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Topic: Prostacyclin



  
 Prostacyclin Therapy Before Pulmonary Thromboendarterectomy in Patients With Chronic Thromboembolic Pulmonary ...
Prostacyclin Therapy Before Pulmonary Thromboendarterectomy in Patients With Chronic Thromboembolic Pulmonary Hypertension -- Nagaya et al.
Prostacyclin Therapy Before Pulmonary Thromboendarterectomy in Patients With Chronic Thromboembolic Pulmonary Hypertension
increased during prostacyclin therapy (before therapy, 51 ±
http://www.chestjournal.org/cgi/content/full/123/2/338

  
 Angiotensin II mediates systemic rebound hypertension after cessation of prostacyclin infusion in sheep -- Robbins et ...
Prostacyclin stimulates the renin angiotensin aldosterone system in man. J.
Higenbottam, T. The place of prostacyclin in the clinical management of primary pulmonary hypertension.
There are reports indicating increased vasoreactivity associated with acute cessation of prostacyclin infusion in humans with
http://www.jap.org/cgi/content/full/85/2/731

  
 Journal of Applied Physiology -- Sign In Page
Combined inhaled nitric oxide and inhaled prostacyclin during experimental chronic...
http://jap.physiology.org/cgi/content/full/86/4/1160

  
 Prostacyclin Analogs as the Brakes for Pulmonary Artery Smooth Muscle Cell Proliferation . Is It Sufficient to Treat ...
Reduction in pulmonary vascular resistance with long-term epoprostenol (prostacyclin) therapy in primary pulmonary hypertension.
Gene transfer of human prostacyclin synthase ameliorates monocrotaline- induced pulmonary hypertension in rats.
our understanding of the antiproliferative effect of prostacyclin
http://ajrcmb.atsjournals.org/cgi/content/full/26/2/171

  
 American Family Physician: Prostacyclin Therapy for Pulmonary Hypertension
Side effects related to prostacyclin use were common, including diarrhea, jaw pain, headaches and flushing.
American Family Physician: Prostacyclin Therapy for Pulmonary Hypertension
Concurrent medications included warfarin in 94 percent of patients, diuretics in 94 percent of patients, digoxin in 76 percent of patients and calcium channel blockers (started before initiation of prostacyclin therapy) in 30 percent of patients.
http://www.findarticles.com/p/articles/mi_m3225/is_9_60/ai_58252697

  
 Cross talk of shear-induced production of prostacyclin and nitric oxide in endothelial cells -- Osanai et al. 278 (1): ...
Although blood flow is a critical regulator of endothelial prostacyclin and NO production in the physiological context of
Comparison of prostacyclin production among conditions with GTP
enhanced flow-induced prostacyclin production to a similar degree
http://ajpheart.physiology.org/cgi/content/full/278/1/H233

  
 Nitric oxide, oxygen, and prostacyclin in children with pulmonary hypertension -- Turanlahti et al. 79 (2): 169 -- Heart
Prostacyclin at 20 ng/kg/min was as effective as NO at 40
Nitric oxide, oxygen, and prostacyclin in children with pulmonary hypertension -- Turanlahti et al.
Nitric oxide, oxygen, and prostacyclin in children with pulmonary hypertension
http://heart.bmjjournals.com/cgi/content/full/79/2/169

  
 Epoprostenol (Prostacyclin) Therapy in HIV-associated Pulmonary Hypertension -- AGUILAR and FARBER 162 (5): 1846 -- ...
Epoprostenol (Prostacyclin) Therapy in HIV-associated Pulmonary Hypertension -- AGUILAR and FARBER 162 (5): 1846 -- American Journal of Respiratory and Critical Care Medicine
http://www.ajrccm.org/cgi/content/abstract/162/5/1846

  
 Drug Watch: Prostacyclin in primary pulmonary hypertension [Oct 1994; 8-4]
Randomized trial of conventional therapy alone vs. conventional therapy plus continuous infusion of prostacyclin in primary pulmonary hypertension.
A group of historical controls from the Mayo Clinic comprised patients studied before the drug was available.
The total number of patients on prostacyclin in all these studies was 149, and the results can only be regarded as preliminary.
http://www.jr2.ox.ac.uk/Bandolier/band8/b8-4.html

