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| | The Pituitary Foundation Newsletter Radiotherapy and pituitary tumours (6) |
 | | In conclusion, radiotherapy has curative potential for pituitary tumours, but is best employed in conjunction with surgery or dopamine agonist (usually bromocriptine) therapy and usually as the second therapy. | | | Recently, the technique of radiosurgery has been applied to the treatment of pituitary tumours. | | | Whilst there is no doubt that surgery is the first treatment for most pituitary tumours (except prolactinomas), a wide 'margin of surgical safety' may not be possible, especially for larger tumours, without risking damage to neighbouring structures such as the optic nerves or major blood vessels. |
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http://www.pituitary.org.uk/newsletter/treatment/6-medmatters.htm
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| | NEOPLASM |
| | Adjuvant therapy in the form of chemotherapy and or radiotherapy is used in high-grade tumours. | | | Pituitary tumours usually present with headaches, which is related to increased tension within the sella turcica and pull on the surrounding dura. | | | The most appropriate surgical approach to Pituitary tumour is transsphenoidal. |
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http://www.health.adelaide.edu.au/paed-neuro/neoplasm.html
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| | Pituitary tumours : CancerBACUP |
| | Tumours affecting the whole of the central nervous system (CNS), which is made up of the brain, the spinal cord and a network of nerves throughout the body, are fairly rare. | | | As the tumour grows it puts pressure on the optic nerve (which leads to the eye) and this often causes headaches and sight problems. | | | Symptoms in men may include impotence (loss of the ability to have an erection). |
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http://www.cancerbacup.org.uk/Cancertype/Brain/Typesofbraintumour/Pituitarytumours
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| | PITUITARY TUMOURS - HYPOPITUITARISM |
| | Reduced pituitary function may also follow either surgery for tumours near the pituitary or result from radiotherapy to the brain for another condition. | | | Vision may be lost if larger pituitary tumours which press on the optic nerves are not treated. | | | If a tumour was pressing on the optic nerves affecting vision, this often improves and can return to normal. |
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http://www.surgerydoor.co.uk/medical_conditions/Indices/P/pituitary_tumours.htm
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| | pituitary tumours - General Practice Notebook |
| | Pituitary adenomas account for between 5% and 10% of intracranial tumours and present as a result of their endocrine effects or because of the compression of the visual pathways. | | | Pituitary microadenomas may be associated with headache and may ultimately expand to cause chiasmal compression. | | | Please read through our terms and conditions: 1. |
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http://www.gpnotebook.co.uk/medwebpage.cfm?ID=1047199752
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| | Pituitary tumour |
| | Treatment options for pituitary tumours include surgery to remove the tumour, radiation therapy and medication. | | | Benign tumours don't spread to other parts of the body, so there is no chance of secondary tumours developing. | | | If surgery is necessary, they will refer you to a neurosurgeon with a special interest in pituitary tumour surgery. |
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http://www.disability.vic.gov.au/bhcv2/bhcarticles.nsf/pages/Pituitary_tumour?open
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| | Cancer Information, Research, and Treatment for all Types of Cancer OncoLink |
| | This approach may be of clinical value in patients with clinically nonfunctioning adenomas to monitor the effects of radiotherapy. | | | Improvement of visual deficit was observed in 3/4 (75%) and ocular paresis in 3/3 (100%) of affected patients. | | | Galanin in human pituitary adenomas: frequency and clinical significance. |
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http://www.oncolink.upenn.edu/types/article.cfm?c=4&s=9&ss=72&id=8346
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| | Sandostatin.com Global for Healthcare Professionals - Acromegaly Treatment |
| | Surgery is most successful in patients who have pituitary tumours no larger than 10 mm in diameter. | | | According to Expert Consensus Guidline, external pituitary radiotherapy should not be used as the primary therapy except under extraordinary circumstances. | | | Transsphenoidal surgery is an invasive procedure performed to remove pituitary tumours. |
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http://www.sandostatin.com/treating_acromegaly/treatment_algorithm
