstrates Dangerous Interaction Between St. John's Wort and an HIV Protease Inhibitor | | | These drugs are among the most potent agents available for treating HIV infection and have been shown to prolong survival and slow the progression of the disease. |
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http://www.thebody.com/nih/st_johns.html
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| | CRISP - Computer Retrieval of Information on Scientific Projects, Abstract Display |
| | Abstract: DESCRIPTION (provided by applicant): Protease inhibitor therapy has greatly increased the lifespan of individuals infected with the human immunodeficiency virus (HIV). | | | Women on protease inhibitor therapy, however, have similar dyslipidemia as men on protease inhibitor therapy, suggesting that the cardioprotective effects of estrogen are lost. | | | Unfortunately, one of the deleterious side effects of protease inhibitor therapy is dyslipidemia which is known to be closely associated with development of atherosclerosis. |
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http://crisp.cit.nih.gov/crisp/CRISP_LIB.getdoc?textkey=6917149&p_grant_num=5R01HL073693-03&p_query=(atherosclerosis)&ticket=16289214&p_audit_session_id=76645215&p_audit_score=35&p_audit_numfound=261&p_keywords=atherosclerosis
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| | The Body: Debate Widens Over Protease Inhibitor Side Effects |
| | Chris Duncombe and colleagues from Sydney, Australia, conducted an observational study on 21 participants with hyperlipidemia and visual evidence of lipodystrophy to evaluate changes in serum lipids after switching protease inhibitor therapy (abstract 12287). | | | Of 135 patients in the Regions Hospital Clinic on protease inhibitor-containing regimens, 48% had elevated lipid levels (compared to 17% of non-protease inhibitor treated patients). | | | Kotler believes it is still unclear if the symptoms are specifically linked with the presence of the protease inhibitors in the body or are the result of effective control of HIV brought about by the use of HAART. |
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http://www.thebody.com/gmhc/issues/julaug98/lipo.html
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| | AEGiS-GMHC: Delavirdine/Protease Inhibitor Interactions |
| | A major issue that remains unresolved with both delavirdine and nevirapine is how these drugs affect the body's metabolism of protease inhibitors. | | | Like the protease inhibitor ritonavir, both NNRTIs affect the CYP3A enzyme system in the liver that breaks down many drugs. | | | The result of these hepatic changes on protease inhibitor blood levels or efficacy has been little explored up to now. |
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http://www.aegis.com/pubs/gmhc/1996/GM100904.html
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| | FDA Approves a Once Daily Protease Inhibitor for HIV Infection |
| | These treatment benefits were observed both in patients who had not been previously treated and in patients who had previously received other anti-retroviral therapy. | | | The Food and Drug Administration (FDA) today announced the approval of Reyataz (atazanavir sulfate), a protease inhibitor to be used in combination with other anti-retroviral agents for the treatment of patients with HIV infection. | | | Currently there are six other protease inhibitors approved by FDA for the treatment of HIV infection. |
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http://www.fda.gov/bbs/topics/ANSWERS/2003/ANS01233.html
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| | A List of Protease Inhibitors for HIV & AIDS |
| | When one PI is used in combination with other anti-HIV drugs – usually a total of 3 drugs – then this combination therapy can block the replication of HIV in a person's blood. | | | Protease Inhibitors (PIs) are a class of anti-HIV drugs. | | | Experimental drugs are italicized, and approved drugs are in regular, non-italicized type. |
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http://www.aidsmeds.com/PIs.htm
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| | Pierce Biotechnology - Halt Protease Inhibitor Cocktail |
| | Inhibit a variety of proteases using Halt Protease Inhibitor Cocktails. | | | SDS-PAGE analysis of the inhibition of protease activity using Halt Protease Inhibitor Cocktails. | | | Lane 2 shows BSA digestion in the presence of Halt Protease Inhibitor Cocktail. |
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http://www.piercenet.com/Objects/View.cfm?type=ProductFamily&ID=02040806
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| | CROI: HIV in Patients with Multiple Protease Inhibitor Mutations Remain Susceptible to Tipranavir |
