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| | Complications: Preeclampsia, Eclampsia and HELLP Syndrome |
 | | Rarely, preeclampsia progresses to a life-threatening condition called eclampsia, which includes convulsions and sometimes leads to coma and death of the mother and baby. | | | Occasionally, a woman’s blood pressure continues to rise despite treatment, and labor must be induced to prevent health problems for the mother and her baby. | | | Women with preeclampsia may also have swelling (edema) of the hands and feet, sudden weight gain (a pound a day or more), blurred vision, severe headaches, dizziness and intense stomach pain. |
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http://www.marchofdimes.com/pnhec/188_1054.asp
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| | Study Finds Aspirin Does Not Prevent Preeclampsia In High-Risk Women |
| | "Women at high risk of preeclampsia should not be given aspirin therapy to prevent the condition, as our study shows it doesn't work." said Dr. Donald McNellis, the NICHD project officer for the study and an author of the paper. | | | Although the high blood pressure accompanying preeclampsia can be treated with blood pressure lowering drugs, the only curative treatment for the overall condition is immediate delivery. | | | The trial, reported in today’s New England Journal of Medicine, was conducted by researchers at the National Institute of Child Health and Human Development (NICHD) Network of Maternal-Fetal Medicine Units, a network of 13 clinical research centers studying various aspects of maternal-fetal medicine. |
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http://www.pslgroup.com/dg/6168a.htm
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| | NGC - NGC Summary |
| | The objectives of therapy for preeclampsia are based on a philosophy of management arising from the knowledge of the pathology, pathophysiology, and prognosis of the disorder for mother and baby. | | | The first is to recognize preeclampsia early; the second is to observe progression of the condition, both to prevent maternal complications by delivery and to determine whether fetal well-being can be safely monitored with the usual intermittent observations. | | | Delivery is always appropriate therapy for the mother but may not be so for the fetus. |
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http://www.guideline.gov/summary/summary.aspx?doc_id=1478
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| | Simple blood test may be able to predict risk of preeclampsia |
| | "Preeclampsia can be devastating, and unfortunately we do not have a way to treat women with this condition," says author Ravi Thadhani, MD, MPH, of the MGH Renal Unit, the study?s senior author. | | | Wolf adds that the possibility of being able to identify at-risk women earlier in their pregnancies could lead to advances in the search for preventive therapies. | | | "Finding a way to predict who will develop preeclampsia is a necessary first step to testing new therapies." |
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http://www.eurekalert.org/pub_releases/2002-04/mgh-sbt040102.php
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| | Prevention Of Preeclampsia With Low-Dose Aspirin In Healthy, Nulliparous Pregnant Women |
| | The incidence of preeclampsia was lower in the aspirin group (69 of 1485 women (4.6 percent)) than in the placebo group (94 of 1500 women (6.3 percent)) (relative risk, 0.7; 95 percent confidence interval, 0.6 to 1.0; P = 0.05), whereas the incidence of gestational hypertension was 6.7 and 5.9 percent, respectively. | | | Furthermore, despite the reduction in the incidence of preeclampsia among the aspirin-treated women, there was no beneficial effect on overall perinatal morbidity, and aspirin was associated with an increased incidence of abruptio placentae. | | | In our study (which involved more women than the other studies), not only was there a small reduction in the incidence of preeclampsia among the women who received aspirin, but also the women in this group in whom preeclampsia did develop were more likely to deliver their infants earlier. |
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http://smi-web.stanford.edu/people/purcell/docs/rsch-nejm-94019534.html
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| | Preeclampsia and eclampsia |
| | About 33% of all patients with preeclampsia will have the condition again with later pregnancies. | | | More information on how preeclampsia and eclampsia develop is needed before recommendations can be made on how to prevent these conditions. | | | Although even carefully monitored patients may develop preeclampsia and eclampsia, close monitoring by practitioners will help decrease the complications of these conditions. |
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http://www.chclibrary.org/micromed/00061670.html
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| | Preeclampsia |
| | The only "cure" for preeclampsia is the delivery of the baby. | | | However, preeclampsia can progress into a life-threatening situation (eclampsia) for both the mother and the fetus. | | | The decision to deliver the baby early is dependent on the severity of the disease and the status of the mother and child. |
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http://www.solveyourproblem.com/medifocus/preeclampsia.html
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| | Preeclampsia -- familydoctor.org |
| | If your doctor sees that your blood pressure is high, he or she will watch you closely for changes that could mean you have preeclampsia. | | | Fortunately, preeclampsia is usually detected early in women who get regular prenatal care, and most problems can be prevented. | | | Does high blood pressure mean I have preeclampsia? |
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http://familydoctor.org/064.xml
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| | [Clinical Preventive Services] Screening for Preeclampsia |