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| | Medicdirect - Comprehensive UK Health Information |
| | Pituitary tumours often impinge upon nerves that connect the eyes to the brain, detailed assessment of the visual field will also be carried out. | | | Pituitary surgery is often carried out through a sinus that is located behind the nose and can be done through one of the nostrils. | | | In patient's in whom the tumour is causing symptoms, surgery is usually the main modality of treatment with peri-operative hormonal treatment undertaken in consultation with an endocrinologist. |
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http://www.medicdirect.co.uk/diseases/default.ihtml?pid=1414&step=4
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| | Pituitary tumours |
| | The treatment is surgery to remove as much of the tumour as possible. | | | It is not so important to remove the entire tumour because radiotherapy after surgery will usually cure the condition. | | | Specific Cancers : Brain Tumours : Treating brain tumours : Which treatment? |
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http://www.cancerhelp.org.uk/help?page=5310
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| | Pituitary Gland Tumours |
| | Pituitary adenomas can cause pressure particularly on the optic nerve which leads to problems with vision and can cause headaches. | | | (For example a prolactin secreting tumour can be treated with a drug called Bromocriptine.) | | | Surgery: Is a common treatment for pituitary tumours. |
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http://www.braintumouraction.org.uk/pituitary.htm
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| | The Society for Endocrinology - Training |
| | Provided this is correctly carried out surgery in pituitary dependant Cushing's disease is effective (because the majority of tumours are microadenomas) in 80%. | | | Anatomical effects are best dealt with by surgery and transphenoidal surgery is the first approach in all but a very small minority. | | | For patients with hypersecretory pituitary tumours making prolactin, cabergoline is now the treatment of choice. |
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http://www.endocrinology.org/sfe/training/ent03/ent03_was.htm
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| | 8th INTERNATIONAL PITUITARY CONGRESS |
| | Special sessions are dedicated to optional hormone replacement therapy and to novel pituitary ligands. | | | There will also be interactive sessions during lunch in which eight different workshops will be presented covering the widest interests of the participants. | | | Apart from state-of-the-art presentations on the diagnosis and treatment of the most frequently occurring human pituitary tumours, many new recent developments in related aspects of their pathogenesis and pathology will be discussed. |
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http://www.pituitarycongress2003.com
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| | Pituitary |
| | Mayo Clinic provides information on pituitary tumors surgeries. | | | Explore these areas of the site to learn more about advances in our understanding and management of pituitary diseases, diagnostic tests, interesting case | | | The Pituitary Group is a multi-disciplinary clinic consisting of that evaluates and treats patients with pituitary adenomas, pituitary cysts, |
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http://hgh.sitesarea.com/q/hgh-pituitary.htm
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| | Pituitary tumour - Wikipedia, the free encyclopedia |
| | Most tumours are benign but are quite serious because of their position close to important brain structures. | | | Once tumours were categorised by their light microscopic appearance but now tumours are more reliably categorised by immunoperoxidase studies. | | | CT scans, MRI and other imaging techniques are important for determining size (and seriousness of tumours), growth over time and treatment options. |
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http://en.wikipedia.org/wiki/Pituitary_tumour
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| | H E TURNER et al.: Angiogenesis and pituitary tumours (Journal of Endocrinology) |
| | The aim of this study was to examine the relationship between angiogenesis and tumour behaviour and response to treatment in pituitary adenomas. | | | Angiogenesis in pituitary adenomas-relationship to endocrine function, treatment and outcome | | | Angiogenesis has been shown to be related to tumour behaviour, prognosis and response to treatment in many different tumour types. |
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http://journals.endocrinology.org/joe/165/joe1650475.htm
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| | Over-expression and over-activation of protein kinase B/Akt in human pituitary tumours |
