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| | TOTAL INTRAVENOUS ANAESTHESIA WITH PROPOFOL |
 | | Depth of anaesthesia for each dog was assessed by the degree of muscle relaxation, toe-pinch withdrawal and palpebral reflex. | | | Langley and Heel (12) stated that the rate of propofol infusion would depend on any other adjunct drugs administered and the degree of surgical stimulation, but is usually from 0.15 to 0.4 mg/kg/min. | | | The dogs were conditioned for the experiments for 2 weeks and just before the experiments commenced, they were judged to be in good general health based on findings at complete physical examination. |
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http://www.isrvma.org/article/57_4_2.htm
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| | Nitric Oxide and Propofol |
| | This made propofol the best controllable intravenous hypnotic from a pharmacokinetic point of view (1,2, 151) Its clinical uses include ambulatory anesthesia, monitored anesthesia care, neuroanesthesia, cardiac anesthesia, pediatric anesthesia and sedation in the intensive care unit (2). | | | Propofol and its clinical relevance with NO Propofol (2,6-diisopropylphenol) is an intravenous anesthetic that is widely used for both induction and maintenance of general anesthesia. | | | Most importantly, propofol has been found to bear antioxidant capacity due to its structural similarity to -tocopherol (15-43), which is strongly related to free radicals. |
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http://www.priory.com/pharmol/propofol.htm
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| | Prevention of pain on injection with propofol |
| | Without any analgesic intervention, the incidence of pain on injection of propofol was about 70%. | | | A number of different interventions have been tried to reduce or prevent the pain on injection, and a systematic review tells us which of these interventions is likely to be effective. | | | Pethidine given with a tourniquet and metoclopramide given with a tourniquet also seemed to be effective. |
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http://www.jr2.ox.ac.uk/bandolier/booth/painpag/Acutrev/Other/Propinjp.html
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| | Anesthesia |
| | In a typical clinical procedure, known as balanced anesthesia, the patient is premedicated with a sedative intended to relieve pre-operative anxiety and facilitate the induction of anesthesia itself (often this is a benzodiazepine such as diazepam or midazolam; otherwise, a barbiturate such as thiopental or nonbenzodiazepine such as propofol may perform this function). | | | And in a study of propofol paralleling the isoflurane and sufentanyl studies of general anesthesia, patients who studied paired associates during surgery showed poor postoperative cued recall, but intact priming | | | Thus, the drugs involved in conscious sedation seem to impair explicit memory, while sparing implicit memory. |
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http://www.institute-shot.com/anesthesia_and_surgery.htm
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| | Information and news articles on propofol |
| | He had been given several other drugs to control pain and consciousness during surgery, including propofol, rocuronium and fentanyl. | | | Then she lay down with her fuzzy duck as Dr. Aly Mageed prepared to put a sedation drug called propofol into a permanent line in her chest. | | | CALMING APPROACH: New methods help children handle pain, fear of... |
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http://drugs.mongabay.com/news/propofol.html
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| | Publications 1997 |
| | Donders, A.R.T. The validity of basic assumptions underlying models for time-limit tests: Design and analysis of speed-accuracy trade-off experiments. | | | Dirksen, R., Ellenbroek, B.A., Van Egmond, J., and Cools, A.R. Responses of propofol in relation to GABA functionality of discrete oparts of the brain of rats. | | | Dirksen, R., Van Rijn, C.M., Ellenbroek, B.A., and Cools, A.R. Oorzaken van een individu-specifieke reactie op propofol: een dierexperimentele studie. |
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http://www.nici.kun.nl/Publications/1997/index.html
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| | Comparative effects of propofol versus fentanyl on cerebral oxygenation state during normothermic cardiopulmonary ... |
| | Department of Anesthesiology and Reanimatology, Gunma University, School of Medicine, Gunma, Japan | | | Comparative effects of propofol versus fentanyl on cerebral oxygenation state during normothermic cardiopulmonary bypass and postoperative cognitive dysfunction | | | Comparative effects of propofol versus fentanyl on cerebral oxygenation state during normothermic cardiopulmonary bypass and postoperative cognitive dysfunction -- Kadoi et al. |
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http://ats.ctsnetjournals.org/cgi/content/abstract/75/3/840
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| | Treatments and Procedures |
| | Pediatric Pain Education, on the Univ of Iowa College of Nursing site ( Link broken 9/04: it might come back online) | | | Several different drugs can be used for sedation during procedures: Versed, Propofol, and Ketamine. | | | Versed (often used in combination with a pain reliever) results in your child being sedated but awake; Propofol causes them to lose consciousness; Ketamine causes them to lose consciousness for a longer period than does Propofol, sometimes it causes hallucinations upon awakening. |
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http://www.acor.org/ped-onc/treatment/treatment.html
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| | MedlinePlus Drug Information: Anesthetics, General (Systemic) |
| | Propofol is used sometimes in patients in intensive care units in hospitals to cause unconsciousness. | | | Propofol has been tested in children to produce loss of consciousness before and during surgery. | | | This may allow the patients to withstand the stress of being in the intensive care unit and help the patients cooperate when a machine must be used to assist with breathing. |
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http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/203043.html
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| | PedsCCM: Case Reports |
| | Lactic acidemia and bradyarrhythmia in a child sedated with propofol. |
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http://anes01.wustl.edu/Rare_cases.html
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| | Diprivan Side Effects, and Drug Interactions - Propofol - RxList Monographs |
| | Diprivan Side Effects, and Drug Interactions - Propofol - RxList Monographs | | | No significant adverse interactions with commonly used premedications or drugs used during anesthesia or sedation (including a range of muscle relaxants, inhalational agents, analgesic agents, and local anesthetic agents) have been observed. | | | Adverse event information is derived from controlled clinical trials and worldwide marketing experience. |
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http://www.rxlist.com/cgi/generic2/propof_ad.htm
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| | propofol rate calculator |
| | For our purposes, use the lower limit of 50 mcg/kg/min. | | | As the doctor prepares to intubate, he asks you to give 2.5 mg/kg of propofol (10 mg/mL) IVP. |
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http://www.manuelsweb.com/propofol.htm
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| | AkabasLab |
| | Williams, D.B. and Akabas, M.H. (2002) Structural evidence that propofol stabilizes different GABA | | | Bali, M. and Akabas, M.H. (2004) Defining the propofol binding site on the GABA |
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http://akabaslab.aecom.yu.edu/publications.html
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| | Pediatrics -- Sign In Page |
| | Continuous Propofol Infusion in 142 Critically Ill Children | | | If you have an individual print subscription to Pediatrics, online access is included. |
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http://www.pediatrics.org/cgi/content/full/110/6/1177
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