| | Clinical experience, however, suggests that early detection and treatment of preeclampsia is beneficial to the patient and fetus.1,5,9,14 This view is based in part on inferences drawn from the apparent effectiveness of regular prenatal care in reducing the complications of preeclampsia-eclampsia. | | | In addition, maternal posture can significantly affect blood pressure in pregnant women;17 the results can be erroneous, for example, if blood pressure is measured with the woman in the supine position. | | | The early detection of hypertension during pregnancy permits clinical monitoring and prompt therapeutic intervention for severe preeclampsia or eclampsia. |
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http://cpmcnet.columbia.edu/texts/gcps/gcps0047.html
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| | High Blood Pressure in Pregnancy - Preeclampsia |
| | The only way to "cure" preeclampsia is to deliver the baby. | | | Other symptoms that seem to occur with preeclampsia include persistent headaches, blurred vision or sensitivity to light, and abdominal pain. | | | According to the National High Blood Pressure Education Program (NHBPEP), preeclampsia does not in general increase a woman's risk for developing chronic hypertension or other heart-related problems. |
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http://catalog.nucleusinc.com/displaymonograph.php?MID=60
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| | Report of the Working Group on Research on Hypertension During Pregnancy |
| | Because of the clear public health concerns engendered by hypertensive disorders of pregnancy, and the urgency of providing new directions in research, the National Heart, Lung, and Blood Institute (NHLBI), with input from the National Institute of Child Health and Human Development (NICHD) convened a Working Group on Research on Hypertension During Pregnancy. | | | A protocol for a similar trial has been developed in the National Institute of Child Health and Human Development's (NICHD) Maternal-Fetal Medicine Units Network and the possibility of a collaborative arrangement of the NHLBI with NICHD in conducting such a trial should be explored. | | | The outcome for mother and infant is worse than for de novo preeclampsia. |
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http://www.nhlbi.nih.gov/resources/hyperten_preg
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| | Preeclampsia |
| | Although no definitive studies show that bed rest improves the outcome for you and your baby when you have preeclampsia, it's true that blood pressure is generally lower when you're at rest. | | | It's also important to be aware of the warning signs of preeclampsia so that you can alert your caregiver and get treated as soon as possible. | | | One theory is that it happens when the placenta fails to implant properly in the lining of your uterus and your arteries in that area don't dilate as they should, so less blood flows to the placenta. |
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http://www.babycenter.com/refcap/pregnancy/pregcomplications/257.html
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| | CTF Full Text Review: Preeclampsia |
| | All showed that low-dose aspirin can effectively reduce pregnancy-induced hypertension and preeclampsia and IUGR associated with the conditions. | | | However, there is grade II-2 evidence that regular prenatal care is associated with a reduced incidence of preeclampsia. | | | However, early detection of hypertension during pregnancy permits clinical monitoring and prompt therapeutic intervention should severe preeclampsia or eclampsia develop. |
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http://www.ctfphc.org/Full_Text/Ch13full.htm
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| | UNC Center for Maternal and Infant Health: Preeclampsia |
| | Ultrasound and monitoring the baby’s heartbeat are used to check the growth and health of the baby. | | | These medicines may be given by mouth or in a vein (IV.) They cause your blood vessels to relax. | | | The only cure is delivery of the baby. |
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http://www.mombaby.org/level2/preec.html
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| | Preeclampsia |
| | The American Medical Association (AMA) points out that not all high blood pressure during pregnancy indicates preeclampsia but should still be treated appropriately. | | | Prenatal care is crucial in spotting the condition in its early stages when it can be treated. | | | One in 20 women in their first pregnancies will develop a condition called preeclampsia. |
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http://www.stayinginshape.com/4drhs/libv/w21.shtml
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| | eMedicine - Preeclampsia (Toxemia of Pregnancy) : Article by Matthew Warden, MD |
| | Medicine is a constantly changing science and not all therapies are clearly established. | | | Seizures remain a great concern for any patient with preeclampsia. | | | The increased blood flow and pressure is felt to lead to capillary dilatation, which damages end organ sites, leading to hypertension, proteinuria, and edema. |
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http://www.emedicine.com/med/topic1905.htm
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| | High Blood Pressure During Pregnancy (Preeclampsia) |
| | Currently, there is no sure way to prevent preeclampsia. | | | Severe preeclampsia affects the mother's blood system, kidneys, brain, and other organs. | | | Your doctor will measure your blood pressure and test your urine at each prenatal checkup. |
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http://www.beryl.net/htl/pregnancy/22208.htm
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| | Blood Chemistry Imbalance Linked to Potentially Fatal Disorder of Pregnancy |