| | "Baseline phenotypic susceptibility to tipranavir was maintained in 69.4% of HIV-1 isolates that were already highly resistant to available protease inhibitors," Dr. Cooper reported. | | | Conference on Retroviruses and Opportunistic Infections, researchers said that 93% of the patients recruited into their study had 10 or more mutations that compromised treatment with available antiretroviral drugs, and 41 of the isolates from the cohort of 216 patients had genotypes that were indicative of resistance to all currently marketed protease inhibitors. | | | Cooper's study examined the extent of susceptibility that the treated patients exhibited despite the multidrug-resistant profile of the virus. |
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http://www.docguide.com/dg.nsf/PrintPrint/1A9B9D608573169E85256CCB00526520
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| | Protease inhibitor definition - HIV: health and medical information about HIV and AIDS |
| | Protease inhibitor definition - HIV: health and medical information about HIV and AIDS | | | Protease inhibitors prevent the cleavage of HIV precursor proteins into active proteins, a process that normally occurs when HIV replicates. | | | Erectile Dysfunction (Impotence) - Read about erectile dysfunction (ED) / impotence includes what it is, how ED is diagnosed, and treatment options. |
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http://www.medterms.com/script/main/art.asp?articlekey=5080
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| | HIV Treatment and Medication - Viracept.com |
| | VIRACEPT is a medicine called a protease inhibitor. | | | Protease Inhibitors l HIV Drug Resistance l About VIRACEPT l How VIRACEPT Works l Benefits of VIRACEPT l | | | VIRACEPT Side Effects l Managing Side Effects l Starting on VIRACEPT l How to Take VIRACEPT l If You Miss a Dose l |
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http://www.viracept.com
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| | Boosted Invirase® (saquinavir mesylate)– A Powerful Protease Inhibitor |
| | Learn how INVIRASE can work for you—and your way of life—to treat and help control HIV. | | | Use and access of this site is subject to the terms and conditions as set out in our Legal Statement and PRIVACY Statement. | | | INVIRASE may be used only if it is combined with ritonavir, which significantly inhibits saquinavir's metabolism to provide plasma saquinavir levels at least equal to those achieved with FORTOVASE. |
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http://www.fortovase.com
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| | PillsPrescriptionRX.com - hcv inhibitor protease |
| | Complete and easy-to-read information on treating HIV & AIDS, including guided treatment lessons, info on drugs, recent news, community forums, & a drug interactions checker. | | | JoltSearch has results for hcv inhibitor protease and much more! | | | Find results for hcv inhibitor protease and anything else you are looking for instantly! |
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http://www.pillsprescriptionrx.com/p/hcv-inhibitor-protease.html
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| | FDA Public Health Advisory - St. John's Wort |
| | Subject: RISK OF DRUG INTERACTIONS WITH ST JOHN’S WORT AND INDINAVIR AND OTHER DRUGS | | | Consequently, concomitant use of St John’s wort with PIs or NNRTIs is not recommended because this may result in suboptimal antiretroviral drug concentrations, leading to loss of virologic response and development of resistance or class cross-resistance. | | | The Food and Drug Administration would like to inform you about results from a study conducted by The National Institutes of Health (NIH) that showed a significant drug interaction between St John's wort (hypericum perforatum), an herbal product sold as a dietary supplement, and indinavir, a protease inhibitor used to treat HIV infection. |
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http://www.fda.gov/cder/drug/advisory/stjwort.htm
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| | PRESS RELEASE Schering-Plough Reports Novel Investigational Protease Inhibitor Shows In Vitro Antiviral Activity in ... |
| | "Hepatitis C protease inhibitors have the potential to have the same impact on HCV therapy that the HIV drugs have had," he said. | | | "Once developed, these protease inhibitors, either alone or in combination with existing therapies, may help in eradicating the hepatitis C virus in patients chronically infected with the disease. | | | More than 300,000 hepatitis C patients worldwide, including 175,000 U.S. patients, have received this combination therapy since its introduction in 2001. |
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http://www.marketwire.com/mw/release_html_b1?release_id=59099
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| | HIV protease inhibitor |
| | These cyclic analogues are potent inhibitors of HIV protease, and the crystal structures show them to be structural mimics of acyclic peptides. | | | Three HIV-1 protease mutant species, glycine 48 converted to valine, leucine 90 converted to methionine and G48V/L90M double mutant, are associated in vivo with resistance to the drug saquinavir. | | | HIV protease, like the other proteins of this virus, is subject to rapid mutation that allows the virus to become resistant to the drug. |