| | The aim of the present study was to assess Akt expression in pituitary tumours as a possible altered pathway to explain our previous findings on low levels of p27 expression in pituitary tumours. | | | Phosphorylated Akt was also over-expressed in pituitary tumours. | | | Transcriptional expression of the two isoforms Akt1 and Akt2, was assessed by 'real-time' quantitative RT-PCR in 45 pituitary tumours and 9 normal pituitaries and protein expression of total Akt and phosphorylated Akt and p27 was assessed in 40 pituitary tumours and 10 normal pituitaries by Western blotting and immunohistochemistry. |
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http://www.endocrine-abstracts.org/ea/0007/ea0007p82.htm
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| | The Australian Pituitary Foundation - Newsletters |
| | Current Surgical Management of Pituitary Tumours (Dr Leigh Atkinson, Brisbane) | | | Other Pituitary Disorders: Non-Secreting Tumours, TSH and Gonadotropin-Secreting Tumours, Non-adenomatous lesions, and 'Incidentalomas' | | | The Emotional and Psychiatric Problems Associated with Pituitary Disease (Dr Peter White, UK Pituitary Foundation) |
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http://www.pituitary.asn.au/patient/pat_newsletters.htm
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| | Re: Can pituitary tumours cause nightmares? If so, how? |
| | So, disturbances in hypothalamic function such as those caused by pituitary tumors can indeed affect the regulation of sleep and emotional behavior. | | | Dear Laura, There is evidence that tumors of the pituitary, which grow to cause damage to a part of the brain called the hypothalamus which is just above the pituitary, do cause abnormalities in sleep and behavior. | | | Also, abnormalities in the function of a hypothalamic neurotransmitter called orexin (or hypocretin) has been found to cause narcolepsy, a syndrome of uncontrollable and inappropriate sleepiness (see the journal Nature Medicine, vol. |
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http://www.madsci.org/posts/archives/2001-08/997817539.Ns.r.html
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| | Endocrine Surgeon |
| | The tumours that arise are in the anterior pituitary and are: | | | Symptoms and treatment of Pituitary tumours in MEN 1 | | | Again this is best treated by transphenoidal surgery to remove the pituitary tumour. |
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http://www.endocrinesurgeon.co.uk/men/men3-4.html
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| | CARDIOVASCULAR SYSTEM |
| | The most common clinical consequence is Cushing's disease: hyperadrenocorticism results from adrenal cortical hyperplasia due to an ACTH-producing pituitary tumour. | | | A tumour which is not functional may have local effects on the optic nerve and may replace other pituitary cells and the hypothalamus. | | | The most common diseases of the pituitary are tumours. |
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http://www.bristol.ac.uk/vetpath/tutorials/endoc/pittum.htm
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| | AG HATRICK et al.: Effects of GH on pituitary tumour recurrence rates (European Journal of Endocrinology) |
| | Methods: This was a non-randomised observational study on patients recruited from the endocrine clinic. | | | Conclusion: Using a representative cohort of hypopituitary patients attending an endocrine clinic, GH replacement was not associated with an increased pituitary tumour recurrence rate. | | | The average length of treatment for the treated group was 3.6 patient years. |
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http://www.eje.org/eje/146/eje1460807.htm
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| | Hexapedia - Endocrinology |
| | Endocrinologists treat disorders of the pituitary, including growth disorders; diseases of the thyroid; diseases of the adrenal glands; diseases of the ovary and testes; and diabetes (although more commonly it is a diabetologist), a disorder of insulin secretion or sensitivity. |
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http://www.hexafind.com/encyclopedia/Endocrinology
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| | H PL et al.: FSH secretion and pituitary tumours (European Journal of Endocrinology) |
| | CLINICAL STUDY: FSH secretion predominates in vivo and in vitro in patients with non- functioning pituitary adenomas | | | Results: A median preoperative LH:FSH ratio of 0.33:1 was found in 38 patients with NFPAs. | | | Peritumourous 'normal' pituitary cell cultures from 20 additional pituitary tumour patients was used for comparison with the NFPA group. |
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http://www.eje.org/eje/fca/EJE01854.htm
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| | Endocrine Disease - Lab Results Page |