  
 Prostacyclins: Pulmonary Hypertension Treatments
Remodulin lasts longer than most prostacyclins like Flolan and is injected subcutaneously (under the skin) with a needle.
As stated above prostacyclin has been shown to improve blood circulation, allow exercise and extend the life of PPH patients who have been unresponsive to conventional therapy.
Most PH patients respond well to prostacyclin treatment and it is considered to be the leading therapy for severe PH.
http://www.pulmonary-hypertension-treatments.com/prostacyclin.html

  
 17{beta}-Estradiol Increases Rat Cerebrovascular Prostacyclin Synthesis by Elevating Cyclooxygenase-1 and Prostacyclin ...
Prostacyclin and thromboxane changes predating clinical onset of preeclampsia.
White FP, Dutton GR, Norenberg MD. Microvessels isolated from rat brain: localization of astrocyte processes by immunohistochemical techniques.
Stimulation of prostaglandin cyclooxygenase and prostacyclin synthetase activities by estradiol in rat aortic smooth muscle cells.
http://stroke.ahajournals.org/cgi/content/full/33/2/600

  
 Prostacyclin for pulmonary hypertension in adults (Cochrane Review)
Reviewers' conclusions: Intravenous prostacyclin or one of its analogues in addition to conventional therapy over 12 weeks appears to improve exercise capacity, NYHA functional class and several cardiopulmonary haemodynamic variables.
All the trials showed an improvement in exercise capacity.
There is some evidence that other routes of administration of the drug may also be effective with fewer side effects, which were mainly related to the indwelling catheter.
http://www.cochrane.org/cochrane/revabstr/ab002994.htm

  
 Prostaglandin H Synthase and Vascular Function -- Davidge 89 (8): 650 -- Circulation Research
prostacyclin) produced by the PGHS pathway generally induce
In regard to the PGHS pathway, there are data to suggest that
Prostacyclin is an important mediator of pulmonary vascular
http://circres.ahajournals.org/cgi/content/full/89/8/650

  
 Nitric Oxide Produced by Endothelial Cells Increases Production of Eicosanoids Through Activation of Prostaglandin H ...
cGMP (10 µmol/L) or a phosphodiesterase inhibitor (1 mmol/L) did not affect prostacyclin production.
as NO and the eicosanoids, prostacyclin and thromboxane.
Our data demonstrated the following: (1) A23187 stimulated NO synthesis along with prostacyclin and thromboxane production.
http://circres.ahajournals.org/cgi/content/full/77/2/274

  
 Combination of nonspecific PDE inhibitors with inhaled prostacyclin in experimental pulmonary hypertension -- Schermuly ...
Combination of nonspecific PDE inhibitors with inhaled prostacyclin in experimental pulmonary hypertension -- Schermuly et al.
oxide (NO) ( 14, 26) and nebulization of prostacyclin (PGI
Combination of nonspecific PDE inhibitors with inhaled prostacyclin in experimental pulmonary hypertension
http://ajplung.physiology.org/cgi/content/full/281/6/L1361

  
 Angiotensin II as a Trophic Factor of White Adipose Tissue: Stimulation of Adipose Cell Formation -- Saint-Marc et al. ...
Based upon in vivo and ex vivo experiments combined
with our previous in vitro observations ( 15, 30) that prostacyclin
Coculture experiments had shown that upon stimulation by AngII, prostacyclin
http://endo.endojournals.org/cgi/content/full/142/1/487

  
 ATP stimulates the release of prostacyclin from perfused veins isolated from the hamster hindlimb -- Hammer et al. 285 ...
vasoactive responses between iloprost and prostacyclin (J. Frisbee, personal communication), the analysis suggests
analysis to estimate the physiological relevance of the prostacyclin
to stimulate the release of of prostacyclin using adenosine.
http://ajpregu.physiology.org/cgi/content/full/285/1/R193

  
 Intraoperative Use of Inhaled PGI2 for Acute Pulmonary Hypertension and Right Ventricular Failure -- Schroeder et al. ...
Inhaled prostacyclin is safe, effective, and affordable in patients with pulmonary hypertension, right heart dysfunction, and refractory hypoxemia after cardiothoracic surgery
Intraoperative inhalation of the long-acting prostacyclin analog iloprost for pulmonary hypertension
http://www.anesthesia-analgesia.org/cgi/content/abstract/91/2/291