| | Other researchers have tried to determine the levels of these compounds in women before they developed preeclampsia. | | | These conditions, in turn, may place the infants at risk for a variety of other birth complications. | | | About 5 percent of first-time mothers and 1 to 2 percent of mothers having subsequent pregnancies develop the condition, Dr. Mills said. |
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http://www.nichd.nih.gov/new/releases/preecpg.cfm
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| | Vitamin C Deficiency May Be Factor for Preeclampsia |
| | This would provide one with the benefit of receiving as yet identified accessory nutrients which would be beneficial in the treatment and prevention of this condition. | | | Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. | | | Normally, the body uses naturally produced nitric oxide (NO) to help keep blood vessels relaxed, which helps keep blood pressure in check. |
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http://www.mercola.com/2001/jun/20/preeclampsia.htm
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| | Preeclampsia |
| | Birthing A New Model Of Aspirin Therapy In Preeclampsia - Science Daily, 4/9/05 | | | Preeclampsia in Pregnancy Increases Risk of Future Cardiovascular Disease and Death - Doctor's Guide, 4/12/05 | | | Aspirin Before Bed May Reduce Risk For Preterm Delivery, Gestational Hypertension And Preeclampsia - Doctor's Guide, 9/27/02 |
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http://qualitycounts.com/fppreeclampsia.htm
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| | Can Preeclampsia Cause Cancer? |
| | The question of why there might be a relationship between preeclampsia and cancer remains unanswered, the study authors say. | | | Women who'd had preeclampsia appeared to have about a 30 percent increased risk of cancer in general, compared with women who had not developed the condition during pregnancy. | | | THURSDAY, March 4 (HealthDayNews) -- Women with a history of preeclampsia may have a higher risk of developing cancer, especially cancers of the stomach, breast, ovary, lung and larynx, a new study says. |
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http://www.healthcentral.com/newsdetail/408/517772.html
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| | Preeclampsia |
| | This allows for the early recognition and treatment of conditions such as preeclampsia. | | | Although there are currently no known prevention methods, it is important for all pregnant women to obtain early and ongoing prenatal care. | | | Preeclampsia does not appear to lead to chronic high blood pressure. |
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http://www.pennhealth.com/ency/article/000898.htm
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| | The elusive preeclampsia factor discovered? |
| | Taken together, as discussed in an accompanying commentary by Peter Carmeliet and Aernout Luttun (of Katholieke Universiteit Leuven, Belgium), these results suggest a plausible scenario of what goes wrong during preeclampsia, and point to molecules and molecular pathways that are potential targets for therapeutic intervention. | | | Irrespective of pregnancy, the exposed rats exhibited several of the hallmark clinical and pathological features of preeclampsia, providing a strong argument for a causal role for sFlt1. | | | A compromised vascular system could explain many of the symptoms of preeclampsia. |
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http://www.eurekalert.org/pub_releases/2003-03/joci-tep022603.php
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| | Preeclampsia: lifeclinic.com |
| | Although smoking has not been associated with an increased incidence of preeclampsia, you should still quit smoking when you become pregnant. | | | To minimize risk to yourself and your baby, work with your doctor to control your blood pressure before your pregnancy, if possible, and after you become pregnant. | | | Although most symptoms of preeclampsia can be managed with medical care, the only real cure is to deliver the baby. |
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http://www.lifeclinic.com/focus/hypertension/why_it_matters-pre.asp
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| | Pregnancy Weekly - Helpful and trusted information about Pregnancy |
| | It's not yet known how effective this is, but what is known is that early diagnosis and care lead to great outcomes for both mother and child. | | | After your baby is delivered safe and sound, your blood pressure will probably return to normal within the next few days or weeks, with or without medication. | | | Moms carrying multiple babies and moms with diabetes, chronic high blood pressure, kidney disease, lupus, hypertension, or a family history of preeclampsia, or any condition their caregiver advises them increases their chances of contracting it, often take a baby aspirin each day of their pregnancy as a preventive measure. |
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http://www.pregnancyweekly.com/topics/preeclampsia.htm
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| | Preeclampsia and Diet |
| | For some time, we’ve known that changes in blood vessels lead to high blood pressure characteristically seen in this condition," said James Roberts, M.D., co-author on the study, director of Magee-Womens Research Institute and professor of obstetrics and gynecology and reproductive sciences. | | | Well, I am no physician, biologist, or researcher, but I think I have discovered a clue from my own personal experience. | | | Untreated, preeclampsia may lead to eclampsia, an end-stage condition involving seizures. |
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http://www.sugaraddict.com/Preeclampsia.html
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| | MedlinePlus: High Blood Pressure in Pregnancy |