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http://pathmicro.med.sc.edu/chime2/hiv-prot-frmleft.htm
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| | FDA Approves Once-Daily Combination of Abbott's Protease Inhibitor Kaletra |
| | FDA approval was based on data from a clinical study of 190 patients new to HIV therapy that compared once-daily and twice-daily Kaletra doses, both administered in combination with once-daily tenofovir and emtricitabine over a 48-week period (Dow Jones/SmartMoney.com, 5/2). | | | Pharmaceutical company Abbott Laboratories on Monday announced that the FDA has approved a once-daily formulation of its antiretroviral protease inhibitor Kaletra, which is used in combination with other drugs for initial treatment of HIV,... | | | The once-daily Kaletra -- which is a combination of the antiretroviral drugs lopinavir and ritonavir and initially was approved in a twice-daily regimen -- will be available in liquid and soft-gel formulations. |
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http://www.medicalnewstoday.com/medicalnews.php?newsid=23867
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| | AllRefer.com - protease inhibitor (Pharmacology) - Encyclopedia |
| | Clinical trials of the protease inhibitor indinavir have shown it to be especially beneficial in combination with the anti-HIV drugs AZT and 3TC, which act by blocking a different enzyme, reverse transcriptase. | | | protease inhibitor[prO´tE-As´´] Pronunciation Key, any of a class of drugs that interfere with replication of the AIDS virus (HIV), by blocking an enzyme (protease) necessary in the late stages of its reproduction. | | | Topics that might be of interest to you: |
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http://reference.allrefer.com/encyclopedia/P/proteas.html
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| | 7th Conference - Abstract 208 |
| | Osteopenia in a Randomized, Multicenter Study of Protease Inhibitor (PI) Substitution in Patients with the Lipodystrophy Syndrome and Well-Controlled HIV Viremia | | | Background: Osteopenia has been observed in patients with diabetes, male hypogonadism and inflammatory bowel disease. |
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http://www.retroconference.org/2000/abstracts/208.htm
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| | HIV Infection: Protease and Protease Inhibitors |
| | Mutations enable HIV to avoid treatments that involve only one drug, so there is growing use of multiple-drug therapies in which both a protease inhibitor AND a reverse transcript inhibitor are combined. | | | Viral protease cuts the long chain into its individual enzyme components which then facilitate the production of new viruses. | | | Inhibitors of this viral protease can be used to fight HIV infection. |
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http://www.cellsalive.com/hiv4.htm
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| | what's a protease inhibitor |
| | A Protease inhibitor, is used as a drug to inhibit HIV viral protease in AIDS patients. | | | But how does this help fight an HIV infection? | | | For these proteins to function, they must be cut into separate proteins. |
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http://www.galaxygoo.org/hiv/protease.html
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| | InterMune - Protease Inhibitor |
| | We are investigating small molecule approaches to treating HCV that are rapidly progressing through preclinical development. | | | With our partner, Array Biopharma Inc., we have identified and characterized several highly potent preclinical protease inhibitor candidates with improved bioavailability over competitive compounds. |
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http://www.intermune.com/wt/itmn/protease_inhibitor
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| | Kaletra: home |
| | KALETRA is a type of medicine called an HIV protease (PRO-tee-ase) inhibitor. | | | KALETRA is for adults and for children age 6 months and older. |
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http://www.kaletra.com
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| | The secretory leukocyte protease inhibitor gene is a target of epidermal growth factor receptor action in endometrial ... |
| | The inhibitor alone had no effect on basal | | | Llewellyn-Jones CG, Lomas DA and Stockley RA 1994 Potential role of recombinant secretory leucoprotease inhibitor in the prevention of neutrophil mediated matrix degradation. | | | Denison FC, Kelly RW, Calder AA and Riley SC 1999 Secretory leukocyte protease inhibitor concentration increases in amniotic fluid with the onset of labour in women: characterization of sites of release within the uterus. |
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http://joe.endocrinology-journals.org/cgi/content/full/184/1/141
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