  
 Development of Nonspecific Interstitial Pneumonitis Associated With Long-term Treatment of Primary Pulmonary ...
Barst, RJ, Rubin, LJ, Long, WA, et al (1996) A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension: the Primary Pulmonary Hypertension Study Group.
Development of Nonspecific Interstitial Pneumonitis Associated With Long-term Treatment of Primary Pulmonary Hypertension With Prostacyclin
Development of Nonspecific Interstitial Pneumonitis Associated With Long-term Treatment of Primary Pulmonary Hypertension With Prostacyclin -- Kesten et al.
http://www.chestjournal.org/cgi/content/full/116/2/566

  
 The Prostacyclin Analogue Treprostinil Blocks NFkappa B Nuclear Translocation in Human Alveolar Macrophages -- ...
Recent studies have demonstrated the therapeutic efficacy of prostacyclin for PPH ( 10-13).
Based on these observations, we hypothesized that prostacyclins
Other properties of prostacyclin may also be important
http://www.jbc.org/cgi/content/full/277/36/33344

  
 The Unique Ligand-binding Pocket for the Human Prostacyclin Receptor. SITE-DIRECTED MUTAGENESIS AND MOLECULAR MODELING ...
our feeling that the endogenous prostacyclin molecule would be
Prostacyclin agonists are now widely used for the treatment
suggested that prostacyclin may also be useful as a therapeutic
http://www.jbc.org/cgi/content/full/278/6/4250

  
 Prostacyclin is an autocrine regulator in the contraction of oviductal smooth muscle -- Arbab et al. 17 (12): 3053 -- ...
It is well established that prostacyclin relaxes vascular
Prostacyclin is an autocrine regulator in the contraction of oviductal smooth muscle
Prostacyclin is an autocrine regulator in the contraction of oviductal smooth muscle -- Arbab et al.
http://humrep.oupjournals.org/cgi/content/abstract/17/12/3053

  
 Subthreshold Doses of Specific Phosphodiesterase Type 3 and 4 Inhibitors Enhance the Pulmonary Vasodilatory Response to ...
Higgenbottam T (1987) The place of prostacyclin in the clinical management of primary pulmonary hypertension.
Subthreshold Doses of Specific Phosphodiesterase Type 3 and 4 Inhibitors Enhance the Pulmonary Vasodilatory Response to Nebulized Prostacyclin with Improvement in Gas Exchange -- Schermuly et al.
Subthreshold Doses of Specific Phosphodiesterase Type 3 and 4 Inhibitors Enhance the Pulmonary Vasodilatory Response to Nebulized Prostacyclin with Improvement in Gas Exchange
http://www.jpet.org/cgi/content/full/292/2/512

  
 A Novel Inhibitory Effect on Prostacyclin Synthesis of Coupling Factor 6 Extracted from the Heart of Spontaneously ...
Results are presented as mean in two experiments.
suggest that there may be undiscovered endogenous prostacyclin
function of this peptide, an inhibitory effect on prostacyclin
http://www.jbc.org/cgi/content/full/273/48/31778

  
 Prostacyclin Receptor Activation and Pial Arteriolar Dilation After Endothelial Injury in Piglets -- Leffler et al. 26 ...
in piglets, current evidence suggests that the role of prostacyclin
microvascular injury is returned by treatment with the prostacyclin
Therefore, the present experiments were designed to test the hypothesis
http://stroke.ahajournals.org/cgi/content/full/26/11/2103

  
 Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern? -- Massiera et ...
and primary preadipocytes from rat and human ( 21), and ii) prostacyclin
Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern?
Obesity is associated with metabolic disorders such as dyslipidemia,
http://www.jlr.org/cgi/content/full/44/2/271

  
 A MULTIDISCIPLINARY APPROACH TO DIABETIC NEUROPATHY TREATMENT
Diabetic neuropathy is a progressive disease that is most probably caused by the effects of a chronic deficiency of prostacyclin and prostaglandins.
Under conditions of hyperglycemia it may restore depressed PGI2 production by the vascular wall (Kunisaki, 1992).
In the case of diabetics, it behaves very much like prostacyclin because it causes prostacyclin to be liberated by the body.
http://www.geocities.com/bsy53/dn/neuropat.html