| | Substances Found in Blood May Predict Development of Preeclampsia (National Institute of Child Health and Human Development) | | | Your Guide to Lowering High Blood Pressure: Preeclampsia in Pregnancy (National Heart, Lung, and Blood Institute) | | | Substance in Urine Predicts Development of Preeclampsia (National Institute of Child Health and Human Development) |
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http://www.nlm.nih.gov/medlineplus/preeclampsia.html
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| | Researchers: High Cholesterol Is Risk Factor for Preeclampsia |
| | The researchers found a strong association between elevated cholesterol and preeclampsia. | | | "This may prove to be one of the few controllable risk factors for preeclampsia, a disorder for which we have no treatment and one that affects thousands of women every year," says Ravi Thadhani, an instructor in medicine at Harvard Medical School. | | | While preexisting diabetes and high blood pressure have been identified as risk factors, standard treatments for those conditions have not been effective in reducing the risk. |
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http://www.news.harvard.edu/gazette/1999/10.07/pree.html
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| | OBGYN.net - Definitions of Preeclampsia |
| | "[Preeclampsia] is determined by increased blood pressure accompanied by proteinuria, edema, or both. | | | This level of proteinuria will generally correspond with about 300 mg. | | | "Gestational proteinuric hypertension may be regarded as synonymous with 'preeclampsia.'" |
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http://www.obgyn.net/english/ob/Preeclampsia_Definitions.htm
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| | preeclampsia research laboratories home page |
| | raising awareness and providing information to women and their families about preeclampsia; | | | Australia has some of the world leaders in research and treatment for preeclampsia. | | | expert information on preeclampsia and stories from patients |
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http://www.preeclampsia.org.au
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| | Pregnancy-Induced Hypertension (PIH) |
| | When researchers measured the levels of these antioxidants in the blood of 30 women with preeclampsia and 44 women without, the found those with preeclampsia had much lower levels. | | | Maternal periodontal disease is associated with an increased risk for preeclampsia. | | | In the Dec. 1997 issue of Journal Watch/Women's Health, there is a synopsis of a Lancet article on Ketanserin, an antihypertensive drug that also prevents platelet aggregation and its ability to reduce the rate of preeclampsia. |
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http://www.gentlebirth.org/archives/pih.html
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| | Preeclampsia Blueprint for Health |
| | , a condition in which blood pressure increases drastically, and, if left unchecked, can endanger the lives of both mother and baby.Since preeclampsia can severely restrict the flow of blood to the | | | • If I get preeclampsia, how will it be treated? | | | If you don't treat it, you may be in danger of developing |
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http://blueprint.bluecrossmn.com/topic/257
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| | NEJM -- Circulating Angiogenic Factors and the Risk of Preeclampsia |
| | Methods We performed a nested case–control study within | | | MAYNARD, S. Soluble Fms-like Tyrosine Kinase 1 and Endothelial Dysfunction in the Pathogenesis of Preeclampsia. | | | mean serum level in the women with preeclampsia was 4382 pg |
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http://content.nejm.org/cgi/content/short/350/7/672
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| | UpToDate Pathogenesis of preeclampsia |
| | Additional signs and symptoms that can occur include edema, visual disturbances, headache, epigastric pain, thrombocytopenia, and abnormal liver function [ 1 ]. | | | Our current understanding of pathologic changes that are seen in preeclampsia and the mechanisms by which they might occur will be reviewed here. | | | The clinical features and management of preeclampsia, and treatment of hypertension during pregnancy are discussed separately. |
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http://patients.uptodate.com/topic.asp?file=pregcomp/17763
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| | Preeclampsia and High Blood Pressure During Pregnancy -- Topic Overview |
| | However, it is closely monitored because it can be a sign of a more serious condition, such as preeclampsia. | | | For this reason, you are likely to be treated with medication to lower your blood pressure if your diastolic blood pressure reading is 100 or higher (this is the second, or lower, number). | | | It can also turn out to be a sign of preeclampsia, a pregnancy-related problem that can become life-threatening for you and/or your fetus. |
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http://my.webmd.com/hw/being_pregnant/hw2837.asp
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| | Pieces of the preeclampsia puzzle -- Luft 18 (11): 2209 -- Nephrology Dialysis Transplantation |
| | Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. | | | has been established in earlier studies of preeclampsia. | | | Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop preeclampsia. |
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http://ndt.oupjournals.org/cgi/content/full/18/11/2209
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| | Preeclampsia Foundation Home |
| | If you are visiting this site because you are not feeling well, please contact your health professional or clinic immediately. | | | This site is dedicated to the memory of Taylor Hope, Harley, Angel and all the other babies and women who have lost their lives to preeclampsia. |
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http://www.preeclampsia.org
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