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| | Propylthiouracil (IARC Summary & Evaluation, Volume 79, 2001) |
 | | The elimination of propylthiouracil in both humans and experimental animals is relatively rapid, and the major metabolic pathway is glucuronidation and excretion in the urine. | | | Propylthiouracil is not considered to be a human teratogen, although a small percentage of infants whose mothers received the drug during pregnancy developed transient hypothyroidism. | | | However, two analyses were published of one cohort study conducted in the United Kingdom and the USA of the cancer risk of patients, mainly women, with hyperthyroidism who had been treated with anti-thyroid drugs. |
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| | Drug Information: Propylthiouracil (Print Version) |
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| | Thyroid.org: Notes March 2005 |
| | During the study period, there were 94 reports of agranulocytosis, of which 18 (19 percent) were fatal, and 85 reports of granulocytopenia (2 fatal [2 percent]) in patients treated with carbimazole. | | | The number of prescriptions for each drug dispensed from 1981 to 2003 was obtained from the Department of Health. | | | Among patients treated with propylthiouracil, there were 12 cases of agranulocytosis (1 fatal [8 percent]) and 14 cases of granulocytopenia (1 fatal [7 percent]). |
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| | Carbimazole and the Thioamide/Thioureylene family |
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| | FDA Patient Safety News: Show #21, November 2003 |
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