  
 The Additive Pulmonary Vasodilatory Effects of Inhaled Prostacyclin and Inhaled Milrinone in Postcardiac Surgical ...
The Additive Pulmonary Vasodilatory Effects of Inhaled Prostacyclin and Inhaled Milrinone in Postcardiac Surgical Patients with Pulmonary Hypertension
The Additive Pulmonary Vasodilatory Effects of Inhaled Prostacyclin and Inhaled Milrinone in Postcardiac Surgical Patients with Pulmonary Hypertension -- Haraldsson et al.
Consequently, we investigated the hemodynamic effects of inhaled
http://www.anesthesia-analgesia.org/cgi/content/abstract/93/6/1439

  
 MedlinePlus Medical Encyclopedia: Cor pulmonale
Calcium channel blockers, intravenous prostacyclin, or the oral medication bosentan may be used to treat pulmonary hypertension.
Diuretics may be given to remove excess fluid from the body.
Surgery may be used to reverse heart defects that cause cor pulmonale.
http://www.nlm.nih.gov/medlineplus/ency/article/000129.htm

  
 Recommendations on the management of pulmonary hypertension in clinical practice -- 86 (Supplement 1): 1 -- Heart
prostacyclin analogue UT-15, but pain at the injection site is
It may be effective in severely ill patients when administered chronically.
Children as young as 8 years have been treated with the subcutaneous
http://heart.bmjjournals.com/cgi/content/full/86/suppl_1/i1

  
 ARTHRITIS RELIEF 120 caplets MO151
Ginger, similar to curcumin, also inhibits the synthesis of thromboxane A2, a promoter of platelet aggregation and increases prostacyclin, an inhibitor of such activity (Medical Hypothesis 20:271, 1986).
In a study published in Prostaglandins Medicine (13:277, 1984), ginger was shown to inhibit platelet aggregation in vitro more effectively than onion or garlic.
http://www.youngagain.info/cgi-bin/product.cgi?id=1737

  
 Heart and Stroke Encyclopedia
Intravenous Prostacyclin — see Primary or Unexplained Pulmonary Hypertension
http://www.americanheart.org/presenter.jhtml?identifier=10000056

  
 Cholestrien Ingredients promotes Healthy Cholesterol Levels -------
Research on humans suggests that policosanol inhibits platelet aggregation, possibly by reducing the formation of thromboxane A2—a potent inducer of platelet aggregation—and increasing the production of prostacyclin, which is a potent inhibitor of platelet aggregation.
Excessive platelet aggregation can lead to the formation of blood clots and increased cardiovascular risk.
http://www.naturalvigor.com/pages/cholestrien2.html

  
 Long term treatment of pulmonary arterial hypertension with beraprost, an oral prostacyclin analogue -- Vizza et al. 86 ...
To evaluate the effects of one year's treatment with beraprost, an orally active prostacyclin analogue, in patients with severe
Long term treatment of pulmonary arterial hypertension with beraprost, an oral prostacyclin analogue -- Vizza et al.
Long term treatment of pulmonary arterial hypertension with beraprost, an oral prostacyclin analogue
http://heart.bmjjournals.com/cgi/content/abstract/86/6/661

  
 Internalization and Sequestration of the Human Prostacyclin Receptor -- Smyth et al. 275 (41): 32037 -- Journal of ...
From The Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104
Internalization and Sequestration of the Human Prostacyclin Receptor -- Smyth et al.
Articles by Smyth, E. Articles by FitzGerald, G. Internalization and Sequestration of the Human Prostacyclin Receptor
http://www.jbc.org/cgi/content/full/275/41/32037

  
 Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor -- Miggin et al. 269 ...
This article has been cited by other articles:
Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor -- Miggin et al.
Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor
http://www.ejbiochem.org/cgi/content/abstract/269/6/1714

  
 Glycosylation of the Human Prostacyclin Receptor: Role in Ligand Binding and Signal Transduction -- Zhang et al. 60 ...
Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania
Glycosylation of the Human Prostacyclin Receptor: Role in Ligand Binding and Signal Transduction -- Zhang et al.
Glycosylation of the Human Prostacyclin Receptor: Role in Ligand Binding and Signal Transduction
http://molpharm.aspetjournals.org/cgi/content/full/60/3/480

  
 Merriam-Webster Online
For More Information on "prostacyclin" go to Britannica.com
Get the Top 10 Search Results for "prostacyclin"
http://www.m-w.com/cgi-bin/dictionary?va=prostacyclin

  
 AJRCCM -- Sign In Page
Pulmonary Artery Pressure-Flow Relations after Prostacyclin in Primary Pulmonary...
http://ajrccm.atsjournals.org/cgi/content/full/165/3/338

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