| | The major use of this assay is in the follow-up of patients with thyroglobulin-secreting thyroid carcinoma. | | | Increased urine HCG - this is formed by tumours having chorionic tissue, such as choriocarcinoma and embryonal carcinoma. | | | The levels of ACTH in turn are controlled higher up in the brain by the hypothalamus. |
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http://www.homepagez.com/pathology/LabResults/endocrineresults.htm
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| | Endocrine Malignancies Resource Directory - CancerIndex |
| | Pituitary Society, The This is an international society dedicated to the study and treatment of pituitary diseases. | | | Patient's information for Pituitary Tumours (CancerNet) Information about the disease, staging, and treatment overviews. | | | The Web site includes patient information about pituitary disorders and pituitary tumors. |
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http://www.cancerindex.org/clinks2e.htm
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| | Endocrine Surgeon |
| | The most common cause of pituitary disease are pituitary tumours. | | | These tumours can cause problems in a number of ways: | | | Other problems that can affect the pituitary are isolated deficiencies in any of the pituitary hormones, a phenomenon known as hypopituitarism. |
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http://www.endocrinesurgeon.co.uk/pituitary/pituitary2.html
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| | Brain Pathol 11(3):313-327; Clonality of Pituitary Tumours: More Complicated than Initially Envisaged? |
| | Early studies showed that sporadic human pituitary tumors are benign adenomas of monoclonal origin. | | | However, the evidence obtained from a number of studies indicate that morphology cannot predict clonality, clonality within a given tumour may be multiple or single, multiple tumours arising on the background of hyperplasia may be of identical or differing clonality, and multiple “sporadic” tumours within a gland may be of differing clonal origin. | | | These observations would be entirely compatible with an initiating stimulus resulting in hyperplasia of specific cell types in the pituitary, which itself gives rise to several distinct clones with variable potential to develop into tumours. |
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http://brainpath.medsch.ucla.edu/brainpath/abstracts/vol11/1103/1103ab0005.html
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| | Sequence analysis and transcript expression of the MEN1 gene in sporadic pituitary tumours |
| | Whilst a multi-step aetiology involving both oncogenes and tumour suppressor genes has been proposed for their development, the target(s) of these changes are less clearly defined. | | | Sequence analysis of all MEN1 coding exons and flanking intronic sequence, in tumours and matched patient leucocyte DNA, did not reveal mutation(s) in any of the 23 tumours studied. | | | A benign polymorphism in exon 9 was encountered at the expected frequency, and in seven patients heterozygous for the polymorphism the tumour showed retention of both copies of the menin gene. |
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http://www.nature.com/bjc/journal/v80/n1/abs/6690319a.html
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| | pituitary gigantism - definition of pituitary gigantism in the Medical dictionary - by the Free Online Medical ... |
| | This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. | | | pituitary gigantism - definition of pituitary gigantism in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia. | | | A rare form of gigantism caused by hypersecretion of pituitary growth hormone, usually the result of a pituitary adenoma. |
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http://medical-dictionary.thefreedictionary.com/pituitary%20gigantism
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| | Localisation and expression of insulin-like growth factor I (IGF-I) and its receptor in the human anterior pituitary ... |
| | However, human pituitary tumours and mouse primary pituitary cell culture contained radioimmunoassayable IGF-I. Similarly, different types of human pituitary tumours contained various high amounts of IGF-I. Thus, it is conceivable that local IGF-I and the IGF-IR may be involved in the progression of pituitary tumours as postulated for other tumour entities. | | | Localisation and expression of insulin-like growth factor I (IGF-I) and its receptor in the human anterior pituitary and pituitary tumours | | | The presence of IGF-I in supporting cells would likely suggest its function as maintenance factor while its occurrence in endocrine cells may imply paracrine/autocrine mediated regulations of endocrine cells by IGF-I which might be a valuable prognostic factor |
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http://www.research-projects.unizh.ch/med/unit40200/area374/p4347.htm
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